Diabetes
Articles tagged with Diabetes
The 28th European Congress of Endocrinology (ECE) hosts the largest gathering of endocrine specialists in Europe
Human islet function, diabetes risk defined by heterogeneous endocrine cell composition
A comprehensive study analyzed human pancreatic islet cells from 299 nondiabetic donors, revealing the impact of endocrine cell composition on islet function and diabetes risk. The study found that the presence of delta cells, which secrete somatostatin, is associated with poorer insulin secretion.
Kumamoto University Professor Emeritus Eiichi Araki awarded Medal of Honor with Purple Ribbon for landmark discoveries in diabetes research
Professor Eiichi Araki's pioneering research on insulin signaling has led to a deeper understanding of the molecular mechanisms of diabetes. His discoveries remain foundational for researchers striving to overcome insulin resistance and improve treatment options.
Popular weight loss, diabetes drugs linked to improved breast cancer survival
A retrospective cohort study examining over 840,000 breast cancer patients found a potential link between GLP-1 RA use and improved outcomes among obese or diabetic patients. GLP-1 RAs were associated with lower risk of death and recurrence over a 10-year follow-up period.
Cannabis compounds may boost metabolic health while supporting weight loss
Researchers have identified potential mechanisms linked to reduced type 2 diabetes risk in chronic cannabis users. A team led by Nicholas V. DiPatrizio found that specific compounds within cannabis regulate metabolism, leading to significant weight loss and improved glucose regulation in obese mice.
Large-scale Nordic study discovers link between polycystic ovary syndrome and heart disease
Hormone health climbs the policy agenda as endocrine leaders meet for European Society of Endocrinology’s first Summit of the Presidents
The summit brought together endocrine leaders to identify opportunities to work closely together on increasing the visibility of endocrine health in policy decisions. Early findings from a workforce survey revealed challenges including long patient waiting times and retention concerns among early-career clinicians.
The 28th European Congress of Endocrinology (ECE) starts tomorrow
New study finds higher dementia risk in insulin-requiring diabetes
Cardiovascular and metabolic diseases are primary drivers of excess US deaths compared to other high-income countries
Postpartum diabetes care falls short as many women skip essential A1C testing
Limit ultra processed foods to lower risk of heart disease, say experts
A European Society of Cardiology consensus report suggests that ultra processed food consumption is linked to cardiovascular disease and death. The report calls for doctors to advise patients on limiting UPF intake to prevent cardiovascular risks.
Common inflammatory genes link pancreatic cancer with obesity and diabetes
A study published in Cancer Medicine reveals that the same genes active in pancreatic cancer are also linked to obesity and diabetes, driving inflammatory and immune pathways. This discovery helps explain poorer cancer outcomes for those with metabolic disease and offers new avenues for targeted treatment.
A new mechanism regulating beta cell mass under stress
Researchers at Kyoto University discovered that ATF6α plays a critical role in enabling the survival and proliferation of beta cells under sustained stress, leading to impaired beta cell mass expansion. The study highlights the potential for developing new therapeutic strategies to preserve and restore beta cell mass in diabetes.
AI model analyses body composition to predict health risks
A study published in Radiology used AI to analyze whole-body MRI scans from over 66,000 participants, revealing that skeletal muscle quality is a strong predictor of diabetes, major cardiovascular events, and mortality. The researchers also found that high visceral fat and low skeletal muscle were associated with increased risks of the...
Both very low and very high heart rates are significantly associated with stroke risk, novel study finds
A new study suggests that both very low and very high resting heart rates are associated with an increased risk of stroke. The research found a U-shaped pattern, with stroke risk lowest at heart rates of 60-69 bpm and highest at below 50 bpm or above 90 bpm.
Not just insulin: early increases in glucagon in type 2 diabetes are linked to fatty liver disease
A recent study shows that people with newly diagnosed type 2 diabetes have elevated glucagon levels following a meal, closely linked to the fat content of their liver. This finding highlights the importance of the liver and glucagon regulation in metabolism.
Grant backs early-career research on metabolism and food choices
A National Institutes of Health grant supports Mary Elizabeth Baugh's research into how metabolic health influences brain systems that shape eating behaviors. The study aims to understand the interactions between metabolic signals and brain circuits engaged in everyday learning and eating behavior.
Multi-pronged plan to address childhood obesity crisis
A coordinated 10-year plan to improve long-term wellbeing and reverse child obesity trends is underway. The GenHEART program, spearheaded by Murdoch Childrens Research Institute, targets heart health, diet, exercise, sleep, and more.
Central nervous system a key player in diabetes pain
More than 50% of people with diabetes develop diabetic peripheral neuropathy, which causes painful sensations like burning, tingling, or shooting pains. The brain and spinal cord can also contribute to pain, as their pain-blocking systems are less effective in people with diabetes.
Predicting genetic risk for Type 1 diabetes just got more accurate thanks to UC San Diego study
The study demonstrates that the T1GRS tool can identify children and adults at high risk for Type 1 diabetes earlier than current methods, enabling preventive measures before the disease develops. The researchers grouped individuals into four sub-types based on genetic features, each with unique clinical profiles and outcomes.
Validation study from Mass General Brigham reveals new tool can predict patients’ genetic risk of eight cardiovascular conditions
Researchers developed a new polygenic risk score (PRS) that estimates a person's inherited risk for eight common cardiovascular conditions. The test combines information from many genetic variants and evaluates a person's risk for coronary artery disease, atrial fibrillation, type 2 diabetes, and more.
Major trial shows continuous glucose monitoring improves blood sugar control in people with type 2 diabetes
A major clinical trial found that real-time continuous glucose monitoring significantly improves blood glucose management in adults with type 2 diabetes treated with basal insulin. Participants using CGM showed greater reductions in HbA1c levels compared to traditional finger prick glucose monitoring.
Vitamin D may help prevent diabetes, depending on your genes
A new analysis of a major clinical trial found that vitamin D supplementation reduced diabetes risk in prediabetic adults with certain variations in the vitamin D receptor gene. The study suggests personalized medical care could delay or prevent diabetes onset for millions of Americans living with prediabetes.
Genetic study finds new pathways involved in cardiometabolic disease
A study published in PLOS Medicine has identified two new genetic pathways contributing to cardiometabolic disease, including heart disease and obesity. The research analyzed lipid metabolites and their link to disease, suggesting that targeting specific metabolic pathways could prevent or lower the risk of disease.
UC San Diego study links diabetes to early Alzheimer’s-related changes in the blood of Latino adults
A UC San Diego study found that diabetes is associated with changes in biological signals in the blood linked to Alzheimer's disease and brain damage in Latino adults. Researchers suggest that metabolic health may play a role in shaping future dementia risk.
World Hormone Day 2026
The European Society of Endocrinology organizes World Hormone Day to educate the public about hormone-related health issues. Global endocrine disorders affect millions worldwide, emphasizing the need for proper hormone balance.
New map reveals that blood vessels play an active role in disease
Researchers have mapped blood vessels in human adipose tissue with unprecedented detail, revealing that they are not only affected by disease but also play an active role in its processes. The study identifies unique cell types with mixed characteristics, suggesting a new approach to treating metabolic diseases.
Midlife fitness linked to longer, healthier lives
A study found that higher midlife cardiorespiratory fitness is strongly associated with later onset of chronic disease, lower overall disease burden, and longer life expectancy. Adults with higher fitness levels developed fewer chronic diseases and spent more years free from serious illness.
Fat cells’ ‘memory’ of prediabetes could make maintaining weight loss after bariatric surgery more difficult
Researchers found that women with prediabetes had persistent changes in gene expression in fat tissue after bariatric surgery, leading to impaired lipid metabolism and greater weight regain. Despite clinical improvement, these molecular alterations may reduce the ability of adipose tissue to adapt after weight loss.
Keto diet may improve beta cell function in people with type 2 diabetes
A ketogenic diet has been shown to improve beta-cell function in patients with type 2 diabetes by decreasing proinsulin secretion and reducing pancreas stress. This improvement is associated with changes in the proinsulin-C-peptide ratio, a biomarker of pancreas stress.
Covid snacking habits and their consequences
A Japanese study examines the long-term effects of COVID-19 lockdowns on individuals with glucose intolerance, revealing a clear divergence in clinical trajectories among those who worsened and improved. Flexible lifestyle adaptation is crucial for restoring metabolic health, suggesting personalized support may improve glycemic control.
AI can use a photo of the eye to estimate retinal age, flag risk for major diseases
A Tohoku University research group developed an AI model that estimates retinal age from a fundus photograph, reflecting biological aging and potential disease risk. The model is non-invasive and can be used as a screening aid, identifying patients who may need further health assessments.
Weight-loss drugs may affect arthritis directly in the joints - new study finds
A new study from Aarhus University reveals that weight-loss drugs containing GLP-1 hormone may influence joint inflammation in arthritis patients. The study found that high doses of GLP-1 in medication could have a dual effect, both through weight loss and by increasing levels in the joints.
Progress in stem cell therapy for type 1 diabetes
Scientists at Karolinska Institutet have created a new method to produce insulin-producing cells from human stem cells, effectively regulating blood sugar levels in laboratory tests and reversing diabetes in mice. The optimized production process yields more mature and purer cells, demonstrating their potential for future treatments.
Diabetes study reveals previously overlooked genes tied to disease, pointing to new therapies
A recent study from The Jackson Laboratory has identified dozens of unexpected genes strongly linked to type 2 diabetes. These genes are key to cell death and vitamin A metabolism, suggesting the disease depends on expression changes that can be targeted for treatment.
Assistance dogs interpret needs of the person they assist non-verbally
A study by the University of Turku reveals that assistance dogs actively contribute to their human's care through continuous interpretation and trust. They anticipate health status, provide mobility assistance, and offer emotional support in ways that humans cannot.
Hidden epidemic: Metabolic disorders drive the next wave of liver cancer
The study reveals that metabolic dysfunction-associated steatotic liver disease (MASLD) is emerging as a major contributor to liver cancer worldwide and in China. Researchers call for integrated global prevention and early detection strategies to address this growing burden.
AI gives doctors early warning of disease “tipping points” — often from a single patient sample
Researchers develop dynamics-driven models to identify disease transitions before symptoms appear, transforming real-time care and personalized treatment. AI systems analyze health data to detect
Clinical guidelines on physical activity and exercise therapy for Chinese adults with type 2 diabetes: A clinical practice guideline from the Chinese Society of Endocrinology
The clinical guideline emphasizes personalized care, recommending pre-exercise cardiovascular risk assessment and individualized exercise prescriptions. Adults with T2D are advised to engage in at least 150 minutes of moderate-intensity aerobic exercise per week, or a combination of aerobic and resistance training.
New cause for diabetes in babies found in non-coding genes
Scientists have identified two non-coding genes as the cause of autoimmune neonatal diabetes in 19 children. The discovery sheds light on the importance of non-protein coding genes and their role in human disease.
Food literacy program helps rural, uninsured patients with diabetes build healthy eating skills
A recent study published in the Journal of Nutrition Education and Behavior found that a Food is Medicine and food literacy education program improved food-related knowledge and practical skills among rural, uninsured adults with type 2 diabetes. The Fresh Start FIM + Food Literacy intervention showed significant overall improvements i...
Researchers predict coronary heart disease in diabetes subgroup
A new study by Lund University researchers found that genetic risk scores can predict coronary artery disease even before diabetes onset. The study identifies a group at high risk of developing both conditions, offering potential for early detection and prevention.
Out-of-pocket spending for insulin by Medicare beneficiaries after monthly caps
A $35 monthly insulin out-of-pocket cap is associated with significantly lower insulin costs, increased access to insulin, and decreased blood glucose levels among Medicare beneficiaries. This finding suggests that federal cost-sharing policies could improve access to essential medications in diabetes.
Women with diabetes less likely to receive preventive care and some screenings
A recent study published in the Journal of General Internal Medicine found that women with diabetes are less likely to receive recommended preventive care services such as conception counseling and breast/cervical cancer screening. This oversight puts them at risk for preventable medical conditions like pregnancy complications.
University of Cincinnati researchers discover clear link between chronic kidney disease and periodontal disease
Researchers found a clear connection between oral health and kidney health, with immune dysregulation and systemic inflammation driving the relationship. The study highlights the need for physicians to integrate oral and renal health into clinical care systems.
New NIH-funded Johns Hopkins Medicine study finds switching to integrase inhibitors from protease inhibitors is associated with new diabetes risk in people with HIV
Researchers found a 38% higher risk of diabetes in adults with HIV who switched from protease inhibitors to integrase inhibitors. The study suggests that medication changes may have adverse metabolic impacts, warranting close monitoring, regardless of weight gain.
Cardiorenal outcomes with tirzepatide compared with dulaglutide in patients with diabetes and cardiovascular disease
A post hoc analysis found that tirzepatide was associated with a lower incidence of a broad composite cardiovascular and kidney endpoint. The study compared tirzepatide with dulaglutide in patients with diabetes and established cardiovascular disease.
Evolocumab to reduce first major cardiovascular events in patients without known significant atherosclerosis and with diabetes
In high-risk patients without known significant atherosclerosis and with diabetes, evolocumab significantly reduced the risk of a first major cardiovascular event. The study found that evolocumab was effective in preventing cardiovascular events in these patient populations.
Targeted cholesterol-lowering therapy can prevent first heart attack or stroke in high-risk patients with diabetes
A clinical trial found that intensive cholesterol-lowering therapy reduced the risk of cardiovascular events by 31% in high-risk patients with diabetes. The treatment, evolocumab, lowered LDL-C levels by approximately 60%, and was well-tolerated.
Multi-task deep learning identifies four MASLD subtypes for precision cardiovascular– liver–kidney–metabolic management
The study developed a novel multi-task deep LASSO algorithm that identified six core clinical indicators, establishing four stable MASLD subtypes with distinct characteristics. The classification system enables targeted interventions, prioritizing fibrosis screening and aggressive cardiorenal protection for specific subgroups.
Implantable islet cells could control diabetes without insulin injections
MIT researchers create an implantable device containing insulin-producing cells that survive in the body for at least 90 days, producing enough insulin to regulate blood sugar levels. The device's improved oxygen generator and electronics enable longer cell lifespan and increased insulin production.
Endocrine Society endorses bipartisan bill to address insulin affordability
The Endocrine Society supports the INSULIN Act to address insulin affordability, setting a $35 monthly cap for people with private insurance and creating a program for uninsured individuals. The bill aims to reduce insulin prices by encouraging competition in the market.
Landmark diabetes trial tests new treatments to bring back ‘hypo’ awareness
A landmark trial is underway to test new treatments that restore the body's natural warning signs for low blood glucose in people with type 1 diabetes. The CLEAR trial compares innovative treatments, including an artificial pancreas system and bespoke psychoeducational programs, to find the most effective way to prevent severe episodes.
B-type natriuretic peptide as a predictor of kidney disease progression in diabetes
A recent study found that B-type natriuretic peptide is independently associated with chronic kidney disease progression in individuals with diabetes. Combining BNP with urinary markers such as UACR improves risk prediction, highlighting its potential role in early detection and management of kidney disease.
New algorithm can better manage type 2 diabetes, study finds
A new algorithm paired with a continuous glucose monitor can help users better manage their type 2 diabetes by recommending insulin-dose adjustments. Participants who used the algorithm saw significant improvements in time spent in a safe blood-sugar range.
Improved heart and kidney outcomes for type 1 diabetes patients taking GLP-1 weight loss drugs
A large study using simulated clinical trial analysis based on medical records found that GLP-1 receptor agonist drugs reduced the risk of major cardiovascular events and end-stage kidney disease in type 1 diabetes patients. The study, led by Johns Hopkins Bloomberg School of Public Health, showed significant risk reductions without in...
Working night shifts makes it harder to manage type 2 diabetes
A study by King's College London found that night shift workers with type 2 diabetes face challenges in maintaining a healthy diet and managing their condition. The research revealed limited access to nutritious food options during night shifts, leading to poorer quality nutrition and greater variability in glucose levels.
Children with obesity are at risk of disease despite normal test results
A new study published in JAMA Pediatrics finds that children with obesity but without metabolic complications still face a significantly increased risk of developing type 2 diabetes, high blood pressure, and abnormal blood lipid levels later in life. Treatment can greatly benefit these children, reducing the risk of future diseases.