Articles tagged with Breast Cancer
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Researchers identified two novel mutations in FGFR1 and PDGFRA, implicated in various cancers, suggesting potential for targeted therapies. The study aims to develop small molecules and antibodies to regulate mutated genes, offering new treatments for glioblastoma and other cancers.
A new study found that a computer-aided mammography detection system increased the detection rate of small invasive cancers by 164% in younger women. The CAD system helped detect these cancers more than five years earlier than without it.
The Mayo Clinic Cancer Center will lead a multidisciplinary team in translational research projects addressing breast cancer causes, prediction, and treatment. The SPORE grant aims to improve survival and quality of life for women with breast cancer.
Tissue stiffness influences cell growth and changes in function by modulating cell contractility, leading to the activation of key growth signaling pathways and increase in cell tension. This study highlights the importance of mechanical forces in tumor development and could lead to the development of new tumor therapies or targets.
A study of 199 families with multiple cases of breast cancer found that women from these families do not have an increased risk of ovarian cancer. Despite this, the genetic mechanism for up to half of hereditary breast cancer remains unknown, prompting ongoing research at Memorial Sloan Kettering Cancer Center.
This year's 25 MacArthur Fellows have made significant contributions to reducing cervical and breast cancer through innovative research. The award comes with a $500,000 grant that recipients can use as they see fit.
Men who survive testicular cancer are at higher risk of developing a second cancer for at least 35 years after diagnosis, mostly due to late side effects of treatment. Cancers such as bladder, colon, and stomach cancers account for most excess risks, with young patients facing even greater dangers.
A Penn research team found that Snail promotes breast cancer recurrence by inducing changes in tumor cell shape and gene expression. High Snail expression predicts rapid tumor recurrence in women treated for breast cancer.
A landmark breast cancer screening trial conducted by UVa Health System found no significant difference between digital and standard x-ray mammography in detecting breast cancer. The trial, DMIST, enrolled nearly 50,000 women and used both digital and film mammograms.
A recent study has identified a molecular pathway linked to breast cancer recurrence, suggesting that the transcriptional repressor Snail may play a role in progression. Genetic screening of human breast cancer samples revealed that high levels of Snail expression predict decreased relapse-free survival.
Researchers at Columbia University Irving Medical Center have developed a new type of virus, called a
The Digital Mammographic Imaging Screening Trial found that digital mammography is as good as film mammography in detecting breast cancer, but may be better for younger women. The study analyzed data from 49,528 women and provides some of the best data gathered on mammogram diagnostic accuracy.
The Digital Mammographic Imaging Screening Trial found that digital mammography improves breast cancer detection in high-risk populations. The study's results corroborate NCI's commitment to exploring advanced technologies to detect cancer earlier and improve outcomes.
A study of 55,371 postmenopausal women found that estrogen-progestin and estrogen therapies increased breast cancer risk by 29% and 10%, respectively, after five years. The association applied to all ethnic groups except African-Americans.
Researchers have identified Notch1 and Jagged1 as markers indicating a patient's probable prognosis for aggressive breast cancer. The study suggests that targeting the Notch signalling pathway may improve treatment outcomes for patients.
Researchers have identified two ADAMTS genes, ADAMTS8 and ADAMTS15, that can help predict disease outcome in breast cancer patients. The study reveals four categories of risk based on gene activity levels, with those in the highest risk category three times more likely to experience recurrence.
Researchers at the University of Pennsylvania School of Medicine have developed a cancer vaccine that uses the bacterium Listeria monocytogenes to boost an immune response against breast tumor-associated antigens. The vaccine was tested in mice with established breast tumors, resulting in complete tumor eradication after 100 days.
Scientists at The Wistar Institute have identified the cancer gene MYC as activating the metastasis gene MTA1, a key regulator of tumor spread. Blocking this pathway may prevent metastasis and inform the development of new therapies.
The study found two relapse peaks after surgery for breast cancer, with 20% of premenopausal patients relapsing within 10 months. Calculations predict that surgery-induced angiogenesis accelerates disease by two years and produces early deaths among screened young women.
A study in New Hampshire found that many women, especially older ones, are not getting regular mammograms. The researchers used registry data to track actual use, finding 36% of women over 40 had never had a mammogram or hadn't had one in 27 months.
A recent study published in the American Journal of Roentgenology found that batch reading mammograms results in lower recall rates and accurate cancer detection. The research analyzed 9,522 screening mammograms, with 1,538 interpreted by batch reading, showing a 20.1% to 16.2% decrease in recall rates.
A recent study confirms that letrozole treatment can improve the survival of women with node-positive disease and reduce metastasis risk. The study also found a 39% reduction in the risk of metastasis among participants receiving letrozole.
Researchers found ER-positive/PR-negative tumors may be more aggressive and respond poorly to tamoxifen, while EDNRB mutations are linked to melanoma risk. Farnesyltransferase inhibitors show promise against aerodigestive tract cancer cells.
Researchers found that women taking letrozole experienced a significantly better overall disease-free survival rate and distant disease-free survival rate compared to those on placebo. This study confirms the protective effect of extended adjuvant letrozole therapy for postmenopausal breast cancer patients.
Researchers found that the 'immune profile' of axillary lymph nodes can independently predict breast cancer recurrence. The study showed that immune cell numbers and composition in these nodes correlated with disease-free survival, outperforming other clinical parameters.
The US Task Force does not recommend routine screening for breast cancer gene mutations in women without a specific family medical history. However, they do suggest screening for women with a history of Ashkenazi Jewish descent, young-onset breast cancer, or multiple relatives with breast and ovarian cancer.
The US Preventive Services Task Force recommends routine genetic counseling for women with a family history of breast cancer or Ashkenazi Jewish descent. A new study found that tiotropium, an inhaled bronchodilator, reduces COPD flare-ups and hospitalizations compared to a placebo.
A new study by Kishan Pandya and colleagues found that gabapentin significantly reduced hot flash severity scores in women with breast cancer. The results suggest that gabapentin can be added to the list of non-hormonal agents for controlling hot flashes in these patients, with further studies needed on higher doses.
Researchers at The Breakthrough Toby Robins Breast Cancer Research Centre discovered the Scaramanga gene, which regulates early breast development and influences nipple number and position. This breakthrough may help understand normal breast formation and connect it to breast cancer.
A recent study has found that obese patients with estrogen-receptor negative (ER-negative) breast cancer are at risk of undertreatment due to reduced chemotherapy doses. The study, published in The Lancet, suggests that obese women with ER-negative disease who receive 85% or more of the recommended first course dose have significantly ...
Researchers found that women with ovarian cancer were more likely to present to physicians with abdominal swelling or pelvic pain up to 12 months before diagnosis. Diagnostic testing showed only a minority of patients received necessary tests, highlighting the need for earlier detection.
A recent study found that 71% of younger women with early-stage breast cancer discuss fertility-related information with healthcare professionals, while 86% discuss menopause. The research aims to educate women about fertility preservation methods and manage menopausal side-effects after treatment.
A large study of over 1000 women with BRCA1 and BRCA2 mutations found that weight loss is associated with a significant reduction in breast cancer risk. Women who lost at least 10 pounds between ages 18-40 had a 65% lower risk, while those who gained 10 pounds or more were at higher risk of developing the disease.
A study found that women are more likely to choose mastectomy over breast-conserving surgery due to fears of recurrence and radiation treatment. Despite this, overall survival rates are the same for both procedures.
Researchers at Sunnybrook Hospital have developed a unique mouse model that enables scientists to study how breast cancer spreads. By analyzing the genetic makeup of tumour cells, they hope to predict which tumours will metastasize and develop new treatments.
Researchers found that screen-detected breast cancers tend to have better prognoses than clinically detected ones, but may not lead to lower mortality. Meanwhile, patients on cetuximab therapy are at risk of hypomagnesemia and require magnesium supplementation. Additionally, men with Klinefelter syndrome may be more likely to develop c...
Researchers found that breast cancer detected by mammography has a substantially better survival prognosis, even after adjusting for stage of disease and tumor characteristics. The study suggests that this is due to the detection of slower-growing tumors, which are more likely to be node-negative.
A study by Carnegie Mellon University found that nutritional interventions and educational programs can significantly improve the quality of life for cancer survivors. Women who received either intervention were less likely to be depressed and more optimistic about their health than those with no intervention.
A study from Ohio State University's Comprehensive Cancer Center discovered a set of microRNAs that can distinguish between normal and cancerous breast tissue. The findings suggest that microRNA expression is correlated with breast cancer's hormone status, metastatic potential, and proliferative rate.
Tumors secrete fatty acids that block cytotoxic T lymphocytes' ability to kill cancer cells, reducing the efficacy of anti-cancer therapies. This discovery raises possibilities for new therapeutic targets and monitoring tumor aggressiveness through free fatty acid levels.
A new technique called the Checkerboard Tissue Microarray (TMA) Method has been developed to accurately predict prostate cancer aggressiveness. This method can help identify markers of aggressive tumors, potentially preventing thousands of men from undergoing unnecessary radical surgery and its severe side effects.
Researchers at McGill University have identified a genetic pathway responsible for breast cancer cell growth, including the FOXA1 gene. This discovery offers a new target for developing more precise treatments with fewer side effects.
Researchers identified 57 predictor genes that can accurately predict breast cancer patients' response to chemotherapy, offering a powerful tool for personalized treatment. These genetic markers can identify patients most likely to benefit from chemotherapy, potentially shifting focus away from standard treatments.
Researchers have discovered that cyclin D1 overexpression disrupts BRCA1's normal role as a cancer inhibitor in breast tumors. Cyclin D1 binds to the same estrogen receptor as BRCA1, negating its tumor suppressor function and promoting cell proliferation.
A combined analysis of two trials found a 40% decrease in risk of events such as recurrences or new cancers when switching from tamoxifen to anastrozole after 2 years. However, more patients experienced bone fractures on anastrozole.
Researchers found that the revised TNM staging system is strongly associated with disease-free survival and overall survival. The new system provides more accurate information about tumor response to chemotherapy, helping doctors determine the best treatment plan for patients.
Research has found a positive association between body mass index, fat-free mass, and waist circumference with an increased risk of myeloid leukemia. Additionally, modifications of the vimentin gene can be detected in fecal DNA of people with colon cancer, potentially serving as a biomarker for the disease.
Scientists discover that cyclin D1, overproduced in half of all breast cancers, can disrupt BRCA1's normal role as a cancer inhibitor. Cyclin D1 interferes with BRCA1 function by occupying the same binding site on estrogen receptor alpha, negating its tumor suppressor role.
Researchers at Stanford University have developed a nanotech-laser treatment that uses carbon nanotubes to selectively kill cancer cells, bypassing normal body tissue. The technique involves coating the nanotubes with folate molecules to target diseased cells, and shining near-infrared light on them to induce heat and destruction.
A study published in the International Journal of Cancer has found three proteins present in the blood of women with breast and ovarian cancer, but not in those without cancer. This breakthrough could lead to a simple blood test for early detection and improved patient outcomes.
A study by Memorial Sloan Kettering Cancer Center has identified a gene set associated with breast cancer metastasis to the lungs. The researchers found that over half of patients with tumors carrying this genetic 'thumbprint' developed lung metastases, whereas only 10% of those without it did.
Scientists pinpoint specific 'genetic endowment' genes that enable breast cancer tumors to metastasize to the lungs. The discovery offers a new set of molecular tools to test tumor biopsies, enabling early diagnosis and targeted treatment.
Researchers at Penn will employ a range of cellular and molecular imaging techniques to analyze genetically engineered mouse models of breast cancer. The goal is to understand the mechanisms underlying breast-cancer progression and develop more effective therapies against aggressive forms of this disease.
A new study suggests that PET imaging can identify which breast cancer patients are likely to respond to chemotherapy, allowing for more effective treatment and improved patient outcomes. This breakthrough could lead to the development of personalized treatment plans, giving patients and doctors more options.
A new study from UNC Health Care found that whole-body PET/CT scanners are highly accurate in detecting the spread and recurrence of head and neck cancer. The scans can pick up cancer where none was thought to exist, allowing for more precise biopsies and treatment planning.
MR spectroscopy enhances breast imaging by identifying chemical compounds in tumors, leading to increased cancer detection rates (94-100%) and improved accuracy (57%). This adds value to existing MR exams, reducing unnecessary biopsies and improving patient outcomes.
A gene called TRPS-1 is over-expressed in 90% of breast cancers, making it a potential target for cancer vaccines. Researchers are exploring its role and developing immunotherapy approaches to treat breast cancer.
A Mayo Clinic study found that breast biopsy utilization rates remained stable over a 12-year period despite the introduction of new technologies. The study also showed that the ratio between malignant and benign results remained stable at one malignancy for every 2.2 benign results.
Research reveals that high TRAIL-R2 expression in breast cancer patients is associated with poorer survival outcomes. The AQUA TM system was used to analyze tissue microarray specimens and identify correlations between receptor expression levels and clinical variables.
Researchers found a link between certain benign breast lesions and increased risk of breast cancer, particularly proliferative and atypical types. Women with non-proliferative forms had no increased risk as long as they didn't have a strong family history.