Articles tagged with Diabetes
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Researchers found that prasugrel may offer an advantage over ticagrelor for individuals with Type 1 or Type 2 diabetes and complex coronary disease. This is because the two medications are not interchangeable, and treatment with prasugrel may provide better benefits in preventing blood clots and adverse cardiac events.
Researchers analyzed insurance claims data from US health insurers to demonstrate the cardiovascular benefits of semaglutide and tirzepatide. Both GLP-1 drugs provide cardioprotective effects, reducing the risk of stroke and heart attack by 18% and 13%, respectively.
The study suggests that SGLT2 inhibitors can benefit patients with varying levels of kidney function and albuminuria. Routine use of these medications may lead to improved kidney outcomes across different patient groups.
The study found clear absolute benefits of SGLT2 inhibitors on kidney, hospitalization, and mortality outcomes regardless of diabetes status and level of urine albumin to creatinine ratio. This benefit suggests a potential therapeutic approach for patients with kidney disease.
Researchers successfully converted human stomach cells into insulin-secreting cells in mice, helping to control blood sugar levels and alleviate diabetes. The approach could potentially be used to treat patients with lost or dysfunctional pancreatic beta cells.
Researchers explore the link between senescent cells and metabolic diseases, highlighting potential treatments known as senotherapeutics. Senolytics, senomorphics, and senosensitizers are interventions aimed at eliminating or suppressing senescent cells to mitigate metabolic disease.
A new study by Mass General Brigham reveals that patients with traumatic spinal cord injuries are at a higher risk of developing chronic health problems, including hypertension, stroke, depression, and diabetes. The study highlights the need for proactive and multidisciplinary long-term care strategies to address these issues.
A study at the University of Gothenburg found that intensive treatment with remote monitoring of glucose levels and weekly healthcare contact significantly improved long-term blood glucose control in people with type 1 diabetes. The treatment also increased patient satisfaction and proved to be safe, with no serious events reported.
A recent study from Houston Methodist reveals how Alzheimer's can disrupt the connection between nerves and blood vessels in fat tissue, worsening heart and metabolic conditions. The research highlights a potential link between neurodegeneration and cardiovascular and metabolic disorders.
A study found that following steps to improve cardiovascular health can reduce the risk of mild cognitive impairment and dementia among people with Type 2 diabetes. Maintaining optimal cardiovascular health may protect brain health even for individuals with a high genetic risk for dementia.
A preliminary study found that low-dose aspirin use was associated with a lower risk of major cardiovascular events, including heart attacks and strokes, among adults with Type 2 diabetes. The analysis of 11,500 individuals over 10 years showed that consistent aspirin use led to significant reductions in cardiovascular event rates.
A new study from Virginia Tech found that weightlifting outmuscles running for blood sugar control in diabetes models. The research compared the effects of endurance and resistance exercise in mice fed a high-fat diet and found that weightlifting was more effective in reducing subcutaneous and visceral fat, improving glucose tolerance,...
A new study found that combining GLP-1 receptor agonist medications with healthy lifestyle habits significantly reduces the risk of major adverse cardiovascular events, including heart attacks and strokes. The research suggests that adopting multiple healthy behaviors can lower cardiovascular risk even further.
Type 2 diabetes has become a global epidemic with unequal burden, driven by ageing, dietary shifts, sedentary behaviour, and early-life exposures. The true cost of diabetes includes significant healthcare and economic burdens, but prevention remains the weakest link.
A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.
The study found that men, Black patients, and those living in low socioeconomic areas were disproportionately affected by the increased amputation rates. The authors emphasize the need for aggressive prevention, early diagnosis, and intensive risk factor management to address the growing burden of diabetes and PAD.
A new study from UC San Diego found that clinical pharmacists can play a crucial role in helping people with cancer and diabetes better manage their blood sugar. The study showed that patients referred to a diabetes management and education clinic led by pharmacists saw meaningful improvements in blood sugar levels over time.
Researchers developed a landmark model predicting 14 complications in diabetes patients over 15 years, showing early treatment makes a difference. The Multiethnic Type 2 Diabetes Outcomes Model for the U.S. (DOMUS) uses real-world patient data from Kaiser Permanente.
A new small molecule drug, RAGE406R, has been developed to disrupt a key cellular pathway responsible for chronic inflammation and associated complications in patients with diabetes. The breakthrough could offer a new therapeutic option for stopping the harmful effects of both type 1 and type 2 diabetes at the source.
Pennington Biomedical researchers will participate in numerous panels and presentations during the conference, sharing their latest findings on obesity treatment and prevention. The institution is well-represented at the event, with faculty members among the experts leading courses, presentations, and speaker panels.
Three new Cochrane reviews found GLP-1 drugs result in clinically meaningful weight loss, but evidence on longer-term outcomes and side effects is limited. The wider use of these drugs should consider social and commercial determinants to avoid deepening existing health inequities.
A new study finds that an AI-powered lifestyle intervention is noninferior to human coaching in achieving a composite outcome in adults with prediabetes and overweight or obesity. The AI-led Diabetes Prevention Program was noninferior to the human-led program in terms of weight reduction, physical activity, and HbA1c levels.
A new study from UC San Francisco found that saturated fat affects the behavior of a protein called PER2, which orchestrates fat metabolism and circadian rhythms. Mice eating a diet high in hydrogenated fats struggled to adapt to winter, whereas those on unsaturated fat diets adjusted easily.
The National Institutes of Health has renewed Pennington Biomedical's Metabolic Basis of Disease Center for five years, providing $2.2M per year to support research on the mechanisms of metabolic health. The center aims to address the obesity epidemic and its related illnesses.
A new study published in PLOS One found that nearly one-third of adults with type 2 diabetes in India achieved remission through a comprehensive mobile-based program combining diet, exercise, stress management, and medical support. The program showed significant improvements in weight, body mass index, glycated hemoglobin levels, fasti...
A study published in Science Advances found that the ketogenic diet can have potentially dangerous impacts on metabolic health, including impaired blood sugar regulation and fatty liver disease. Mice fed the diet developed severe metabolic complications, with some changes starting within days.
A randomized clinical trial showed that DMEK graft success is comparable between diabetes-positive and non-diabetes donor corneas after 1 year. The study's findings support the use of diabetes-positive donor corneas for endothelial keratoplasty procedures.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
The study found that 1-year DMEK success rates were high regardless of donor diabetes status. No restrictions on using tissue from donors with diabetes for DMEK are recommended based on the results.
A study at Kyoto University found that nearly half of Japanese medical students and residents held misconceptions about diabetes, such as a genetic cause or shorter life expectancy. The research suggests that clinical lectures may not be enough to address the stigma, highlighting the need for improved medical education curricula in Japan.
UCSF researchers found a key cellular switch driving pulmonary fibrosis and developed a new therapy to block it in mice. The treatment works by preventing healthy lung cells from converting to harmful cell types, reducing scarring and improving lung function.
Scientists found that CtBP2 levels decrease with age, but are higher in long-lived individuals. This biomarker may estimate the degree of aging and overall health status.
A new trial finds that empagliflozin and intranasal insulin safely improve brain health in people with mild cognitive impairment and early Alzheimer's disease. The medications target metabolic and vascular problems, improving memory, brain health, and blood flow.
The four-day training program equipped postdoctoral fellows with state-of-the-art methods for clinical research in obesity, metabolism and nutrition. Participants deepened their skills in gold-standard methodologies crucial for advancing clinical and translational research.
Researchers at Wayne State University are exploring the feasibility and acceptability of virtual reality-based Mindfulness-Based Stress Reduction (MBSR) as a tool to reduce stress in young adults with type 1 diabetes. The study aims to assess the effects of MBSR-VR on glycemic control, mindfulness, and psychological distress.
A study found that participants taking GLP-1 agonists experienced delayed effects after drinking alcohol, leading to reduced intoxication. The research provides early data for larger studies testing whether these drugs can help reduce alcohol use.
A new study shows that just 30 minutes of less sitting per day can improve the body's ability to utilize fats and carbohydrates for energy production. Participants who successfully reduced sedentary time showed improvements in metabolic flexibility and fat burning during light-intensity exercise.
Researchers found that a combination of nicotinamide, a-lipoic acid, thiamine, pyridoxamine and piperine reduced AGEs, sticky plaque-like molecules, to curb hunger, lower insulin resistance and extend lifespan in mice. The compounds also reversed some molecular hallmarks of hypothalamic aging.
Researchers discover that genetic glitches in the blood system, caused by aging, can spark obesity, diabetes, and fatty liver disease. Simple blood tests may help identify at-risk individuals to prevent chronic illnesses.
A comparative effectiveness study found that liraglutide, semaglutide, and dulaglutide have similar risks for kidney and cardiovascular outcomes in veterans with type 2 diabetes. Head-to-head trials are needed to confirm these findings.
Researchers developed noninvasive on-skin biosensors that analyze sweat and skin biomarkers for real-time diabetes management. These sensors offer a painless and continuous monitoring solution, transforming daily diabetes care.
Poor blood sugar control in adolescence increases the risk of painful future complications for people with type 1 diabetes. Children diagnosed with type 1 diabetes at a young age have trouble controlling their blood sugar as teens and are more likely to develop neuropathy in adulthood.
Researchers show low-molecular-weight kraft lignin restores insulin sensitivity and slashes blood glucose levels in diabetic rats. The fractionation process is simple, scalable, and cost-effective, positioning lignin as a renewable and non-toxic active ingredient for functional foods or therapies.
A new lab-designed protein has been discovered to regulate blood glucose levels, offering a potential new treatment avenue for people with Type 1 diabetes. The substance combines insulin and glucagon into one molecule, signaling the liver to respond naturally.
Long-term exposure to fine air pollutants like PM2.5 can impair metabolic health by disrupting the normal function of brown fat through complex epigenetic changes. The study identified two enzymes, HDAC9 and KDM2B, as key drivers of this process.
Scientists at Scripps Research discovered a new kind of cell that helps protect insulin production, paving the way to understanding how researchers could prevent or reverse type 1 diabetes. Vascular-associated fibroblastic cells (VAFs) act as molecular peacekeepers in the pancreas, actively protecting insulin-producing cells from the i...
A growing number of patients on GLP-1 receptor agonists may experience altered FDG uptake patterns on oncological PET-CT scans, potentially leading to misdiagnosis. Researchers recommend documenting medication histories to inform interpretation and developing national guidance.
Research presents evidence suggesting that metabolically active visceral fat is associated with more advanced stages of endometrial cancer and lymph node metastases. The study found no strong correlation between visceral fat volume and its metabolic activity.
Researchers exploring how exercise stress affects cellular adaptations and disease risk, focusing on mitochondrial energy sensing and AMPK activation. The study aims to determine if increasing mitoAMPK activity can mitigate diabetes in skeletal muscle.
Researchers discovered a new pathway that could help people with diabetes avoid dangerous hypoglycemia by restoring the function of delta cells. These cells, previously unknown to play a role in blood sugar regulation, release somatostatin to pause insulin production when necessary.
Researchers found that continuous glucose monitoring metrics correlated with hemoglobin A1c in patients with diabetes, but weakened or disappeared in those with prediabetes and normal glycemic control. CGMs are useful as behavioral tools for people without diabetes, but do not directly reflect longer-term blood sugar control.
A new study reveals a group of immune cells called efferocytic macrophages (eMacs) in the pancreas that can render T cells inactive, protecting insulin-producing beta cells and preventing Type 1 diabetes. The findings offer hope for new therapies for the chronic autoimmune disease.
A new study found that around one in seven Black and one in 63 South Asian men in the UK carry a genetic variant known as G6PD deficiency, which can cause delays in type 2 diabetes diagnosis. Men with this deficiency are diagnosed four years later than those without it.
A study conducted at the University of Eastern Finland found that group-based and online lifestyle counselling can help middle-aged and older men adopt healthier dietary habits, leading to a lower risk of type 2 diabetes. Those with a high genetic risk for type 2 diabetes saw the most significant benefits from fibre-rich diets.
Scientists develop novel experimental screening method to identify highly selective peptides with high therapeutic potential, enabling precise recognition of proteins involved in cancer and diabetes. The technique uses biologically- and chemically-modified bacteriophages to screen up to 1 billion peptides simultaneously.
A pioneering study from George Mason University researcher Raedeh Basiri found that daily mango consumption improves blood glucose control and enhances insulin sensitivity in adults with prediabetes. The high-sugar mango proved more beneficial than a low-sugar granola bar, reducing body fat.
A binational study found nearly 6 in 10 US adults and 3 in 10 Japanese adults discontinued semaglutide within 12 months of treatment. Patients with established cardiovascular disease and chronic kidney disease had higher discontinuation rates, highlighting the need for alternative treatments.
Researchers at the University of Copenhagen discovered two new ciliary proteins that regulate cell communication and may lead to the development of new treatments for chronic diseases. The study found that defective cilia can disrupt signaling in almost all tissues and organs, leading to various diseases.
A study of 92 individuals with type 2 diabetes found that those who overeat due to emotional reasons are less likely to lose clinically significant weight while taking GLP-1 receptor agonists. In contrast, individuals who eat in response to external stimuli tend to respond well to the therapy.
New research finds that GLP-1 receptor agonists (GLP-1RAs) significantly reduce the risk of death and major cardiovascular events in psoriasis patients. GLP-1RAs also show promise in reducing alcohol and substance abuse, with a 65% lower risk of alcohol abuse.