Articles tagged with Cerebellar Ataxia
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Home high-intensity aerobic training outperforms home balance training in improving ataxia symptoms, fatigue, and aerobic fitness among those with cerebellar ataxias. Regular training maintained benefits at 1 year.
Scientists found that cooling or warming the striatum region slows down or speeds up activity patterns, which correlates with rats' timing judgements. This provides evidence for the 'population clock hypothesis', suggesting that brains use decentralized and flexible sense of time.
A new study identifies the FGF14 gene as the most common genetic cause of late-onset ataxia in Quebec, a debilitating neurodegenerative condition. The discovery opens treatment possibilities and may lead to improved diagnosis for thousands of people worldwide.
Researchers have identified a well-concealed genetic variation in the FGF14 gene causing late-onset cerebellar ataxia, a brain disorder affecting coordinated movement. The study's findings could lead to new diagnostic tools and treatments for patients suffering from this condition.
Researchers at McGill University have discovered that exercise can restore health to cells in the cerebellum, a part of the brain affected by SCA6. The treatment also works on mice with other movement disorders, suggesting potential applications for other conditions.
A recent clinical trial conducted by Prof. Alexandra Durr's team found that riluzole does not improve symptoms in patients with spinocerebellar ataxia type 2, but provided valuable biomarkers for future trials. The study involved 45 patients and revealed a good tolerance and absence of adverse effects.
A Mayo Clinic study found that nearly three-quarters of patients with autoimmune cerebellar ataxia were women. The median duration from symptom onset to last follow-up was 25 months, with 51 patients experiencing physician-reported neurologic improvement with immunotherapy and cancer therapy.
A study of 118 adults with autoimmune cerebellar ataxia found that nonparaneoplastic disorders, detection of PMP antibodies, and GAD 65 antibodies predicted better immunotherapy response and neurological outcomes. Among the patients, 45.8% showed physician-reported neurologic improvement.
A study in Movement Disorders reveals that certain cerebellar ataxias can be effectively treated with regimens such as prescription drugs, high doses of vitamin E, and gluten-free diets. Early treatment is crucial to prevent neurological deterioration in these conditions.
Researchers have identified a novel candidate gene, SEL1L, in Finnish Hound dogs with early-onset progressive cerebellar degeneration. The study reveals a single nucleotide change in the SEL1L gene causing an amino acid change and endoplasmic reticulum stress.