Research on the causes and treatment of heart disease. Covers light exposure and heart health, sex differences, heart-in-a-dish models, and cardiac risk.
A survey of older adults with heart conditions found that their sexual health impacts mood and well-being, but most healthcare professionals do not offer this information. Patients favor conversations with healthcare professionals about sexual health, including topics like medication side effects and anxiety before sex.
A preliminary study found that neighborhoods previously subjected to redlining had higher rates of heart disease, Type 2 diabetes, and cardiovascular risk factors due to reduced access to healthy foods. Researchers analyzed data from over 11,000 U.S. Census tracts across 38 states, controlling for population size.
A new study found that obesity-related heart disease deaths increased by 180% in the US over two decades, with significant disparities among middle-aged men, Black adults, and residents of Midwestern states. The analysis also revealed unexpected patterns, such as Vermont having the highest death rate for obesity-related CVD deaths.
A new version of the MESA heart disease risk score that doesn't include race predicts heart disease risk just as well as the original score. The study aims to assess the implications of including race in clinical risk prediction models and broaden their potential use.
Dr. Jeffrey Popma joins CRF as Chief Scientific and Strategic Officer, bringing decades of clinical and research experience to drive forward pivotal programs and initiatives. His leadership will shape CRF's future and fuel innovation at the Clinical Trials Center.
Clinicians should avoid using 'never words' that can scare, offend, or diminish agency in patients and families dealing with serious illness. Researchers recommend alternative language and methods for clinicians to identify their own never words.
Symbiosis has developed an adjustable TMVR system, ValSync, which can adapt to complex anatomies. The company aims to overcome current limitations and improve patient eligibility, safety, and procedure time with its three-step process.
Researchers found using a fan with skin wetting reduces heat-induced cardiac strain in older people in hot and humid conditions. However, in very hot and dry conditions, fan use had an adverse effect, while skin wetting alone was effective in reducing heart work.
A new Australian study found that night shift workers who eat meals or snacks during their shift have significantly worse glucose tolerance compared to those who fast. Insulin sensitivity is also disrupted among all participants, regardless of their eating habits.
A randomized trial found that large-bore mechanical thrombectomy was superior to catheter-directed thrombolysis in reducing clinical deterioration, ICU admissions, and readmissions. LBMT also showed faster symptom improvement and shorter hospital stays compared to CDT.
A research team at SickKids and U of T has developed a robotic system that allows scientists to test numerous potential therapeutics in arrhythmogenic cardiomyopathy, a leading cause of sudden cardiac death among young adults. The technology enables the identification of five potential therapies for the condition.
The CLEAR SYNERGY (OASIS 9) trial found that routine colchicine use did not reduce cardiovascular death, myocardial infarction, stroke, or ischemia-driven revascularization after acute myocardial infarction. Colchicine therapy was associated with a significant reduction in C-reactive protein levels.
The ECLIPSE trial found that routine orbital atherectomy had similar outcomes as conventional balloon angioplasty before stent implantation. Procedural complications were largely similar between groups, with no reduction in target vessel failure.
A new study found that early aortic valve intervention in patients with asymptomatic severe aortic stenosis and myocardial fibrosis did not reduce the incidence of all-cause death or unplanned aortic stenosis hospitalization. However, it did show benefits in reducing emergency hospitalizations and preventing symptom development.
Researchers investigated the molecular mechanism of Fuzi's cardioprotective effects on heart failure. Fuzi water decoction and alkaloids were found to regulate apoptosis, proliferation, and anti-fibrosis in heart failure models, with ABC transporters potentially being a key pathway for their action.
A randomized trial found early TAVR to be safe and effective for patients with asymptomatic severe AS, reducing the risk of composite endpoints and favorable health status outcomes. Patients who received early TAVR had better left-ventricular and left-atrial health compared to those on clinical surveillance.
A new study provides deeper understanding of Myotonic Dystrophy Type 1 (DM1) by revealing an unexpected link between the cardiac condition and SCN5A protein. The research found that reducing fetal SCN5A expression did not correct heart defects, suggesting alternative approaches may be needed to address the condition.
Researchers used ex vivo lentiviral gene therapy to treat MPS IVA in mice, achieving partial correction of bone pathology and complete correction of heart pathology. The study suggests potential for novel therapies to treat patients with MPS IVA.
Researchers developed an algorithm that splits obesity into 5 separate diagnostic profiles with contrasting risk of developing obesity complications. This can help clinicians identify individuals who need early interventions, improving disease prediction and treatment.
A new study finds that prolonged exposure to arsenic in water contributes to the development of ischemic heart disease. Decade-long arsenic exposure up to the time of a cardiovascular disease event was associated with the greatest risk. The study suggests stronger regulations would provide significant benefits to the population.
Gladstone researchers have identified a complex molecular connection between immune cells and fibroblasts that contributes to fibrosis in the heart, which may lead to new treatments for heart disease and other fibrotic conditions.
A new study suggests that immunotherapy may be an effective treatment strategy for heart failure by blocking scar tissue formation and improving heart function. Researchers identified a type of fibroblast cell responsible for scar tissue and used a monoclonal antibody to reduce its formation, showing promising results in mouse models.
The Cardiovascular Research Foundation recognizes 29 leading institutions for their contributions to groundbreaking research advancing interventional cardiovascular medicine. The 2024 SET-10 rankings celebrate institutions making significant impacts across various categories, including basic science and clinical research.
Research suggests standing for long periods does not improve cardiovascular health and may increase circulatory issues. Sitting for over 10 hours a day was found to increase cardiovascular disease risk, highlighting the need for regular movement throughout the day.
Researchers found that certain factors increased the risk of death after sepsis, including advanced age, dementia, heart disease, cancer, and previous hospitalizations. A total of 50.6% of patients with sepsis died within two years, highlighting the need for closer monitoring and follow-up care.
A new study found that HDL particle quality declines over time in women after menopause, increasing risk of episodic memory loss. Women with smaller, more functional HDL particles are less likely to experience cognitive decline.
Researchers at Indiana University are developing next-generation ophthalmoscopes to spot early warning signs of diseases like Alzheimer's, diabetes, and heart disease with a simple eye scan. The technology uses machine learning and AI to reduce diagnosis time from days to minutes.
Biomedical engineer Jeff Saucerman has received a $3.1 million NIH grant to study low-density lipoprotein receptor 1 and its impact on heart failure and treatment outcomes after a heart attack.
A study by UC San Francisco found that more screen time is associated with severe symptoms of depression, anxiety, inattention, and aggression in 9-10 year olds. The effects were small but consistent, with activities like video chatting and playing video games strongly linked to depressive symptoms.
An interdisciplinary study found associations between exposure to environmental phenols like BPA and triclocarban and altered cardiac electrical activity, particularly in women with higher body mass indexes. Researchers identified moderate changes to cardiac electrical activity that could exacerbate existing heart disease or arrhythmias.
Researchers at Karolinska Institutet have identified a new potential risk marker for cardiovascular disease in older women. Low levels of an anti-inflammatory antibody are associated with a higher risk of heart attack and coronary heart disease, independent of other known risk factors.
A modelling study suggests that reducing tobacco smoking globally to 5% by 2050 could increase life expectancy and prevent millions of premature deaths. Accelerating actions to eliminate tobacco smoking could result in up to 1.5 additional years of life expectancy among males and 0.4 years among females.
A recent study found that limiting food consumption within a 10-hour window per day improved key indicators of heart health in adults with metabolic syndrome. The study demonstrated significant reductions in blood sugar and cholesterol levels, as well as lower levels of hemoglobin A1c, a marker of long-term blood sugar management.
A clinical trial found time-restricted eating improved blood sugar regulation and reduced markers of metabolic dysfunction in adults with metabolic syndrome. Participants who followed a customized eight-to-ten-hour eating window saw significant improvements compared to standard treatments.
Research found that babies conceived through assisted reproductive technology have a 36% higher risk of major heart defects compared to naturally conceived babies. The study also showed that multiple births are associated with an even greater risk of congenital heart defects.
The American Heart Association joins a $10 million grant from the Global Cardiovascular Research Funders Forum for international scientific research on cardiovascular health in women. The International Research Challenge aims to address significant gaps in research, diagnosis, and care for women worldwide.
A new individualized risk prediction tool has been developed to predict the severity of heart disease in people suffering from Long QT syndrome. The test analyzes genetic mutations associated with the condition and can identify those at high risk of sudden cardiac death, allowing for tailored treatment.
A remote monitoring program called DIG IT improved blood pressure control and reduced heart disease risk in underserved patients. The study found that patients who used the program had a 31-point average drop in systolic blood pressure and nearly 73% reached their blood pressure goals within three months.
A study from the University of Copenhagen detected lipid biomarkers in obese children that indicate a higher risk of developing type 2 diabetes, liver, and heart disease later in life. A one-year lifestyle intervention lowered these biomarkers, demonstrating the importance of early intervention for children with obesity.
The global stroke burden has increased significantly over the past three decades, driven by rising levels of air pollution, high temperatures, and metabolic risk factors. The study found that the number of people experiencing new strokes rose to 11.9 million in 2021, with an additional 93.8 million survivors and 7.3 million deaths.
Researchers found that adopting an electronic patient management system for direct oral anticoagulants reduced off-label dosing by 8%, while also decreasing the rate of blood clots and strokes. The online dashboard, used at over 120 hospitals, highlights treatment optimization and improves patient safety.
New study finds that extended estrogen suppression using aromatase inhibitors for hormone receptor-positive postmenopausal breast cancer is safe and does not increase the risk of coronary artery calcification. The duration of treatment and presence of osteoporosis were not associated with increased coronary artery calcification scores.
Regular moderate coffee or caffeine intake is associated with a lower risk of new-onset cardiometabolic multimorbidity. The study found that moderate consumption could play an important protective role in almost all phases of CM development.
The new European Society of Cardiology Guidelines recommend regular screenings for Peripheral Arterial Disease (PAD) to prevent complications. The guidelines also emphasize personalized treatment plans, including lifestyle changes, medication, and efficient blockage treatments.
Researchers at WVU are working on a project to inhibit the myeloperoxidase enzyme, which feeds pancreatic cancer growth. By targeting this enzyme, they hope to boost the body's immune system to fight cancer, showing promise in mouse models and potential for future clinical trials.
A new study based on Women's Health Initiative data suggests that certain estrogen-based hormone therapies may have a beneficial impact on cardiovascular biomarkers, except for triglycerides. The study found significant improvements in HDL-C and LDL-C levels, as well as reductions in insulin resistance and lipoprotein(a) levels.
A new study found an association between breast arterial calcifications and cardiovascular disease in women, suggesting mammograms could be a warning sign. Women with breast arterial calcifications were more likely to experience atherosclerotic heart disease, with a 23% increased risk compared to those without.
A $15 million gift from Sally Ross Soter will support the Go Red for Women Venture Fund, investing in health companies targeting cardiovascular, metabolic, and neurologic solutions for women. The fund aims to close the gap in women's health investment and translate research into better patient care.
A Cornell University-led collaboration has developed a machine learning model that uses cell-free molecular RNA dregs to diagnose pediatric inflammatory conditions, including Kawasaki disease and Multisystem Inflammatory Syndrome in Children. The diagnostic tool accurately determines the patient's condition while monitoring organ health.
Researchers developed a tri-culture heart-on-a-chip model of cardiomyocytes, fibroblasts, and endothelial cells to mimic in vivo cardiac behavior. The study successfully replicated endothelial cell morphology and functionality, as well as cardiac function with increased contractility.
Researchers at the University of Illinois Chicago have identified a cellular pathway essential to obesity-induced atrial fibrillation. Blocking NOX2, an enzyme that produces reactive oxygen species, may prevent and reverse changes in heart structure and function caused by high-fat diets.
A recent systematic review and meta-analysis of 28 studies with 1.2 million participants found that wearable technology can accurately detect conditions such as heart rate variability, blood pressure, oxygen levels, sleep quality, skin temperature, hydration, and stress levels. The study suggests that wearable activity trackers could r...
Researchers in human nutrition developed an innovative tool to assign a healthy hydration recommendation score to governments, promoting water and discouraging sugary beverages. The study analyzed 93 countries with dietary guidelines, finding that 48 had complementary messages encouraging water and reducing sugary beverage intake.
Researchers at University of California San Diego have identified a novel mechanism of cardiac inflammation that may prevent heart failure after a heart attack. The borderzone, surrounding the infarcted area, is found to be a key region for this inflammation, with heart muscle cells playing a dominant role in initiating it.
Researchers have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease. The treatment approach may represent a potential long-term universal treatment for MSUD.
The UofL Green Heart Louisville Project found that residents living in neighborhoods with more trees showed lower levels of general inflammation, a risk indicator for heart disease. The study showed a 13-20% reduction in inflammation, corresponding to a nearly 10-15% reduced risk of heart attacks and certain cancers.
Researchers highlight the importance of screening for urinary symptoms in men, linking them to cardiometabolic disorders. The study recommends addressing these conditions to identify and treat underlying heart problems early, potentially reducing morbidity and mortality among men.
Researchers developed a treatment approach using lipid nanoparticles to deliver mRNA therapy for MSUD, extending survival and reducing serum leucine levels. The study also identified a novel AAV variant with desirable biodistribution properties for targeting peripheral organs.
A recent study published in JAMA Psychiatry found that children with persistently raised inflammation are at a higher risk of experiencing serious mental health disorders, including psychosis and depression, in early adulthood. The research also discovered that those who experienced inflammation at a young age were more likely to devel...
Researchers discovered that pythons' hearts grow 25% in the first 24 hours after eating, with specialized genes kicking into action to boost metabolism fortyfold. This process could lead to novel treatments for cardiac fibrosis and other modern-day ailments.