International team develops standardized guidelines for assessing lymphoma treatment response, incorporating new imaging technologies. The revised guidelines aim to improve therapies and facilitate the development of new treatments.
A team of researchers at Penn State has discovered a master regulator that controls metabolic responses to essential amino acid deficiency, leading to profound effects on fat metabolism. The discovery may lead to new treatments for obesity and protein malnutrition, particularly in underdeveloped nations where malnutrition is prevalent.
Researchers at Brown University have identified GABP as a critical transcription factor that restarts cell division, a process fundamental to development, renewal, and cancer growth. Disrupting GABP may lead to new cancer treatments.
New studies using meta-analysis found a significant link between high vitamin D levels and reduced risk of breast and colorectal cancers. Individuals with the highest blood levels of 25-hydroxyvitamin D had the lowest risk of these cancers, with potential protective effects achievable through diet, supplements, or sunlight exposure.
Researchers from Massachusetts General Hospital discover that isoflurane, a commonly used anesthetic, can lead to generation of amyloid-beta protein and apoptosis in brain cells. The study suggests caution when using the anesthetic for elderly patients at risk of Alzheimer's disease.
Researchers propose an alternative hypothesis for pingo-like features forming underwater: methane hydrate decomposing beneath the seafloor releases gas, squeezing up sediments. Geologic fieldwork and chemical analysis suggest warming seafloor sediment triggers decomposition of buried hydrates.
A study analyzing Hodgkin disease treatment found that patients are at increased risk of fatal heart attacks for at least 25 years after treatment. Cardiovascular disease is the second leading cause of death in long-term survivors, with myocardial infarction being the most common cause.
China's growing investment in nanoscience aims to capture a significant share of the $3 trillion global nanotech market. The country plans to increase its research and development capabilities over the next 15 years, with a focus on emerging technologies like nanotechnology.
A new study found that those who desire all potential partners equally are less likely to be desired in return, while those who have a special connection with one person are more likely to receive romantic interest. Researchers used speed-dating methodology to observe initial attraction and discovered that being too selective can be a ...
A new study by UC Berkeley scientists finds that male sweat contains a chemical called androstadienone, which increases cortisol levels and affects women's hormonal balance. The study suggests that inhaling this chemical could be used to raise cortisol levels in patients with diseases like Addison's disease.
A new study found that patients who received aprotinin during coronary artery bypass graft surgery had a higher risk of death over five years compared to those who did not receive the drug. The study, published in JAMA, also found that safer alternatives like aminocaproic acid and tranexamic acid were available.
A new study finds that immigration has contributed to declines in interracial marriages in the US, particularly among Hispanic and Asian Americans. Education plays a key role in defining who participates in interracial marriages, with highly educated individuals more likely to cross racial lines to marry. African American intermarriage...
Studies by LA BioMed researchers found that close contacts of patients with CA-MRSA infection may be at higher risk of acquiring an infection. The findings suggest that CA-MRSA strains are more transmissible than traditional S. aureus strains, emphasizing the need for cautious treatment and contact isolation.
A study found 5 genetic variations associated with the risk of nonfatal venous thrombosis in postmenopausal women, highlighting potential new targets for prevention and treatment. The findings suggest that genetic factors may play a significant role in the development of this condition.
The Pediatric Exclusivity Program has generated over 300 pediatric studies and labeling changes for more than 115 products. The program's economic return is highly variable among products, with blockbuster medications producing substantial profits while others yield modest returns.
Aging animals show reduced AMPK activity in skeletal muscle, leading to decreased mitochondrial function and increased intracellular fat content. This decline contributes to insulin resistance and type 2 diabetes.
Researchers found that housekeepers' perceived levels of exercise positively impacted their health, with significant weight loss and improved blood pressure. The study suggests the placebo effect plays a role in exercise's benefits.
A recent study suggests that overactive bladder is less common in Finland than previously thought. The condition was identified in 6.5% of men and 9.3% of women, with urinary frequency and nocturia being more prevalent among those with the condition.
Renowned nutrition expert Dr. Irwin Rosenberg emphasizes the need for more research on vitamins and minerals, highlighting the limitations of current evidence. He advocates for standardized regulations on multivitamin products to ensure customer safety and informed marketing.
Researchers discover xanthine oxidoreductase (XOR) as a key player in early fat cell development, suggesting potential for new obesity treatment. XOR inhibition blocks fat formation and improves metabolic outcomes in mice.
A study published in the Journal of the National Cancer Institute found that women with breast cancer who received growth factors during chemotherapy had a higher risk of developing leukemia or myelodysplastic syndrome. The absolute risk is small, but it should be considered when making treatment decisions.
A new report by the European Society for Medical Oncology warns that Europe's aging population is driving a major increase in cancer cases and deaths. The report estimates that there were 3.2 million new cancer cases diagnosed in 2006, with lung cancer remaining the leading cause of death.
A new study found that hairy cell leukemia survivors have an increased risk of developing certain cancers, including Hodgkin lymphoma and thyroid cancer. Meanwhile, a new test may be able to identify patients with a specific type of gene mutation that indicates an inherited form of colorectal cancer or potential response to certain drugs.
A study by Durham University found that nearly two-thirds of English mortgage holders have almost all their savings tied to their home. This means nearly a quarter are taking a diversified approach, balancing investments between home ownership and other financial portfolios.
Researchers have developed a novel approach for the direct synthesis of polymeric nanocapsules with surface elements that can recognize specific target cells. The method uses disk-shaped monomers with polymerizable groups, which link together to form hollow spheres with uniform sizes and tailored surfaces.
A recent study finds that human population size and affluence are the primary drivers of environmental stressors, whereas urbanization, economic structure, and age of population have limited impact. The researchers used global average productivity to compare environmental tradeoffs and human-induced stressors in the environment.
Researchers at the University of Rochester found that playing action video games for 30 hours per week improved spatial resolution and visual acuity. The study showed significant improvements in identifying letters presented in clutter, even beyond the part of the visual field where players typically engage with the game.
The new guidelines emphasize the importance of treating both diabetes and cardiovascular diseases simultaneously. The guidelines recommend using stress testing and echocardiography to confirm a diagnosis of valvular heart disease, and emphasize the need for precise risk stratification before treatment decisions are made.
Researchers found that surgically removing the vagus nerve in mice prevented or reversed insulin resistance and high blood pressure. The study suggests altering vagal nerve activity could provide a novel treatment approach for diabetes and hypertension.
Researchers have constructed a protein out of amino acids not found in natural proteins, discovering they can form a complex, stable structure resembling a natural protein. This finding could help scientists design effective drugs that won't be degraded by enzymes or targeted by the immune system.
Clinical trials show statin therapy promotes regression of coronary atherosclerosis through significant reductions in LDL-C and increases in HDL-C. Patients experiencing substantial decreases in LDL-C (<87.5 mg/dL) and percentage increases in HDL-C (>7.5%) exhibit notable atheroma regression.
Researchers found that SPECT/CT imaging enhances sentinel node identification in overweight patients with breast cancer. The study suggests this improved technique can reduce the need for unnecessary surgery and improve treatment outcomes.
A study published in Cell Metabolism reveals that the MAT1 gene plays a crucial role in regulating energy production in heart cells. Researchers found that infant mice lacking MAT1 developed catastrophic heart failure, highlighting the importance of this gene in maintaining cardiac function.
A multi-country study found that more prominent text messages and graphic pictures on cigarette packages are effective in affecting smokers' behaviors. The study analyzed data from four countries and found that recent changes in health warnings were associated with increased effectiveness, while US warnings had the least impact.
A University of Houston research team has been awarded a $1.6 million grant to build the most powerful magnetic field sensor to date. The sensor, which could be hundreds or thousands of times more sensitive than current models, will have applications in both military and medical fields.
Researchers have identified a novel biological pathway that may contribute to cases of mental retardation and autism, with mutations in two genes causing brain abnormalities and milder symptoms than classical forms of Cornelia deLange syndrome.
Research reveals that teenagers are more fearful of losing their sight than lung cancer or stroke, yet only a small percentage understand the link between smoking and blindness. The study found that just 5% of respondents correctly identified the risk, with even fewer among smokers.
A recent study found that women conceiving in spring are most vulnerable to preterm birth, with rates increasing from summer (8.4%) to winter and fall. The research analyzed data from over 75,000 deliveries and suggests that seasonal variations in immune system exposure may play a role in preterm birth risk.
Scientists have discovered that human proteins evolve slowly due to dual coding regions in their DNA, which slows down the rate of evolution. This knowledge can be used to develop more effective gene therapy techniques and potentially treat genetic disorders.
A recent study published in Archives of General Psychiatry found that individuals experiencing loneliness are at a significantly increased risk of developing Alzheimer's disease. The research, conducted over four years, analyzed data from 823 older adults and revealed that loneliness was associated with a 51% increased risk of developi...
A recent study suggests that the 'probe to bone' test, used to diagnose bone infections in people with diabetes, may not be as reliable as thought. The test, which feels for bone inside a wound, is only slightly better than chance when used alone.
A team of researchers at Delft University of Technology used HREM to observe collective transport of gold atoms in a thin layer. The findings demonstrate a rapid progress in real-time nano-microscopy, enabling the precise positioning of atoms with accuracy.
The March of Dimes has allocated $3 million to support eight scientists' research on predicting and preventing preterm birth. Five projects focus on immune responses, while others investigate the role of genetic factors, circadian rhythms, and potassium balance.
Researchers discovered that APOE genotypes increase susceptibility to cerebral palsy in newborns. The study found a threefold-elevated risk for children with quadriplegia/triplegia and more severe motor impairment.
The incidence of autism and two other childhood neuropsychiatric disorders increased significantly among Danish children between 1990 and 2004. This trend suggests a broader pattern in childhood mental illness, with the exception of obsessive-compulsive disorder.
Researchers found that splice-enhancer domains, which code for specific amino acids, influence protein evolution and are subject to selective pressure. Smaller exons near intron-exon boundaries also evolve more slowly.
A University of Missouri-Columbia researcher is deploying sensors on a mid-ocean ridge to capture rare underwater data, providing valuable insights into volcanic activity and its effects on ocean chemistry. The project aims to improve our understanding of the Earth's oceans, which cover over 70% of the planet.
A study published in PLoS Biology finds that low levels of toxic substances cause critical stem cells to prematurely shut down. The research identifies a common molecular trigger for the effects of toxicant exposure, offering new insights into damage caused by toxicant exposure and potential methods to evaluate chemical safety.
A recent study by RAND Corporation found that only 28% of HIV-positive unmarried parents have made legal arrangements for who will care for their children if they die. This lack of planning can lead to emotional and behavioral problems in children, making guardianship plans essential.
Researchers found that the poorest people in developing countries are least likely to use contraception, with significant regional variations. The authors emphasize the need for governments and international health organizations to focus on providing contraceptive services to those with very low incomes.
Researchers at UT Southwestern Medical Center found that a supplemental therapy teaching pain coping and biofeedback skills can reduce jaw disorder pain and health-care costs. The therapy improved pain management and reduced doctor visits among study participants.
A study of 823 individuals with an average age of 80 found that loneliness was associated with a 51% increased risk of developing Alzheimer's disease. The findings suggest that loneliness may contribute to the risk of dementia through mechanisms other than Alzheimer's disease pathology.
The Rong Li lab team has identified a crucial pathway controlling asymmetric meiotic cell division in mouse oocytes, allowing for genomic reduction while maintaining essential building blocks. This finding provides insights into the molecular signals driving egg maturation and its significance for reproductive health.
Researchers found a strong association between high blood pressure during pregnancy and increased coronary calcification later in life. Women who developed hypertension during pregnancy were at a 57% higher risk of cardiovascular disease, including type-2 diabetes and heart disease.
A study by Wei-Jian Jiang found that successful stent placement reduces the risk of stroke for individuals with severe artery blockage. The risk was comparable to those with moderate blockage, suggesting that stents may not be beneficial for all patients at high risk.
A team of researchers has discovered that ancient rocks from Quebec, Canada, contain iron carbonates believed to have formed in an atmosphere with extremely high CO2 levels. This suggests that high concentrations of greenhouse gases may have helped Earth avoid global freezing in its youth.
The number of very elderly beginning dialysis increased from 1996 to 2003, with one-year survival rates remaining at around 50%. Ambulatory techniques for diagnosing sleep apnea were found to be as effective as polysomnography.
A study by University College London finds that male-killing bacteria active in many insect species, including butterflies, increase female promiscuity and reduce male effort during mating. In the absence of males, females become more sexually rampant, while males exhibit signs of fatigue and reduced sperm quality.
Scientists at Georgia Tech have found that the electrical conductance of metal nanowires varies due to a pair of atoms, known as a dimer, shuttling back and forth between the bulk electrical leads. This discovery has significant implications for the development of nanotechnology and nanodevices.
Researchers used bioassay-guided evolution to identify more efficient antibiotic-producing mutants in Escherichia coli, reconstituting the biosynthetic pathways of sugars to yield a new antibiotic. This approach opens doors for harnessing genetics to investigate polyketide synthases and biosynthetic engineering.