Articles tagged with Esophageal Cancer
Researchers are using cloning to recreate esophageal cancer development, identifying potential targets for therapies before the disease becomes fatal. The goal is to develop effective drugs in a fraction of the time it takes Big Pharma.
The American Society for Gastrointestinal Endoscopy has released an updated guideline on screening and surveillance of Barrett's esophagus, aiming to improve patient outcomes. The guideline addresses various endoscopic procedures and technologies used in screening and surveillance, including advanced imaging and sampling modalities.
Researchers from Osaka University found that lymph node responses to neoadjuvant chemotherapy are more effective in predicting disease recurrence and patient survival than primary tumors. This finding could lead to improved treatment strategies and increased survival rates for patients with metastatic esophageal cancer.
A new nomogram developed by researchers can accurately predict the likelihood of occult lymph node metastases in esophageal cancer. This tool may help clinicians identify high-risk patients who would benefit from neoadjuvant therapy, leading to more informed treatment discussions and potentially improved patient outcomes.
A phase I clinical trial combining telomelysin and radiotherapy achieved an impressive 85% overall response rate (ORR) and complete tumor eradication in most patients. The therapy was safe and effective, even for elderly patients with health complications.
Researchers at Case Western Reserve University have identified two molecular pathways that could lead to new treatments for esophageal cancer. By blocking the JNK and TGF-beta pathways, tumors can be slowed in growth and even regressed in mice. The study's findings suggest a new targeted therapeutic avenue for this deadly form of cancer.
A study found a significant increase in high-grade dysplasia and esophageal adenocarcinoma among patients with Barrett's esophagus over the past 25 years. The prevalence of these conditions increased despite a decrease in BE length, highlighting the importance of careful examination during index endoscopy.
A new esophageal cancer screening test called EsophaCap has been developed using genetic biomarkers to detect the deadly disease. The test involves swallowing a small capsule that dissolves into a sponge, which collects genetic material from the entire length of the esophagus and is then sent for analysis.
Researchers at Osaka University found that mapping residual esophageal tumors can predict long-term prognosis and direct personalized treatment plans. The study identified four tumor remnant patterns, with specific associations to disease factors such as prognosis and metastasis risk.
A genomic duplication in Caucasians could contribute to the high incidence of esophageal adenocarcinoma. Researchers found that African-Americans have a protective genetic variant, GSTT2, which may help prevent cancer. Flavonoids derived from cranberries show promise as a potential chemoprevention agent.
A study of over 280,000 people found a significant association between work stress and increased risk of colorectal and esophagus cancers. However, no link was observed for prostate, breast, or ovarian cancers, with the relationship varying by region.
Researchers found a unique microbial signature for esophageal cancer that could help identify at-risk individuals and develop alternative therapeutic strategies. The study suggests that analyzing the oesophageal microbiota may provide innovative diagnostic tools to improve the management of this condition.
Researchers discovered that cancer-associated genetic mutations are prevalent in healthy esophageal epithelium tissue, accumulating with age. By middle age, over half of the tissue contained mutant clones, suggesting a potential origin for esophageal cancers.
Researchers at the University of Texas at Arlington have developed a new nanoparticle-based platform that can simultaneously image and treat esophageal cancer cells. The platform uses near-infrared fluorescence for better tissue imaging and tumor targeting properties, making it easier to detect and guide surgeons in removing tumors.
A new trial presented at ASCO18 shows that PET scans can improve treatment outcomes for esophageal cancer patients. Patients who responded to induction chemotherapy had a median overall survival of 46 months, while those who did not respond had a 27-month median survival, significantly better than previous studies.
A breath analysis test showed good diagnostic accuracy for esophagogastric cancer in a study of 335 patients, including those already diagnosed with the disease. The test identified abnormally regulated volatile organic compounds in the breath associated with esophagogastric cancer.
A new study presented at the AATS Annual Meeting shows that patients with malignant lymph nodes following preoperative therapy were less likely to survive than those with no cancer. The study found a strong association between pathologic nodal response and improved survival, highlighting the need for optimized neoadjuvant strategies.
Researchers have found associations between esophageal cancer and lead-rich soils, lung cancer and copper-rich terrains, brain tumors and arsenic-rich areas. The study's findings suggest that the geochemical composition of soil could influence cancer distribution patterns in Spain.
Dechen Lin receives grant funding to research esophageal adenocarcinoma, the most common type of esophageal cancer in the US. He aims to understand its evolution from Barrett's esophagus and develop prevention strategies.
A new study examines the evolutionary dynamics of cancer development in Barrett's Esophagus patients, revealing influences that lead some cells to remain stable while others become cancerous. The research provides insights into the genetic and chromosomal variations that predict progression to esophageal adenocarcinoma.
A recent study published in Annals of Internal Medicine found that consuming hot tea at high temperatures is associated with a significant increase in the risk of esophageal cancer. The research, which followed over 450,000 participants for nine years, suggests that abstaining from hot tea may be beneficial for individuals who drink al...
A University of Houston researcher is developing a new approach to prevent esophageal cancer by targeting precursor lesions like Barrett's esophagus. By cloning stem cells from these lesions, the researcher hopes to identify drugs that can selectively kill them before they progress to cancer.
A study of over 120,000 patients found that certain bacteria in the mouth are associated with an increased or decreased risk of developing esophageal cancer. The presence of Tannerella forsythia was linked to a 21% increased cancer risk, while Streptococcus and Neisseria were associated with a 24% decrease in risk.
A recent study published in Cancer Research found that certain oral microbiota are associated with an increased risk of esophageal cancer. Bacteria such as Tannerella forsythia and Porphyromonas gingivalis were linked to higher risks of esophageal adenocarcinoma and squamous cell carcinoma, respectively.
Basal progenitor cells have been identified as the 'cell of origin' for Barrett's esophagus, a condition that can lead to esophageal adenocarcinoma. The discovery promises to accelerate the development of precise screening tools and therapies.
A new study by a University of Texas at Arlington researcher found that zinc supplements can significantly inhibit esophageal cancer cell growth without affecting normal cells. This discovery provides a potential pathway for better esophageal cancer prevention and treatment.
The MIRO trial found that hybrid minimally invasive esophagectomy (HMIO) significantly reduces postoperative morbidity compared to open oesophagectomy. Long-term results show improved three-year overall survival in the HMIO group, indicating an oncologically sound procedure.
Researchers at Allina Health have found robotic-assisted surgery to be effective and safe for a select group of patients undergoing transhiatal esophagectomy. The study, which analyzed data from 100 patients, highlights the benefits of robotic technology in improving surgical outcomes.
A study led by the University at Buffalo found a significant association between periodontal disease and increased cancer risk in postmenopausal women. The study revealed that women with a history of gum disease had a 14% higher risk of overall cancer, as well as higher risks for gallbladder and esophageal cancers.
A large cohort study found that women with periodontal disease were at increased risk of developing any type of cancer, with the strongest association seen for esophageal cancer. Certain cancers were associated with higher risks in smokers or nonsmokers with periodontal disease.
The NRG-RTOG 0436 trial found that adding an epidermal growth factor receptor (EGFR) inhibitor to a chemo-radiation regimen does not improve overall survival for patients with locally advanced esophageal cancer. The trial showed no significant benefit from the addition of EGFR inhibitor cetuximab to standard treatment.
The Penn researchers will study the role of microbiota and microenvironment in developing Barrett's esophagus and esophageal adenocarcinoma. Their goal is to advance knowledge of the disease and identify novel biomarkers and therapies.
The university will investigate genetic determinants of Barrett's Esophagus and esophageal adenocarcinoma, developing a new molecular marker for detection. The research aims to improve non-invasive diagnostic approaches and treatment of esophageal cancer.
A retrospective study found that treatment improved overall survival in elderly patients with early-stage esophageal cancer. Surgery and local therapies such as chemoradiation showed significantly improved five-year overall survival rates compared to observation, with a median age of 84 years.
The ESOTRAC device combines multi-spectral optoacoustic tomography and optical coherence tomography to visualize sub-surface tissue features, enabling early-stage detection of esophageal cancer. This technology aims to reduce unnecessary biopsies and improve treatment efficacy.
Maunil Bhatt, a Boston University School of Medicine resident, received a Global Surgery Research Fellowship Award for his project on screening esophageal squamous cell cancers in rural India using the EsophaCap device. He plans to train and teach in low-income countries to address disparities in access to surgical care.
Researchers analyzed 559 esophageal and gastric cancer samples to discover two main types of esophageal cancer differ markedly in molecular characteristics. The study suggests grouping patients according to molecular subtype for more effective clinical trials and new treatment approaches.
Researchers from Kumamoto University found a significant association between the presence of Fusobacterium nucleatum in esophageal cancer tissue and poor survival outcomes. The study suggests that this oral bacterium may contribute to esophageal cancer development via chemokines.
A study found that Japanese patients with esophageal cancer who tested positive for DNA from Fusobacterium nucleatum had shorter cancer-specific survival compared to those without the bacterium. The presence of F. nucleatum was associated with poorer outcomes and may serve as a biomarker for prognosis.
Researchers at Arizona State University developed a new method to predict which BE patients are at risk of developing cancer. The study highlights the power of studying genetic diversity as a reliable predictor of cancer development and spread.
Researchers at University Hospitals Seidman Cancer Center have identified a rare gene variant associated with familial Barrett esophagus (FBE) and esophageal cancer. The study found that this mutation disrupts normal esophageal lining maturation, increasing disease risk.
Researchers at Eindhoven University of Technology have developed a new computer analysis method to detect early stages of esophageal cancer in people with Barrett's esophagus, which can be as accurate as top specialists. The method aims to improve the detection and treatment of esophageal cancer, reducing the need for invasive surgery.
A new study aims to identify individuals at highest risk of esophageal adenocarcinoma by analyzing DNA methylation patterns. The research team will use a two-year project to develop a screening test that can detect Barrett's esophagus patients who should start getting frequent endoscopies.
A Swedish cohort study found that surgeons need to perform at least 15 operations to obtain stable survival results during the first months after oesophagectomy. The learning curve for achieving optimal long-term survival takes 60 operations, highlighting the importance of proper mentorship and training programs.
Researchers found that Porphyromonas gingivalis is present in 61% of patients with esophageal squamous cell carcinoma (ESCC), a type of esophageal cancer. The bacteria was only detected in 12% of tissues adjacent to the cancerous cells, suggesting it may be a risk factor for ESCC.
A study published in the JNCI: Journal of the National Cancer Institute found that PET scans did not improve two-year survival rates for lung and esophageal cancer patients. The researchers suggest potential overuse of PET scans in detecting recurrence, warranting efforts to decrease unnecessary utilization.
A FAU bioengineer has received an NIH grant to develop a novel biodegradable polymer stent for treating inoperable esophageal cancer. The stent, designed to prevent complications while delivering anti-cancer drugs, aims to improve patient comfort and outcomes.
A study published in JAMA Internal Medicine estimates that cigarette smoking is responsible for nearly half of deaths from 12 smoking-related cancers among adults aged 35 and older. Lung cancer accounts for a significant proportion of these deaths, with approximately 80% of cases attributed to smoking.
Researchers found that genomic mutations in the TP53, APC, and CDKN2A genes were present in 75% of progressors with Barrett's esophagus. This ability to detect mutations in non-neoplastic mucosa can improve early detection and surveillance for patients at heightened risk for esophageal cancer.
Patients with locally advanced esophageal cancer who survive 5 years after surgery are at risk for recurrence, new primary cancers, and chronic pulmonary disease. Continued surveillance is necessary to mitigate these risks, particularly for patients with nodal metastases.
A new cell sampling device accurately identified patients with reflux symptoms who warrant endoscopy to diagnose Barrett's esophagus, with a sensitivity of 87.2% in high-risk cases. The minimally invasive test was well-received by participants, with no adverse effects reported.
Researchers from the University of Pittsburgh School of Medicine discovered a pool of stem cells in the esophagus, which could lead to new treatments for esophageal cancer and Barrett's esophagus. The study found that these stem cells divide slowly compared to other cells in the esophagus, suggesting they may play a role in tissue rene...
A study analyzing medical professional liability claims related to esophageal cancer screening found that the risks of claims arising from acts of commission and omission are similarly low. The authors suggest that physicians balance the risk of complications from diagnostic procedures, even if those complications are rare.
Researchers found that taller individuals are less likely to develop esophageal cancer and its precursor, Barrett's esophagus. The study, which included data from 1,000 cases of esophageal cancer and twice as many cases of Barrett's esophagus, consistently demonstrated an inverse association between height and these conditions.
Researchers found that traditional surgical resection provided significantly better outcomes with an 87.6 percent five-year survival rate compared to endoscopic resection at 76 percent. The study suggests that endoscopic treatment is safe and effective for low-risk T1a cancer patients, but should only be offered to those with unfavorab...
A systematic review compared the efficacy and safety of radiofrequency ablation (RFA) and complete endoscopic resection (EMR) for dysplastic Barrett's esophagus. Both treatments were found to be effective in short-term treatment, but RFA had lower short-term adverse event rates. Long-term esophageal strictures were more common with EMR.
Researchers developed a new biomarker for detecting Barrett's esophagus and esophageal adenocarcinoma through non-invasive brushing technique. The biomarker, vimentin methylation, has potential to improve screening and decrease mortality from this deadly disease.
A study found that radiofrequency ablation significantly reduced the risk of progression to high-grade dysplasia and cancer in patients with Barrett esophagus and low-grade dysplasia. Treatment resulted in a 25% lower absolute risk of progression.
A new study from the University of Southern California Keck School of Medicine found that long-term survivors of esophagectomy with gastric pull-up can enjoy a satisfying meal and good quality of life. The study concluded that pessimism about the long-term quality of life after esophagectomy is unwarranted.
Researchers from Chinese Academy of Medical Sciences and BGI Shenzhen identified important alterations of tumor-associated genes and tumorigenic pathways in esophageal squamous cell cancer. They found 8 significantly mutated genes related to ESCC, including a novel gene FAM135B that enhances cellular malignant phenotypes.