Articles tagged with Epilepsy
People with epilepsy who fail to take their medication regularly are three times more likely to die compared to those who adhere to treatment. Hospital visits and emergency room visits also increase during periods of non-compliance, highlighting the importance of consistent medication adherence.
Researchers discovered that BK channels become abnormally active after a seizure, leading to neuronal overexcitability, which may be associated with epilepsy development. A BK channel antagonist reversed abnormal excitability, offering new hope for individuals suffering from epilepsy.
Researchers have pinpointed the mutated gene responsible for childhood absence epilepsy, a condition characterized by frequent seizures. The discovery may provide insight into developing effective treatments and cures for this form of epilepsy.
A mutated gene has been discovered as the key behind epilepsy and mental retardation specific to women, thanks to new research at the University of Adelaide. The study found that women carry both a 'good' and 'bad' gene, while men only carry the bad gene, leading to the condition affecting only females.
A randomized controlled trial confirms the efficacy of the ketogenic diet in reducing epileptic seizures in children with drug-resistant epilepsy. The study found significant seizure reductions in children assigned to the ketogenic diet, compared to those on a control diet.
A study published by the American Academy of Neurology found that young women taking phenytoin for one year experienced significant bone loss compared to those on other epilepsy medications. Women taking phenytoin lost an average of 2.6% bone density in the femoral neck, a risk factor for fractures after menopause.
The study found that psychotherapy is one of the most effective treatments for nonepileptic seizures, followed by education and psychopharmacology. Neurologists and psychiatrists often work together to care for patients with NES, but barriers to treatment adherence include insurance limitations and lack of experienced practitioners.
Researchers identified a mechanism by which seizures increase production of a drug transport protein in the blood-brain barrier, leading to reduced medication effectiveness in epilepsy patients. This discovery offers promising new therapeutic targets to improve treatment outcomes.
Researchers are testing Metformine, a diabetes medication, to treat epilepsy by targeting the brain's energy sensing mechanism. Early results suggest it may reduce seizure frequency without affecting learning and memory.
Researchers explore a new approach to treating epilepsy by using the diabetes drug metformine, which targets metabolic pathways similar to a ketogenic diet. The study's findings suggest that metformine may suppress over-active nerve cells by removing excess energy production.
Epilepsy patients face challenges in communicating with healthcare professionals about medication-related side effects. Advocates propose strategies to improve patient-physician communication and individualized treatment plans.
A study from UC Irvine suggests that epilepsy is associated with an abundance of neuron 'hubs' in the brain, which can lead to seizures. These hub networks promote the onset of seizure activity by amplifying brain signals.
Researchers identified the detailed structure of a GABA receptor type implicated in conditions like epilepsy and pre-menstrual tension. The discovery provides hope for developing drugs to block or stimulate the receptors, potentially leading to new treatments for these conditions.
A team of scientists has made a significant breakthrough in understanding conscious perception by showing how single neurons react to perceived and nonperceived images. The study found that neurons respond with an 'all-or-none' firing rate when pictures are recognized, enabling the prediction of recognition beyond chance.
Researchers at Stanford Medicine used hypnosis to help doctors diagnose the cause of seizure-like events in children. Eight out of nine cases were found to be non-epileptic, caused by psychological stress, which require a different treatment approach than true epileptic seizures.
Research published by the American Academy of Neurology found no difference between oxcarbazepine and placebo in reducing migraine attacks. The study suggests that other epilepsy drugs like topiramate and gabapentin may be more effective due to their ability to regulate GABA neurotransmitters.
A modified version of the Atkins diet has been shown to significantly reduce epileptic seizures in adults with epilepsy. The high-fat, low-carbohydrate diet can lead to the production of ketones, which may help control seizures. While side effects were mild, compliance was a challenge for some patients.
Researchers found that human auditory neurons can detect subtle frequency differences down to a tenth of an octave, surpassing other mammals. This sensitivity may be linked to musical skill and cognitive abilities such as working memory.
A new study found that leptin can delay the onset of seizures in rodents, suggesting it may be a key player in how a ketogenic diet combats epilepsy. The authors propose dietary changes and intranasal administration of leptin as potential treatments.
Researchers at Yale University have shown that early treatment of epilepsy-prone rats with ethosuximide can suppress seizures and reduce their frequency even after treatment is stopped. This breakthrough could lead to preventing epilepsy in genetically susceptible people.
Research at Emory University found that therapeutic drug monitoring for lamotrigine during pregnancy reduces increased seizure activity and improves health outcomes. The study's findings suggest a potential benefit for pregnant women with epilepsy, allowing for targeted dosage adjustments to minimize risk.
The American Academy of Neurology recommends a routine electroencephalogram (EEG) and brain scans, such as CT or MRI, for adults experiencing their first unprovoked seizure. These diagnostic tools can help identify brain abnormalities that caused the seizure and predict seizure recurrence in approximately one in four patients.
Patients with focal epilepsy tend to underreport seizures, with up to 85.8% of nighttime seizures going unreported. Seizure documentation accuracy was not correlated with cognitive function or educational level, but patients who documented seizures had better verbal memory performance.
Researchers at Baylor College of Medicine found that inheriting two genetic mutations for epilepsy can actually reduce seizure frequency and severity. This discovery could lead to new gene-directed therapies for treating epilepsy.
Scientists have found a way to prevent seizure-induced structural changes in brain cells, which can lead to cognitive impairments such as memory loss and reduced attention spans. The breakthrough discovery uses a drug called FK506, which blocks the breakdown of actin, a molecule essential for cell structures.
Scientists at the University of Pennsylvania identified distinct patterns of brain activity associated with successful memory formation and retrieval. The study's findings may help neurosurgeons reduce cognitive deficits in epilepsy patients by identifying neural signatures of successful memory storage and retrieval.
A new once-daily lamotrigine extended-release formula effectively controls partial seizures in people already taking one to two medications. The study found significant reductions in seizure frequency and improved medication adherence, making it a promising option for those with epilepsy.
A recent study published in The Lancet reveals that mental disorders are more common in rural settings in Mozambique compared to urban areas. The research found higher lifetime prevalence rates for psychoses, mental retardation, and seizure disorders in rural households.
Research found 90% of patients with multiple aura types had seizures originating from the non-dominant side of their brain. Epilepsy surgery was effective in stopping seizures in over half of study participants.
Researchers at Purdue University developed miniature devices to predict and prevent epileptic seizures by detecting neural signals in the brain. The system records data from 1,000 channels, enabling better prediction of seizure onset. A nanotech sensor for glaucoma treatment is also being developed.
Researchers at the University of California, Irvine have discovered a novel molecular switch that modulates nerve cell activity, offering new possibilities for treating mood disorders and epilepsy. The study shows a link between gut protein cholecystokinin and brain's natural marijuana-like compounds.
The innovative university-industry team will develop a microsystem-on-a-chip, a neural interface that records or stimulates neural activity wirelessly. The new system will be fully implantable and communicate through digital data streaming, allowing people with paralysis to control assistive devices.
A clinical trial is underway to assess the safety and efficacy of intravenous carbamazepine in adult patients with epilepsy. The new treatment aims to provide an alternative to oral therapy during hospitalization or when oral administration is not feasible.
Scientists at Georgetown University Medical Center found that brain areas process signals as progressive waves, coordinating a collective pattern from millions of neurons. This challenges traditional models and has the potential to help understand Parkinson's disease, epilepsy, and Alzheimer's.
University of Florida researchers are creating a brain chip to decode signals and stimulate neurons, aiming to treat conditions like paralysis and epilepsy. The technology has the potential to revolutionize medicine, allowing patients to control prosthetic devices with their thoughts.
Scientists found evidence of a new type of communication between nerve cells in the brain, which may be linked to epilepsy. The discovery suggests that excitatory nerve cells are coupled together by gap junctions, potentially leading to cross-talk and altered brain function.
A study published in The Lancet Neurology found that people with epilepsy are three times more likely to commit suicide than the general population. Women with epilepsy face an increased risk, as do those diagnosed with the condition in the previous six months.
For people with temporal lobe epilepsy, epilepsy surgery can eliminate seizures in 60-85% and improve quality of life, but also lead to memory problems in 25-40%. Quality of life scores remain stable for those with seizures only.
Biomedical engineers at Duke University found that deep brain stimulation alleviates disease symptoms by creating an informational lesion through rapid-fire electrical pulses. This technique can be reversible and adjustable, offering a promising treatment for movement disorders and other conditions.
Researchers found that rapid syphilis screening during pregnancy can prevent congenital syphilis cases and improve child survival. Lithium also showed promising results in a mouse model of spinocerebellar ataxia, a devastating neurodegenerative disorder with no existing treatments.
Increasing SUMO levels could help treat diseases like epilepsy by reducing over-excitation in brain cells. The discovery provides new insights into the causes of brain disorders and potential targets for drug development.
A study of 187 two-year-old children found that those whose mothers took valproate during pregnancy had a higher risk of lower IQ. Children exposed to valproate showed an IQ in the mental retardation range at a rate of 24%, compared to 12% for carbamazepine and phenytoin, and 9% for lamotrigine.
Researchers at Johns Hopkins have discovered that zinc pyrithione, an active ingredient in dandruff shampoos, can calm overexcited nerve cells, potentially treating seizures. The compound works by allowing more potassium flow through defective channels, restoring normal nerve cell activity.
Researchers have created a mouse model of infantile spasms, which closely resembles human cases and responds to current treatments. This model could lead to new treatments for thousands of young children suffering from these catastrophic seizures.
Researchers have localized two new genes associated with febrile seizures in infancy and childhood, which could improve the understanding, treatment, and prevention of this disorder. The study found that chromosome 3 was shared by all family members who had febrile seizures, while a modifier gene on chromosome 18 may also be involved.
A study published in Neurology found that retigabine, a new epilepsy drug with a unique mechanism of action, is both safe and effective. In the study, participants who received the highest dose of retigabine experienced an average reduction of 35% in seizure frequency compared to those receiving a placebo.
Scientists at MIT have developed a way to reversibly silence brain cells using pulses of yellow light, potentially leading to the development of optical brain prosthetics. The method could enable specific treatments with few or no side effects, offering new hope for neurological and psychiatric diseases.
Researchers found that tooth-brushing can induce seizures in individuals with epilepsy, possibly linked to lesions in the somatosensory area of the brain. The study suggests a potential link between rhythmic stimuli and seizure activity.
A case report suggests that light streaming through whirling helicopter rotor blades during medical air transport can cause symptoms ranging from nausea to full-blown seizures. Researchers recommend shielding patients' eyes to prevent this under-recognized but highly preventable complication.
Scientists at Karolinska Institutet have discovered a mechanism controlling how the brain maintains equilibrium in neuronal activity. A rare cell type, Martinotti cell, acts as a safety device by sending inhibitory signals to surrounding pyramid cells when activated excessively.
A clinical trial found that nearly 600 adults with newly diagnosed epilepsy experienced few to no seizures while taking levetiracetam as a single therapy. The study also showed that patients remained seizure-free for at least six months at the lowest dose level.
Researchers found that some dogs are responding to seizures caused by psychological conditions, rather than epilepsy. People with psychogenic seizures need psychiatric evaluation and treatment, not specialized training for epileptic seizures.
Researchers found that epilepsy patients can reliably predict when they are likely to have a seizure, with 32% accuracy. Accurate predictions also indicate reduced risk of seizures, providing reassurance and improved quality of life for those with epilepsy.
Researchers found that new neurons generated in response to epilepsy have reduced excitability and increased inhibitory connectivity, potentially alleviating the disorder. These findings suggest that therapies aimed at inducing neurogenesis could prove effective.
Researchers at UW-Madison discover 2-deoxy-glucose blocks epileptic seizures in lab rats, a potential cure for up to half of all epileptic patients. The compound works by clogging cellular enzymes, allowing the body to use alternative energy sources.
Researchers at MIT are developing a device that can detect and prevent epileptic seizures by measuring brain activity. The new technology builds on an existing therapy and could be refined to work with a headband or baseball cap. If successful, it would allow more patients to use the therapy on demand.
A critical review found that repeated administration of antiepileptic drug therapy leads to diminishing results in preventing seizures. Acquired tolerance is responsible for this effect, with some patients developing cross-tolerance to similar medication, posing a significant concern for medically intractable epilepsy
Researchers conducted a retrospective study of 31 Dutch SCADD patients and their relatives to describe genetic, biochemical, and clinical characteristics. The study found a birth prevalence of at least 1:50,000, with developmental delay, epilepsy, and hypoglycemia being common symptoms.
The National Institutes of Health has awarded a $2 million grant to Yale University for the purchase of a 7-Tesla human magnetic resonance imaging system. This high-end instrumentation will facilitate ultra-high resolution studies in various medical fields, including diabetes and epilepsy.
A Stanford study found that boosting neuropeptide Y levels in the thalamus and hippocampus can reduce seizures. Researchers discovered that valproic acid increases neuropeptide Y production by 50% in these areas, offering a potential new approach to treating epilepsy with fewer side effects.