Articles tagged with Diabetes
Researchers developed a genetic risk score to analyze risk of type 1 diabetes in patients with MODY, identifying 16% with atypical type 1 diabetes. The score, now adopted as part of NHS testing, provides a diagnosis for patients with negative MODY tests.
The global burden of chronic kidney disease in women has grown, with 359 million cases in 2021, driving increasing mortality rates and disability-adjusted life years. Postmenopausal women and women of reproductive age are particularly vulnerable to metabolic and behavioral drivers that can be modified to reduce risk.
A randomized clinical trial found that pregnant women who followed a strength training program had a 0% incidence of gestational diabetes, compared to 7.3% in the control group. The program also improved quality of life and reduced pregnancy symptoms.
Research shows a link between dollar store food quality and higher rates of obesity, high blood pressure, and type 2 diabetes. Traditional grocery store access is associated with better health metrics, according to a new study published in BMC Public Health.
A new book by University of Virginia Health System expert Daniel J. Cox outlines a practical alternative to medication for managing pre-diabetes and type 2 diabetes. The GEM program emphasizes smart eating, physical activity, and listening to the body to regulate blood sugar levels.
Scientists create a biomimetic zona pellucida coating called BZP to mimic the natural barrier on egg cells, protecting donor islets from the immune system and reducing blood sugar levels in diabetic mice for 100 days. This approach could lead to a promising commercial cell therapy platform for treating various diseases.
Researchers highlight unanticipated benefits of GLP-1 medications, including reduced inflammation and lower risk of certain cardiovascular and musculoskeletal conditions. However, questions remain about lean body mass and nutritional health following weight loss associated with these medications.
Researchers at UT Health San Antonio have uncovered how the liver's internal clock coordinates the release of proteins that regulate metabolism. The findings suggest that understanding this internal clock could help guide future research on metabolic disease and inform optimal timing for meals and medication.
Researchers are seeking 450 participants to explore the health effects of adopting a vegetarian or vegan diet among younger adults with overweight or obesity. Over 12 months, participants will follow a plant-based diet and have regular health checks to measure their health outcomes.
The Lancet Diabetes and Endocrinology Commission on Obesity definition of obesity was found to have similar diagnostic accuracy as other definitions. The study compared the commission's definition with those from other reputable sources, including the World Health Organization (WHO) and the National Institutes of Health (NIH).
Tirzepatide has been shown to reduce the risk of heart attacks and hospitalizations due to infections in people with type 2 diabetes and obesity. The study found a relative risk reduction of about one-third, corresponding to a 36% reduced risk of infection-related hospitalization.
Researchers engineered a biochemical halo of interleukin 10 to suppress immune rejection of pancreatic beta cells, enabling implanted insulin-producing cells to control blood sugar for over 100 days. The approach could lead to a cure for Type 1 diabetes and improve outcomes for implantable therapies.
Researchers tracked nearly 80,000 adults with type 2 diabetes over ten years, finding those who consistently took their prescribed medication stayed free of serious heart and circulatory complications for over seven extra months. Low adherence was linked to a higher risk of cardiovascular disease, especially in younger adults.
Researchers found that people with well-controlled HIV have more fibrosis in their fat tissues, leading to insulin resistance and type 2 diabetes. The study also identified a blood marker of scarred fat, which may help predict metabolic future for individuals with HIV.
A new online test, MEDWACS, can detect people with prediabetes or undiagnosed type 2 diabetes with high accuracy. The test measures seven parameters, including thigh length, which is linked to a person's risk of developing the condition.
Researchers from Pennington Biomedical Research Center propose a new framework for defining and diagnosing obesity, which considers the effects of excess adiposity on organs and tissues. This approach provides a more biologically grounded and clinically actionable method for guiding treatment decisions.
Researchers developed stronger stem cell-derived extracellular vesicles to rebuild damaged microvessels and heal diabetic wounds more effectively. The treatment improved tissue remodeling, restored angiogenesis, and reduced oxidative stress in mouse and miniature pig models.
A study at USC discovers a common genetic variant in Indigenous American populations that silences the microprotein MENTSH, restoring it improves insulin signaling and blocks diet-induced weight gain. MENTSH-based therapies could offer a precision-medicine approach to Type 2 diabetes.
A 16-week personalized exercise intervention improved glycemic regulation, physical fitness and reduced abdominal fat while increasing skeletal muscle mass. Cognitive impairment also showed significant improvements in working memory, perceptual speed and executive function.
A new survey found that Native American adults are open to healthier eating based on traditional Indigenous foods, with 78% willing to try a whole food, plant-based diet. However, only 13% are aware that such diets can help prevent or improve type 2 diabetes.
A qualitative study identified four self-care decision-making patterns among adults with multiple cardiometabolic conditions, including past experiences and leveraging resources. Effective self-care behaviors can improve quality of life for these patients, particularly those with type 2 diabetes, coronary heart disease, and stroke.
Researchers have identified transmembrane 4 L six family member 1 (TM4SF1) as a highly selective surface marker of senescent β-cells in both mice and humans. This discovery provides an important step toward developing targeted senotherapies that could preserve insulin secretion and slow the progression of type 2 diabetes.
Researchers identified endotrophin as a biological marker that rises and falls with changes in body fat, reflecting changes in metabolic health. The study suggests endotrophin could serve as a valuable biomarker and therapeutic target for reducing obesity-related health risks.
Researchers found that individuals with higher modifiable risk factors, such as high blood pressure and obesity, have more widespread plaque buildup and unstable plaques prone to rupture. The study's findings highlight the importance of early intervention to control these risk factors and prevent future events.
A randomized controlled trial found that medically tailored grocery deliveries improved blood sugar control among adults living with type 2 diabetes who have public health insurance. The study also showed benefits for food-related outcomes, filling an evidence gap in the integration of food-based interventions into routine diabetes care.
Use of newer GLP-1 receptor agonists like semaglutide and tirzepatide was associated with a significant reduction in alcohol-related hospital admissions among adults with type 2 diabetes and obesity. The findings suggest a potential role for these medications in treating alcohol-use disorder.
Researchers analyzed data from 2,201,446 women and found associations between adverse pregnancy outcomes and an increased long-term risk of developing peripheral artery disease. Women who experience gestational diabetes, preeclampsia, or preterm delivery have a significantly increased risk of PAD later in life.
The Pennington-Louisiana Nutrition Obesity Research Center has received a five-year, $5.66 million renewal grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The award reaffirms Pennington Biomedical's position as a national leader in nutrition, obesity, and metabolic health research. The center su...
The 2026 American College of Cardiology/American Heart Association/Multisociety Dyslipidemia Guideline reclassified approximately one-quarter of adults, with two-thirds reassigned to lower-risk categories and one-third to higher-risk categories. This shift was driven by differences in risk factors among males, non-Hispanic Black indivi...
A Northwestern University study found that average total payments per user for GLP-1 drugs more than doubled from 2017 to 2022. This raises concerns about the long-term affordability of these medications, which may be taken by patients for years or decades.
The meeting will explore breakthroughs in diabetes prevention and treatment, as well as innovative approaches to monitoring astronauts' health in space. Researchers will also discuss potential targets for slowing or preventing Alzheimer's disease in people with Down syndrome, and advancements in cervical cancer screening.
Researchers found a slight association between GLP-1 medications and ischemic optic neuropathy, a condition causing reduced blood flow to the optic nerve. The risk remains low, but clinicians should be aware of this potential association, particularly in patients with Type 2 diabetes.
A new review calls on Mexico to add liver health to its existing chronic disease programs, citing the country's high liver disease prevalence. Liver disease affects nearly half of Mexican adults and is linked to diabetes and obesity.
A major international study led by Curtin University found diabetes risk is linked to both excess body fat and poor muscle health, with nearly 15% of people with sarcopenic obesity developing type 2 diabetes within 10 years. Maintaining muscle strength and mass may be as important as managing body weight in assessing diabetes risk.
Mouse study uncovers how oxygen-sensing transcription factors regulate muscle physiology, improving glucose tolerance and producing erythropoietin. The findings suggest that selectively targeting each isoform can lead to different physiological outcomes.
A study published in PLOS Medicine found that British Bangladeshi and British Pakistani individuals are more likely to develop multimorbidity, a condition where people experience multiple chronic illnesses simultaneously. The research identified sociodemographic and genetic factors that increase the risk of developing these conditions,...
Researchers have found that GLP-1 agonists can normalize genetic pathways involved in pulmonary fibrosis, a lung disease associated with Long COVID. The treatment has shown promise in reducing the risk of fibrous buildup, suggesting potential benefits for people with type 2 diabetes and severe COVID-19 symptoms.
A new study maps the changing RNA modification landscape of sperm during development and shows that type II diabetes can disrupt this molecular program. The findings suggest that paternal metabolic disease can impact male fertility and potentially offspring health.
A randomized clinical trial found that long-acting analogue insulin glargine was associated with less time spent in dangerous hypoglycemia and fewer nighttime low blood sugar events. However, benefits only emerged after a year into the trial.
Researchers have identified high rates of overweight/obesity (82%) and hypertension (higher than statewide average) in Franklin Parish, with income levels linked to lower hypertension rates. Older residents are also more likely to have undiagnosed high cholesterol and diabetes.
Dr. Logan Townsend joins Pennington Biomedical to study the connection between metabolic disease and mental health, investigating circulating factors influencing anxiety and depression. His research program aims to improve both metabolic and mental health outcomes.
A new study from the University of Copenhagen suggests that longer sleep is linked to more stable blood sugar levels in healthy 18-year-olds, even among those with no previous health issues. The researchers tracked participants over two weeks and found a two-way relationship between sleep duration and blood sugar stability.
Researchers call for hearing tests to be a standard part of diabetes care due to its high prevalence among adults with type 2 diabetes. A systematic review of 29 studies found that hearing loss is a significant yet under-recognised complication, affecting daily conversations and quality of life.
A new study found that GLP-1 receptor agonists can improve long-term health for people with peripheral artery disease (PAD), managing blood sugar and weight loss while reducing inflammation and improving blood vessel function. The benefits were highest among participants with severe PAD and obesity.
A CU Anschutz study reveals reduced mitochondrial efficiency in healthy yet sedentary individuals, which may precede the development of major diseases like cancer, diabetes, and Alzheimer's. Regular exercise acts as a literal shield for cellular health, helping mitochondria seamlessly switch between burning fat and carbohydrates.
Researchers mapped pancreatic islet development in 123 pediatric organ donors without diabetes, revealing insights into the root causes of type 1 and 2 diabetes. The study provided a detailed map of the growing pancreas and connected findings to islet function.
A new study reveals that excessive fibrin deposition drives chronic inflammation in diabetic periodontitis. A targeted peptide successfully stops this inflammation and promotes periodontal bone regeneration, offering a potential universal therapeutic strategy for various immune-mediated diabetic comorbidities.
A study by the University of São Paulo found that people with diabetes who have had COVID-19 tend to recover more slowly and experience more long COVID complications, including greater physical and cognitive difficulties. The study also found a higher risk of cardiovascular complications, such as heart attacks and angina.
Hanyang University researchers developed AI-guided microneedle patches that actively change shape at physiological temperature to help close wounds while delivering regenerative therapy and antibacterial protection. The platform accelerates wound closure and improves tissue regeneration compared with conventional approaches.
New therapies using regulatory T cells, known as Tregs, could target diseases with inflammation, such as cancer and autoimmune conditions. Early evaluations show good tolerance and safety profiles, but precision is key to tailoring treatments for specific patients.
A review published in Diabetes Care suggests that physical exercise could play a role in promoting immune regulation, preserving beta-cell function, and reducing inflammation in type 1 diabetes. The evidence highlights the potential benefits of exercise on immune profiles displaying anti-inflammatory characteristics.
The team proposes a novel model that suggests RNA editing defects may initiate autoimmune responses in type 1 diabetes. Their research could reveal new mechanisms underlying the disease and lead to prevention and treatment breakthroughs.
Research suggests GLP-1 receptor agonists modulate immune responses and reduce inflammation in skin diseases. Studies indicate improvements in psoriasis severity indices following treatment with these drugs.
New research found that GLP-1 RA users showed weaker associations between impulsivity and violent crime, suggesting these medications may lessen risk factors. The study analyzed data from a US survey of adults who used GLP-1 medications.
A novel treatment approach for diabetic macular edema has shown promise in reducing treatment burden and cost without compromising visual outcomes. The '1 + 1 + PRN' sequential regimen involves fewer injections, which may improve patient adherence and quality of life.
The Critical Path Institute's Type 1 Diabetes Consortium is strengthening regulatory science and evidence frameworks for disease-modifying therapies. The expanded C-peptide evidence base supports ongoing evaluation of the biomarker as a drug development tool.
A recent study found that long naps may increase the risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD) in people with type 2 diabetes. MASLD is characterized by excessive fat buildup in the liver, which can lead to chronic disorders like NAFLD.
Adults with prediabetes who undergo lifestyle intervention show a lower burden of multimorbidity compared to those not receiving the intervention. Lifestyle programs can persistently reduce the development of chronic conditions in this population.
The study found a significant increase in type 1 diabetes cases among Hispanic/Latino adolescents in Puerto Rico, from 10.1 per 100,000 in 2009 to 24.1 in 2021, with an average annual increase of 4.1%. This trend has important implications for patient care and public health.
A recent study of 42,000 adults taking blood pressure medications and GLP-1s found higher rates of hypotension events, including dizziness and fainting. The study highlights a potential safety concern for patients aged 65 and older and those with diabetes.