Articles tagged with Fever
Researchers find that the RANK protein and its ligand regulate the body's fever response, helping to fight infection. Female mice lacking RANK in the brain have increased body temperatures compared to males, with a link to sex hormones and reproductive biology.
A study by University of Bonn researchers has found a link between the influenza virus and fever, revealing that the immune system's RIG-I protein plays a key role in triggering high temperatures. This discovery could lead to new therapeutic strategies for treating severe viral infections.
Randomized controlled trials show prophylactic paracetamol administration can reduce fever and antibody responses to vaccines in children, but also highlights the need for careful weighing of benefits and risks. The study concludes that prophylactic use should no longer be routinely recommended.
Researchers at McGill University Health Centre have discovered the mechanism by which hemozoin activates the immune system, leading to inflammation and fever in malaria patients. The study provides a new direction for developing vaccine-like treatments to limit the severity of the disease.
A new climate-based model predicts Dengue fever epidemics up to 40 weeks in advance with 83% accuracy, providing crucial time for public health authorities to mobilize resources. The model can be expanded to include Latin America and the Caribbean, where disease incidence has increased dramatically over the past 25 years.
Researchers at Tulane University are developing detection kits for Lassa viral hemorrhagic fever, which affects 300,000-500,000 people annually in West Africa, causing 5,000 deaths. The $7.07 million NIH grant will help complete the development and commercialization of these kits to aid public health and bioterrorism defense.
Researchers suggest that autism symptoms may be reversible due to dysregulation of the locus coeruleus, a bundle of neurons processing sensory signals. The new theory proposes that fever can stimulate this system, potentially restoring its normal function.
A NASA study successfully predicted the 2006-2007 Rift Valley fever outbreak in northeast Africa using a blend of climate measurements and satellite data. The prediction gave public health officials up to six weeks' notice, allowing them to implement disease mitigation measures and lessen human impact.
Researchers at the University of Texas Medical Branch discovered a major virulence factor for Rift Valley fever virus that has a dual mechanism. The protein NSs promotes viral replication by attacking a host cell protein, preventing interferon beta production and allowing the virus to replicate unchecked.
Researchers Higgs and Gould examine climate's impact on West Nile, Chikungunya, Rift Valley fever, and Bluetongue viruses' spread. Climate change is linked to the northward expansion of Culex imicola midge species, facilitating Bluetongue virus dispersal.
Two experts disagree on whether all African children with fever should be treated presumptively with antimalarial drugs. Blaise Genton and colleagues argue that declining malarial transmission rates support changing the policy, while Mike English and colleagues claim there is not enough evidence to abandon presumptive treatment.
Researchers found that bavituximab, a PS-targeting antibody, can cure lethal virus infections in animal models of cytomegalovirus and Lassa fever. The drug showed potent anti-viral activity and may represent a new class of drugs for treating viral infections.
Researchers identified localized clusters of dengue cases in rural Thai villages, suggesting that targeted mosquito control measures could reduce transmission. The study's findings provide valuable insights into the spread of dengue virus and inform potential prevention strategies.
Researchers in FLUTEST project provide improved bird flu diagnosis and early warning systems, while AFRISK project aims to detect and prevent African Swine Fever imports into EU member states. Global warming may be increasing disease spread in Europe.
Research led by the University of New South Wales found that individuals with atopic diseases such as asthma and hay fever are up to 40% less likely to develop NHL if they have multiple conditions. Chronic atopy is associated with a reduced risk, particularly in B-cell NHL cases.
Researchers link fever to life-threatening changes in the heart's electrical cycle of LQT-2 patients, a genetic condition characterized by prolonged QT intervals. Fever triggers abnormal electrical currents in heart cells, potentially leading to ventricular arrhythmias and heart failure.
A newly discovered arenavirus, Chapare virus, has been identified in a fatal hemorrhagic fever case in rural Bolivia. The virus produces clinical hemorrhagic symptoms similar to those associated with other New World arenaviruses, but genetically it is distinct from Junin, Machupo, Guanarito, and Sabia viruses.
Research conducted by Miami Research Associates found that Wellmune WGP supplementation reduced the incidence of medically verified fever in healthy subjects. Additionally, the study showed significant improvements in physical energy and emotional well-being, with no need for work or school absences due to cold-like symptoms.
Researchers have successfully tested Ebola vaccines in primates, triggering a cell-mediated response and producing effective protection. The candidates are now set to be tested on humans for the first time, offering hope for controlling outbreaks and protecting healthcare workers.
A study of 27 children with periodic fever, aphthous ulcers, pharyngitis and adenitis (PFAFA) found that tonsillectomy was nearly always effective in resolving symptoms. Despite no clear explanation for why the surgery works, doctors are optimistic about its potential to improve treatment outcomes.
A study published in PLOS Medicine found that Chikungunya virus-infected mothers rarely harm infants early in pregnancy but can cause severe problems, including brain injury, in babies born near the time of delivery. Researchers recommend clinicians monitor babies exposed to chikungunya around delivery for supportive treatment.
The Uukuniemi virus structure reveals how bunyaviruses infect host cells by changing shape in acidic environments, a mechanism shared with influenza and dengue viruses. The discovery may aid in developing drugs for treating hemorrhagic fever and encephalitis.
Researchers found that lower transmission rates increase dengue deaths by reducing the development of immunity to new strains during a critical cross-immunity period. This allows the virus to gain entry into cells and cause more severe infections.
A Dutch study found that tonsillectomy was not cost-effective for mild or moderate throat infection symptoms in young children. The procedure increased annual costs by 46% without significant health benefits, according to the study.
Researchers have identified a key pathway involved in autoinflammatory diseases, including arthritis and certain types of cancer. Mutant forms of the PSTPIP1 protein can activate pyrin, leading to excessive IL-1 beta production and inflammation.
New research reveals fever responses differ among closely related mouse species, suggesting reproductive strategy plays a role. Fast-living mice tend to use fever less often than slow-living counterparts, highlighting the trade-offs between immune defenses and other physiological processes.
A Queensland University of Technology study found that Australian parents administer medication incorrectly and overly frequently when it comes to managing childhood fever. The study revealed that 4% of parents gave paracetamol too often and 32% administered ibuprofen at incorrect intervals.
Dr. Andrej Romanovsky has been awarded a $1.8 million grant to study the mechanisms of fever and hypothermia in systemic inflammation. His research aims to gain insight into the therapeutic use of anti-inflammatory drugs.
A new study found that genetic variation in the foraging gene can protect against heat-induced neural failure, leading to potential rapid protection of brain function during extreme fevers. Researchers suggest this could lead to ways to rapidly protect the brain from damage due to extremely high fevers in mammals, including humans.
Researchers at Beth Israel Deaconess Medical Center discovered the key site in the brain where a hormone called prostaglandin E2 causes fever responses during infections. This discovery sheds light on the adaptive function of fever in protecting the body from illness, including increased sensitivity to pain and achiness.
Researchers identified common DNA variations that underlie susceptibility to fever after smallpox vaccination. Eight genetic alterations increased the likelihood of fever, while a few reduced it. The study raises the possibility that these genetic variations may also influence fever risk after other live-virus vaccines.
A new study published in The Journal of Infectious Diseases has identified eight gene clusters associated with altered susceptibility to fever after smallpox vaccination. These genetic variations are linked to the interleukin-1 (IL-1) gene complex and the interleukin-18 gene on chromosome 11.
A study of nearly 600 people with hay fever symptoms found that workers missed an average of one hour of work per week during peak seasons. Diagnostic testing followed by proper treatment may help reduce missed work days.
A new study reveals that severe dengue infections are more common than previously thought, with 23% of patients requiring hospitalization. The study suggests that the World Health Organization's definition of dengue hemorrhagic fever may be too narrow, potentially leading to misdiagnosis and delayed treatment.
Researchers have developed a new screening method to detect MCAD deficiency in newborns, reducing the number of undiagnosed cases. Early detection improves treatment options and reduces mortality rates, with one-quarter of patients dying before diagnosis is known.
Researchers at University of Texas Medical Branch have discovered a way to identify the biochemical profile of an inappropriate immune response to viral infection. The study uses a protein-scanning chip and computer database to examine over 1,200 protein interactions in guinea pigs infected with two different strains of Pichinde virus.
The GreeneChip System is a comprehensive tool for differential diagnosis of infectious diseases, including viruses, bacteria, fungi, and parasites. It can be used on various samples and has been tested with positive results in cases where other methods failed to implicate a microorganism.
Researchers have identified a key mechanism by which Filoviruses, including Ebola and Marburg, cause immunosuppression. By targeting specific amino acid sequences, new drugs may be developed to disrupt the virus's ability to shut down the immune system.
A six-week experimental allergy treatment has relieved hay fever symptoms for at least two years in a clinical trial. The novel DNA-based drug AIC blocks the seasonal rise in ragweed-specific IgE and reduces IL-4, hinting at successful immune system reprogramming.
Researchers developed a DNA-based vaccine to protect against ragweed allergies, showing a 60% reduction in symptoms. The vaccine works by suppressing acute reactions and helping the body regulate chronic inflammation.
A Tulane University study suggests that bats may have been responsible for the origin of the deadly Marburg hemorrhagic fever outbreak in the Democratic Republic of Congo. The research identified multiple genetic variants of the virus, indicating repeated introductions from a primary reservoir rather than person-to-person spread.
The study suggests that eczema and hay fever prevalence has plateaued or declined in recent years, while hospital admissions for these conditions have stabilized. Systemic allergies, including anaphylaxis, food allergy, and urticaria, have shown a significant increase in rates over the past few decades.
A study of 49 patients diagnosed with West Nile fever found that half experienced ongoing health complaints, including fatigue, memory problems, and depression, similar to those who had more severe forms of the disease. The research suggests that West Nile virus may cause a spectrum of illness and damage to the brain.
Researchers found that FDG PET scans can accurately diagnose fevers of unknown origin in half of cases, eliminating the need for further tests. The study suggests that FDG PET offers an effective tool for early diagnosis, risk stratification, and treatment, reducing hospital stays.
The Chikungunya outbreak in the Indian Ocean affects several islands and India, with a large portion of populations infected. The disease is caused by the chikungunya virus, spread by mosquito bites, and has no specific treatment. Genetic analysis reveals unique molecular features among outbreak strains.
Researchers have developed a vaccine that prevents haemorrhagic fever developing in monkeys infected with the deadly Marburg virus. The vaccine was found to be highly effective as a post-exposure treatment, with all treated monkeys surviving for at least 80 days.
A recent review of studies found that parents' knowledge about fever treatment is poor, leading to increased overdoses of paracetamol and ibuprofen in children. The study suggests that education programs for parents can help improve their attitudes and practices towards treating childhood fevers.
Researchers at Columbia University's Mailman School of Public Health have developed a rapid and highly sensitive diagnostic test for pathogens responsible for disease outbreaks. The new test, known as MassTag PCR, can simultaneously identify multiple agents and reduce the time needed for differential diagnosis.
Researchers tracked individuals infected with EBV, RRV, or Q fever and found post-infective fatigue syndrome lasting six months or longer. The study suggests that brain damage during acute infection phase may be responsible for chronic fatigue symptoms.
A University of Chicago study found that daily doses of pseudoephedrine hydrochloride were as effective as montelukast sodium in relieving hay fever symptoms without additional side effects. Pseudoephedrine was slightly more effective in reducing congestion and had a lower risk of sleep problems compared to montelukast.
Scientists from five institutions identify five vaccine targets for an East Coast fever subunit vaccine, which triggered a strong immune response in lab tests. The researchers used the genome sequence of the parasite responsible for the disease to develop the vaccine.
A 12-year-old girl from rural Hunan, China died of acute respiratory distress syndrome after developing fever and cough. Her 9-year-old brother recovered after treatment with antiviral medication. The investigation highlights the need for improved infection control measures in backyard farming settings.
A study analyzing 35 soldiers' remains identified lice carrying DNA from Bartonella quintana and Rickettsia prowazakii, linking these diseases to Napoleon's retreat from Russia. The findings suggest louse-borne diseases were a major factor in the army's decline.
Researchers at Tulane University have received a multi-million dollar grant to develop diagnostic tests for hemorrhagic fevers, such as Lassa fever. The goal is to create tests that can be performed in biosafety level 1 labs, making them accessible in West Africa.
Researchers have discovered a novel mechanism used by tick-borne flaviviruses to counteract the natural ability of interferon to combat the virus. The study found that NS5 protein blocks immune defenses, preventing the immune system from stopping the spread of the virus and helping the body recover from infection.
Patients with fever of unknown origin have a higher risk of developing cancer, particularly haematological and sarcomas, than the general population. After several years of follow-up, diagnostic bias is believed to be a contributing factor to the association.
A randomised study found that butterbur extract was as effective as conventional antihistamines in treating symptoms of intermittent allergic rhinitis. The extract also did not cause drowsiness, making it a potentially useful treatment option for patients who cannot tolerate other therapies.
Rocky Mountain spotted fever, a bacterial disease caused by Rickettsia rickettsii, can be effectively treated with specific antibiotics if caught early. Symptoms include body-wide aches, headache, sudden high fever, sore throat, and nausea, often accompanied by a telltale spotty rash.
A promising new vaccine candidate has shown protection against Lassa fever in macaque monkeys, offering hope for a potential vaccine. The vaccine's effectiveness and safety will need to be further assessed in larger studies.
A new experimental vaccine has shown promising results in protecting nonhuman primates from Lassa fever. The vaccine, developed using a non-pathogenic form of vesicular stomatitis virus as a carrier, has been successfully tested with all vaccinated monkeys surviving infection.