Articles tagged with Esophageal Cancer
18F-FDG PET/CT is highly sensitive and accurate for whole-body staging of recurrent esophageal cancer, suggesting potential improvements in patient survival. The imaging modality also shows promise in guiding salvage treatment to early recurrence lesions.
Researchers identified a new cancer gene, UTX, common to many cancers and affecting gene regulation. The UTX protein modifies chromatin structure, altering histone modification and impacting gene activity.
Researchers found ALDH2-deficiency linked to increased esophageal cancer risk from moderate alcohol consumption. Clinicians can identify deficiency through flushing response and counsel patients to reduce drinking.
Scientists warn that East Asians who drink heavily may be at increased risk of esophageal cancer due to an enzyme deficiency. Heavy drinking in these individuals can lead to a significant increase in the risk, particularly among those with two copies of the inactive gene variant.
A Kaiser Permanente study found that drinking one glass of wine a day may lower the risk of Barrett's Esophagus by 56%. The study also suggests that antioxidants in wine may neutralize oxidative damage caused by gastroesophageal reflux disease, which is a risk factor for Barrett's Esophagus.
A Million Women Study found that low to moderate alcohol consumption among women increases cancer risk for breast, liver, rectum, and upper aero-digestive tract cancers. The risk is highest after one drink per day, with an excess of about 15 cancers per 1000 women.
Researchers found that oxaliplatin combined with capecitabine provided a safe, well-tolerated, and effective treatment for patients with metastatic esophageal squamous cell cancer. The combination showed significant clinical benefits, including partial responses in 43.8% of patients and a median overall survival of 10.0 months.
Researchers identified anthocyanins in black raspberries as effective in preventing esophageal cancer in rats. The study demonstrates the importance of anthocyanins as preventive agents in black raspberries and validates similar in vitro findings.
Researchers have found strong links between smoking and two forms of esophageal cancer, as well as a form of stomach cancer. Drinking alcohol is strongly associated with one form of esophageal cancer, with the risk increasing fivefold for those who drink four glasses a day.
A study published in Cancer Prevention Research found that variations in a common gene pathway may affect esophageal cancer risk, with seven genotypes showing significant association and four more borderline significance. The risk of esophageal cancer increased with an increase in unfavorable genotypes present.
Researchers have identified 11 single-nucleotide polymorphisms that show a significant association with esophageal cancer. Individuals with more than four unfavorable genotypes are three times more likely to develop the disease.
Research found that people with H. pylori strains carrying a gene called CagA were almost half as likely to get adenocarcinoma of the esophagus. The study suggests that declining rates of H. pylori in developed populations may contribute to the increase in esophageal adenocarcinomas.
Researchers found that endoscopic therapy was successful in treating esophageal cancer, with a 90% success rate and low recurrence rates. Patients treated endoscopically had higher survival rates compared to those who underwent surgery.
A new biologic therapy called TNFeradeTM improved the median survival of patients with locally advanced esophageal cancer from 9.7 to 48.4 months. Researchers found that most tumors were adenocarcinomas and could be treated with surgery after combination therapy, showing promise for this treatment approach.
A recent study published in World Journal of Gastroenterology demonstrates that lithium inhibits the proliferation of esophageal squamous cell carcinoma cells by targeting GSK-3beta. This finding suggests a novel possibility for the treatment of esophageal cancer with lithium chloride, providing new hope for patients with this disease.
A study found that community-based use of treatment for US gastroesophageal adenocarcinoma varies depending on clinical and non-clinical factors. Chemotherapy and chemoradiation are associated with improved survival rates, while anatomic site differentiation is crucial for effective treatment.
Researchers found that freeze-dried black raspberry powder restored activity to 460 genes in animals with esophageal cancer, many associated with cell proliferation and death. The study identified 53 genes important for early cancer development, which may be targeted by chemoprevention agents.
A study published in the Journal of the American College of Surgeons found that elevated plasma DNA levels are a reliable marker of recurrent esophageal cancer. Plasma DNA levels rose before clinical evidence of recurrence in most patients, indicating its potential as a biomarker for disease monitoring.
Researchers found that NSAIDs can reduce adenoma burden by 64% and prevent advanced adenomatous polyp detection by 35%. Additionally, celecoxib has shown promise in preventing post-ERCP pancreatitis.
Researchers have developed a smaller endoscope that can take high-quality color pictures in confined spaces, potentially saving lives by detecting treatable conditions before they turn into cancer. The device is designed for low-cost screening and doesn't require anesthesia or sedation.
A team of scientists has developed a tissue-engineered, organotypic 3D culture system of esophageal squamous cell cancer, revealing the genetic mutations and tumor microenvironment driving the disease. The model also highlights the critical role of stromal fibroblasts in cancer progression.
Research associates ADH2 and ALDH2 polymorphisms with increased esophageal cancer risk, particularly in individuals who consume alcohol. The study found that certain genetic variants can modulate individual differences in alcohol-oxidizing capacity and drinking behavior, leading to a higher risk of developing esophageal cancer.
Research found that obese individuals are six times more likely to develop esophageal cancer compared to those of healthy weight. A combination of obesity, acid reflux, and smoking significantly increased the risk of adenocarcinomas of the esophagus.
The studies identified new proteins involved in coronary heart disease, clusterin responsible for colorectal cancer progression, and potential biomarkers for esophageal cancer detection. These findings may lead to improved diagnosis and therapies for these diseases.
Early metabolic imaging with PET accurately identifies patients responding to chemotherapy for esophageal cancer, noting a remarkably favorable outcome for metabolic responders. This study supports the use of PET-response-guided treatment to tailor multimodality therapy based on tumor biology.
Testicular cancer survivors have a higher risk of dying from noncancer causes, including infections and circulatory diseases. Chemotherapy treatment in the 1970s also increases this risk. Researchers highlight the need for additional long-term follow-up studies to better understand secondary complications.
A new light-based probe built by researchers at Duke University has successfully detected the earliest signs of cancer in cells lining internal organs. The device uses changes in laser light scattering to identify pre-cancerous conditions, offering a promising alternative for early diagnosis and treatment.
Researchers found that those with three or more cancer biomarkers who used aspirin had a 30% risk of esophageal cancer after 10 years, compared to 79% without NSAIDs. The study identified four genetic abnormalities predictive of esophageal cancer progression.
A new study at the University of Michigan Health System found that obese patients who underwent a procedure called transhiatal esophagectomy had outcomes similar to lean counterparts. The study suggests that the procedure is safe for obese patients, but results may vary in hospitals with lower volumes.
A study by OHSU researchers has found that using a 'skinny scope' in an office setting is as accurate, less expensive and less risky than the gold standard -- sedated upper endoscopy. The procedure was well-tolerated and more immediately informative for patients.
A study found that H. pylori infection increases the risk of noncardia gastric cancer but decreases the risk of cardia gastric cancer. This may explain changing cancer rates in Western countries over the past century.
A recent study found that acid exposure triggers an enzyme, NOX5-S, leading to increased hydrogen peroxide production and DNA damage in cells. This process may contribute to the development of esophageal cancer.
Researchers found that ACE inhibitor use was associated with a 55% risk reduction for esophageal cancer, a 48% reduced risk of pancreatic cancer, and a 47% reduced risk of colon cancer. The studies suggest that ACE inhibitors may play a valuable role in advancing current treatment options for multiple cancers.
Researchers at Mayo Clinic have found a significant association between acid reflux and esophageal cancer, with patients who experience acid reflux having a 30- to 125-fold increased risk of developing esophageal cancer. The study also discovered susceptibility genes in familial Barrett's esophagus and esophageal cancer.
Researchers argue that surgery is most effective approach in many patients, improving five-year survival rates compared to chemotherapy and radiation. The study found that en bloc esophagectomy results in fewer cancer deaths than transhiatal resection.
A study published in Annals of Surgery found that PET imaging was 88% accurate in identifying patients without disease after chemoradiation. This technology has the potential to change clinical practice by helping some patients avoid surgery.
Researchers used PET scans to evaluate response to chemoradiation in esophageal cancer patients. The study found that PET was 88% accurate at identifying patients without disease, potentially changing clinical practice and allowing some patients to avoid surgery.
A light-based device probe has been developed to detect early cancer signs in the esophagus, emitting light that scatters when it hits the cell nucleus. The technology could be adapted to detect pre-cancerous cells on any organ's surface, potentially increasing the likelihood of cancer detection.
Two new studies uncover significant associations between certain autoimmune disorders and an increased risk of non-Hodgkin lymphoma. Meanwhile, a separate study suggests that consuming carbonated soft drinks may decrease the risk of esophageal adenocarcinoma, contrary to previous findings.
Researchers at Yale University found no direct evidence to support the theory that carbonated soft drinks contribute to esophageal adenocarcinoma risk. Instead, they discovered an inverse association between diet soda consumption and reduced risk of this cancer subtype in men and women.
A study published in Gastroenterology found that nearly 2% of the general population has Barrett's esophagus, a condition linked to increased risk of esophageal cancer. The study highlights the need for screening and awareness among patients and physicians.
Researchers found that people with Barrett's esophagus who regularly took NSAIDs like aspirin had a one-third reduced risk of esophageal adenocarcinoma. The protective effect wears off quickly, and the risk reverts back to never users after three years of discontinuing use.
Researchers found that patients with Barrett mucosa had tumors diagnosed earlier, were smaller in size, and had a better five-year survival rate. Conversely, adenocarcinomas without detectable Barrett epithelium may be more advanced stages of the same disease, leading to poorer outcomes.
A new technique called laparoscopic inversion esophagectomy (LIE) has been developed to improve the removal of diseased tissue from the esophagus. LIE eliminates technical obstacles that plagued the original procedure, allowing for faster recovery and fewer complications.
Researchers found that statin use was associated with significant reductions in the risk of both pancreatic and esophageal cancers. Statins were shown to reduce the risk of pancreatic cancer by 59% and esophageal cancer by 56%.
Researchers developed a genetic blueprint that predicts response to two chemotherapy drugs and/or radiation therapy in esophageal cancer patients. The study found six gene variants associated with improved survival rates, with certain combinations more effective than others.
Researchers found that overweight patients, those with moderate income, and women survived longer with esophageal and stomach cancer. Premature birth significantly increases the risk of esophageal adenocarcinoma, potentially linked to gastroesophageal reflux disease.
Researchers investigated protein pattern reproducibility, DNA methylation for cervical cancer screening, and tissue zinc concentrations associated with reduced esophageal cancer risk. They found that some methods are not biologically plausible, while others may be useful diagnostic tools.
A study found that African Americans are half as likely to receive surgery for esophageal cancer, experiencing poorer survival rates and undertreatment. The disparity is attributed to factors such as age, socioeconomic status, and pre-existing health conditions, highlighting the need for equal access to quality cancer care.
Researchers found that zinc supplements reversed precancerous conditions in the esophagus and tongue of zinc-deficient rats. The study suggests that zinc supplements may prevent the development of esophageal or oral cancers, which are associated with nutritional zinc deficiency.
A recent study investigated whether NCI cancer centers have better outcomes due to their designation. The research found that perioperative mortality was lower at these centers for four out of six procedures, but five-year survival rates did not differ significantly between the two types of institutions.
Studies found that morbidly obese patients experience high rates of GERD symptoms, including heartburn and acid regurgitation. Additionally, a systematic review revealed a significant dose-dependent association between body mass index and risk of esophageal adenocarcinoma.
Researchers found no clear association between atrazine exposure and cancer in a large cohort study. Additionally, studies on alcohol consumption and gastric cancer incidence revealed mixed results, while an animal study demonstrated the potential of mammaglobin-A immunotherapy as breast cancer treatment.
A study of 138,307 men found exclusive pipe smoking increased risk for six cancers and three diseases, with highest risk in larynx, lung, and oropharynx. Pipe smoking was associated with smaller but similar risks to cigar smoking, while larger than cigarette smoking.
Researchers found a significant association between H. pylori infection and reduced risk of esophageal adenocarcinoma, but a two-fold increased risk of squamous-cell carcinoma. Gastric atrophy was not linked to disease risk, suggesting an alternative pathway from H. pylori to cancer.
A new study found that a rapid increase in the incidence of esophageal and gastric cardia adenocarcinomas is linked to modifiable risk factors such as smoking, being overweight, and gastroesophageal reflux. High serum levels of vitamin E are associated with reduced risk of upper gastrointestinal cancers.
Research highlights the link between high animal fat intake and increased breast cancer risk, as well as the benefits of gynecologic surgeries in reducing ovarian cancer risk. Protein overexpression is also linked to esophageal cancer development, suggesting a potential target for prevention.
Researchers found that low blood levels of selenium are a risk factor for progression of Barrett's esophagus and that higher levels of selenium may inhibit the progression of this condition. The study suggests that adequate selenium consumption may lower cancer risk in people with Barrett's esophagus.
A minimally invasive esophagectomy procedure has been shown to improve survival rates and reduce hospital stays for patients with esophageal cancer. The study, which evaluated 221 patients, found that median hospital stays were seven days compared to over 10 days for open procedures.
A recent study published by researchers at the University of Southern California found that polyphenols in tea may be associated with a lower risk of gastric and esophageal cancer. The study followed 18,244 men aged 45-64 in Shanghai, China, and found that those who consumed more tea had a 50% lower risk of developing these cancers.