Articles tagged with Breast Cancer
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A new study found that blocking VEGFR-3 prevented lymphangiogenesis in a mouse model, potentially inhibiting tumor metastasis. The study suggests that targeting VEGFR-3 may be a viable therapeutic strategy to prevent lymphatic vessel growth and tumor spread.
A study found that women taking SSRIs with CYP2D6 variant alleles had lower tamoxifen metabolite levels, potentially impacting treatment efficacy. The authors suggest testing CYP2D6 genetic variants to personalize tamoxifen therapy.
Researchers found that 50% of c-MYC-induced mammary cancers persisted in mouse models despite c-MYC gene blockage. Residual cancer cells quickly recovered malignant properties after treatment and eventually progressed to independent growth states.
Researchers found that reduced CRBP-I function compromises RAR activity, leading to loss of cell differentiation and tumor progression. The study suggests that somatic CRBP-I loss may contribute to breast cancer development and highlights the need for further research into vitamin A's role in cancer prevention.
Researchers found women with invasive lobular carcinoma have a different disease type, benefiting from tailored treatment approaches. Alternative therapies like hormonal treatments may be more effective for this rare form of breast cancer.
Women diagnosed with breast cancer through physical examination are more likely to undergo chemotherapy and mastectomy compared to those detected by screening mammography. The study found that cancers detected by mammography were smaller and had lower rates of lymph node spread, allowing for less-toxic treatment options.
Women with breast implants after mastectomy have a lower mortality rate from breast cancer compared to those without implants, suggesting that breast implants may improve survival. The study of over 4,000 women found that implant recipients had a 12.4% mortality rate, half that of non-implant recipients.
Researchers at MIT have created a new mouse model of cancer syndrome by introducing point mutations in the tumor suppressor gene p53. The study shows that these subtle mutations can lead to a broad range of tumors in mice, potentially providing insights into treating cancers with similar genetic profiles.
Benjamin Raphael, a UCSD postdoctoral researcher, has been awarded a $500,000 Burroughs Wellcome Fund Career Award to analyze tumor genome architectures and identify genes important for tumor growth. His work aims to develop cancer diagnostics and understand how tumors behave and progress.
A recent study by UT Southwestern Medical Center found that one-third of long-term disease-free breast cancer patients have circulating tumor cells (CTCs), which are often associated with a higher risk of recurrence. However, the presence of CTCs in these patients after 20 years post-mastectomy is notable due to their low risk of recur...
An observational study found no increased risk of late-stage breast cancer for women screened every 2 years, except for those in their 40s. Annual screening may also not benefit women with dense breasts.
A study found that women at high risk of breast cancer have difficulty deciding whether to take tamoxifen, with factors such as personal history, physician advice, and perception of risk playing a significant role. Anxiety and psychological distress also influence decision satisfaction.
A study of 129 women with high breast cancer risk found that personal history and physician advice influenced decision-making, while perception of risk and lack of information also played a role. Women were more likely to take tamoxifen if they had an abnormal biopsy or received a doctor's recommendation.
A study of 124 radiologists found that the accuracy of mammographic interpretation is more closely related to characteristics such as direct feedback and training than years of experience or volume. The study suggests that increasing volume requirements may not improve performance.
A study of 646 breast cancer survivors in Quebec found that only slightly more women were unemployed at the end of three years compared to a similar group without cancer. Most women who stopped working did so voluntarily, and negative events like firings were rare in both groups.
A recent study found that ethanol exposure increases tumor size, blood vessel density, and VEGF levels in chick embryos, supporting the hypothesis that ethanol-induced angiogenesis contributes to cancer progression. The study provides new insights into the mechanisms underlying alcohol's association with various types of cancer.
A new molecular test uses a panel of genes to predict the risk of breast cancer recurrence and identify patients who will benefit from chemotherapy. The test shows that women with low risk of recurrence do not derive much benefit from chemotherapy, while those with high risk have a large benefit.
A recent re-analysis of large clinical trials found that chemotherapy significantly improves survival rates in patients with ER-negative tumors, reducing the risk of death by 56 percent. The study suggests that chemotherapy has a greater impact on ER-negative patients than previously thought.
The phosphatidylinositol 3 kinase (PI3K) pathway is crucial in breast cancer development, with aberrant levels and mutations affecting critical growth factor receptors. Researchers believe targeting central nodes in this pathway can effectively treat the disease.
A large phase III trial showed that sequential treatment with ELLENCE delivered superior disease-free and overall survival compared to FEC 100 alone. The sequential regimen resulted in a 17% reduction in relapse risk and a 23% reduction in mortality risk.
A new study by Fox Chase Cancer Center finds that a shortened course of radiation therapy for women after lumpectomy may be a viable alternative to traditional six-week treatments. The four-week treatment schedule showed comparable skin toxicity levels to longer courses, with most side effects resolving within six weeks.
Researchers at Thomas Jefferson University have developed a method to detect cancer gene activity outside the body, which could lead to earlier detection and treatment of breast cancer. The technique uses genetic probes to visualize sites of cancer gene activity, allowing for potential early diagnosis and targeted treatment.
The Advexin therapy, which delivers normal p53 genes to cancer cells, resulted in significantly smaller tumors and increased infiltration of T-lymphocytes, a key component of the immune system. After surgery, researchers found higher levels of normal p53 mRNA and an increase in the p53 protein, suggesting improved cancer response.
A study presented at the SABCS showed a 30 percent reduction in breast cancer recurrence when postmenopausal women with hormone-receptor-positive breast cancer were switched from tamoxifen to AROMASIN after 2-3 years. This finding supports ASCO recommendations for adjuvant therapy with aromatase inhibitors.
Researchers found that patients with basal-like and erbb2+ subgroups had the highest rates of pathological complete response to chemotherapy, while luminal tumors showed minimal response. The study suggests stratifying patients into molecular subgroups for more accurate treatment predictions.
A new study by Loyola Medicine found that tamoxifen or other hormonal therapy alone may not be sufficient to treat hormone-dependent breast cancer. Chemotherapy proved more effective in stopping cancer recurrence, especially when combined with tamoxifen.
The MammaPrint test uses gene expression profiling to assess recurrence risk in breast cancer patients, providing valuable assistance for oncologists. Approximately 70% of breast cancer patients are stage I and II, with nearly 50% under age 60.
A validation study has shown that a 70-gene signature is more effective than current standard criteria in predicting the time to distant metastasis and overall survival in breast cancer patients. The results have the potential to reduce chemotherapy prescriptions by up to 20% and improve quality of life for many women with breast cancer.
The ATAC study's 5-year follow-up results show anastrozole increased disease-free survival and reduced cancer recurrence, with fewer side effects compared to tamoxifen. Anastrozole is now considered the preferred initial adjuvant endocrine treatment for postmenopausal women with hormone-receptor-positive localised breast cancer.
A study published in JAMA found that MRI can accurately detect breast cancer with a high sensitivity rate of 88.1%, but its effectiveness decreases when ruling out malignancies. The technology is most beneficial for patients with difficult-to-interpret mammograms.
A study found breast MRI had a high sensitivity of 88.1% for detecting breast cancer, but moderate specificity of 67.7%. The imaging modality did not significantly improve outcomes for patients with mammographically or clinically suspicious lesions.
An international trial found that breast MRI significantly detected more cancers than mammography in high-risk young women with dense breast tissue. The study recommended MRI as a supplement to mammography for this group, improving cancer detection and potentially reducing mortality rates.
The study found that raloxifene reduced invasive breast cancer incidence by 59% and ER-positive invasive breast cancer by 66%, leading to a 66% and 76% reduction in these cancers after 8 years. No effect on ER-negative or non-invasive cancers was observed.
A study of over 20,000 women found tamoxifen reduces contralateral breast cancer risk by 47% in both African American and white populations. However, tamoxifen use is associated with a higher risk of thromboembolic events, particularly when combined with chemotherapy.
A new study found that smokers who start screening at age 50 or older have a risk for developing lung cancer similar to those who smoked heavily for many years. Annual CT screening can identify high percentages of Stage I diagnoses, the most curable form of lung cancer.
A new biopsy technique combining ultrasound and fine needle aspiration can reliably determine whether lymph nodes are malignant in women with breast cancer. The method allows for the identification of cancerous nodes without the need for sentinel lymph node sampling or axillary node dissection, saving patients from additional surgery.
Urinary incontinence and abdominal pain are key symptoms of ovarian cancer, with crampy abdominal pain being the most common symptom. The study found that women often ignore or downplay these symptoms, leading to delayed diagnosis.
BRCA1 mutations are found in only 5% of breast and ovarian cancers, but loss-of-function mutations can significantly increase cancer risk. Researchers review preclinical and clinical evidence to determine if BRCA1 function can predict chemotherapy response, highlighting the need for prospective studies.
A study of 189 breast cancer patients found no association between paclitaxel chemotherapy and radiation pneumonitis. No hospitalized cases or deaths from the side effect occurred, regardless of treatment group.
A recent study by the University of Texas M. D. Anderson Cancer Center has found no link between taxane-based chemotherapies and pneumonitis in breast cancer patients. The research, led by Tse-Kuan Yu, analyzed 189 breast cancer patients who received either radiation therapy or chemotherapy followed by radiation.
Researchers have discovered a lethal attraction between HER2-positive breast cancer cells and organs, explaining why this form of breast cancer is so invasive. The study found that breast cancer cells overexpressing HER2 proteins also ramp up production of CXCR4, leading to a strong chemical signal that attracts them to specific organs.
A large population study has found that most ovarian cancers in families with at least one woman with breast cancer are not related to BRCA1/2 mutations. Instead, other factors may contribute to the increased risk of ovarian cancer in these families.
Researchers at Mayo Clinic found that celecoxib reduces mammary gland tumor mass through apoptosis and regulates prostaglandin pathways. The study suggests celecoxib may be used to prevent and treat breast tumors.
A study of 806 women with early stage breast cancer found that regular physical activity significantly reduced the risk of weight gain and improved breast cancer prognosis. Physical activity was assessed during an in-person interview as part of the Health, Eating, Activity and Lifestyle (HEAL) study.
A new radiotherapy regime has been shown to significantly reduce local disease recurrence rates in young women with breast cancer. The treatment involves adding a boost dose of radiation to the tumour bed, resulting in a 5-year local recurrence rate of 8.5% in women under 35 years old.
IU researchers aim to capitalize on human genome data and powerful bioinformatics approaches to develop better therapies for ovarian and breast cancer patients. The study will focus on genetic and molecular consequences of DNA modifications to improve predictive models.
A new study found that racial differences and poverty significantly impact mammography use among poor, rural women over 40. Native American and African American women had lower knowledge of breast cancer screening procedures compared to white women. The study sheds light on the need for targeted interventions to improve cancer screenin...
Researchers identify LRP6 as a potential missing link in the cancer-causing chain, promoting cell proliferation and tumorigenesis. The study found increased LRP6 gene activity in human tumor samples from patients with breast and colon cancers.
A study found that African-American and Native American women had less information and more inaccurate beliefs about breast cancer screening compared to Caucasian women. Women cited pain, embarrassment, and lack of time as major reasons for not getting screened, highlighting the need for targeted interventions.
Dr. Jeffrey K. Springston, a UGA professor, has been awarded a $3 million grant to investigate the effectiveness of CD-ROMs versus person-to-person telephone consultations for promoting breast cancer screening. The study aims to determine which method is more cost-effective and can help increase mammography screenings among women.
A new protein, Rab25, has been associated with increased aggressiveness in both breast and ovarian cancers. Low levels of Rab25 protein expression were found to be linked to better clinical outcomes, with patients experiencing higher survival rates when tumors expressed low levels of the protein.
A new analysis by California Department of Health Services reveals breast cancer is the nation's fastest-growing rate, even as Asian Americans experience a lower death rate from cancer. This disparity highlights the need to address Westernization and increase cancer screening among Asian American women.
The Hmong community in California is disproportionately affected by certain types of cancer, such as nasopharyngeal and liver cancer, which are often diagnosed at late stages. This is largely due to limited access to education, awareness, and screening services, highlighting the need for increased efforts to address these disparities.
Researchers found ductal lavage detected only half of cancers in breasts with known cancer, possibly due to failure to yield fluid or cells misclassified as benign. The procedure's lack of effectiveness casts doubt on its use as a screening tool for high-risk women.
A study found that chemotherapy, but not tamoxifen, is linked to an increased risk of stroke in breast cancer patients. Women who had not completed menopause and those with a history of hypertension or diabetes were more likely to experience a stroke. The researchers conclude that women can use tamoxifen without concern for stroke risk.
A study found that late-stage breast cancer cases were often associated with an absence of screening, followed by absence of detection or a potential breakdown in follow-up care. Women from lower socioeconomic backgrounds and those without a family history of breast cancer were more likely to be in the absence-of-screening group.
A study found that women without recent mammograms were more than twice as likely to be diagnosed with late-stage breast cancer. The research highlights the importance of regular screenings, particularly for underserved populations.
A study suggests chemotherapy, not tamoxifen, is linked to increased stroke risk in women with breast cancer. Chemotherapy remains a key component of treatment despite this finding.
A pilot study found that ductal lavage detected only half of the cancers in breasts with known cancer. The procedure's effectiveness is limited by poor agreement between cytologic analysis and microscopic results. Mammography and physical examination remain the most effective methods of early detection.
A new Group Health study examines the link between hormone therapy (HT) and breast density in women of various categories. The study found that estrogen-only therapy increases breast density, while progesterone use does not; longer HT use and older age at first use also increase breast density.