Researchers developed new methods for detecting drug-induced hepatotoxicity using 3D cell cultures and mass spectrometry imaging, identifying biomarkers and effective interventions. A zeolite-based protein corona method was also used to characterize plasma proteins, enabling the identification of low-abundance proteins and their potent...
A study published in Cancer Research identifies a novel mechanism by which liver cancer develops, involving the aberrant activation of the Wnt signaling pathway and the gene GREB1. The research reveals that GREB1 is responsible for integrating conflicting cellular states of differentiation and proliferation, leading to tumor promotion.
Researchers identified three immune cell types within tumor niches that determine which patients respond positively to checkpoint blockade immunotherapy. The study may inform new approaches to cancer treatment.
A new study found that obesity is associated with an increased risk of certain cancers, with stronger links in female patients for gallbladder and endometrial cancer. The study also revealed differential effects between sexes on colorectal, esophageal, and liver cancer.
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A new study from the USC Norris Comprehensive Cancer Center found that immigrant adults with liver cancer have a significantly higher five-year survival rate compared to those born in the US. The study identified disparities in survival rates across different racial and ethnic groups, with immigrants demonstrating better outcomes.
Researchers identified high expression of glypican-1 in primary solid tumors, correlating with poor prognosis in various cancer types. Suppression of GPC1 attenuated cancer cell proliferation, suggesting its potential as a novel diagnostic tool and target for therapy.
Researchers at City University of Hong Kong identified lysyl hydroxylase 1 (LH1) as a key factor in promoting confined migration of liver and pancreatic cancer cells. The study found that LH1 promotes metastasis by stabilizing Septin2, which enhances the actin network.
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Researchers found a molecular staple called NIHCOLE that helps liver cancer cells repair broken DNA, making them resistant to radiotherapy. Understanding this mechanism may lead to the development of new strategies to combat liver cancers with poor prognosis.
Researchers successfully applied AlphaFold AI to an end-to-end platform, discovering a novel target and developing a potent hit molecule for liver cancer. The study demonstrates the potential of AI-powered drug discovery to accelerate treatment development.
Researchers from prominent institutions discuss hepatocellular carcinoma's pathogenesis, genomic heterogeneity, and targeted therapy options. The review aims to characterize HCC's complexities and develop clinically relevant biomarkers for better management.
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Researchers at USC Keck School of Medicine found that liver cancer cells hijack circadian clock proteins to replicate and spread. Inhibiting these proteins can prevent cancer cell multiplication and potentially improve outcomes for patients with liver cancer.
Researchers found that plasma GH levels are a potential biomarker for predicting treatment outcomes in patients with advanced HCC treated with Atezo/Bev. The study showed significantly superior overall survival and non-significant trend in favor of GH-low patients compared to GH-high patients.
Researchers at HKUMed identify Δ42PD-1 as a key player in suppressing killer T cells and promoting tumor growth in HCC. Targeting this protein with an antibody can inhibit tumor growth and increase functional killer T cells, offering new hope for immunotherapy against HCC
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Researchers found that dietary saturated/trans fats, but not cholesterol, can trigger hepatic angiogenesis and lymphangiogenesis in mice, leading to the promotion of hepatic tumors. This process is driven by the JNK-HIF1α-VEGF-C axis.
Researchers found that P2-HNF4α expression is associated with p-STAT3 and c-Myc expression in NAFLD patients, suggesting potential biomarkers for hepatocellular carcinoma (HCC) risk. Additionally, p-STAT3 expression was linked to hypertension, while c-Myc expression was associated with advanced fibrosis.
Researchers discovered three essential amino acids - leucine, valine, and tryptophan - as potential metabolic biomarkers for HCC. The study used metabolomics to analyze the differences in tumor and non-tumor tissue metabolomes, revealing striking differences that could aid in diagnosis.
A new study published in JAMA Surgery compares robotic liver resection with open liver resection for treating hepatocellular carcinoma. Robotic liver resection is found to be a safe treatment option for patients with compromised liver function, achieving comparable oncologic efficacy to traditional open surgery.
A new AI-powered blood test, DELFI, has been developed to detect liver cancer with high accuracy. The test detected over 80% of liver cancers in a study of 724 individuals, with an overall sensitivity of 88% and specificity of 98%.
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Researchers evaluated modified CEUS using perfluorobutane for diagnosing hepatocellular carcinoma in high-risk patients. The study found no significant difference in sensitivity, specificity, or accuracy between modified CEUS and CT/MRI LI-RADS v2018.
Researchers at VCU Massey Cancer Center have found strong evidence for testing a novel drug in liver cancer treatment. MDA-9 inhibition may be an effective approach for hepatocellular carcinoma (HCC), with potential synergies with other therapeutics.
A randomized phase III trial shows that adding radiation therapy to systemic therapy can delay tumor progression and lengthen survival without compromising quality of life. The combination of SBRT and sorafenib appears more effective than the drug on its own.
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Adding stereotactic body radiation therapy (SBRT) to sorafenib significantly improves overall survival, progression-free survival, and time to tumor progression in patients with advanced hepatocellular carcinoma. SBRT was shown to be effective without increasing toxicity.
Researchers have discovered that reduced TGFBR2 abundance is significantly associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. An AI-based process accurately identified HCC tissue, confirming the biomarker's potential for early detection.
A proof-of-concept study developed three machine learning models to predict posttreatment recurrence in early-stage hepatocellular carcinoma patients. The models achieved high accuracy using imaging data alone, while combining clinical data did not significantly improve performance.
Researchers from Keck School of Medicine found a strong association between PFOS exposure and liver cancer risk, with the strongest link seen in the top 10% of PFOS exposure. The study suggests that PFOS may disrupt normal liver function, leading to non-alcoholic fatty liver disease and increased risk of liver cancer.
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Researchers developed a new technology that can detect early-stage hepatocellular carcinoma using nanoparticles, which are released by tumor cells and can be detected in circulation. The technology, called HCC EV SPA, has the potential to enable rapid and affordable detection of the disease, leading to improved survival rates.
Researchers discovered that liver cancer cells modify their metabolism to leave them susceptible to disruptions in arginine supply, a key molecule. A three-pronged approach targeting tumor metabolism, blocking survival-promoting responses, and starving tumors of arginine can induce senescence, making cancer cells killable.
A new study published in the Journal of the American College of Surgeons suggests that liver transplantation is a viable option for older patients with liver cancer, offering a significant survival benefit. The research compares outcomes between patients over 70 who received liver transplants and those who underwent ablative treatments...
Researchers at Cedars-Sinai Cancer have identified a novel immune checkpoint pathway that could lead to better understanding and treatment of hepatocellular carcinoma. The study suggests that blocking this pathway, combined with immunotherapy, may provide a new therapeutic strategy for liver cancer.
A new review analyzes the efficacy of current non-invasive methods for assessing non-alcoholic fatty liver disease (NAFLD) and associated conditions. Blood-based biomarker tests and imaging methods are explored, with some showing promise in early diagnosis and staging liver disorders.
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Researchers identified two novel biomarkers that predict response to immunotherapy and adverse events in liver cancer patients. The study's findings enable more effective and individualized treatment of primary liver cancer hepatocellular carcinoma (HCC) patients, with fewer side effects.
A new tsRNA, tRF-Gln-TTG-006, has been identified in the serum of liver cancer patients as a promising biomarker for early diagnosis and prognosis. This discovery provides valuable information on the relationship between tsRNAs and liver cancer development.
Researchers found that sequencing drug combinations can enhance the anti-tumor immune response in liver cancer, potentially reducing toxic drug exposure. The new strategy primes the tumor with an immune checkpoint inhibitor before using a multikinase inhibitor, enhancing its effectiveness.
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The American Gastroenterological Association (AGA) has issued new clinical practice guidelines on systemic therapy for HCC, emphasizing the importance of consulting a multidisciplinary team of healthcare professionals. The guidelines provide specific patient scenarios and treatment options to help hepatologists make informed decisions.
Codiak BioSciences' exoASO-STAT6 demonstrates potent anti-tumor efficacy by reprogramming tumor-associated macrophages to an M1 phenotype, showing promise as a monotherapy candidate for hepatocellular carcinomas and other cancers. The company plans to initiate Phase 1 clinical trials in the first half of 2022.
A team of researchers has reprogrammed the tumor microenvironment of liver cancer by using mRNA nanoparticles, restoring the function of the p53 master regulator gene. The approach increased antitumor immune responses in hepatocellular carcinoma laboratory models and shows promise for treating HCC and other cancers.
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A new Chinese Medical Journal study explores the risks of non-alcoholic steatohepatitis (NASH) turning into liver cancer. Early detection through simple medication and lifestyle changes can prevent NAFLD from progressing to more severe conditions, such as cirrhosis and hepatocellular carcinoma.
The American Society for Radiation Oncology (ASTRO) has released a new clinical guideline outlining the use of external beam radiation therapy (EBRT) to treat adult patients with primary liver cancers. The guidelines emphasize multidisciplinary care and provide evidence-based recommendations on indications, dosing, techniques, and trea...
Researchers have described a dynamic genomic landscape of tumour heterogeneity in hepatocellular carcinoma, highlighting the need for novel strategies targeting heterogeneous tumors. The study, published in National Science Review, used multi-omic data to reveal variations in genetic and transcriptomic profiles across patients.
Researchers have developed a CRISPR/Cas9 gene editing system to enhance the effectiveness of sonodynamic therapy, allowing tumors to be effectively shrunk in a mouse model of liver cancer. The technology reduces antioxidant defense systems, increasing cancer cell death from the treatment.
New study suggests inhibiting Shp2 in tumor cells may boost tumor growth and survival, complicating its use as a potential cancer therapy for HCC.
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A Singapore clinical trial has introduced a new way to treat advanced hepatocellular carcinoma by combining nivolumab, an immunotherapy drug, with yttrium-90 resin microspheres radioembolisation. The study shows promising results in treating intermediate and advanced HCC, with an overall response rate of 30.6%.
A new analysis of US national data finds that external-beam radiation therapy is a proven treatment option for patients with unresectable liver cancer but is rarely prescribed, with only 3.6% of patients receiving it. The study suggests that institutional and regional practice patterns play a key role in driving treatment decisions.
A study published in The Journal of Nuclear Medicine found that PSMA PET/CT is more accurate than conventional CT in detecting hepatocellular carcinoma metastases. This led to a change in management plans for nearly half of the patients, enabling them to receive effective treatment.
A collaborative research between Owkin and Cleveland Clinic has developed an AI model that predicts liver cancer recurrence following liver transplantation. The model outperformed traditional scoring systems and showed promise for improving patient outcomes.
A recent study published in AJR found that gallbladder polyps can fluctuate significantly in size and number over time. The authors suggest revising guidelines to reflect this variability, with no cases of gallbladder carcinoma identified in patients who underwent cholecystectomy.
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The most common form of liver cancer is on the rise in rural areas, with men aged 60-69 and non-Hispanic Blacks disproportionately affected. Urban areas, however, have seen a decline in HCC rates since 2013, including among younger individuals and certain ethnic groups.
Research from Osaka City University reveals that hepatocellular carcinoma survival decreases as poorly differentiated tumor size increases. Tumors over 5cm have a significantly higher risk of early recurrence and spreading to other parts of the body.
Researchers identified a hub candidate network involving RNA binding protein interacting with circular RNA in hepatocellular carcinoma. The study provides insights into the mechanism of HCC and potential biomarker identification.
Researchers found that miR-513b-5p attenuates autophagy and tumor growth in liver cancer cells by targeting PIK3R3. The study suggests miR-513b-5p as a promising therapeutic target for hepatocellular carcinoma.
Researchers have shown that targeted radio-wave therapy is safe and effective in treating hepatocellular carcinoma (HCC), the most common type of liver cancer. The therapy improved overall survival by more than 30% in patients with well-preserved liver function, as well as those with more severe disease.
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Researchers have identified distinct metabolic phenotypes in hepatocellular carcinoma subtypes, providing insights into precise personalized treatment options. The study revealed a poor prognosis subtype strongly correlated with immune pathway up-regulation and unsaturated fatty acid accumulation.
The study investigated the association of the IGF/CTP score with overall survival and progression-free survival in CTP class A patients with advanced HCC treated with sorafenib. In these patients, IGF/CTP score B was associated with shorter PFS and OS, indicating a more accurate predictive tool for treatment outcomes.
A recent genetic study published in PLOS Genetics has identified MAGEA3, a gene associated with poor prognosis in liver cancer, as a potential target for new treatments. The study found that blocking the expression of MAGEA3 in liver cancer cells can prevent their growth and death, offering hope for developing new therapies.
Research reveals liver cancer incidence is 2.6 times higher in Indigenous Australians compared to non-Indigenous patients. Mobile liver clinics and regular ultrasound surveillance can help prevent the disease, according to expert calls for action.
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This study investigated the effect of culturing hepatocellular cancer cells in more native conditions, revealing slower doubling times, increased glycolytic enzymes, and mutations in mitochondrial DNA. The results showed increased resistance and sensitivity for cells cultured in native conditions, highlighting new insights into tumor b...
The study found that hepatocellular carcinoma develops on a background of chronic inflammation and fibrosis, with tumor-associated macrophages playing a key role. The researchers characterized the inflammatory microenvironment in two HCC mouse models, revealing divergent phenotypes of liver macrophage subsets and their contribution to ...
Researchers discovered that a Western diet high in fat and cholesterol can lead to obesity, diabetes, and Non-alcoholic steatohepatitis (NASH), which progresses to liver cancer, kidney disease, and cardiovascular disease. Switching to a normal chow diet improves NASH and liver fibrosis, prevents cancer progression and mortality.
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A study published in Oncotarget found a distinct global DNA hypermethylation pattern and gene expression signature in liver cancer among patients with Indigenous American ancestry. This molecular subtype of HCC preferentially affects people with Indigenous ancestry, highlighting the importance of considering anthropological background ...
A Mount Sinai study found immunotherapy to be significantly less effective in liver cancer patients with non-alcoholic steatohepatitis (NASH), while also fueling tumor growth. The research highlights the need for refined therapeutic strategies to treat both tumors and underlying liver disease.