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Buying time through 'hibernation on demand'

Researchers at the Fred Hutchinson Cancer Center have made a groundbreaking discovery that enables temporary metabolic hibernation in mice, reducing oxygen dependence and potentially extending organ preservation time before transplantation. This technique could also accelerate wound healing in diabetic patients and improve cancer treat...

SourceFred Hutchinson Cancer Center·JournalScience·DateApr 21, 2005

UCSF study: Pediatrician's judgment often better than clinical guidelines for treating infant fever

A recent UCSF study found that pediatricians' clinical judgment may be more effective than strict adherence to guidelines in managing febrile illnesses in infants. The study analyzed data from 3,066 infants and found that experienced clinicians using clinical judgment may reduce unnecessary hospitalizations and improve treatment outcomes.

Long-term follow-up of mortality in patients with community-acquired pneumonia

A large-scale study found that long-term mortality in community-acquired pneumonia patients is influenced by factors such as age, nutritional status, and preexisting illnesses. The severity of pneumonia at initial presentation surprisingly did not predict mortality, with lower-grade fever actually linked to higher long-term death rates.

SourceInfectious Diseases Society of America·JournalClinical Infectious Diseases·DateNov 21, 2003

Nitric oxide has important role in fever regulation, new study says

A recent study by Dr. Wieslaw E. Kozak found that nitric oxide has a distinct role in fever regulation, involving three different enzymes: neuronal nitric oxide synthase, inducible nitric oxide synthase, and endothelial nitric oxide synthase. The researchers used knockout mice to study the impact of these enzymes on fever response.

SourceMedical College of Georgia at Augusta University·JournalJournal of Applied Physiology·DateMay 30, 2003

Q Fever microbe's genome is deciphered

The complete DNA sequence of Coxiella burnetii, the Q Fever microbe, has been deciphered, revealing information on its biology and ability to cause disease. Researchers found that the genome appears to be in the early stages of reduction, with numerous genes involved in virulence and interactions with its host.

SourceThe Institute for Genomic Research·JournalProceedings of the National Academy of Sciences·DateApr 14, 2003

Concern over safety of yellow fever vaccine

Two fatal cases of haemorrhagic fever associated with yellow fever 17DD substrain vaccine were reported in Brazil, highlighting the need to review the vaccine's safety. The cases led Philippe Marianneau and colleagues from Institut Pasteur to emphasize the importance of investigating mechanisms of attenuation of yellow-fever virus.

SourceThe Lancet_DELETED·JournalThe Lancet·DateJul 12, 2001