Articles tagged with Diabetes
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A cohort study found that GLP-1RAs like semaglutide and tirzepatide lower risk of dementia, stroke, and all-cause mortality in adults with type 2 diabetes and obesity. The findings suggest potential neuroprotective benefits beyond glycemic control.
Researchers have discovered a high representation of genes associated with obesity and type 2 diabetes in RNA cargo within extracellular vesicles. The study provides a roadmap for integrating EV transcript profiling with genetic approaches, which could inform the development of novel diagnostic and therapeutic strategies.
A new study found that consuming pistachios every night for 12 weeks altered bacteria in the gut of adults with prediabetes, increasing beneficial short-chain fatty acids like butyrate. The changes may offer long-term health benefits, potentially slowing Type 2 diabetes development or reducing inflammation.
Despite supply shortages and insurance coverage obstacles, patients taking GLP-1 medications achieve clinically significant weight loss when paired with intensive lifestyle interventions. The study found that consistent medication courses combined with lifestyle changes and support remain the most effective weight-loss program option.
A study presented at the Endocrine Society's annual meeting found that socially isolated older adults are 34% more likely to have diabetes and 75% more likely to have poor blood sugar control. Social isolation is being recognized as a critical social determinant of health, highlighting its importance in caring for older patients.
An international team has uncovered a new mechanism by which mitochondria and peroxisomes work together to defend against oxidative stress, maintaining cellular health. This discovery challenges the long-standing idea that cellular defense is confined within individual compartments.
A recent study published by Fujita Health University found that poor oral health can increase the risk of lifestyle-related diseases such as diabetes and heart disease. The researchers examined 118 individuals aged 50 or above and found significant links between oral function test results and blood test results.
Researchers identified TMEM9B-AS1, a long non-coding RNA that regulates cellular functions, as significantly reduced in skeletal muscles of people with type 2 diabetes. Its absence disrupts protein production, leading to muscle weakness and loss.
Researchers at MIT developed an implantable device that can store glucagon to counteract hypoglycemia, a life-threatening condition for people with Type 1 diabetes. The device, about the size of a quarter, contains a small reservoir made of 3D-printed polymer and can be triggered remotely or automatically by a sensor.
A new study found that older people with diabetes who do not control their blood sugar levels are three times more likely to develop eye disease than those with controlled blood sugar levels. High glucose levels were also linked to an increased risk of glaucoma and macular degeneration.
A pilot study evaluated Nutri, a clinical decision support tool for brief diet counseling in safety-net clinics. PCPs found the system usable and satisfactory, while patients effectively engaged with the intervention.
A team of researchers from The University of Osaka has made a breakthrough in weight loss treatment by developing a one-time genome editing approach that introduces a GLP-1 receptor agonist gene. This innovative method enables the body to produce its own weight-loss medication, reducing the need for regular injections.
A study of 679 patients found that longer GLP-1RA treatment, not having diabetes, and higher body fat were associated with better weight reduction. Higher muscle mass and metabolic rate also contributed to successful weight loss in patients with overweight or obesity.
Preliminary research suggests that climate change can lead to a reduction in nutritional quality in food crops, with potential devastating consequences for human health. The study found that elevated CO2 levels and hotter temperatures can exacerbate this decline, particularly affecting essential proteins, minerals, and antioxidants.
A study of 168,547 postmenopausal women found that excess weight is associated with a 31% higher risk of breast cancer in those with cardiovascular disease. Higher BMI also increases the risk in women without cardiovascular disease, although to a lesser extent.
Researchers found significant differences in gut microbiota composition between pregnant women with and without gestational diabetes. A diagnostic model based on genus-level markers showed high precision for early detection of the condition, offering new opportunities for prevention and personalized management.
Researchers at Stanford Medicine discovered that a common signaling pathway protects airways from damage caused by toxins like wildfire smoke or respiratory viruses. The drug, which activates the pathway, protected mice with influenza or COVID-19 infections, while blocking it caused severe damage to their airways.
A study published in the Journal of Epidemiology & Community Health found that a pro-inflammatory diet during pregnancy may raise a child's risk of developing type 1 diabetes. The research, which followed pregnant women from Denmark, found a 16% increase in risk for each unit increase in dietary measure of inflammatory food intake.
A new study found that the newer generation of effective diabetes medications are not reaching enough patients. The study analyzed data from over 40,000 records and found that only 20% of patients with type 2 diabetes were taking GLP-1 drugs within a year of diagnosis, and less than 15% were taking SGLT2 drugs.
A new international study found that replacing regular bread with oat β-glucan-enriched bread did not significantly improve long-term blood sugar control. The CarbHealth study involved nearly 200 participants and aimed to test whether a simple dietary swap could yield measurable health benefits.
A team of international scientists successfully 3D printed functional human islets using a novel bioink, paving the way for more effective and less invasive treatment options. The bioprinted constructs maintained their structure without clumping or breaking down and showed promising results in laboratory tests.
Researchers have developed a new genetic risk score to identify type 1 and type 2 diabetes in Chinese populations. The test was tested on over 5,000 patients and showed improved accuracy in diagnosis, particularly for those with high family risk of developing type 1 diabetes.
A global coalition of experts released the Copenhagen Declaration, a framework to revolutionize diabetes care and research globally. The declaration outlines four urgent strategies to close gaps in treatment and innovation, with a focus on low- and middle-income countries.
A study analyzing 40 years of health data from a small farming community found that specific ranges within normal blood glucose levels are associated with lower mortality risks. Individuals with one-hour post-glucose load blood glucose levels below 170 mg/dL had significantly fewer deaths due to heart disease and cancer.
Researchers at Osaka Metropolitan University have identified the REDD2 gene, which is activated by metabolic stress and damages pancreatic β-cells, leading to reduced insulin secretion and the onset of diabetes. Suppressing REDD2 expression protects β-cells from damage, even under stress from overeating, preventing the onset of diabetes.
Research published in Occupational & Environmental Medicine found a strong association between working in person-contact roles and an increased risk of developing type 2 diabetes. High levels of emotional demands and confrontation were particularly linked to a higher risk, especially among those with low social support at work.
A clinical trial found that semaglutide, a Type 2 diabetes drug, improved blood sugar levels and weight loss in adult Type 1 diabetes patients who use automated insulin delivery systems. The study showed that 36% of patients taking semaglutide achieved target blood glucose levels and lost at least 5% of their body weight.
A new preclinical study from Weill Cornell Medicine found that a combination of small molecules extended the survival of transplanted pancreatic islets in female mice, while adding two molecules to the mixture boosted cell survival in male mice. This breakthrough could allow physicians to treat more patients with fewer cells.
A new potential drug treatment has shown promising results in reducing blood sugar levels and increasing fat burning in people with type 2 diabetes and obesity. The treatment activates metabolism in skeletal muscle, promoting healthy weight loss and preserving muscle mass, a key factor in metabolic health.
Early-phase clinical trials of a new weight management medication amycretin have confirmed its safety and tolerability. The medication targets two specific receptors to help control blood sugar and appetite, showing promise in treating overweight, obesity, and type 2 diabetes.
A new clinical trial found that taking semaglutide once weekly significantly improves blood sugar levels and leads to substantial weight loss in adults with Type 1 diabetes. The study involved 72 participants across four medical centers and showed a 36% improvement rate compared to the placebo group.
Critical Path Institute's Translational Therapeutics Accelerator awards $250,000 to researchers advancing a promising therapeutic pathway for type 1 diabetes. The project aims to address key challenges in T1D treatment, including beta-cell preservation and immune system modulation.
The University of Gothenburg, AstraZeneca, Knut and Alice Wallenberg Foundation, and Region Västra Götaland are partnering to tackle metabolic disorders. The SEK 200 million initiative aims to deepen understanding of obesity's mechanisms and develop effective treatments.
A new study published in the Journal of the American Heart Association found that residents in U.S. coastal counties near ocean waters with high concentrations of microplastics are at higher risk for Type 2 diabetes, coronary artery disease, and stroke. The study analyzed data from 152 counties and found a significant association betwe...
Research reveals shared genetic associations between type 2 diabetes mellitus and subcortical brain volumes, including hippocampus and amygdala. The study identifies 229 loci associated with T2DM and 220 loci with subcortical brain structures, providing critical genetic evidence for risk prediction and early intervention strategies.
A new study published in npj Digital Medicine found that an interactive artificial pancreas system, using digital twins, improved blood sugar control and reduced hemoglobin A1c levels in type 1 diabetes patients. The system adapts to users' changing bodies and allows them to test changes to the system's parameters in a safe simulation ...
A new study finds that a lower-sodium DASH-style diet can produce clinically meaningful reductions in blood pressure for adults with type 2 diabetes. The study, which modified the original DASH diet for people with type 2 diabetes, achieved a 5-point reduction in systolic blood pressure, resulting in lower risks of stroke, cardiovascul...
A University of Oxford study found that an intensive low-energy diet programme significantly improved eating disorder symptoms in people with type 2 diabetes and excess weight at risk of developing eating disorders. The programme showed benefits persisting six months after completion.
Researchers at Tufts University have designed a new compound that incorporates structural elements of four hormones - GLP-1, GIP, glucagon, and PYY - to create a single weight loss drug. This chimera peptide aims to address the drawbacks of current weight loss drugs, such as nausea and limited efficacy.
A new study from the University of Colorado Anschutz Medical Campus shows that primary care clinics can effectively introduce continuous glucose monitors (CGMs) into their practices. The study found that both self-guided and virtual CGM initiation services were successful, regardless of clinic size or diabetes expertise.
Fermenting legume pulses increases their antioxidant activity by up to 83% and their capacity to regulate Type 2 diabetes markers by up to 70%, according to a study. Red lentil and green split pea exhibited the greatest improvements in antioxidant scavenging activity and protein solubility.
The use of GLP-1 receptor agonists among diabetes patients is associated with a higher risk of developing incident neovascular age-related macular degeneration. Further research is needed to understand the underlying mechanisms and trade-offs between benefits and risks.
The Greaux Healthy initiative aims to prevent and treat childhood obesity through partnerships with healthcare providers, educators, and families. The program has developed tools and resources for four priority populations, including expectant families, preschool-aged children, school-aged children, and adolescents and young adults.
A recent study found that nearly 1 in 6 adults with hypertension and 3 in 10 with diabetes were unaware of their condition by 2021-2023. Young adults and women are disproportionately affected by a lack of awareness.
Research suggests that consuming more phytosterols could lower the risk of heart disease and type 2 diabetes. Higher intake was associated with better insulin regulation, reduced inflammation, and differences in the gut microbiome. This supports a healthy plant-based dietary pattern rich in vegetables, fruits, nuts, and whole grains.
A new study published in the American Society for Nutrition found that higher linoleic acid levels were associated with lower risks of heart disease and type 2 diabetes. The research used blood markers to measure linoleic acid levels in nearly 1,900 people, suggesting that this omega-6 fatty acid may support cardiometabolic health.
Researchers developed a new approach to identify healed diabetic foot ulcers at risk of reopening based on trans-epidermal water loss measurements. High TEWL values were linked to increased wound recurrence and shorter time to recurrence, suggesting functional skin barrier defects are a critical factor in wound healing.
A NIH-funded study has identified trans-epidermal water loss as a reliable predictor of diabetic foot ulcer recurrence. Participants with high TEWL were 2.7 times more likely to experience wound recurrence, highlighting the importance of skin barrier function in wound healing.
Researchers have uncovered unique molecular fingerprints for insulin sensitivity, challenging traditional binary classification of people with type 2 diabetes. These signatures can help identify individuals at risk earlier than current methods, paving the way for personalized treatments and precision medicine.
A Japanese study found that choosing the right type of meal can extend meal duration and encourage more mindful eating. Researchers discovered that traditional bento-style meals with individual components promoted longer meal times and more chewing compared to fast food.
A new study from Mass General Brigham found that patients with diabetes who started statin therapy immediately reduced the rate of heart attacks and strokes by one-third compared to those who delayed treatment. The study analyzed data from over 7,000 patients and used artificial intelligence to gather information.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
BYU researchers found that sugar from beverages like soda and fruit juice is consistently linked to a higher risk of developing type 2 diabetes. In contrast, dietary sugars from whole fruits, dairy products, or whole grains do not cause metabolic overload in the liver.
Four Weill Cornell Medicine investigators received the Ritu Banga Healthcare Disparities Research Awards to tackle disparities in cancer care, racial and ethnic differences in pediatric Hodgkin lymphoma, and access barriers to high-quality surgical cancer care. The awards support innovative research aimed at improving health outcomes f...
A new study by the Physicians Committee for Responsible Medicine found that participants following a vegan diet lost an average of 11 pounds, compared to no significant weight loss for those on a portion-controlled diet. The study suggests that replacing animal products with plant-based foods, even those considered unhealthy, can be an...
A study found that children exposed to higher levels of air pollution experienced rapid weight gain and higher BMI by age 13, leading to increased insulin resistance in their mid-20s. The study suggests early interventions can help reduce the risk of chronic disease.
Researchers analyzed data from the Women's Health Initiative, a large cohort study, and found that using metformin increases the likelihood of reaching age 90 or older. The use of metformin was associated with a 30% lower risk of death before age 90 compared to sulfonylurea.
A new study published in Science Advances reveals that a single gene plays a big role in how the liver stores energy, which is critical for overall health and managing diseases like type 2 diabetes. The research found that when this gene is more active, the liver tends to store more energy as glycogen.
Research found that workforce participation among people with diabetes remains low, despite significant health improvements, due to factors like health complications and workplace barriers. The study suggests expanded access to anti-obesity medications could have positive effects on the labor market.
GLP1-RA treatment is associated with improvements in quality of life, restrained eating, and emotional eating behavior. The treatment also provides reassurance regarding its psychiatric safety profile.