Articles tagged with Heart Disease
Cardiac diseases cause pathological growth leading to heart failure. Researchers found epigenetic marks responsible for this growth are lost in disease, allowing cells to switch back to fetal form and leading to irregular rhythms. This finding points to a new strategy for epigenetic therapy.
A large study published in The BMJ found that high intake of major saturated fatty acids increases the risk of coronary heart disease. Replacing these fats with polyunsaturated, monounsaturated, or plant-based sources can reduce this risk by 6-8%.
A new study led by Harvard T.H. Chan School of Public Health researchers found that consuming high amounts of four major saturated fatty acids increases the risk of coronary heart disease. Replacing these fats with healthier alternatives, such as whole grains and plant proteins, may reduce this risk.
A large study published in The BMJ found that prediabetes, defined as impaired fasting glucose or impaired glucose tolerance, is associated with an increased risk of cardiovascular disease and all cause mortality. The study's findings support a lower cut-off point for defining prediabetes, including as low as 5.6 mmol/L.
A Yale-led research team identified a protein called ALK1 that binds to LDL cholesterol, facilitating its transport into cells. This finding could lead to a new therapeutic approach for reducing atherosclerosis and slowing heart disease.
The BLUEPRINT project has discovered how variation in blood cell characteristics and numbers affects the risk of complex diseases such as heart disease and autoimmune diseases. Genetic differences affecting some characteristics are linked to increased risk of heart attack, rheumatoid arthritis, and other common autoimmune diseases.
Li Qian's research focuses on cardiac reprogramming, converting scar tissue cells into functional cardiomyocytes. Her long-term goal is to see her approach used in patient care within five to 10 years.
Researchers have developed a long-acting drug delivery capsule that can safely stay in the stomach and deliver medicine for up to two weeks, potentially providing a new way to combat malaria and other infectious diseases.
Researchers found that high levels of pessimism were associated with an increased risk of CHD-induced mortality, even after adjusting for known physiological risk factors. Optimism did not appear to have any protective effect on this risk.
Researchers at the University of Colorado Anschutz Medical Campus found a strong association between a genetic mutation and left ventricular noncompaction, a rare form of heart muscle disease. The study sequenced nearly 5,000 genes in 335 patients with a family history of the disease to identify common genetic variants.
Postmenopausal women who experience weight cycling are at increased risk of sudden cardiac death and coronary heart disease deaths. Researchers found that normal-weight women who lost and regained weight had a higher risk of sudden cardiac death than those with stable weight.
A large-scale genetic study found a strong link between the inability to safely store excess fat and increased risk of type 2 diabetes and heart disease. The study identified 53 regions of the genome associated with insulin resistance, highlighting the importance of peripheral fat tissue in energy storage.
A recent study found that the incidence of coronary heart disease in the US declined by nearly 20% between 1983 and 2011. The decline was attributed to improvements in diabetes treatment and control, as well as changes in awareness and prevention efforts.
A new study of over 200,000 cancer survivors found that those diagnosed at younger ages have a higher risk of death from heart disease. Cancer survivors diagnosed between 15-19 years old had a 4.2 times higher risk compared to the general population.
Food cooked at high temperatures may contain toxic chemicals that raise the risk of heart disease. Researchers found that traditional South Asian cooking methods can lead to the formation of trans-fatty acids and other toxins, which are linked to higher heart disease rates in some communities.
Researchers have created computer models of blood flow through the heart's upper left chamber that may help predict stroke risk. The study found that a corkscrewlike motion helps move blood efficiently through the atrium, whereas an enlarged and diseased heart fails to form this motion, increasing the risk of developing a blood clot.
The study highlights the importance of understanding the risks of obesity and its effects on overall health. Americans perceive diet and exercise as the most effective long-term weight loss method, despite medical professionals recommending a range of treatments.
A study published in the Journal of the American College of Cardiology found that white coat hypertension is associated with an increased risk of heart disease in older patients. Researchers analyzed data from over 650 patients and found that those diagnosed with white coat hypertension were more likely to experience cardiovascular eve...
A study published in the Journal of the American College of Cardiology found that low and very high levels of 'good cholesterol' are associated with an increased risk of dying from heart disease, cancer, and other causes. Raising HDL levels does not appear to reduce a person's risk of heart disease.
Researchers found resveratrol reversed mouse heart dysfunction by improving pumping efficiency and reducing oxidative damage. The study suggests potential for resveratrol and similar substances to treat Chagas cardiomyopathy in humans.
Research shows vitamin D engages with genes influencing longevity, slowing aging-related protein misfolding and increasing lifespan by 33%. The study provides a link between aging and disease, offering new insights into the potential benefits of vitamin D supplementation.
Researchers at MDI Biological Laboratory found that early-life stress increases adult vulnerability to diseases like arthritis, asthma, cancer, diabetes, heart disease, and mental illness. Chronic exposure to cortisol in zebrafish embryos leads to abnormal immune systems and signs of chronic inflammation.
A study of over 1.2 million UK women found that lower education levels and living in deprived areas increased the risk of coronary heart disease due to smoking, obesity, and physical inactivity. Lifestyle factors accounted for most of the social inequalities in heart disease risk, with smoking being the most significant factor.
A study of over 2,700 participants found that taking calcium supplements may increase the risk of developing atherosclerosis and heart disease. Meanwhile, a diet high in calcium-rich foods appears to be protective.
Dr. Calum MacRae wins $75M One Brave Idea research award from AHA, Verily and AstraZeneca to uncover causes of coronary heart disease. The research project will focus on identifying novel markers in people genetically prone to heart disease.
A substantial proportion of birth weight variation is attributed to genetic differences, with some 1/6th of the difference being due to genetics. The study also found a link between genetic differences in early growth and increased risk of adult diseases.
A historical analysis examines the sugar industry's role in coronary heart disease research and suggests the industry sponsored research to influence the scientific debate. The study highlights the importance of having reviews written by people without conflicts of interest and the need for financial disclosure.
A novel TAVI device has been developed to replace heart valves in patients with rheumatic heart disease, offering a simplified approach that does not require advanced cardiac surgical facilities or sophisticated cardiovascular imaging. The procedure can be performed without rapid ventricular pacing, making it more tolerable for patients.
Eating red meat increases significant risks for diabetes, heart disease, stroke, and certain cancers. The production of red meat also creates an environmental burden with impacts on greenhouse gas emissions and water use.
A new study from UC Berkeley finds that living in overtly racist communities can shorten the lives of both blacks and whites due to increased heart disease and circulatory issues. Blacks are most negatively impacted by racial bias, with higher rates of heart disease-related deaths in counties with high levels of racism.
A national survey found that over half of Americans know of heart valve disease but less than a quarter understand its symptoms. The condition affects over five million people and can be serious, highlighting the need for increased awareness and education.
Research reveals that patients under 50 who survive a heart attack are at almost twice the risk of dying from heart disease, largely attributed to smoking and other factors. Younger survivors have higher cardiovascular disease risk factors, including high blood pressure, diabetes, and obesity.
The CE-MARC 2 trial found that cardiovascular magnetic resonance (CMR) and myocardial perfusion scintigraphy (MPS) significantly reduced rates of unnecessary angiography compared to guideline-directed care. These findings suggest that functional imaging should be adopted on a wider basis, even in high-risk patient subgroups.
A study found that cardiovascular magnetic resonance-guided care reduces unnecessary angiography in patients with suspected coronary heart disease, but was not significantly different from myocardial perfusion scintigraphy-guided care. The strategy did not affect major adverse cardiovascular event rates or disease detection rates.
Research found moderate physical activity reduces risk of acute cardiovascular event by over 30%, and CVD mortality by 54%. Regular exercise is associated with lower risk, even with other health factors.
A clinical trial has shown that metformin can promote a patient's ability to repair their own damaged blood vessels by increasing vascular stem cells. This could lead to improved treatment options for Type 1 diabetes patients at risk of developing heart disease.
Research suggests that younger women with coronary heart disease are vulnerable to the damaging effects of psychological stress on their heart. The study found that stress-induced, reduced blood flow occurred more frequently in younger women than men, especially among those under 50 years old.
The Arab uprising and subsequent wars have had a devastating impact on the region's health, with many countries experiencing downward turns in life expectancy. The study reveals that infant mortality rates are rising, and chronic diseases such as diabetes and heart disease are becoming increasingly prevalent.
UK cardiovascular deaths plummeted by almost 70% over 30 years, but prevalence remained unchanged. Drug and surgical treatments on the rise, particularly among men.
A new study reveals how blood flow dynamics within blood vessels may influence the development or rupture of plaques, potentially leading to early interventions in treating heart disease. The research improves predictions of circumferential wall stress and identifies weak spots on a vessel wall that are likeliest to fail.
A new study by the American Heart Association reveals that limited access to nearby stores selling fresh food may increase residents' risk of developing signs of early heart disease. The research found that healthy food stores within one mile of their home significantly reduced or slowed the progression of coronary artery calcium buildup.
African American participants in the Jackson Heart Study show lower risks for heart attacks and strokes with more heart-healthy metrics, yet only 17% meet these criteria. The study highlights a persistent inequity in heart health among this group, despite known prevention strategies.
A new cost-effectiveness tool provides guidance on preventing and treating rheumatic heart disease, recommending prioritization of primary prevention services. The tool suggests that prevention is more cost-effective than treatment, with primary prevention being likely to be cost-saving in the long-term.
A recent Cornell University study suggests that circulating trimethylamine N-oxide (TMAO) may be a biomarker of differences in the gut microbiome rather than a cause of heart disease. Researchers found that healthy men with elevated TMAO levels after consuming eggs and beef also had high counts of firmicutes, a type of bacteria that co...
The National Institutes of Health awards a four-year grant to analyze the molecular signals influencing gene-expression patterns that can lead to heart disease. The research aims to understand the mechanisms of cardiac diseases and identify potential therapeutic targets.
A recent study by Cynthia Levine suggests that people who fit better with their culture have healthier eating habits. In the US, independent behavior predicts a healthy diet, while in Japan, interdependence is linked to healthier eating.
A study published in The BMJ found that higher total physical activity levels are strongly associated with a lower risk of five common chronic diseases. Most health gains occur at a level of 3000-4000 MET minutes a week, suggesting that current recommended minimum levels may not be sufficient to achieve larger reductions in risks.
A new study of over 1 million people found that doing at least one hour of physical activity per day can eliminate the increased risk of death associated with sitting for 8 hours a day. The study also highlights the significant economic burden of physical inactivity, with estimated costs of over $67 billion annually.
The study found that genetic signatures predict education, height, BMI, and heart disease more strongly today than in the past. The role of genes decreased for education but increased for BMI and heart disease due to environmental factors.
Researchers found that community-based behavioral lifestyle intervention programs improve health-related quality of life by nearly 10% among participants. Those with lower baseline quality of life showed the greatest improvement, with scores increasing from 61.8 to 74 after completing the year-long program.
A new study by University of Stirling researchers found that early-life exposure to infections does not lead to increased risk of death in adulthood. Contrary to previous theories on long-lasting inflammation, the study suggests improved adult conditions such as healthcare and diet are responsible for recent increases in lifespan.
A new study found that spending 2.5 hours per week on recreational physical activity can lower the risk of coronary heart disease in women under 50 by 25%. The benefits of physical activity for cardiovascular health have been shown in previous studies, but this research focused on younger women.
Researchers at Australian National University have identified over 1,000 RNA-binding proteins in the heart that could lead to a cure for heart disease. These proteins interact with RNA and play a crucial role in regulating genome function.
A European-wide research programme is investigating why great apes are prone to heart disease, with a focus on chimpanzees and gorillas. The Ape Heart Project aims to improve heart screening in zoos and gain insights into the management and welfare of primates in human care.
Biophysicists at FAU discover that plastic cell deformation is caused by microscopic damage to the cytoskeleton. This finding helps characterize diseased cells more accurately, enabling better understanding of cancer, lung diseases, and heart diseases.
A study of 500,000 people found that shared lifestyle and surroundings contribute significantly to a person's risk of disease. Factors such as shared living space and eating habits make a major contribution to diseases like high blood pressure and heart disease.
Children born with heart disease have an increased risk of developing type 2 diabetes after age 30, according to a new study. Those with cyanotic congenital heart disease face the highest risk. The incidence of diabetes by age 45 was significantly higher in CHD subjects compared to the general population.
Researchers found that pre-stroke risk factors, including high blood pressure, diabetes, and smoking, significantly influence future stroke and dementia risk. After one year post-stroke, survivors retain a high risk of recurrent strokes or dementia for at least five years.
Scientists have identified a regulatory system in collagen that regulates enzyme activity, potentially shedding light on disease processes. The study reveals that collagen defects can spontaneously form and heal, with tension eliminating defects in tendons.
A Kaiser Permanente study found national heart disease and stroke mortality rates slowing down since 2011, with some experts attributing the decline to increases in obesity and diabetes, which may be driving a recent slowdown.