Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
UCLA scientist Tara TeSlaa is developing a new approach to record nutrient use in specific cell types, aiming to build maps of cellular metabolism across tissues and conditions. Her lab will use stable isotope tracing to create a molecular record of nutrient use, allowing for more accurate interpretations of nutrition research.
A human trial has shown that the diabetes drug empagliflozin reduces inflammatory cell clumps and promotes metabolic reprogramming in patients with obesity and prediabetes. This finding suggests that the medication may have heart-protective benefits beyond weight loss.
Researchers found that minimally and highly processed meals with matched nutritional profiles produced distinct metabolic responses and activity in the brain's reward system. The study suggests that food processing may affect how the body and brain respond to food, potentially leading to overconsumption and long-term health effects.
Research found that unfavorable social determinants of health are associated with a higher risk of dementia in adults with and without type 2 diabetes, with particularly strong associations observed among women with T2D. The study also found that diabetes-related dementia risk varies across social environments.
The study found a 24-fold increase in new GLP-1 prescriptions among new mothers, with women with type 2 diabetes and gestational diabetes showing the highest rates. Prescribing increased fastest among those diagnosed as obese or overweight before pregnancy.
A new study finds that high fasting glucose has surpassed tobacco use as the leading risk factor for pancreatic cancer in the US, while China faces a dual metabolic-tobacco burden. China recorded more absolute cases, but lower age-standardized rates, with a peak burden at ages 60-74.
Researchers found substitution effects between obesity-labeled and diabetes-labeled GLP-1 receptor agonists, which vary by state coverage policies. The study suggests that these effects could impact coverage decisions for obesity treatment in Medicaid.
A new study found that eating with a companion reduces blood glucose spikes and improves glucose recovery, suggesting that human physiology is inherently social. The researchers call this principle Social Physiology, which states that the human body regulates itself more efficiently in the presence of social partners.
Researchers have found that an oral medication called Danegaptide can protect against vision-threatening damage in Non-Proliferative Diabetic Retinopathy (NPDR), a leading cause of blindness in working-age adults. The study highlights a new therapeutic approach that could replace or complement frequent, invasive eye injections for mill...
Researchers found that strokes among adults ages 20-54 nearly doubled over nearly three decades, even as short-term survival after stroke improved. The increase was driven by ischemic stroke, with rates rising from 23.8 cases per 100,000 person-years in 1993-1994 to 47.3 cases per 100,000 person-years in 2020.
A preliminary study led by UC San Francisco found that reducing ultra-processed food intake significantly improved symptoms of depression and anxiety in participants, who reduced their intake by over 85%.
A new study published in Childhood Obesity found that nearly one in six children prescribed GLP-1 medications experience nutritional deficiencies, with vitamin D being the most common, within one year.
Researchers at Pennington Biomedical developed GVC-Calc to analyze continuous glucose monitoring data, providing a scalable and transparent approach. The platform supports batch processing, integrates individual-level data with cohort-level results, and offers consensus clinical metrics alongside exploratory measures.
Dr. Mark Walker led a seminar on pre-eclampsia, a condition that affects 2-4% of pregnancies and can be life-threatening. The seminar reviews current knowledge, strategies for prevention, and highlights a critical global health challenge, particularly in low-income and middle-income countries.
Researchers identified a distinct risk profile for young adults with early-onset fatty liver disease, associated with genetic factors and metabolic conditions like type 2 diabetes. The study highlights the need for more accurate liver screening and assessment for individuals at greatest risk.
The EASD has published its first evidence-based clinical practice guideline on diabetes distress, emphasizing the importance of assessing and managing emotional burdens in adults with type 1 and type 2 diabetes. The guideline aims to improve clinical care and outcomes by incorporating a person-centered approach to diabetes care.
UCLA researchers are launching a phase 1/2 clinical trial to evaluate the safety and efficacy of JAK inhibitors in preventing immune checkpoint inhibitor-induced type 1 diabetes. The trial aims to test whether these drugs can protect insulin-producing cells in patients who develop diabetes after cancer immunotherapy.
A new study suggests that individuals with diabetes who focus on tightly controlling their blood sugar levels may be missing out on enjoyable activities due to the associated burden. Higher glucose variability and better sleep quality on the previous day were associated with improved quality of life on the following day.
A clinical trial found significant improvements in pain and sensation in people with treatment-resistant painful diabetic neuropathy after receiving spinal cord stimulation. The study also observed early evidence of increased density of small nerve fibers in the skin, which may indicate potential long-term benefits.
A new study by KTU researchers explores whether artificial intelligence can uncover patterns in glucose data to predict changes and assess hypoglycaemia risk. The model achieved high accuracy in forecasting glucose levels and performing well on patients with unseen data.
A new study found that weight loss injection semaglutide may reduce asthma attacks by up to 40% in people with airways diseases like asthma and COPD. Semaglutide also led to a 20% reduction in COPD flare-ups.
The INSULIN Act would cap out-of-pocket insulin costs at $35 per month for people on private insurance, establishing a resource center and hotline for uninsured individuals. The Endocrine Society applauds the bipartisan bill, which aligns with its Insulin Access and Affordability Position Statement.
A study found that SGLT2 inhibitors increase the risk of ketoacidosis in patients with type 2 diabetes who have high blood glucose, low body weight, or a history of ketoacidosis. The risk persists throughout treatment duration, highlighting the need for better support for high-risk patients.
A nationwide study found that early initiation of statins after type 2 diabetes diagnosis was associated with a 15% lower relative risk of dementia over 10 years. Statin treatment was also linked to a 10% lower risk of dementia in patients who initiated treatment between one and five years after diagnosis.
Researchers found that impaired peroxisomal function can increase insulin secretion while promoting insulin oxidation and disrupting pancreatic beta cell maturity. Healthy peroxisomes play a role in protecting insulin from oxidative modification and degradation, and helping beta cells maintain their specialized characteristics.
A study found that higher breastfeeding intensity is associated with more favorable early postpartum lipid profiles among women with prior gestational diabetes. Greater breastfeeding intensity may be linked to a more favorable early cardiometabolic profile in these women.
A clinical trial found that a ketogenic diet significantly improves metabolic health in people with obesity, with 50% of participants no longer meeting the criteria for prediabetes. The diet also showed the greatest improvements in liver health and insulin sensitivity.
Researchers developed a risk calculator that estimates short-term risk of diabetes complications using routine health data. The tool analyzes insurance claims and electronic health record data to provide monthly, encounter-level risk estimates.
The University of Louisville is launching the Nutrition and Metabolic Health Center to tackle chronic diseases, with a focus on prevention and new treatments. Researchers will investigate the impact of nutrition and environmental factors on health, with the goal of improving prevention and treatment options.
The 2026 Childhood Obesity Conference, 'Be the Reason Kids Greaux Healthy,' will explore strategies for preventing and treating childhood obesity, bringing together healthcare professionals, researchers, educators, and community leaders. The conference will feature keynotes, sessions, and poster presentations on emerging topics in pedi...
A study found that type 2 diabetes in lean Africans is caused by a shortage of insulin, not insulin resistance, unlike in overweight individuals. This disparity leads to different disease processes and treatment responses, with lean patients often developing eye damage and strokes, while overweight patients are more likely to have high...
Researchers developed a genetic risk score to analyze risk of type 1 diabetes in patients with MODY, identifying 16% with atypical type 1 diabetes. The score, now adopted as part of NHS testing, provides a diagnosis for patients with negative MODY tests.
The global burden of chronic kidney disease in women has grown, with 359 million cases in 2021, driving increasing mortality rates and disability-adjusted life years. Postmenopausal women and women of reproductive age are particularly vulnerable to metabolic and behavioral drivers that can be modified to reduce risk.
A randomized clinical trial found that pregnant women who followed a strength training program had a 0% incidence of gestational diabetes, compared to 7.3% in the control group. The program also improved quality of life and reduced pregnancy symptoms.
Research shows a link between dollar store food quality and higher rates of obesity, high blood pressure, and type 2 diabetes. Traditional grocery store access is associated with better health metrics, according to a new study published in BMC Public Health.
A new book by University of Virginia Health System expert Daniel J. Cox outlines a practical alternative to medication for managing pre-diabetes and type 2 diabetes. The GEM program emphasizes smart eating, physical activity, and listening to the body to regulate blood sugar levels.
Scientists create a biomimetic zona pellucida coating called BZP to mimic the natural barrier on egg cells, protecting donor islets from the immune system and reducing blood sugar levels in diabetic mice for 100 days. This approach could lead to a promising commercial cell therapy platform for treating various diseases.
Researchers highlight unanticipated benefits of GLP-1 medications, including reduced inflammation and lower risk of certain cardiovascular and musculoskeletal conditions. However, questions remain about lean body mass and nutritional health following weight loss associated with these medications.
Researchers at UT Health San Antonio have uncovered how the liver's internal clock coordinates the release of proteins that regulate metabolism. The findings suggest that understanding this internal clock could help guide future research on metabolic disease and inform optimal timing for meals and medication.
Researchers are seeking 450 participants to explore the health effects of adopting a vegetarian or vegan diet among younger adults with overweight or obesity. Over 12 months, participants will follow a plant-based diet and have regular health checks to measure their health outcomes.
The Lancet Diabetes and Endocrinology Commission on Obesity definition of obesity was found to have similar diagnostic accuracy as other definitions. The study compared the commission's definition with those from other reputable sources, including the World Health Organization (WHO) and the National Institutes of Health (NIH).
Tirzepatide has been shown to reduce the risk of heart attacks and hospitalizations due to infections in people with type 2 diabetes and obesity. The study found a relative risk reduction of about one-third, corresponding to a 36% reduced risk of infection-related hospitalization.
Researchers engineered a biochemical halo of interleukin 10 to suppress immune rejection of pancreatic beta cells, enabling implanted insulin-producing cells to control blood sugar for over 100 days. The approach could lead to a cure for Type 1 diabetes and improve outcomes for implantable therapies.
Researchers tracked nearly 80,000 adults with type 2 diabetes over ten years, finding those who consistently took their prescribed medication stayed free of serious heart and circulatory complications for over seven extra months. Low adherence was linked to a higher risk of cardiovascular disease, especially in younger adults.
Researchers found that people with well-controlled HIV have more fibrosis in their fat tissues, leading to insulin resistance and type 2 diabetes. The study also identified a blood marker of scarred fat, which may help predict metabolic future for individuals with HIV.
A new online test, MEDWACS, can detect people with prediabetes or undiagnosed type 2 diabetes with high accuracy. The test measures seven parameters, including thigh length, which is linked to a person's risk of developing the condition.
Researchers from Pennington Biomedical Research Center propose a new framework for defining and diagnosing obesity, which considers the effects of excess adiposity on organs and tissues. This approach provides a more biologically grounded and clinically actionable method for guiding treatment decisions.
Researchers developed stronger stem cell-derived extracellular vesicles to rebuild damaged microvessels and heal diabetic wounds more effectively. The treatment improved tissue remodeling, restored angiogenesis, and reduced oxidative stress in mouse and miniature pig models.
A study at USC discovers a common genetic variant in Indigenous American populations that silences the microprotein MENTSH, restoring it improves insulin signaling and blocks diet-induced weight gain. MENTSH-based therapies could offer a precision-medicine approach to Type 2 diabetes.
A 16-week personalized exercise intervention improved glycemic regulation, physical fitness and reduced abdominal fat while increasing skeletal muscle mass. Cognitive impairment also showed significant improvements in working memory, perceptual speed and executive function.
A qualitative study identified four self-care decision-making patterns among adults with multiple cardiometabolic conditions, including past experiences and leveraging resources. Effective self-care behaviors can improve quality of life for these patients, particularly those with type 2 diabetes, coronary heart disease, and stroke.
A new survey found that Native American adults are open to healthier eating based on traditional Indigenous foods, with 78% willing to try a whole food, plant-based diet. However, only 13% are aware that such diets can help prevent or improve type 2 diabetes.
Researchers identified endotrophin as a biological marker that rises and falls with changes in body fat, reflecting changes in metabolic health. The study suggests endotrophin could serve as a valuable biomarker and therapeutic target for reducing obesity-related health risks.
Researchers found that individuals with higher modifiable risk factors, such as high blood pressure and obesity, have more widespread plaque buildup and unstable plaques prone to rupture. The study's findings highlight the importance of early intervention to control these risk factors and prevent future events.
Researchers have identified transmembrane 4 L six family member 1 (TM4SF1) as a highly selective surface marker of senescent β-cells in both mice and humans. This discovery provides an important step toward developing targeted senotherapies that could preserve insulin secretion and slow the progression of type 2 diabetes.
Use of newer GLP-1 receptor agonists like semaglutide and tirzepatide was associated with a significant reduction in alcohol-related hospital admissions among adults with type 2 diabetes and obesity. The findings suggest a potential role for these medications in treating alcohol-use disorder.
Researchers analyzed data from 2,201,446 women and found associations between adverse pregnancy outcomes and an increased long-term risk of developing peripheral artery disease. Women who experience gestational diabetes, preeclampsia, or preterm delivery have a significantly increased risk of PAD later in life.
A randomized controlled trial found that medically tailored grocery deliveries improved blood sugar control among adults living with type 2 diabetes who have public health insurance. The study also showed benefits for food-related outcomes, filling an evidence gap in the integration of food-based interventions into routine diabetes care.
The Pennington-Louisiana Nutrition Obesity Research Center has received a five-year, $5.66 million renewal grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The award reaffirms Pennington Biomedical's position as a national leader in nutrition, obesity, and metabolic health research. The center su...
The 2026 American College of Cardiology/American Heart Association/Multisociety Dyslipidemia Guideline reclassified approximately one-quarter of adults, with two-thirds reassigned to lower-risk categories and one-third to higher-risk categories. This shift was driven by differences in risk factors among males, non-Hispanic Black indivi...