Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
A Northwestern University study found that average total payments per user for GLP-1 drugs more than doubled from 2017 to 2022. This raises concerns about the long-term affordability of these medications, which may be taken by patients for years or decades.
The meeting will explore breakthroughs in diabetes prevention and treatment, as well as innovative approaches to monitoring astronauts' health in space. Researchers will also discuss potential targets for slowing or preventing Alzheimer's disease in people with Down syndrome, and advancements in cervical cancer screening.
Researchers found a slight association between GLP-1 medications and ischemic optic neuropathy, a condition causing reduced blood flow to the optic nerve. The risk remains low, but clinicians should be aware of this potential association, particularly in patients with Type 2 diabetes.
A new review calls on Mexico to add liver health to its existing chronic disease programs, citing the country's high liver disease prevalence. Liver disease affects nearly half of Mexican adults and is linked to diabetes and obesity.
A major international study led by Curtin University found diabetes risk is linked to both excess body fat and poor muscle health, with nearly 15% of people with sarcopenic obesity developing type 2 diabetes within 10 years. Maintaining muscle strength and mass may be as important as managing body weight in assessing diabetes risk.
Mouse study uncovers how oxygen-sensing transcription factors regulate muscle physiology, improving glucose tolerance and producing erythropoietin. The findings suggest that selectively targeting each isoform can lead to different physiological outcomes.
A study published in PLOS Medicine found that British Bangladeshi and British Pakistani individuals are more likely to develop multimorbidity, a condition where people experience multiple chronic illnesses simultaneously. The research identified sociodemographic and genetic factors that increase the risk of developing these conditions,...
Researchers have found that GLP-1 agonists can normalize genetic pathways involved in pulmonary fibrosis, a lung disease associated with Long COVID. The treatment has shown promise in reducing the risk of fibrous buildup, suggesting potential benefits for people with type 2 diabetes and severe COVID-19 symptoms.
A new study maps the changing RNA modification landscape of sperm during development and shows that type II diabetes can disrupt this molecular program. The findings suggest that paternal metabolic disease can impact male fertility and potentially offspring health.
A randomized clinical trial found that long-acting analogue insulin glargine was associated with less time spent in dangerous hypoglycemia and fewer nighttime low blood sugar events. However, benefits only emerged after a year into the trial.
Researchers have identified high rates of overweight/obesity (82%) and hypertension (higher than statewide average) in Franklin Parish, with income levels linked to lower hypertension rates. Older residents are also more likely to have undiagnosed high cholesterol and diabetes.
Researchers call for hearing tests to be a standard part of diabetes care due to its high prevalence among adults with type 2 diabetes. A systematic review of 29 studies found that hearing loss is a significant yet under-recognised complication, affecting daily conversations and quality of life.
A new study found that GLP-1 receptor agonists can improve long-term health for people with peripheral artery disease (PAD), managing blood sugar and weight loss while reducing inflammation and improving blood vessel function. The benefits were highest among participants with severe PAD and obesity.
Dr. Logan Townsend joins Pennington Biomedical to study the connection between metabolic disease and mental health, investigating circulating factors influencing anxiety and depression. His research program aims to improve both metabolic and mental health outcomes.
A new study from the University of Copenhagen suggests that longer sleep is linked to more stable blood sugar levels in healthy 18-year-olds, even among those with no previous health issues. The researchers tracked participants over two weeks and found a two-way relationship between sleep duration and blood sugar stability.
A study by the University of São Paulo found that people with diabetes who have had COVID-19 tend to recover more slowly and experience more long COVID complications, including greater physical and cognitive difficulties. The study also found a higher risk of cardiovascular complications, such as heart attacks and angina.
A CU Anschutz study reveals reduced mitochondrial efficiency in healthy yet sedentary individuals, which may precede the development of major diseases like cancer, diabetes, and Alzheimer's. Regular exercise acts as a literal shield for cellular health, helping mitochondria seamlessly switch between burning fat and carbohydrates.
Researchers mapped pancreatic islet development in 123 pediatric organ donors without diabetes, revealing insights into the root causes of type 1 and 2 diabetes. The study provided a detailed map of the growing pancreas and connected findings to islet function.
A new study reveals that excessive fibrin deposition drives chronic inflammation in diabetic periodontitis. A targeted peptide successfully stops this inflammation and promotes periodontal bone regeneration, offering a potential universal therapeutic strategy for various immune-mediated diabetic comorbidities.
Hanyang University researchers developed AI-guided microneedle patches that actively change shape at physiological temperature to help close wounds while delivering regenerative therapy and antibacterial protection. The platform accelerates wound closure and improves tissue regeneration compared with conventional approaches.
New therapies using regulatory T cells, known as Tregs, could target diseases with inflammation, such as cancer and autoimmune conditions. Early evaluations show good tolerance and safety profiles, but precision is key to tailoring treatments for specific patients.
A review published in Diabetes Care suggests that physical exercise could play a role in promoting immune regulation, preserving beta-cell function, and reducing inflammation in type 1 diabetes. The evidence highlights the potential benefits of exercise on immune profiles displaying anti-inflammatory characteristics.
The team proposes a novel model that suggests RNA editing defects may initiate autoimmune responses in type 1 diabetes. Their research could reveal new mechanisms underlying the disease and lead to prevention and treatment breakthroughs.
Research suggests GLP-1 receptor agonists modulate immune responses and reduce inflammation in skin diseases. Studies indicate improvements in psoriasis severity indices following treatment with these drugs.
New research found that GLP-1 RA users showed weaker associations between impulsivity and violent crime, suggesting these medications may lessen risk factors. The study analyzed data from a US survey of adults who used GLP-1 medications.
A novel treatment approach for diabetic macular edema has shown promise in reducing treatment burden and cost without compromising visual outcomes. The '1 + 1 + PRN' sequential regimen involves fewer injections, which may improve patient adherence and quality of life.
The Critical Path Institute's Type 1 Diabetes Consortium is strengthening regulatory science and evidence frameworks for disease-modifying therapies. The expanded C-peptide evidence base supports ongoing evaluation of the biomarker as a drug development tool.
A recent study found that long naps may increase the risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD) in people with type 2 diabetes. MASLD is characterized by excessive fat buildup in the liver, which can lead to chronic disorders like NAFLD.
Adults with prediabetes who undergo lifestyle intervention show a lower burden of multimorbidity compared to those not receiving the intervention. Lifestyle programs can persistently reduce the development of chronic conditions in this population.
The study found a significant increase in type 1 diabetes cases among Hispanic/Latino adolescents in Puerto Rico, from 10.1 per 100,000 in 2009 to 24.1 in 2021, with an average annual increase of 4.1%. This trend has important implications for patient care and public health.
A recent study of 42,000 adults taking blood pressure medications and GLP-1s found higher rates of hypotension events, including dizziness and fainting. The study highlights a potential safety concern for patients aged 65 and older and those with diabetes.
A comprehensive analysis of solid-organ transplant recipients found that both existing and new-onset diabetes significantly increase mortality risk. Organ transplant recipients who developed or have diabetes after surgery had a higher risk of death compared to those without diabetes, with kidney recipients having the highest risk.
Researchers at Sanford Burnham Prebys Medical Discovery Institute found that enhancing protein-folding processes can help prevent harm to insulin-producing cells. The study revealed the importance of a chaperone protein called binding immunoglobulin protein and its cochaperone protein p58 IPK in maintaining proper proinsulin folding.
Research published in Frontiers in Endocrinology reveals gestational diabetes influences fetal metabolic programming, shaping future risk of obesity and diabetes. Biomarkers such as leptin and adiponectin may identify children at increased risk, enabling personalized preventive strategies.
Researchers at UVA are testing the SIPsmarter program to reduce sugary drink consumption among children and their parents. The study aims to improve beverage quality and overall health outcomes in rural areas with high rates of sugary drink consumption.
Persons with diabetes are at higher risk of periodontitis, tooth loss, and peri-implantitis. Poor blood sugar control exacerbates these risks, highlighting the importance of close collaboration between healthcare and dental care providers.
A new study by Pennington Biomedical and collaborators found that Americans with the highest levels of obesity are undergoing fewer surgical procedures overall. Despite the increasing prevalence of extreme obesity, these individuals appear to be receiving proportionally fewer surgical interventions each year. The research highlights gr...
A new oral GLP-1 medication, elecoglipron, has been shown to significantly reduce blood glucose levels and bodyweight in adults with type 2 diabetes. The study found that up to 89.6% of participants achieved an HbA1c level of 7%, while 72.3% experienced at least 5% weight reduction.
A new study found that the Inflation Reduction Act's $35 out-of-pocket cap on insulin prescriptions led to lower costs and increased insulin usage among Medicare patients. However, the impact was limited to a small portion of U.S. patients, with higher costs remaining for many.
A new analysis tracks global sugar-sweetened beverage tax adoption across 183 countries, revealing South Asia's significant lead in tax implementation. The study found that countries with higher burdens of type 2 diabetes and obesity are more likely to adopt taxes, but not necessarily those with high rates of sugary drink consumption.
The Medicare $35 insulin out-of-pocket cap implemented in 2023 decreased and stabilized insulin out-of-pocket cost, increasing insulin use. This finding can inform policies to boost insulin access among users with high out-of-pocket cost.
A new study found that dihydropyridine calcium-channel blockers (DCCBs) may be associated with poorer kidney outcomes in people with type 2 diabetes, even among those receiving modern kidney-protective treatments. DCCBs were linked to a higher risk of major adverse kidney events.
Researchers from Pennington Biomedical will showcase their latest findings on prevention, care, and cures for diabetes and obesity at the American Diabetes Association's 2026 Scientific Sessions. The sessions will highlight cutting-edge advancements driving progress in diabetes research and management.
A new study published in JAMA Network Open found that removing olfactory groove meningioma may improve blood sugar control and weight in some patients with diabetes. The research team tracked long-term changes in hemoglobin A1c levels after tumor removal surgery.
A new study reveals how Philip Morris Companies Inc. used cigarette research and flavor engineering to design Lunchables, a successful ultra-processed food for children. The company's strategy was based on optimizing 'technical synergies' between tobacco and food divisions.
A new observational study suggests that the way ultra-processed foods are made contributes to health risks like diabetes, heart disease, and early death. Even after accounting for nutritional quality, researchers found that people who ate more ultra-processed foods had worse health outcomes.
The FLOW trial shows that semaglutide significantly improved health-related quality of life in adults with type 2 diabetes and chronic kidney disease. Health utility scores and self-rated general health scores improved with semaglutide, but declined with placebo.
The study found that participants in the 'Healthy Living' online program experienced moderate improvements in their blood sugar levels, blood pressure, and body mass index (BMI). The program was designed to support self-management of type 2 diabetes and showed promising results in England.
Researchers at Pennington Biomedical published the first study to estimate pediatric obesity prevalence among US children and adolescents aged 5-18 years using the new Lancet Commission definitions. The study found that many children are already experiencing measurable health impairments associated with obesity.
A new model predicts retinal degeneration in diabetics based on 71 plasma proteins. The Pro-DRN model can help doctors identify patients at risk earlier, potentially preventing neurodegeneration and vision loss.
A recent study found that semaglutide, a widely used GLP-1 drug, slows down the accumulation of biological aging markers in adults with HIV. The treatment reduced chronic immune activation, visceral and ectopic fat, and reprogrammed certain cells, which may help explain its effects on multiple aging clocks.
Massachusetts Medicaid members who received medically tailored meals experienced significantly fewer health emergencies, including 31% fewer hospitalizations and 20% fewer emergency department visits. The program also resulted in lower per-person healthcare costs of $3,433, offsetting 98% of the program's cost.
Researchers highlight latest developments in pathology, diagnosis, and treatment of MASLD and IPFD, revealing correlations with chronic diseases like liver cancer and pancreatic cancer. Innovative treatments, such as AI-driven approaches and organ-targeted therapies, show promise for precision prevention and therapy.
A study from UC San Francisco researchers reveals that regulatory differences around the world are slowing the development and adoption of biosimilars. The lack of standardization in biosimilar approval processes is a major obstacle for these cheaper alternatives to expensive biologics, which could lower costs for patients.
The global incidence of type 1 diabetes nearly tripled over the past three decades, while health inequalities worsened. Lower-income countries carry a disproportionately large share of T1DM-related deaths and years of life lost due to disparities in access to insulin treatment and healthcare resources.
A study published in JAMA found that sitting less with greater light-intensity movement and steps was associated with significantly lower risks of adverse pregnancy outcomes. Adverse pregnancy outcomes include hypertensive disorders, gestational diabetes, preterm birth, and small for gestational age
A new study reveals that metabolic dysfunction in offspring is caused by excess microRNA in sperm from obese fathers. After weight loss, these molecular marks disappear, and offspring develop normally. Research suggests that interventions promoting health and longevity may trigger an increase in this enzyme expression.
Research finds gestational diabetes significantly increases risk of type 2 diabetes in women with normal pre-pregnancy weight. The study, published in eClinicalMedicine, analyzed over 1.15 million Swedish mothers and found elevated blood sugar levels predict future type 2 diabetes.
Researchers have found that screening for early-stage type 1 diabetes in children can be implemented sustainably in general pediatric practice, identifying most children who will later develop stage 3 clinical type 1 diabetes. The study suggests that families without a family history of the disease should also be screened.
Researchers developed an innovative hydrogel called Amniogel to support insulin-producing cells after transplantation, achieving normal blood sugar levels in diabetic mice for at least 100 days. This breakthrough opens the door to developing a bioartificial pancreas that could eliminate the need for insulin injections.