About The Study: This cross-sectional study of the Global Burden of Disease 2021 study data found that, among the U.S. population of 332.7 million, disorders affecting nervous system health impacted 180.3 million U.S. individuals and were the top cause of disability. Conditions with the greatest collective disability were stroke, Alzheimer disease and
other dementias, diabetic neuropathy, and migraine. The U.S. should prioritize efforts to combat these conditions with development and implementation of new and effective prevention strategies, therapeutics, and focused rehabilitation.
Corresponding Author: To contact the corresponding author, John P. Ney, MD, MPH, email john.ney@yale.edu .
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(doi:10.1001/jamaneurol.2025.4470)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Neurology