Articles tagged with Epilepsy
UC Berkeley researchers developed a mathematical model of the brain's electrical activity during seizures, which may aid in understanding and treating epilepsy. The model, compared with real-world data from electrodes implanted in a patient, suggests that strong coherent waves of electrical activity are responsible for seizure spread.
Research suggests that people with a history of depression are at a higher risk of developing epilepsy, while those with epilepsy may be more likely to experience depression. Studies have found common biological mechanisms underlying both conditions, including abnormal neurotransmitter secretion patterns.
A review of nutritional modalities for treating epilepsy suggests that diets high in fat and polyunsaturated fatty acids may be effective in controlling seizures. The Atkins diet has shown promise as an easier-to-follow alternative to the ketogenic diet, although its success depends on implementation.
A study of 325 patients who underwent temporal lobe removal found that early seizures after surgery were eight times more likely to lead to persistent epilepsy. This suggests that some individuals may have epilepsy that is more persistent and resistant to treatment.
A random screening of 19 approved human medications revealed that anticonvulsants like ethosuximide and trimethadione increased lifespan in C. elegans worms by delaying age-related declines in neuro-muscular activity.
A new driving regulation in Japan allows people with epilepsy to obtain a driver's license after a seizure-free period of two years. The survey results highlighted the need for cooperation between authorities and the Japanese Epilepsy Society to further amend regulations and educate the public, patients, and professionals.
A new study suggests that implantable pacemakers could identify and prevent potentially fatal cardiac abnormalities in patients with epilepsy. The devices monitored heart rhythms during seizures, revealing that four patients had periods of asystole and received permanent pacemaker insertion.
A 30-year follow-up study of adults with epilepsy found that those on long-term medication had higher rates of unemployment and lower socioeconomic status. Despite being in remission, participants still taking antiepileptic drugs (AED) showed similar outcomes to those on medication.
A Mayo Clinic study found that patients with well-controlled epilepsy have a very low risk of injury from seizures. The study examined records of 247 patients and found that 80% of injuries were cuts or bruises that did not cause serious health consequences.
A study using antibody microarrays measured levels of over 500 proteins in tissue samples from patients with epilepsy and Alzheimer's disease, identifying increased signal transduction proteins as a possible new target for treatment. This discovery could lead to the development of new medications for these conditions.
Researchers found that switching from brand phenytoin to generic phenytoin can lead to increased seizures in epilepsy patients. Additionally, a study on concussion history and symptom reporting found that athletes with previous concussions reported fewer symptoms immediately after the injury but more symptoms one week later. The Americ...
Researchers discovered that patients with medically intractable epilepsy may develop new adult brain cells post-operatively. This cell generation could be the cause of recurring seizures and provide a potential target for future treatment and prevention strategies.
A new study by Mayo Clinic suggests that the ketogenic diet can be safely initiated as an outpatient treatment for children with epilepsy, offering improved acceptability and comfort. The study found no significant differences in long-term seizure control or mental improvement between inpatient and outpatient groups.
A study by Grant Butterbaugh and colleagues found that adult patients with left temporal lobe epilepsy were more likely to experience learning disabilities. The researchers suggest that medically treated but uncontrolled seizures in the language-dominant side of the brain may contribute to these findings.
A recent study published in Epilepsia found that selective amygdalohippocampectomy (SAH) surgery can lead to verbal memory loss in patients, especially those who underwent left temporal lobe surgery. The study revealed that 30% to 50% of patients who underwent SAH on the left side showed no recovery of verbal memory after 12 months.
Researchers identified a brain region that processes sound location and motion, with impaired function leading to 'cortical motion deafness'. The study provides evidence of an auditory motion module within the right posterior superior temporal gyrus.
A five-year head-to-head trial of three common anti-epileptic drugs will enroll 439 children aged two to 13. The study aims to determine the best initial medicine for childhood absence epilepsy, which affects 10-15% of all epilepsy cases in children.
A team of researchers led by Guy A. Caldwell found that worms with a mutated LIS1 gene experience convulsions similar to those in humans with lissencephaly, a rare birth defect. The study reveals the mutated protein's impact on neuronal trafficking and neurotransmitter release, providing insights into the complexities of epilepsy.
A team of researchers found that impaired Kv4.2 ion channels in neurons can lead to increased excitability and seizure frequency in epilepsy. Inhibiting the ERK enzyme may provide a new therapeutic target for treating this condition.
Researchers developed a new approach to interpreting brain electroencephalograms that provides an unprecedented view of thought in action. The technique uses Independent Component Analysis to separate signals from different areas of the brain, enabling detailed insights into neural dynamics.
A study of 6,044 women aged 65 and older found that those taking epilepsy drugs lost bone mass at nearly twice the rate of non-users. This increases the risk of hip fractures by 29% over five years. Researchers recommend screening for osteoporosis and counseling on calcium and vitamin D supplements.
Scientists discovered that deleting three circadian genes in mice results in severe epilepsy and accelerated aging. The mice lacking all three genes are prone to epileptic seizures and display early mortality, with a significant increase in deaths on Mondays and Thursdays due to sound-induced attacks.
Fetal imaging technologies like DTI and fMRI enable early diagnosis and treatment of brain abnormalities, improving outcomes for patients with epilepsy, autism, and Alzheimer's. Researchers presented advancements in detecting seizure origins and understanding autistic brain function through innovative imaging techniques.
Recent studies on marijuana use among multiple sclerosis and epilepsy patients have yielded mixed results, highlighting the need for further research to determine its efficacy. Patients reported using marijuana therapeutically to manage pain, spasms, mood, sleep, and stress, but also experienced side effects and variable doses.
Researchers analyzed 770 seizure records to investigate the possible link between lunar phases and frequency of epileptic seizures. The study found that epileptic seizures were lowest during the full moon and highest in its last quarter.
The American Academy of Neurology has released a guideline evaluating the treatment of infantile spasms, a severe form of epilepsy. The guideline recommends adrenocorticotropic hormone (ACTH) as a short-term treatment option, but notes that there is insufficient evidence to recommend optimum dosage and length of treatment.
Research highlights disparities in stroke risk among Mexican-Americans and findings on treatment advancements for conditions like sickle cell disease and epilepsy. Studies also explore dementia prevalence in HIV-infected populations and the impact of diabetes and military service on neurological diseases.
The guidelines provide a rigorous analysis of the safety, efficacy, and mode of use of new antiepileptic drugs, offering clinicians evidence-based assessments for treatment decisions. The guidelines address concerns about side effects and liver metabolism, providing guidance on using newer drugs safely and effectively.
Researchers studied 87 women with epilepsy and found that nearly 40% experience catamential patterns where seizures fluctuate with menstrual cycles. Progesterone lozenges may help reduce seizure frequency and severity during monthly hormonal changes.
A five-year study found that four commonly prescribed antiepileptic drugs were associated with varying levels of birth defects, developmental disabilities, and death in children. The study revealed that lamotrigine may cause less harm compared to other medications, while valproate posed the highest risk.
Patients with uncontrolled epilepsy have significantly lower levels of DHA in their red blood cell membranes compared to healthy individuals. This deficiency may contribute to seizure severity and inform potential treatment strategies involving DHA supplementation.
Surgery for medically intractable temporal lobe epilepsy shows variation among ethnic groups, with African Americans receiving surgery at significantly lower rates than non-Hispanic whites. The study suggests that racial disparities exist but do not appear to be related to differences in access to care.
A novel mutation in the SCN1A gene has been discovered in a family with generalized epilepsy with febrile seizures plus (GEFS+), a condition characterized by unusual brain activity. This finding may lead to improved diagnoses, treatments, and genetic counseling for affected individuals.
The American Academy of Neurology and American Epilepsy Society have developed guidelines for treating newly diagnosed and difficult-to-manage epilepsy. The guidelines evaluate the safety, efficacy, and mode of use of eight new anti-epileptic drugs, offering a rigorous analysis that clinicians can use to make treatment decisions.
Women with epilepsy face difficulties during puberty, pregnancy, menstruation, and menopause, leading to changes in seizure severity and increased risk of fetal loss and birth defects. Doctors can help women balance medication risks by adjusting dosages or switching medications while minimizing harm.
The new guidelines will help physicians select the correct treatment based on individual patient needs, reducing reliance on outdated data. Current insurance policies can lead to inadequate treatment due to cost containment measures, but the guidelines aim to address this issue and improve patient outcomes.
Epileptic seizures result from brain dysfunction, with early diagnosis and treatment crucial to preventing irreversible damage. The stigma surrounding epilepsy exacerbates the condition's impact on daily life and quality of life.
Individuals with first-time epileptic seizures after 60 years are three times more likely to experience a subsequent stroke. This increased risk justifies screening for vascular risk factors and treatment to prevent stroke in elderly patients with epilepsy.
A specific mutation in the KCNMB1 gene is associated with lower blood pressure, according to a study published in JCI. Researchers found that individuals with this mutation had lower diastolic blood pressure compared to those without it. The study suggests that targeting the beta1 subunit may have therapeutic potential for treating hyp...
A new study has found that Bim regulation plays a crucial role in determining hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. The researchers suggest that understanding the molecular mechanisms underlying this relationship may lead to new therapeutic strategies for treating these conditions.
Recent studies demonstrate the accuracy of epilepsy diagnosis by doctors (96%), shedding light on dementia risk factors among adults with Down syndrome. Additionally, gabapentin shows significant effectiveness in treating chronic daily headaches, according to a study by The Australian Gabapentin Chronic Daily Headache Group.
Epilepsy can develop as people age, often due to common health problems like stroke, cancers, or heart diseases. The NCOA and Epilepsy Foundation launch an initiative to educate about epilepsy in the elderly, emphasizing subtle symptoms and effective treatment options.
A limited study of six patients found that the Atkins diet helped two children and one young adult remain seizure-free for up to 20 months. The researchers suggest that the diet may be a trial run for individuals considering the ketogenic diet, but its use should be cautious due to the small study size.
A recent study analyzed patients treated with Keppra and found it to be well-tolerated and more effective in the oldest age group, those 60 years and older. The rate of epilepsy occurring in the elderly is twice that of people under 65, making treatment challenging due to multiple health conditions and medications.
Researchers found that levetiracetam monotherapy can be an effective and well-tolerated treatment option for adults with new onset and difficult-to-control epilepsy. After one year of treatment, 53% of patients were seizure-free, with some experiencing significant reductions in seizure frequency.
A study analyzing 62 movies across four continents found that epilepsy is often stereotyped, with males shown as violent and females as exotic and vulnerable. The dramatic potential of seizures may contribute to these portrayals.
Researchers studied neurons in the olfactory bulb and found that they only undergo subtle changes in response to environmental stimuli. These findings challenge previous theories of brain rewiring and may offer insights into disorders such as epilepsy and Alzheimer's disease.
A cheap and easy way to treat Parkinson disease involves infusing the ketone body D-beta-HB, which restores mitochondrial respiration and protects against neurodegeneration. This novel therapy supports a critical role for mitochondrial defect in Parkinson disease and offers new hope for treatment.
Scientists at Sick Kids have identified a new gene, NHLRC1, that causes Lafora disease, a severe form of adolescent epilepsy. The discovery explains the condition in 90% of families and opens up new avenues for research into both epilepsy and normal brain function.
A study found that 63% of patients with intractable epilepsy who underwent surgery remained seizure-free for over eight years. The duration of epilepsy before surgery was a significant factor in predicting seizure freedom, with patients having longer episodes more likely to remain free from seizures.
The Pfizer Inc team won the Heroes of Chemistry award for developing Neurontin, a medication controlling seizures in children. This breakthrough led to improved quality of life for many children with epilepsy, demonstrating the valuable role chemists play in improving lives.
Researchers found prolonged fever-induced seizures increase brain's production of endocannabinoids, leading to long-term modifications in neural receptors linked to them. This can result in an increased susceptibility to seizures until adulthood.
Researchers develop novel gene therapy platform using AAV to deliver galanin, a neuroactive peptide that suppresses seizure activity. The treatment reduces sensitivity to focal seizures in laboratory rats, offering hope for treating temporal lobe epilepsy patients.
A recent study suggests that reducing the seizure-free interval from 12 to three months does not significantly increase total crashes. The researchers found that seizures-related crashes increased by 11, while deaths due to seizure-related crashes decreased.
A study published in Archives of Neurology found that patients with moderate to severe brain injuries who inherited the epsilon 4 variation of apolipoprotein E (apoE) gene were more likely to develop seizures. The finding sheds light on post-traumatic epilepsy's pathophysiology and may lead to new therapies.
The KEPPRA international Phase IV SKATE study achieved a significant reduction in partial seizures in 49% of patients, with a seizure freedom rate of 17.2%. The study showed favourable efficacy across various subtypes of partial seizures.
A double-blind study found that patients taking topiramate experienced poorer word recognition and verbal memory compared to those on valproate. The research aims to improve seizure treatment with minimal side effects.
A Chinese study found nearly 50% higher lifetime prevalence of epilepsy and a 30% higher treatment gap than estimated, with 41% of cases never receiving proper treatment. Successful treatment of 60-70% of cases could benefit China's economy.
New research presented at the AAN Annual Meeting includes promising treatments for MS, potential therapeutic targets for worsening ataxia in ALS, and a connection between Chlamydia infection and increased stroke risk. Statins also show promise in reducing cognitive decline and improving recovery from stroke.
The study finds that adding Keppra to standard therapy can lead to seizure freedom in refractory patients with a moderate increase in costs. This results in significant healthcare savings, making it a cost-effective alternative.