Hepatocellular Carcinoma
Articles tagged with Hepatocellular Carcinoma
Real-world effectiveness and safety of coblopasvir plus sofosbuvir in the treatment of chronic hepatitis C infection in Wenzhou, Eastern China
Efficacy of sequential transarterial chemoembolization after stereotactic body radiation therapy versus radiation therapy alone for recurrent hepatocellular carcinoma
Long-term dynamic virological response patterns and clinical outcomes in hepatitis B virus-related cirrhosis
Tumor vaccines in hepatocellular carcinoma: advances, challenges, and the path toward precision immunotherapy
Recent studies have explored tumor vaccine platforms, including peptide, dendritic cell, and nucleic acid-based vaccines. Personalized neoantigen vaccines are refining precision in HCC treatment, but challenges persist due to immunosuppressive tumor microenvironments and heterogeneity.
Immune checkpoint inhibitor–induced liver injury: a critical appraisal of treatment and rechallenge controversies
Guideline recommendations for immune checkpoint inhibitor-induced liver injury (ICILI) vary, with corticosteroids and biopsy indications differing among organizations. Rechallenge after ICILI is feasible in selected patients, with low recurrence rates, but standardized algorithms are needed.
LINC00862–RBM47 positive feedback loop suppresses hepatocellular carcinoma progression
Researchers from Shandong Second Medical University and Wuhan University identified LINC00862 as a tumor suppressor that forms a triplex-mediated transcriptional activation driving tumor suppression in HCC. The study reveals a bidirectional regulatory loop between LINC00862 and RBM47, which reinforces tumor suppression.
MSU study demonstrates faster discovery of therapeutic drugs through AI
A team of researchers at MSU used machine learning to predict how chemicals will influence gene expression, leading to the discovery of promising compounds for the treatment of liver cancer and a chronic lung disease. The study results from years of interdisciplinary work across multiple disciplines and institutes.
Uncovering a key signaling pathway linking liver cancer and fibrosis
Researchers from Institute of Science Tokyo reveal the SPP1–CD44–Hedgehog signaling pathway as a key driver of fibrosis in liver tumors, hinting at its potential as a therapeutic target. The study provides valuable insights into how liver tumors actively shape their surroundings, driving the onset and progression of fibrosis.
UBE2V1 promotes hepatocellular carcinoma progression by forming a positive feedback loop with HIF-1α
A positive feedback loop between UBE2V1 and HIF-1α drives HCC progression by facilitating tumor growth and metastasis. UBE2V1 promotes HCC progression by competing with HIF-1α for VHL protein binding, leading to sustained HIF-1α stabilization.
Machine-learned biomarker identifies those at high risk for liver cancer
A study by RIKEN researchers identifies a MYCN-driven biomarker that predicts the risk of liver cancer. The biomarker, known as the MYCN niche score, uses machine learning to analyze gene expression patterns and indicates whether a tumor-free liver is at high risk for developing tumors.
Hypoxia-induced m⁶A demethylation drives hepatocellular carcinoma progression by stabilizing Gal-1
Researchers uncover a hypoxia–m⁶A–Gal-1 regulatory axis that fuels HCC progression by stabilizing Galectin-1 (Gal-1) mRNA, promoting malignant phenotypes. Functional experiments confirmed Gal-1's role in enhancing HCC cell proliferation, migration, invasion, and EMT-driven phenotypic plasticity.
Prognostic nutritional index predicts outcomes in hepatocellular carcinoma treated with atezolizumab and bevacizumab
This study investigates the prognostic value of PNI in patients receiving first-line Ate/Bev therapy for unresectable HCC. The high-PNI group showed improved treatment outcomes, including lower adverse events and longer overall survival.
Protein induced by vitamin K absence or antagonist II in primary liver cancer: Basic research insights and clinical applications
PIVKA-II is a valuable tool for early detection, prognostication, and therapeutic response monitoring in HCC. Its integration into multi-parametric models enhances diagnostic accuracy and enables dynamic risk stratification.
Quality and quantity? The clinical significance of myosteatosis in various liver diseases
Myosteatosis is a key predictor of poor clinical outcomes across a spectrum of liver diseases, with associations to severe disease phenotypes, hepatocellular carcinoma, and increased mortality. Nutritional intervention, exercise prescription, and potential management strategies are proposed to address this condition.
A cigarette compound-induced tumor microenvironment promotes sorafenib resistance in hepatocellular carcinoma via the 14-3-3η-modified tumor-associated proteome
Smoking exposure induces tumor microenvironment promoting sorafenib resistance in HCC by modifying the 14-3-3η proteome. Arsenic trioxide suppresses tumor progression with synergistic effect when combined with sorafenib.
Nutrient-stimulated hormone-based therapies: A new frontier in the prevention and management of MASH-associated hepatocellular carcinoma
Nutrient-stimulated hormone-based therapies (NuSHs) show promise in managing MASH and preventing HCC progression. NuSHs improve metabolic parameters, reduce liver fat and fibrosis, and modulate immune-metabolic pathways that drive hepatocarcinogenesis.
LLM treatment advice agrees with physician recommendations in early-stage HCC, but falls short in late stage
Large language models (LLMs) provide treatment recommendations for early-stage hepatocellular carcinoma (HCC) that align with clinical guidelines. However, their performance is limited in late-stage disease, where they prioritize tumor factors over liver function. LLMs should be used as a supplement to clinical expertise.
The latest study highlights global HCC burden: over 680,000 new cases in 2022, with 78.4% attributable to nine modifiable risk factors
A recent study reveals that over 680,000 new cases of hepatocellular carcinoma were estimated worldwide in 2022, with 78.4% attributable to nine modifiable risk factors. The majority of HCC cases are preventable, and the study emphasizes the need for targeted preventive programs.
New study identifies promising three-lncRNA signature for early detection of non-metastatic liver cancer in Egyptian patients
A study has uncovered a promising three-lncRNA signature that could improve early diagnosis and treatment strategies for non-metastatic hepatocellular carcinoma. The lncRNAs HEIH, MIAT, and HOTAIR were found to be significantly elevated in cancerous tissues.
Consensus on the management of liver injury associated with targeted drugs and immune checkpoint inhibitors for hepatocellular carcinoma (version 2024)
The Chinese Society of Hepatology outlines a structured framework for monitoring, diagnosing, preventing, and managing drug-induced liver injury in patients with hepatocellular carcinoma. Key risk factors include underlying liver disease, genetic predisposition, and drug-specific factors.
Lenalidomide promotes melarsoprol-activated cGAS-STING-mediated immunotherapy for hepatocellular carcinoma
Researchers developed a nanoparticle system combining lenalidomide and melarsoprol to activate the cGAS-STING pathway, promoting immunotherapy for HCC. The combination therapy significantly reduced tumor growth and improved survival in mouse models.
Lactate–acetate interaction between tumor-associated macrophages and cancer cells drives hepatocellular carcinoma metastasis
Researchers found that tumor-associated macrophages produce acetate through a metabolic interaction involving lactate and the lipid peroxidation–ALDH2 pathway. This acetate promotes histone H3 acetylation and epithelial-mesenchymal transition in hepatocellular carcinoma cells, enhancing metastasis.
O-GlcNAc transferase promotes metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma by facilitating the degradation of PTEN
Researchers found OGT expression is higher in MASLD-HCC tissues, promoting tumor growth. OGT modifies PTEN, impairing its function and activating the PI3K/Akt pathway.
Molecular markers and risk models guide precision care in liver cancer surgery
A study of over 3,000 patients identified molecular hallmarks driving hyper-progression recurrence in liver cancer, enabling tailored surgical decisions and targeted therapies. Predictive models and nomograms stratify patients before and after surgery, guiding more effective strategies.
Targeting glypican-3 for liver cancer therapy
Glypican-3 is a key driver of hepatocellular carcinoma progression, facilitating metastasis and tumor microenvironment remodeling. Immunotherapy targeting GPC3 has shown preliminary safety and antitumor activity in clinical trials, with ongoing research focusing on optimized patient selection and disease monitoring.
Hepatocellular carcinoma risk stratification for cirrhosis patients: Integrating radiomics and deep learning computed tomography signatures of the liver and spleen into a clinical model
A new clinical model integrating CT signatures predicts HCC risk more accurately than existing models, stratifying patients into high-risk and low-risk groups. The study enhances individualized surveillance and improves patient outcomes for cirrhosis patients.
Serum-derived hsa_circ_101555 as a diagnostic biomarker in non-hepatocellular carcinoma chronic liver disease
hsa_circ_101555 demonstrated high diagnostic accuracy in differentiating non-HCC CLD patients from healthy controls. Serum levels correlated with advanced liver disease scores and inflammation markers.
PANoptosis: A new allyin the fight against liver cancer
PANoptosis, a hybrid form of cell death, is being explored as a strategy to tackle liver cancer. By integrating apoptosis, pyroptosis, and necroptosis pathways, PANoptosis triggers both direct tumor killing and immune reprogramming.
Blood microbial DNA distinguishes liver cancer from metastatic lesions
A blood test using microbial DNA analysis can distinguish primary liver cancer from colorectal cancer that has spread to the liver, according to a new study. The test reveals distinct bacterial 'fingerprints' for each cancer type, making it a powerful tool for non-invasive diagnosis and potential future therapy guidance.
ATOX1 promotes hepatocellular carcinoma carcinogenesis via activation of the c-Myb/PI3K/AKT signaling pathway
This study found that ATOX1 promotes hepatocellular carcinoma (HCC) growth by activating the c-Myb/PI3K/AKT signaling pathway. ATOX1 also reduces copper accumulation and increases reactive oxygen species (ROS) production, leading to apoptosis in HCC cells.
Cumulative hepatitis B surface antigen/hepatitis B virus DNA ratio in immune-tolerant hepatitis B patients
A study found that in immune-tolerant HBV patients, a cumulative HBsAg/HBV DNA ratio below 1.791 is associated with a lower risk of disease progression, while those above this threshold face increased risk. Early antiviral treatment may improve clinical outcomes for these patients.
Reducing the global burden of liver cancer: Recommendations from The Lancet commission
The Lancet commission emphasizes the need for concrete goals to reduce hepatocellular carcinoma's growing disease burden. The authors propose a 2% annual reduction in age-standardized incidence rates and recommend evidence-based strategies to tackle viral hepatitis, alcohol consumption, environmental risk factors, and disparities in he...
Damon Runyon Cancer Research Foundation awards $4.2 million to clinical cancer researchers
The Damon Runyon Cancer Research Foundation has awarded $4.2 million to five new Clinical Investigators conducting patient-oriented cancer research. The awards will support the development of new treatments for cancer patients, with a focus on enhancing efficacy and safety.
UCLA study identifies key protein that helps liver cancer resist heat-based treatment
Researchers found Galectin-1, a sugar-binding protein, plays a critical role in helping hepatocellular carcinoma cells resist thermal ablation and thrive after being treated with high heat. Blocking Gal-1 can make thermal ablation more effective and reduce the risk of recurrence.
Longitudinal study sets new survival benchmark for patients with advanced biliary tract cancer
A new study published in the Journal of Hepatology shows that durvalumab plus GemCis significantly improves overall survival for patients with advanced biliary tract cancer. The three-year follow-up analysis found that over twice as many participants treated with durvalumab plus GemCis remained alive compared to those treated with a pl...
Researchers discover new genetic target that could shape the future of liver cancer treatment
Researchers have discovered that TAF2 plays a pivotal role in the growth of liver cancer and can help promote tumor formation. The study's findings suggest that targeting TAF2 could lead to more effective treatments for liver cancer.
Epigenetic drivers of liver cancer: unraveling mechanisms behind hepatocellular carcinoma
Research highlights the critical role of epigenetic changes in hepatocellular carcinoma development, including DNA methylation and histone modifications. Noncoding RNAs also play a key role in HCC pathogenesis and may serve as biomarkers for diagnosis and prognosis.
Liver cancer survival rates reflect income disparities
A study published in The Lancet Regional Health – Europe found that patients with low household income were more likely to be diagnosed late and receive less effective treatment for liver cancer. This highlights the need for targeted screening in deprived areas to improve early diagnosis and survival rates.
Unlocking a new era in liver cancer treatment: The power of neddylation-targeted therapies
Recent research has focused on neddylation modification as a key driver of tumor cell proliferation, migration, and survival. Neddylation inhibitors have demonstrated significant efficacy in disrupting cancer cell growth by selectively inhibiting the neddylation pathway.
The potential oncogenic role of serum-derived hsa_circ_101555 as a non-invasive diagnostic/prognostic marker in patients with hepatocellular carcinoma
The study found that serum-derived hsa_circ_101555 showed excellent diagnostic accuracy in differentiating HCC patients from healthy controls. It also demonstrated a prognostic role in predicting tumor progression and response to therapy, with significant correlations with markers of liver inflammation and tumor features.
Hepatocellular carcinoma and the role of liver transplantation
Hepatocellular carcinoma is the most prevalent form of liver cancer, and liver transplantation offers a curative treatment option for appropriately selected patients. Bridging therapies, such as radiofrequency ablation and transarterial chemoembolization, can improve survival outcomes post-transplant by preventing tumor progression.
Uncovering the molecular drivers of liver cancer
A study published in Journal of Proteome Research reveals that inflammation and aging contribute to the development of non-viral liver cancer. Researchers analyzed gene expression and metabolites in normal and affected samples, identifying potential therapeutic targets for chemoprevention.
GTF3C2 promotes the proliferation of hepatocellular carcinoma cells through the USP21/MEK2/ERK1/2 pathway
GTF3C2 expression is upregulated in HCC tissues, promoting tumor growth and poor survival outcomes. The GTF3C2/USP21/MEK2/ERK1/2 pathway regulates HCC cell proliferation and tumor growth.
Hope for a complete cure for hepatocellular carcinoma: Combining lenvatinib and pembrolizumab with transarterial chemoembolization improves efficacy in treating hepatocellular carcinoma
A phase 3 study found that combining lenvatinib and pembrolizumab with transarterial chemoembolization significantly extended progression-free survival and showed a trend toward extending overall survival in patients with unresectable non-metastatic hepatocellular carcinoma. The treatment may lead to a complete cure.
Beyond the cure: Navigating hepatocellular risk and surveillance after hepatitis C eradication in the direct-acting antiviral era
Direct-acting antivirals have reduced HCV-related morbidity and mortality, but hepatocellular carcinoma (HCC) risk persists in certain populations. Risk factors include pre-treatment cirrhosis, metabolic disorders, and advanced fibrosis, highlighting the need for tailored surveillance strategies.
Immune subtyping and NK cell targeting: A new frontier for immune checkpoint inhibitor treatment in hepatocellular carcinoma
Researchers identified two immune subtypes of HCC patients with varying overall survival rates and immunity levels. Subtype 1-associated NK cells showed improved response to docetaxel and thalidomide, suggesting new hope for ICI treatment in HCC.
Statin use and risk of hepatocellular carcinoma and liver fibrosis in chronic liver disease
A recent cohort study published in JAMA Internal Medicine found that statin use was associated with a reduced risk of hepatocellular carcinoma and hepatic decompensation in patients with chronic liver disease. This suggests that statins may play a role in preventing the progression of liver disease and reducing the risk of liver cancer.
Chinese researchers develop system for predicting hepatocellular carcinoma recurrence
A research team developed a new system that uses spatial immune profiling to predict hepatocellular carcinoma (HCC) recurrence. The system, called TIMES, was trained on a dataset of 61 HCC patients and achieved an accuracy of 82.2% in predicting recurrence risk.
Fluorescence-guided surgery for hepatocellular carcinoma: From clinical practice to laboratories
Recent developments in fluorescent probes offer improved specificity and sensitivity for detecting hepatocellular carcinoma (HCC). Next-generation probes are being developed to enhance tissue penetration depth and probe specificity, potentially improving surgical outcomes.
Clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine
Research identifies six clusters of metabolic dysfunction-associated steatotic liver disease (MASLD) with varying pathophysiology and clinical outcomes. These clusters may enable personalized risk prognosis and treatment through lifestyle modification programs and targeted therapies.
Synthetic RIG-I-agonist RNA induces death of hepatocellular carcinoma cells
A synthetic retinoic acid-inducible gene I (RIG-I) agonist RNA has been shown to induce innate immune signaling and death of hepatocellular carcinoma cells in vitro. The addition of recombinant interferon-b potentiated this cell death, suggesting a potential new mechanism for treating patients with liver cancer.
Unraveling the role of the Wnt pathway in hepatocellular carcinoma: From molecular mechanisms to therapeutic implications
The Wnt signaling pathway is essential for HCC development, promoting cell proliferation, migration, and immune evasion. Targeting this pathway holds significant promise for therapeutic strategies, including small molecule inhibitors, monoclonal antibodies, and gene therapies.
Antineoplastic effects of icaritin: molecular mechanisms and applications
This article examines the molecular mechanisms underlying icaritin's anti-cancer properties and discusses recent progress in its application. Icaritin, a prenylflavonoid natural product, shows diverse pharmacological effects, including anti-inflammatory, immune-regulatory, and anti-oxidation properties.
Candidate genes in canine hepatocellular carcinoma for molecular targeted therapy
Researchers at Osaka Metropolitan University assessed target genes in canine hepatocellular carcinoma (HCC) to develop molecular targeted therapies. The study identified potential gene targets, including PDGFB, which may improve treatment options for unresectable HCC.
Scientists develop novel adjuvant delivery system to enhance cancer vaccine effectiveness
Researchers at Terasaki Institute develop lipopeptide hydrogels to deliver peptide-based cancer vaccines, demonstrating sustained release and enhanced immune cell uptake. The system shows promise in overcoming limitations of traditional peptide-based vaccines.
Chinese Medical Journal review highlights senescence’s dual role in liver disease and emerging therapies
Researchers reveal senescence's impact on liver health, from repair and regeneration to chronic disease progression. Emerging therapies, such as senolytic treatments, aim to selectively eliminate senescent cells while preserving healthy tissue.
Dose-dependent relationship between alcohol consumption and the risks of hepatitis b virus-associated cirrhosis and hepatocellular carcinoma: A meta-analysis and systematic review
A meta-analysis found a dose-dependent relationship between alcohol consumption and the risks of cirrhosis and HCC in HBV patients, with daily alcohol consumption exceeding 12g increasing risk by 6.2% and 11.5% respectively.
NRG Oncology study suggests the addition of SBRT to systemic therapy improves outcomes for select patients with locally advanced hepatocellular carcinoma
A Phase III clinical trial found that stereotactic body radiotherapy (SBRT) added to sorafenib improved progression-free survival and overall survival in patients with locally advanced hepatocellular carcinoma, particularly those with macrovascular invasion. The study also showed improvements in quality of life for these patients.
Research Spotlight: Improving liver cancer outcomes through enhanced immunotherapy
Researchers have made significant breakthroughs in treating liver cancer, with a new study revealing the potential of anti-CXCR4 therapy to reprogram the 'cold' microenvironment. The combination of anti-CXCR4 and PD1 blockades enhances intratumoral dendritic cell activation and immune responses against hepatocellular carcinoma.