Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
A six-year study of people aged 40-70 found that those with diabetes and high blood pressure experience greater cognitive decline compared to their healthy counterparts. The study suggests controlling hypertension and diabetes before age 60 may help preserve mental abilities later in life.
Current diagnostic criteria for diabetes are based on morning measurements, but patients tested in the afternoon may have higher fasting plasma glucose levels, leading to incorrect diagnoses. The study suggests that applying current criteria to afternoon patients could miss up to half of undiagnosed cases.
Researchers in Canada are developing a class of drugs for chronic pain with fewer side effects. Canadian scientists also presenting promising treatments for Hepatitis C and non-insulin dependent diabetes by targeting key enzymes involved in the diseases.
A study found that antidiabetic drugs are less effective in mice without adipose tissue, suggesting a possible connection between fatty liver disease and diabetes. The authors also noted that the drugs still had some beneficial effects on lipid metabolism in these animals.
A University of North Carolina at Chapel Hill study found that 7% of healthy North Carolina schoolchildren already have three risk factors for heart disease and type II diabetes. Obesity is the sole significant predictor of these risk factors, with obese children 53 times more likely to develop insulin resistance syndrome.
Researchers identified gene locations involved in fat deposition and diabetes risk, with effects influenced by a mother's weight. Mice with genetic predisposition for diabesity were less obese if nursed by a lean foster mother, hinting at the role of maternal environment in triggering obesity and diabetes.
Scientists have developed genetically-altered mice that resist diet-induced obesity and insulin resistance by producing uncoupling protein-1 in muscle tissue. This protein burns excess energy as heat instead of storing it as fat, mirroring the effects of exercise on weight loss.
The NIH-funded program will bring together researchers from the Center for Biomedical Inventions and the Touchstone Diabetes Center to develop novel therapies for type II diabetes. Researchers aim to translate basic science into medical therapy, exploring new approaches in treatment and delivery methods.
University of Iowa researchers found that injecting angioblasts, precursor cells for endothelial cells, accelerates blood flow restoration in diabetic mice. This breakthrough has implications for treating diabetes-related circulatory problems and improving limb health.
Columbia University researchers have identified a target molecule called RAGE that contributes to cellular damage in diseases like diabetes, cancer, and Alzheimer's. Blocking RAGE has shown promise in halting or reversing cellular damage in animal studies.
A study of homeless people in Toronto shelters found that 72% had difficulties managing their diabetes due to factors like shelter diet and medication logistics. The authors recommend improving care by establishing secure areas for insulin administration and assessing shelter meals.
A new study by University of Michigan researchers found that smokers who receive a diabetes diagnosis are more likely to quit smoking, but some still continue despite the increased health risks. The study analyzed data from over 1,600 middle-aged adults and confirmed past findings that certain demographics, such as African American or ...
UCSD School of Medicine scientists have successfully cultured human beta cells that can produce insulin indefinitely. The immortal cell line holds promise for treating people with diabetes through transplantation, potentially offering an unlimited source of insulin-producing tissue.
The Immune Tolerance Network will fund a multicenter clinical trial of the Edmonton Protocol, aiming to assess its effectiveness and long-term risks in treating type 1 diabetes. The trial will involve up to 32 new transplants at eight clinical centers across North America and Europe.
A new study by Northwestern University Medical School researchers found that high blood sugar levels are associated with an increased risk of pancreatic cancer death. The study analyzed data from nearly 40,000 men and women who were screened for cardiovascular disease risk and followed up for an average of 25 years.
A study published in The New England Journal of Medicine found that a high-fiber diet can lower blood glucose levels and decrease insulin levels in patients with type II diabetes. Patients who consumed 50 grams of fiber per day showed a 10% reduction in glucose levels, compared to the recommended 24 grams of fiber per day.
The IDEATel project aims to improve health and access to care for rural and inner-city residents with diabetes. The four-year grant will study the efficacy of telemedicine in enhancing patient quality-of-life and reducing healthcare costs.
Researchers at the University of Pittsburgh have developed transgenic mice that overexpress hepatocyte growth factor, leading to increased beta cell proliferation and insulin production. The study suggests that this approach may lead to new therapies for diabetes by enabling islet cells to proliferate and produce insulin more effectively.
A recent study reveals that long-term nerve damage in diabetic rats can be reversed by treatment with an insulin-like protein. The protein may prevent or alleviate certain nerve complications associated with diabetes, such as irregular blood pressure control and digestive issues. Researchers are hopeful about the potential therapeutic ...
A recent study found that insulin-like growth factor I (IGF-I) can reverse nerve damage in diabetic rats, with 80% fewer swollen nerve endings observed. The protein may compensate for the loss of a healthy factor or be a nourishing agent itself.
A recent study by Wake Forest University School of Medicine found a high diabetes rate among Lumbee Indians, with approximately 9% of adults in Robeson County diagnosed. The study suggests that diabetes is a major concern for the Lumbee community and highlights the need for increased healthcare awareness and prevention efforts.
A study found that 15% of dental patients with periodontal disease have undiagnosed diabetes, while 56% have high cholesterol. The study highlights the importance of routine physical examinations and preventative care for patients with risk factors.
Scientists used peptide injections to divert the immune system and prevent disease progression in mice with type-I diabetes. The study suggests peptide-based immunotherapy may be effective for people at risk of developing the autoimmune disease.
Researchers at the University of Utah have discovered a naturally-occurring antibody that significantly reduces diabetic symptoms in mice. The study's findings suggest that masking the foreign nature of affected cells may prevent immunological processes that cause diabetes. Eighty percent of treated mice did not develop diabetic symptoms.
A study of 5,888 senior citizens found that only those with high levels of atherosclerosis or diabetes and the ApoE4 gene are at high risk for cognitive decline. The majority of elderly people showed no significant decline in cognitive function over 10 years.
A recent study by Ohio State University researchers found that obese Black teenagers have a significantly higher risk of developing type II diabetes as adults compared to their white counterparts. The study highlights the need for early aggressive weight management in Black teens, given racial and ethnic differences in glucose metabolism.
A study of 3000 children aged 5-17 found a clear relationship between abdominal fat and abnormal serum lipids and insulin levels. This suggests that childhood obesity may predict later development of diabetes and heart disease.
People with diabetes are at increased risk of getting periodontal disease, which can lead to problems with blood sugar control and complications like vision problems and cardiovascular disease. Clinical studies show that people with severe periodontal disease are six times more likely to have poor glycemic control.
Researchers at the University of Pennsylvania School of Medicine have discovered a key step in regulating PPAR-gamma receptors, which control insulin sensitivity. The finding may lead to drugs with fewer side effects and greater efficiency for treating adult-onset diabetes.
Scientists have isolated the WFS1 gene responsible for Wolfram Syndrome, a rare form of insulin-dependent diabetes. The disorder is characterized by insulin-secreting cell death and progressive neurodegeneration, leading to blindness and premature death. Understanding this gene may lead to new treatments for common forms of diabetes.
A new clinical trial by the NHLBI reveals that women who undergo CABG or angioplasty procedures survive at a rate nearly identical to men. The study found that being female was an independent predictor of higher survival, with women having 60% of the risk of death compared to men.
A study published in Nature Medicine suggests that the diabetes drug troglitazone may increase the risk of colon cancer by activating the PPAR receptor, which promotes tumor formation in the colon. The study found that mice treated with troglitazone developed a significantly greater number of colon polyps than those not treated.
Women who develop diabetes during pregnancy face an increased risk of later developing type-2 diabetes. Using the mini-pill, progestin-only birth control pills, may put these women at a higher risk of developing chronic form of the disease, warns USC researchers.
A Lewin study confirms Diabetes Treatment Centers of America's Diabetes NetCareSM program improves health status by increasing eye exams, foot exams, and cholesterol screenings. The program also reduces medical costs, including hospital admissions and inpatient costs.
A study suggests that conjugated linoleic acid (CLA), a fatty acid in red meats and cheeses, can prevent the onset of diabetes in laboratory animals. CLA appears to work as well as new diabetes-fighting drugs, thiazolidinediones.
Researchers found that patients with poor diabetes control had depleted antioxidants, increasing the risk of complications. Taking antioxidant supplements like vitamin C or E may help prevent these complications.
Researchers at University of Toronto developed a more accurate glucose intolerance testing method, providing consistent results and reducing nausea. The new standardized test meal will help detect changes in blood sugar before signs of diabetes develop.
A study found that individuals taking nisoldipine had a higher rate of fatal and non-fatal heart attacks compared to those taking enalapril, sparking concerns about the safety of calcium antagonists for certain populations. The American Heart Association advises against panic and emphasizes the need for consultation with physicians.
A study of 101 adolescents with insulin-dependent diabetes mellitus found that young people are more likely to adhere to treatment plans when given empowering messages. Health professionals may need to shift their communication strategy from focusing on risks to emphasizing the benefits and capabilities of following a treatment plan.
A new study reveals that insulin resistance, a precursor to diabetes, is caused by a cellular 'short circuit' triggered by excessive protein phosphorylation and TNF secretion, potentially explaining the link between obesity and insulin resistance.
Morbidly obese pregnant women can reduce their risk of developing gestational diabetes by engaging in moderate physical activity, a new study has shown. The study found that the presence or absence of exercise, not its frequency or duration, was the key factor in reducing diabetes risk.
A new study reveals that adult-onset diabetics may be suffering from an 'imbalancing act' caused by a key enzyme called PFK, which regulates glucose metabolism. The researchers found that mice with abnormally high levels of the PFK-L sub-unit developed symptoms of Type II diabetes.
A new oral vaccine approach is being developed to protect pancreatic cells and prevent the autoimmune disease type I diabetes. Early trials have shown promising results using a combination of insulin and cholera toxin.
Treatment with low-dose diuretic cuts strokes and heart attacks in older patients with diabetes, with a significant reduction in cardiovascular events. The study shows diuretic therapy as a first-choice treatment for this population, alongside lifestyle changes.
Researchers have identified two interacting genes linked to adult-onset diabetes, which regulate gene expression in the liver, kidney, and intestine. The discovery opens up new avenues for treating this complex disorder.
A year-long study found that implantable insulin pumps effectively controlled blood glucose levels, reduced fluctuations in blood glucose, and mild hypoglycemia by 68% compared to daily injections. The pump also eliminated weight gain associated with injections and improved patients' quality of life.
UT Southwestern Medical Center is part of a nationwide clinical study to test an oral insulin capsule on people at moderate risk for developing type I diabetes. The study aims to determine if the intervention can prevent or delay the disease.