Articles tagged with Diabetes
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A study found that using SGLT2i drugs in patients with gout and type 2 diabetes can lead to lower rates of starting urate-lowering therapy, NSAIDs, and diuretics. This could streamline care and reduce medication burden for these patients.
A new study found that providing financial vouchers to offset medication costs can significantly improve glycemic control among patients with uncontrolled Type 2 diabetes. After six months, participants receiving performance-based incentives saw a clinically substantial reduction in HbA1c levels.
A cohort study of 47,000 adults found that males had a 63% greater risk of all-cause mortality compared to females after adjusting for demographic and behavioral factors. The study suggests intrinsic biological factors, such as sex hormones or immune response, may contribute to these sex differences in mortality.
Scientists at the University of Florida and Linköping University discovered protein markers in umbilical cord blood associated with future insulin-dependent diabetes. The study suggests that these markers can be used to predict type 1 diabetes in early childhood, potentially allowing for targeted interventions and lifestyle changes.
Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly lowers risks of limb events, cardiovascular events, all-cause mortality, and kidney disease progression compared to dipeptidyl peptidase-4 inhibitors in patients with diabetes. GLP-1 RAs are preferred for secondary prevention in this high-risk population.
Researchers are developing next-generation adaptive insulin delivery systems using machine learning algorithms and ultra-rapid-acting U-500 insulin to personalize glucose control without manual intervention. The project aims to give people with Type 1 Diabetes their time, attention, and peace of mind back.
A new study from the University of Victoria found that higher insulin levels at age 47 predicted younger onsets of hot flashes and night sweats. Insulin may be a stronger predictor of hot flashes when taking other metabolic variables into account, while body mass index (BMI) appeared more closely associated with estrogen level changes.
Researchers found that higher testosterone levels reduced risk, while increased estradiol levels increased cardiovascular risk in male participants. In contrast, women with diabetes showed no significant link between hormone levels and cardiovascular outcomes.
A randomized clinical trial found that a smart speaker-based intervention significantly improved mental distress, quality of life, and diabetes self-care among older adults with type 2 diabetes. This easily implemented self-management strategy may enhance health outcomes in this population.
A research team at Kumamoto University has developed a breakthrough drug-delivery platform using a small-intestine-permeable cyclic peptide, enabling efficient oral delivery of insulin. This approach achieves a pharmacological bioavailability of approximately 33–41% relative to subcutaneous injection.
Researchers developed an AI model called DiaCardia that accurately identifies individuals with prediabetes using only ECG data. The model achieves impressive accuracy and generalizability, even in single-lead ECG data, opening possibilities for home-based screening.
A groundbreaking study reveals B cells' detrimental role in progressing Type 1 diabetes by interfering with regulatory T cells. The findings suggest targeting B cell-Treg interactions could offer new therapeutic strategies for preserving beta cells and improving patient outcomes.
A new review by the Physicians Committee for Responsible Medicine found that ultra-processed plant-based foods like breads and cereals lower type 2 diabetes and hypertension risk. Whole grains and plant-based meat alternatives also have health benefits due to their fiber, micronutrients, and phytochemicals.
A UK-wide childhood screening program for type 1 diabetes has been shown to be effective in detecting early stages of the disease. By identifying children at risk, families can prepare for a potential diagnosis and receive timely treatment, reducing the need for emergency hospitalizations.
Obesity is a chronic health condition associated with harm to health, affecting more than one-third of the US population. A new American Heart Association scientific statement emphasizes socioeconomic and structural barriers to obesity prevention and management.
Exposure to PFAS is associated with insulin resistance and altered insulin secretion, identifying pregnancy as a key vulnerable period. Gestational diabetes increases the risk of pregnancy complications and long-term health risks for both mother and child.
A recent review of bamboo consumption found promising health benefits, including improved metabolic health, reduced inflammation, and antioxidant activity. However, caution is advised due to potential risks associated with raw or improperly prepared bamboo.
Research highlights racial-ethnic differences in pregnancy-related high blood pressure risk, with Pacific Islanders and Filipinos more likely to develop a hypertensive disorder. Early identification and treatment can help prevent serious complications for both pregnant individuals and their infants.
The new program combines limb preservation, amputation care, and reconstructive solutions like osseointegration to improve identity, functional outcome, and quality of life for patients. Patients will receive coordinated, personalized, and expert care that supports their recovery and promotes sustained overall health.
A novel photodynamic platform combines antibacterial action, hemostasis and pain relief under natural sunlight, enabling painless, antibiotic-free therapy for infected diabetic wounds. The treatment demonstrates rapid hemostatic capability and a pronounced analgesic effect.
A comprehensive genomic characterisation of E. coli strains isolated from diabetic foot ulcers reveals high diversity and antibiotic resistance. The study provides valuable insights into the specific pathogens involved in diabetic foot disease and suggests potential targets for improved treatment strategies.
Tufts researchers have developed a method to biosynthetically produce tagatose, a rare sugar with potential health benefits. Tagatose is 92% as sweet as sucrose and has about 60% fewer calories, making it an attractive alternative to conventional sugar substitutes.
A new study reveals that people with an unexpectedly high metabolic BMI have up to a five times higher risk level for diseases such as diabetes and fatty liver. Metabolic BMI is based on advanced metabolomic analyses and identifies obesity-linked changes in metabolism that can be present even at normal weight.
The study reveals that diabetes poses a significant challenge for healthcare systems and economies worldwide. The economic impact of diabetes is substantial, with an estimated global cost of up to $152 trillion, equivalent to 1.7% of GDP, when informal care is factored in.
Scientists at The Wertheim UF Scripps Institute have designed potential diabetes drugs that reprogram insulin-resistant cells into a healthier state while limiting side effect risks. The compounds target PPAR gamma, a master regulator of fat cell and insulin metabolism.
A study of over 12 million US births found a persistent rise in gestational diabetes rates every year since 2016, increasing health risks for mothers and babies. The condition affects all racial and ethnic groups, with American Indian and Pacific Islander populations showing significantly higher rates.
A study led by UC Riverside scientists found that a father's microplastic exposure can trigger metabolic dysfunctions in his offspring, with female offspring being more susceptible. The research used mouse models and found altered sperm small non-coding RNA profiles and increased risk of diabetes in female offspring.
Researchers at Lund University have discovered a cell's protective mechanism against excessive hydrogen peroxide, a key free radical. The study shows that the channel in the cell membrane closes automatically when high concentrations of hydrogen peroxide are detected, preventing damage and cell death.
A systematic review found that pancreatic cancer surgery significantly increases the risk of new-onset diabetes mellitus (NODM), particularly in patients with known risk factors. The study analyzed 45 studies and found an overall incidence of NODM of 24.5%, with a higher rate in those who underwent distal pancreatectomy.
A new study found that gestational diabetes alters the placenta's molecular processes, disrupting gene expression and potentially leading to complications in newborns. The research identified a key protein, SRSF10, that may contribute to these disruptions, offering potential therapeutic targets for preventing pregnancy complications.
The University of Texas at San Antonio has received a $7 million gift commitment from Ed and Linda Whitacre to advance research, student success, and athletics. The gift will fuel groundbreaking discovery in metabolic health and strengthen the institution's role in improving health outcomes for South Texans.
A landmark study published in Nature Metabolism reveals how citrin deficiency, a rare genetic disorder, triggers fat buildup in the liver despite being lean. The research also discovers a hormone that reduces cravings for sweets and alcohol, providing new therapeutic targets for MASLD and fatty liver disease.
Research from King's College London reveals that reversing prediabetes through lowering blood sugar levels significantly reduces the risk of heart problems and death. People who achieved remission had a 58% lower risk of cardiovascular death, while those with normalised glucose levels saw a 42% reduction in major adverse events.
A preliminary study suggests that GLP-1 drugs, used for diabetes and weight loss, may be linked to a lower risk of developing epilepsy. Researchers found an association between the use of these drugs and a reduced risk of epilepsy, with semaglutide showing the strongest correlation.
Pennington Biomedical Research Center launched its first international scientific symposium in Riyadh, Saudi Arabia, exceeding expectations with distinguished audience engagement and new institutional contacts.
Researchers have uncovered a microbial metabolite called trimethylamine (TMA) that can block a key immune pathway and improve blood sugar control. TMA, produced by gut bacteria from dietary choline, targets IRAK4, a protein that triggers inflammation and insulin resistance in diabetic individuals.
A study found that mitochondria in people with type 2 diabetes and fatty liver disease have impaired ability to utilize ketone bodies for energy production. This defect was greater than the overall decline in mitochondrial function, suggesting a potential new target for improving energy metabolism in diabetes.
A multicenter randomized controlled trial demonstrates the advantages of continuous real-time glucose monitoring over finger-prick testing in managing gestational diabetes. The study found that only four percent of women with rt-CGM gave birth to above-average weight children, compared to ten percent in the control group.
A large study found that people with type 1 and type 2 diabetes have a higher risk of sudden cardiac death, particularly in younger adults. The research also showed that sudden cardiac death contributes to shorter life expectancy for those with diabetes.
Dr. Anna Gloyn has been awarded the fifth Transatlantic Alliance Award for her pioneering research on genetic mechanisms of diabetes and precision medicine. Her collaborative work with colleagues across Europe and the United States has significantly advanced our understanding of the genetic basis of diabetes.
Researchers found that oral bacteria from tooth infections can worsen diabetes risk through IL-17-driven inflammation. The study revealed a mechanistic link between Porphyromonas gingivalis-induced periapical disease and systemic metabolic dysfunction.
Researchers at MIT have developed a shoebox-sized device that can measure blood glucose levels using Raman spectroscopy, potentially replacing finger pricks for people with diabetes. The device's accuracy is similar to that of commercially available continuous glucose monitoring sensors.
A research team at Max-Planck-Gesellschaft found that pregnant mice exposed to fatty food smells developed more pronounced obesity and insulin resistance in their offspring. The brains of the offspring showed similarities to those of obese adult mice, suggesting a potential link between maternal diet and child health.
A nationwide observational study from SWEDEHEART reveals that patients with type 1 diabetes have a significantly higher risk of stent complications compared to those without diabetes. The study emphasizes the need for adapted treatment and follow-up strategies for this patient group.
Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.
A five-year NIH-funded study will explore the role of glucagon hormone in human metabolism, focusing on its impact on insulin secretion, glucose regulation, and energy balance. The research aims to clarify glucagon's function and inform more effective drug development for obesity and Type 2 diabetes treatment.
A cross-sectional study found that US population faces significant challenges with nervous system disorders, impacting 180.3 million people, mainly due to stroke, Alzheimer's disease, diabetic neuropathy, and migraine conditions.
A study found that women with obesity who stopped using GLP-1 receptor agonists experienced more gestational weight gain and a higher risk of preterm delivery, gestational diabetes, and hypertensive disorders. The research suggests that discontinuation of these medications may impact pregnancy outcomes.
The study found that GLP-1 receptor agonists are increasingly used for postpartum weight loss in overweight women without a documented diabetes diagnosis. The primary indication for use was weight reduction, suggesting a potential shift in treatment guidelines.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
A new study by UC San Francisco combines genetic risk with cardiovascular disease risk factors to predict who is more likely to develop dementia. The expanded view may help those worried about dementia, as lifestyle changes and improved control of illnesses can reduce brain damage and potentially delay or prevent symptoms.
A University of California, Riverside-led study found a community-based health program improving lifestyle changes in low-income, rural Latinas. The program, ¡Coma, Muévase y Viva!, combined health education, cooking demos, and exercise, resulting in increased healthy habits, weight loss, and improved chronic disease management.
A new type of DNA damage, glutathionylated DNA adducts, accumulates at high levels in mitochondrial DNA, affecting energy production and stress response. The discovery sheds light on how cells sense and respond to stress, with potential implications for diseases like cancer and diabetes.
Researchers developed a probe to visualize lipid breakdown in living cells, revealing differences in breakdown rates among individual droplets. The study found that an enzyme called ATGL drives these variations, which may contribute to abnormal lipid metabolism in liver cancer cells.
A study comparing GLP-1 RAs found that all three drugs are relatively safe options for patients with type 2 diabetes, with minimal differences in kidney and cardiovascular risks. Liraglutide had a lower risk of all-cause mortality compared to dulaglutide.
A new study led by Prof. Maayan Salton and Dr. Tal Schiller found that gestational diabetes alters the placenta's genetic messages, causing hundreds of errors in protein synthesis. The key protein SRSF10 appears to contribute to this process, suggesting a potential therapeutic target for mitigating its effects.
A new study reveals that sons born to mothers with type 1 diabetes show early signs of vascular dysfunction in their blood vessels, even before metabolic health is affected. The research suggests that this sex-specific effect could help clinicians assess risk and prevent cardiovascular disease earlier in life.
A comprehensive review identifies exosomes as critical mediators in the process of obstructive sleep apnea (OSA)-related diseases. OSA-induced intermittent hypoxia and sleep fragmentation alter exosome secretion and content, disrupting cell function and leading to various comorbidities.
A recent USC study tracked 85 young adults over four years and found that increased ultra-processed food consumption was linked to elevated blood sugar and early signs of diabetes risk. The researchers also discovered that limiting UPF intake can help prevent disease.
Researchers found that taking metformin in addition to standard care after catheter ablation reduced episodes of atrial fibrillation in people with obesity. The study suggests that lifestyle and risk factor modification efforts can be aided by metformin, and future studies are needed to confirm these findings.