Articles tagged with Chronic Inflammation
Researchers have identified a new starting point for therapy by targeting SSAT enzyme in psoriasis, restoring regulatory T cell function and breaking inflammation cycle. This approach could lead to a promising alternative treatment option with fewer side effects.
Researchers found that training the innate immune system can exacerbate inflammatory bone loss in models of chronic diseases like periodontitis and arthritis. The study suggests that a previously thought beneficial effect of trained immunity may actually contribute to harm in certain contexts.
A study found that pro-inflammatory molecules contribute to benign prostatic hyperplasia (BPH) in aging men, especially those with metabolic syndrome. Men with BPH had higher levels of pro-inflammatory markers and lower anti-inflammatory substances, suggesting a link between inflammation and prostate conditions.
A University of Cincinnati researcher has been awarded a $2.1 million grant to investigate postoperative pain at the molecular and cellular levels. The goal is to develop new, safer non-addictive treatments for chronic pain conditions, including lower back pain and pain associated with diabetes or chemotherapy treatments.
Researchers at Case Western Reserve University developed a method to detect inflammation using antibodies, potentially leading to blood tests for disease-specific biomarkers. The breakthrough also holds promise for drug discovery.
A recent study explores the connection between chronic inflammation and arrhythmia development, identifying potential therapeutic targets for preventing and treating AF. The research team discovered that interleukin-1 beta (IL-1β) triggers atrial fibrillation by activating its receptors on macrophages.
Researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition. The treatment, baricitinib, selectively blocks specific inflammatory pathways, reducing inflammation and suppressing the overactive immune response that contributes to the disease.
A new study explains how scratching aggravates inflammation and swelling in a type of eczema called allergic contact dermatitis. Scratching activates mast cells, which drive itchiness and inflammation, but also triggers the release of substance P, which protects against bacteria.
New research reveals that scratching an itch can boost immune defenses against bacterial infections at the injury site, while also triggering inflammation. The study found that scratching activates pain-sensing neurons that release substance P, which stimulates mast cells to increase inflammation.
A study by TU Wien found that nerve stimulation is more effective when synchronized with the body's natural rhythms, particularly during systole and inspiration. This technology has potential for non-invasive treatment of chronic diseases.
Researchers developed a novel CD45-PET probe to detect inflammation using positron emission tomography (PET) imaging. The probe targets CD45, abundantly expressed on immune cells, revealing clear images of affected organs in disease models.
Researchers reveal senescence's impact on liver health, from repair and regeneration to chronic disease progression. Emerging therapies, such as senolytic treatments, aim to selectively eliminate senescent cells while preserving healthy tissue.
Researchers at Uppsala University found that people with psoriasis have invisible inflammation in their small intestine, which can lead to gastrointestinal problems and an increased risk of developing Crohn's disease. Half of the study participants had a leaky gut, allowing bacteria and harmful substances to leak through the intestinal...
The study developed floating nanoballoons to improve ibuprofen's bioavailability and sustained release its anti-inflammatory effects. The formulation showed superior edema inhibition in acute inflammation studies, reducing TNF-α, hs-CRP, and IL-6 levels, while increasing anti-inflammatory IL-10 levels.
A pilot study found that qigong significantly decreases chronic low back pain in US military veterans, improving physical function and reducing sleep disturbance. The holistic practice also showed positive effects on PTSD, depression, anxiety, and social roles, highlighting its potential as a nonpharmacological treatment option.
Researchers discover immune cells regulate blood sugar levels by stimulating glucagon production in the pancreas. This complex neuroimmune-hormonal circuit reveals a new way the body maintains stable glucose levels, especially during periods of low energy.
Researchers found that wearable devices can identify, differentiate, and predict flares in IBD by analyzing circadian patterns of heart rate variability, heart rate, oxygenation, and daily activity. The study showed that these metrics changed up to seven weeks before flares developed, enabling continuous disease monitoring.
Additional research is required to explore the relationship between COPD and metabolic syndrome, focusing on outcomes, intervention trials, and health services research. This will help shift from a COPD-focused approach to an integrated care approach considering all comorbidities.
A recent study published in the Journal of the COPD Foundation found that childhood smoking before age 15 significantly increases a person's risk of developing chronic obstructive pulmonary disease (COPD) later in life. The research examined a nationally representative sample of adults and accounted for secondhand smoke exposure, highl...
Researchers at USF and TGH Cancer Institute found a potential link between the Western diet and chronic inflammation that drives tumor growth. Chronic inflammation fueled by poor dietary choices plays a vital role in colorectal cancer growth and progression.
A new implantable device, inspired by a tree branch, uses DNA sensors to continuously monitor inflammation biomarkers in the body. The device accurately measures protein biomarkers of inflammation in diabetic rats and has potential applications for managing acute and chronic conditions.
A recent study by Krishna Rao Maddipati suggests that chronic inflammation has a distinct etiology, differing from acute inflammation. The study proposes increasing anti-inflammatory compounds to treat chronic inflammation, potentially leading to new advancements in cancer therapy.
Researchers are conducting a multi-year study to understand small airway abnormalities and their role in emphysema development. The SPIROMICS Study of Early Disease Progression (SOURCE) aims to provide novel insights into COPD progression and inform the development of new therapies.
A multicenter national clinical trial is being conducted to study whether giving antibiotics at the start of labor induction can decrease C-sections in pregnant women with obesity. The trial aims to enroll nearly 800 women and analyze infection rates, complications, and microbiome changes.
A team of researchers, including Binghamton University's Ahyeon Koh, is working on an innovative project to treat inflammatory bowel diseases like Crohn's and ulcerative colitis. The goal is to create a 'cell factory' in the body that can produce pharmaceuticals to alleviate symptoms.
A new study suggests that immune system imbalances may trigger and sustain depressive symptoms, particularly in high-risk groups. The review challenges traditional neurotransmitter-focused theories and offers insights into the complex interactions between inflammation and depressive symptoms.
Researchers found elevated levels of cytokines in the blood of long COVID patients, which could explain cardiovascular symptoms. The study also showed that these trace-level cytokines had a direct effect on cardiomyocytes, the heart's pumping cells.
Researchers mapped how HSV-1 enters the brain, infects critical regions, and triggers neurological diseases. The virus was found in areas controlling vital functions, such as sleep and movement, and interacted with immune cells that led to chronic inflammation.
Researchers propose a comprehensive biomarker-based approach to assess cardiovascular risk by combining markers of chronic inflammation with cardiac health indicators. This approach reveals the significant impact of aging-related inflammation, or 'inflammaging,' on heart health and opens new avenues for targeted interventions.
Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.
A new study found that children diagnosed with IBD before the age of six show biological changes associated with the disease at birth. This suggests that these children are part of a severely affected subgroup, making preventive options crucial for their investigation. The study's findings could lead to earlier screening and potentiall...
Researchers investigate how liver necroptosis triggers inflammation in both organs, leading to cognitive impairment. Studying aging mouse models, they found that liver necroptosis causes systemic inflammation affecting brain function.
Researchers at TUM found that mitochondrial dysfunction in mice leads to chronic intestinal inflammation and changes in the gut microbiome. The study suggests potential new treatments targeting mitochondrial pathways or addressing the connections between the microbiome and mitochondria.
A new study found that nearly six in ten Americans have pro-inflammatory diets, increasing the risk of health problems like heart disease and cancer. Anti-inflammatory foods such as garlic, ginger, and turmeric can help combat chronic conditions like diabetes and depression.
Researchers found that fever temperatures increase helper T cell metabolism, proliferation and inflammatory activity, while causing mitochondrial stress, DNA damage and cell death in a specific subset of Th1 cells. These findings may explain how chronic inflammation contributes to cancer development and suggest a fundamental way cells ...
Associate Professor Justine Tigno-Aranjuez received a $1 million NSF CAREER Award to study the impact of the NOD2 pathway on inflammation. Her research aims to understand how lipid mediators are produced and how they influence inflammation.
A new study found that cystic fibrosis patients with more severe disease characteristics exhibit shorter leukocyte telomere length and greater LTL attrition. This association may accelerate aging and increase susceptibility to age-related diseases, emphasizing the importance of early CF diagnosis and timely therapeutic intervention.
A pioneering £4.8m eight-year programme will harness artificial intelligence to investigate the link between nutrition, health inequality and the development of multiple long-term conditions. The InflAIM project aims to identify new ways to slow the progression of multiple long-term health problems in people most at risk.
Researchers have identified key cellular interactions and microenvironments that contribute to the development of chronic kidney disease (CKD) after acute kidney injury (AKI) in mice. The study, published in Nature Communications, provides new insights into how damaged cells interact within disease-promoting microenvironments.
The UofL Green Heart Louisville Project found that residents living in neighborhoods with more trees showed lower levels of general inflammation, a risk indicator for heart disease. The study showed a 13-20% reduction in inflammation, corresponding to a nearly 10-15% reduced risk of heart attacks and certain cancers.
Researchers found that administering PEPITEM to older mice reduced exaggerated immune responses, indicating a potential geroprotective agent. The study also revealed an age-related decline in the PEPITEM pathway, which could be rescued by the peptide.
Researchers found that the frequency of activated TREG cells remained elevated during treatment and continued to be high even after the virus was eliminated. Inflammatory features, such as increased TNF signaling, were sustained in TREG cells, indicating long-term immune system changes induced by the chronic infection.
A study found that higher levels of inflammation in early adulthood may negatively affect cognitive skills like planning, focus and processing information in middle age. Those with consistently high or moderate inflammation had poorer performance in processing speed and executive function.
Scientists at Brigham and Women's Hospital have identified a metabolic switch in the gut that helps regulate immune tolerance and protect against harmful intestinal inflammation. This discovery could lead to new strategies for promoting remission in patients with inflammatory bowel disease.
Researchers found that aged mouse gut microbes increase inflammation in young mice, suggesting a link between microbiome changes and aging-induced inflammatory processes.
Researchers at Bielefeld University discovered that certain gluten-derived molecules, including the 33-mer deamidated gliadin peptide (DGP), form nanosized structures that accumulate in gut epithelial cells and lead to leaky gut syndrome. This triggers chronic inflammation and autoimmune responses in celiac disease patients.
A study published by Cornell University researchers found that more frequent positive contact with nature is associated with reduced inflammation levels. The study, which analyzed data from the Midlife in the U.S. survey, suggests that enjoying nature can help prevent or manage diseases linked to chronic inflammation.
A new hypothesis suggests that chronic inflammation is spreading among people at unprecedented rates, affecting cognitive ability to address critical issues. The authors propose a mechanism where the brain creates its own copy of bodily inflammation, leading to impaired cognition, emotion, and behavior.
Research reveals that physical inactivity and chronic inflammation drive secondary aging, altering gene expression in skeletal muscle. The study identified approximately 4,000 genes affected by physical inactivity and inflammation, while fewer than 200 were linked to primary aging.
Research from the German Cancer Research Center reveals that repetitive changes in female reproductive organs over time lead to chronic inflammation and fibrosis, which may contribute to increased uterine cancer risk. The study mapped the effects of estrous cycle, pregnancy, and aging on the reproductive tract.
Researchers discovered that fasting raises arachidonic acid levels, which inhibit the NLRP3 inflammasome and reduce chronic inflammation. This finding may explain how calorie restriction protects against diseases linked to Western diets.
Researchers at University of Tsukuba discovered a correlation between hypoxia levels and clinical symptoms in UC patients. Lower oxygen saturation in the rectal mucosa was associated with greater severity of colitis, making this method a potential tool for objective measurement of disease activity.
A new exhalation delivery system using fluticasone directly targets the sinuses, reducing symptoms and inflammation in patients with chronic rhinosinusitis. The system showed significant improvements compared to a placebo, providing hope for non-invasive treatment options.
A new study by University of Florida researcher Arch Mainous III found that people with chronic inflammation living in poverty have a significantly increased risk of dying from heart disease (127% increase) and cancer (196% increase) within 15 years. The study analyzed data from over 95 million Americans ages 40 and over, highlighting ...
Researchers have shown that combining poverty with chronic inflammation worsens health outcomes, increasing heart disease and cancer mortality rates. The study analyzed data from nearly 95 million adults and found a synergistic effect of poverty and inflammation on mortality.
A post-hoc analysis of the CANTOS trial found no effect of canakinumab on frailty incidence or self-reported function. The study suggests that inflammation may not be a causal factor in the development of frailty in these participants.
A multicenter, retrospective study of Japanese patients treated with JAK inhibitors found impressive remission rates and low disease activity. The study's results contradict previous concerns about the effectiveness of these drugs, suggesting they may be a viable option for patients with other health problems.
A recent study found a compelling link between vitamin B12 deficiency and chronic inflammation, which can lead to various health problems. The research revealed an inverse relationship between vitamin B12 levels and inflammatory markers in humans and mice, suggesting that higher vitamin B12 levels may lower inflammatory markers.
Researchers found persistent inflammation in intestines of patients 20 years post-radiotherapy, even with targeted treatments. This could lead to chronic symptoms like tenesmus and frequent diarrhea.
Researchers at the University of Virginia Health System discovered that improper calcium signaling in mitochondria accelerates chronic inflammation, leading to age-related conditions. Increasing calcium uptake in macrophages may help prevent harmful inflammation and its effects on the brain.