Articles tagged with Chronic Inflammation
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A new study in mice suggests that forcing the turnover of specific immune cells called microglia can reverse cognitive and behavior problems associated with concussions. The findings provide a potential pathway for developing post-concussion therapies to ward off long-term mental health issues.
Researchers at Universitat Autonoma de Barcelona developed a new treatment that reduces chronic inflammation in multiple sclerosis mice models by administering Maresin-1, a lipid mediator. The substance significantly reduced cytokine levels and protected neurons from demyelination.
High blood pressure can cause long-lasting changes in the structure of vascular smooth muscle cells, stiffening arterial walls and increasing the risk of cerebrovascular disease. Researchers found that a signaling pathway triggered by E–T coupling is involved in this process, leading to inflammation and vascular remodeling.
Researchers have developed a new treatment for chronic inflammation by targeting the ASC protein with nanobodies, which can dissolve harmful molecular complexes and counteract inflammation. The treatment has shown promising results in mouse models, alleviating symptoms of rheumatoid arthritis and gout.
A study at Karolinska Institutet has revealed that a subgroup of innate lymphoid cells (ILCs) can accumulate in the intestinal mucosa of patients with inflammatory bowel disease (IBD). These immature cells can be influenced by gut environment factors, leading to increased cell division and cytokine production.
Researchers at the University of Illinois created quantum dots to visualize macrophages in fat tissue, shedding light on chronic inflammation's role in diseases. The new technology enables accurate cell counting and tracking over time, offering a potential diagnostic tool for insulin resistance and metabolic syndrome.
A clinical trial at UC Davis Health showed that cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy, stopping deterioration of upper limb and heart functions. The therapy appears to be safe and effective in improving skeletal muscle and cardiac function.
A biodegradable nanoparticle has shown promise in reducing skin and lung scarring in mice with scleroderma. The treatment targets specific immune cells responsible for the disease's chronic inflammation and scarring.
Researchers have identified how IL-36 cytokines instruct proinflammatory CD4+ T cells to accumulate in the inflamed intestine, worsening disease. This discovery offers fresh insights into targeting these proteins as a new therapeutic option for childhood IBD patients.
Researchers at TUM discover that intestinal bacteria interact with Paneth cells in the gut mucus layer, leading to chronic inflammation. This finding may lead to new treatments for IBD.
A recent study by researchers at Case Western Reserve University found that Candida tropicalis fungus can trigger chronic inflammation in the gut microbiome of Crohn's disease patients. This imbalance of fungi and bacteria can create a predisposition to inflammatory bowel disease.
Researchers at Brigham and Women's Hospital discovered a new mediator, 4S, 5S-epoxy-resolvin, that resolves acute inflammation and stimulates tissue regeneration. The study found that this mediator also controls granuloma formation in human leukocytes.
Researchers at Karolinska Institutet discovered that omega-3 fatty acids activate the GPR32 receptor, which reduces inflammation in blood vessels and prevents atherosclerosis. This breakthrough discovery paves the way for new strategies to treat and prevent cardiovascular disease using omega-3 fatty acids.
A study by Weill Cornell Medicine investigators found that antibodies secreted in the gut help control pathogenic forms of gut fungi like Candida albicans. However, patients with Crohn's disease often have impaired antibody function, leading to an overgrowth of harmful fungi.
A new study from Ohio State University suggests that giving social support to others is essential for boosting one's health. The research found that people who were available to provide social support experienced lower inflammation levels, whereas those who only received support did not show the same benefits.
A new study published in Gut Microbes found that exercise intervention reduced pain and lowered inflammatory substances in people with arthritis. Exercise increased levels of cannabis-like substances called endocannabinoids, which may help treat certain conditions.
A study found that D-glyceric acid treatment improved metabolism, blood parameters, and reduced low-grade inflammation in healthy volunteers aged 50-60 years. The compound's activation of mitochondrial metabolism may help interrupt the spiral of persistent systemic inflammation and improve liver function.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
Researchers found that activated neutrophils release proteins like galectin-9, triggering chronic inflammation and oxidative stress. Early screening for HIV is crucial, and finding ways to reduce negative effects of the infection could be key to improving outcomes.
A new study suggests that drinking 100% orange juice significantly reduces interleukin 6, a well-established marker of inflammation, in both healthy and high-risk adults. However, the results did not quite reach statistical significance for two additional inflammatory and oxidative stress markers.
Researchers comprehensively review T-cell responses to respiratory viral infections and chronic obstructive pulmonary disease (COPD), highlighting key characteristics of peptide-reactive T-cells. The review aims to improve understanding of the underlying mechanisms, leading to more effective immune protection and treatment methods.
Pancreatic cells display adaptive response to repeated inflammatory episodes, reprogramming gene expression and epigenetic regulation that cooperates with mutant KRAS to promote tumor formation. Inflammation drives long-term changes in epithelial cells that select for cancer-causing mutations.
A new study published in Science identifies a specific molecule, C1q, that plays a key role in the long-term effects of traumatic brain injury. The researchers found that an antibody treatment could prevent the development of negative outcomes such as sleep disruption and inflammation.
Researchers created a polymer coating that releases Lasioglossin-III, an AMP with broad-spectrum antibacterial activity, targeting specific infectious bacteria and preventing airway complications. The coating demonstrated significant antibacterial activity and prevented bacterial adherence to the tube.
A new study has found that harmful body fat can increase the risk of dementia and stroke, with grey matter atrophy being a key indicator. The research used genetic data from over 336,000 individuals to establish a link between obesity and declining brain health.
Two studies by CU Cancer Center researchers found that chronic inflammation can serve as a key factor in the development of leukemia. Chronic inflammation reduces the fitness of normal cells, hindering their ability to reproduce and creating space for cancer-causing mutations to proliferate. The findings support the theory of adaptive ...
Recent generations show a worrying decline in health compared to previous generations, with poorer physical health, higher levels of unhealthy behaviors, and more depression and anxiety. The researchers found that measures of physical health have worsened from the Baby Boomer generation through Gen X and Gen Y.
Researchers aim to understand how physical health affects mental health in senior cats, with potential implications for early detection and monitoring of chronic inflammation. The study may also provide insights into the relationships between physical and cognitive health in feline patients.
A recent study published in Circulation reveals that immune cells can activate inflammation in the heart by modifying proteins, leading to structural changes and cardiac dysfunction. The researchers have identified a potential target for new treatments, an agent that binds to specific molecules altering cardiac proteins.
Researchers found that propylene glycol and vegetable glycerol cause gut inflammation by breaking down zipper-like junctions between cells. Chronic e-cigarette use can lead to a 'leaky gut,' allowing microbes and molecules to seep out, resulting in chronic inflammation.
Researchers at the Buck Institute have identified chronic inflammation as a driver of NAD+ decline, a key metabolite central to an efficient and healthy metabolism. Senescent cells activate CD38, which degrades NAD+, leading to age-related diseases. Blocking CD38 activity may offer a new target for therapeutic interventions.
A recent study from University of California, Berkeley reveals that disrupted nightly sleep leads to chronic inflammation, which is linked to atherosclerosis and cardiovascular disease. The findings suggest that poor sleep quality can be an important risk factor for heart health, highlighting the need for improved sleep hygiene.
Scientists at UC Berkeley have identified a molecular 'switch' that controls chronic inflammation, which can contribute to devastating diseases. Removing a small bit of molecular matter through deacetylation switches off the immune machinery, potentially reversing age-related conditions.
Researchers have identified chronic inflammation as the primary driver of accelerated aging, leading to a range of diseases including Alzheimer's, atherosclerosis and cancer. This discovery opens up new avenues for early diagnosis, prevention and treatment of these conditions.
Chronic inflammation is linked to 50% of all deaths worldwide, causing heart disease, cancer, diabetes and more. Identifying new biomarkers for early diagnosis and better treatment can help reduce chronic disease and improve health.
A study of 1,400 UK children found that exposure to adverse experiences and stress at a young age is associated with elevated levels of inflammation in the blood. The researchers also found that this association persists into young adulthood.
A new pathway has been identified as a potential treatment target for Crohn's disease, a form of inflammatory bowel disease that affects millions in the US. The study suggests that blocking a specific protein receptor may ameliorate inflammation and fibrosis in CD patients.
A new study found that people with middle-age chronic inflammation may experience cognitive decline in the decades leading up to old age. Researchers discovered a correlation between high levels of inflammation and steeper declines in thinking and memory skills, particularly in areas of memory.
A Western diet characterized by low fiber and high fat and sugar content can lead to increased chronic inflammation, higher mortality rates, and more severe sepsis severity in mice. The study identifies molecular markers that could predict patients at high risk for severe sepsis or require aggressive treatment.
A study published in Cell Reports reveals a critical connection between chronic inflammation and the development of colon cancer. Researchers found that persistent inflammation leads to increased levels of myeloid-derived suppressor cells and interleukin-10, which ultimately silence tumor suppressors and contribute to cancer growth.
A study of over 1,500 participants found that rising chronic inflammation in middle age was associated with brain damage and poor cognition. Researchers suggest reducing inflammation through lifestyle changes may help prevent or delay dementia.
Researchers at FAU and Charité hospital in Berlin will conduct studies on immune-epithelial communication in IBD. They aim to develop medication targeting bowel inflammation and improve treatment outcomes.
A recent study found that yogurt consumption can improve the integrity of the intestinal lining and reduce pro-inflammatory molecules, thereby reducing chronic inflammation. The study enrolled 120 premenopausal women who consumed either low-fat yogurt or non-dairy pudding for nine weeks, showing significant improvements in certain key ...
A study of nearly 6,000 Americans found that mid-life chronic inflammation may be linked to an increased risk of frailty and overall poorer health decades later. Having high levels of inflammation in middle age was associated with a 39% higher odds of frailty approximately 24 years later.
A study found that obese men have higher levels of inflammatory markers in their seminal fluid and lower sperm quality, correlating with body mass index (BMI). Chronic inflammation in the male reproductive organs may explain the link between obesity and reduced fertility.
Research suggests that pure maple syrup's inulin content can support a healthy gut microbiome, which is linked to reduced chronic inflammation. The discovery of additional compounds with antioxidant properties further supports the health benefits of pure maple syrup.
Researchers identified MMP9 as a tumor suppressor role in colitis-associated cancer (CAC), which is driven by chronic inflammation. The study found that MMP9 suppresses tumors by activating the MMP9-Notch1-ARF-p53 axis pathway.
Early and aggressive treatment with biologic drugs may halt progressive bone loss in patients with RA. Biologic therapies targeting specific cytokines and signaling pathways show protective effects on the skeleton.
A new study identifies food stuffs that can prevent chronic inflammation, a leading cause of death. Diets rich in fruits and vegetables, particularly polyphenol-rich foods, protect against age-related inflammation and chronic diseases.
A study found that chronic exposure to interleukin-1 causes overproduction of immune cells, resulting in an imbalanced blood system. This imbalance can lead to inefficient oxygen delivery, immunodeficiency, and increased cancer risk. Researchers suggest that therapies may be able to reverse the effects of chronic inflammation on blood ...
EPFL scientists found that chronic inflammation can lead to metaplasia, where regenerating cells grow into new, aberrant types. This can cause eye cells to turn into skin, resulting in blindness and disorders associated with chronic inflammation.
Researchers identified GlycA, a molecular byproduct of inflammation, as a predictor of premature death due to infections. High GlycA levels indicate chronic inflammation, which damages the body and increases susceptibility to severe infections.
A new DNA vaccine targeting p62 has shown promising results in alleviating chronic inflammation and osteoporosis by exploiting the protein's role in autophagy. The vaccine, currently in phase I clinical trials, may offer a safe treatment for inflammatory bone loss.
Chronic inflammatory conditions are directly associated with several types of cancer, but the cellular mechanisms behind this link were unclear. An international team of scientists has identified a multistep process showing how these cancers develop, providing potential therapeutic targets for halting tumor cell formation.
Researchers discovered two microRNA molecules that control chronic inflammation, with one promoting and the other preventing the condition. The study sheds light on the role of T follicular helper cells in chronic inflammation and offers hope for preventive measures.
Researchers at the University of Copenhagen have discovered a new type of regulatory blood cell that can fight hyperactive T-cells causing chronic inflammation in multiple sclerosis. The cells express FoxA1, which suppresses inflammation and degeneration of the brain.
Researchers have identified a key protein called TL1A that drives chronic inflammation, leading to diseases like arthritis. The discovery provides hope for developing targeted biological medicines to halt disease progression and alleviate symptoms.
A new study by University of Iowa researchers found that staph bacteria superantigens trigger pro-inflammatory molecules in fat cells, amplifying inflammation and potentially leading to diabetes. Chronic exposure to these toxins creates a 'perfect storm' for inflammation, worsening the risk of developing diabetes.
A study of 3044 civil servants found that chronic exposure to high interleukin-6 levels was associated with a lower likelihood of healthy aging, including impaired musculoskeletal functioning and diabetes. Maintaining low interleukin-6 levels may facilitate successful aging by reducing the risk of these age-related diseases.
Research finds that socioeconomic status is strongly associated with an increased risk of developing type 2 diabetes, with chronic inflammation being a key mediator. The study analyzed data from the Whitehall II cohort study, which followed over 10,000 British civil servants since the mid-1980s.