New Jersey researchers receive national award
In 1975, medicinal chemists Miguel A. Ondetti and David W. Cushman designed captopril, the first of an innovative class of drugs controlling high blood pressure and heart disease.
Hypertension
Articles tagged with Hypertension
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UT Southwestern researchers move closer to explaining cyclosporine-induced hypertension
UT Southwestern researchers identified a specific protein in sensory nerves that contribute to cyclosporine-induced hypertension. The study found that mice lacking this protein experienced no increase in blood pressure when administered cyclosporine.
New research shows snoring can be a warning sign for high blood pressure
A five-year study found that people who snore are one and a half times more likely to have high blood pressure, with risk increasing with severity of sleep problem. The study suggests that physicians should consider hypertension when SDB is present.
NIH study to examine causes of hypertension
Researchers aim to identify a faulty switch in the brain controlling pain, which may also contribute to high blood pressure. The study could provide doctors with an additional tool to prevent hypertension and potentially lead to a new drug treatment.
Exercise and weight loss effective in reducing high blood pressure for overweight individuals
A study published in Archives of Internal Medicine found that a combination of exercise and weight loss significantly reduces high blood pressure in overweight individuals. The researchers, led by James A. Blumenthal, Ph.D., randomly assigned 133 sedentary men and women to either aerobic exercise alone or a behavioral weight management...
Yale scientists identify genetic form of hypertension in pregnant women
Researchers discovered a mutation in the mineralocorticoid receptor gene linked to severe hypertension in pregnant women. The findings suggest that progesterone may exacerbate hypertension in pregnancy and could lead to clinical trials of salt restriction.
Mutation causes dangerously high blood pressure during pregnancy
Researchers discovered a mutation in the mineralocorticoid receptor gene, leading to dangerously high blood pressure in pregnant women. The mutation renders the receptor more sensitive to progesterone, causing excessive salt retention and skyrocketing blood pressure.
Penn study finds no adverse cardiovascular effects from Viagra in men with existing heart disesae
Researchers from Penn University School of Medicine investigated the safety of Viagra in men with severe coronary artery disease. The study revealed no direct adverse cardiovascular effects from Viagra use, but a small beneficial effect on coronary blood flow reserve was observed.
Treating hypertension in the patient with type 2 diabetes: Statement by Claude Lenfant, M.D., Director, National Heart, Lung, and Blood Institute
The National Heart, Lung, and Blood Institute recommends a more aggressive approach to treating high blood pressure in patients with type 2 diabetes. This is based on studies showing significant reductions in diabetes-related strokes, small blood vessel damage, and deaths when blood pressure is brought under control.
NHLBI study shows large blood pressure benefit from reduced dietary sodium
A recent study by the NHLBI found that reducing dietary sodium can significantly lower blood pressure in people with and without hypertension. The study, which involved 412 participants, showed that the lowest sodium intake produced the greatest blood pressure reduction, regardless of diet type.
Sleep apnea likely to lead to hypertension
Researchers found that even mild to moderate sleep apnea significantly increases the risk of hypertension, with graver levels associated with higher likelihood. The study used data from the Wisconsin Sleep Cohort Study and found a substantial risk of hypertension in those with mild to moderate sleep apnea.
New research shows important differences in the response to antihypertensive treatment depending on age and sex
New research from the HOT Study reveals significant differences in the response to antihypertensive treatment between age and sex groups. Women with hypertension achieve target blood pressures more easily than men, while older patients exhibit improved blood pressure control and lower risk of adverse events.
Systolic -- not diastolic -- blood-pressure reading should define hypertension, new NIH clinical advisory states
A new NIH clinical advisory statement recommends using systolic blood pressure as the primary criterion for diagnosing and treating hypertension in middle-aged and older Americans. This shift aims to improve outcomes by targeting systolic pressure, which is associated with a higher risk of heart disease.
NHLBI issues new clinical advisory on systolic blood pressure
The NHLBI has released a clinical advisory emphasizing the importance of systolic blood pressure in diagnosing and treating hypertension in middle-aged and older adults. The guideline recommends reducing systolic blood pressure to less than 140 mm Hg to reduce heart attack, heart failure, and stroke risk.
High blood pressure, cholesterol and weight increase dementia risk
A new study finds that men with high blood pressure, weight and cholesterol levels in their 50s are more likely to develop vascular dementia in their late 70s. The research suggests that reducing these risk factors may help delay the onset of dementia, but more large-scale studies are needed to confirm the findings.
Scientists pump genome for hypertension genes
Researchers have located 67 gene regions in hypertensive rats that are also linked to high blood pressure in humans. This study uses a genome-wide approach to pinpoint the exact genes involved in human hypertension, accelerating the search for potential treatments.
Lower blood pressure during pregnancy
A study by a University of Michigan School of Nursing professor found that moderate exercise can lower diastolic blood pressure in pregnant women, reducing the risk of developing gestational hypertension. The randomized trial involved 16 high-risk women who engaged in treadmill or bicycle exercise three days a week for 10 weeks.
NHLBI study shows relationship between sleep apnea and hypertension
A large-scale NHLBI study found a significant relationship between sleep apnea and hypertension, with middle-aged adults at highest risk. The study revealed that even moderate levels of sleep apnea can increase the risk of hypertension in all participants, regardless of age or weight.
Hypertension drug effective at preventing atherosclerosis
Researchers found that Losartan reduced fatty streak development in monkeys fed a high-fat diet by 50%, suggesting the drug's potential in preventing atherosclerosis. The study suggests treating hypertension and cholesterol together may improve heart attack prevention statistics.
High blood pressure, medications increase diabetes risk
A study led by Johns Hopkins found that patients with high blood pressure taking beta blockers were 28% more likely to develop diabetes than those not taking the medication. In contrast, thiazide diuretics were associated with a lower risk of diabetes.
Depression and anxiety linked to hypertension
A two-decade study found that depression and anxiety are associated with an increased risk of developing hypertension. The risk was highest among black women, who faced a substantially higher risk compared to white women and men. Controlling for other risk factors did not change the result.
Blood pressure during sleep may be important too
A Mayo Clinic study found that blood pressure levels differ equally between day and night, potentially increasing the risk of heart disease and stroke. The researchers monitored 240 healthy people for 20 consecutive hours, revealing significant variations in blood pressure during sleep.
Study stopped early: high blood pressure drug less effective than diuretic
A large clinical trial, ALLHAT, has stopped part of its study due to Cardura being less effective at lowering blood pressure and preventing heart failure. The study compared Cardura with a diuretic, finding those taking Cardura had more serious hypertension complications
NHLBI stops part of study -- high blood pressure drug performs no better than standard treatment
The NHLBI halted a study on high blood pressure treatments after an independent review found that an alpha-adrenergic blocker, doxazosin, was less effective than the diuretic chlorthalidone in reducing cardiovascular disease. The study compared newer drug treatments with conventional and less costly treatment options.
Patients' beliefs and behaviors about health lifestyle and medications may help tailor high blood pressure management method
Researchers found four distinct groups with varying adherence rates, medication use, and lifestyle habits. Group A and B members have better health outcomes due to effective medication and lifestyle regimens.
Link between hopelessness and hypertension
A study of 616 middle-aged men from Finland found that those experiencing high levels of hopelessness were three times more likely to develop hypertension. The link between hopelessness and cardiovascular disease is considered a critical factor in increased risk, independent of other known risk factors.
UI study looks at cellular mechanism involved in hypertension
A University of Iowa researcher has found that ion channels in the kidney play a critical role in regulating blood pressure and that a hormone called vasopressin stimulates these channels to increase sodium absorption, leading to hypertension. The study provides new insights into Liddle's syndrome, a rare genetic form of hypertension.
Estrogen shows promise in warding off heart disease in young rats
Researchers found that supplemental estrogen prevented hypertension in 3-month-old female rats with healthy hearts, but not in 17-month-old rats who already had hypertension. The study suggests that estrogen supplementation may be beneficial for women nearing or going through perimenopause, where estrogen levels decline.
Vitamin C can reduce high blood pressure, study finds
A 500mg daily vitamin C supplement reduced systolic, diastolic, and mean blood pressures by approximately 9% in hypertensive patients. Vitamin C's antioxidant properties may help protect nitric oxide levels and maintain healthy blood pressure.
High blood pressure increases risk of cognitive decline in elderly
A study published in Neurology found that high blood pressure is associated with a higher risk of severe cognitive decline, particularly in those with untreated or uncontrolled hypertension. The study suggests that controlling high blood pressure may help prevent or delay dementia.
Personal approach reduces high blood pressure in black men
A two-year study of 309 hypertensive urban African American men found that personalized care improved blood pressure control rates by an average of 39%. The team intervention showed a slightly higher improvement rate compared to the standard education and referral group.
Hypertension and atherosclerosis may have a common cause, researchers say
Researchers found that the anti-hypertensive drug Losartan inhibited atherosclerosis development in monkeys by 50% compared to untreated controls. This suggests treating hypertension with Angiotensin II-blockers may slow or prevent atherosclerosis progression.
Emotional support during conflict situations elevates blood pressure in African-American boys
African-American adolescent boys who received emotional support during conflict situations had higher blood pressure reactivity than those with problem-solving or no support. Emotional support may be perceived as negative by these adolescents, leading to increased cardiovascular reactivity.
Pet dog or cat controls blood pressure better than ACE inhibitor, UB study of stockbrokers finds
A University at Buffalo study found that pet dog or cat owners experienced significantly reduced cardiovascular measures during stressful situations compared to non-pet owners. The study showed that having a pet helped to stabilize heart rate and blood pressure in response to mental stress.
Decreased pain perception may help to identify hypertension risk
Research suggests that decreased perception of pain, or hypoalgesia, may precede the onset of hypertension in individuals at high risk. The study found that men and women with hypertension are more likely to suffer an unrecognized myocardial infarction due to suppressed chest pain during episodes of myocardial ischemia.
Researchers find elevated cholesterol is risk factor for preeclampsia
Elevated cholesterol levels are associated with an increased risk of preeclampsia, a pregnancy complication that can lead to seizures, liver or kidney failure, and premature delivery. Women with high cholesterol before pregnancy are more likely to develop the condition, which affects thousands of women each year.
Patients taking high blood pressure medication benefit from frequent dental care
A study suggests that frequent dental visits can eliminate gingival overgrowth recurrence in patients taking nifedipine for high blood pressure. This regimen significantly reduces gum swelling and associated health risks.
New study confirms importance of systolic blood pressure
A new study from the National Heart, Lung, and Blood Institute finds that systolic blood pressure is more accurate than diastolic pressure in identifying patients with hypertension. The study suggests that future treatment guidelines may emphasize systolic pressure, which correctly classified nearly 96% of patients.
Education may help the fight against high blood pressure
A recent study suggests that teens from low-SES neighborhoods with higher educated parents exhibit reduced blood pressure responses to stress. This finding reinforces the importance of education in mitigating health risks for adolescents.
Hormone linked to body weight may help regulate blood pressure
Researchers have found a potential link between leptin and high blood pressure in a study of over 300 healthy adults. Higher levels of leptin were associated with higher diastolic blood pressure, suggesting that leptin may play a role in regulating blood pressure.
Genetic variants linked to higher risk of high blood pressure in African Americans
Researchers identified two gene variants that may govern the body's ability to regulate levels of an enzyme called renal kallikrein, which can affect salt and water balance. The study found that variations in the human tissue kallikrein gene are associated with higher blood pressure in African Americans.
UCSF team identifies gene crucial to blood pressure regulation
A UCSF team has identified a key gene, sgk, that regulates blood pressure by mediating the effects of aldosterone. The discovery could lead to more effective therapies for hypertension and low blood pressure, two conditions affecting millions of Americans.
Research Shows That Noncompliance Is Responsible For Half The Cases Of Nonresponse To Antihypertensive Drug Treatment
Research finds that noncompliance with prescribed antihypertensive drugs leads to approximately half of the failures in controlling high blood pressure. A special electronic medication container, eDEM Monitor, identifies clinically unrecognized noncompliance.
Statement from Claude Lenfant, M.D., NHLBI Director, on Trends in Hypertension
The NHLBI Director notes a decline in hypertension levels from the 1950s to the 1980s, but reports that recent data show a slowdown in blood pressure control rates and a slight increase in stroke rates. The study highlights the need for continued efforts to prevent and treat hypertension.
Advertising May Influence Physicians' Choice Of Blood Pressure Drugs
A study found a significant increase in advertising for calcium channel blockers and ACE inhibitors, paralleling a trend away from beta blockers and diuretics. The authors suggest that pharmaceutical marketing efforts may have contributed to this shift, despite scientific evidence favoring the older drugs.
Children Of Smokers Suffer Negative Health Effects Later In Life
Research suggests that children who grow up in smoking households experience small but lasting negative effects on their health, including higher blood pressure and heart rate. The study found that even though the children were not exposed to tobacco smoke at home, they still had higher baseline rates, putting them at risk for hyperten...
Low Educational Level Increases Risk For Congestive Heart Failure
A study found that low educational level increases the risk of congestive heart failure by 35% compared to those with more education. The strongest risk factors for developing CHF were diabetes, high blood pressure, overweight, smoking, and physical inactivity.
Morning Coffee Boosts Blood Pressure, Stress Hormones All Day
A study by Duke University Medical Center scientists found that habitual coffee drinkers experienced increased adrenaline, noradrenaline, and blood pressure when consuming caffeine. This heightened response can lead to damage in the heart over time.
Study Shows Link Between Hypertension And Infertility
Researchers at Vanderbilt University Medical Center discovered that mice lacking the EP2 receptor exhibit salt-sensitive hypertension and reduced fertility. The study found that PGE2 excretion increased in response to high salt diets, leading to unmasked constrictor receptors and development of hypertension.
Dash Diet Lowers Blood Pressure, Particularly In Blacks
A recent study published in Archives of Internal Medicine reveals that the DASH diet can effectively lower blood pressure, particularly among African Americans with hypertension. The diet, which emphasizes fruits, vegetables, and low-fat dairy products, resulted in an average 13-point drop in blood pressure among participants.
"Job Strain" Linked To High Blood Pressure, Heart Disease Risk
A large longitudinal study found that job strain is a significant risk factor for high blood pressure and heart disease. Men with highly demanding jobs experience higher blood pressure, while those who move to less demanding roles see their blood pressure decrease over time.
High Blood Pressure Can Lead To Mental Decline
Researchers found that elevated blood pressure is a strong predictor of changes in brain structure and related cognitive functioning. All participants showed declines in mental abilities over time, with higher blood pressures associated with greater declines, particularly for visual-spatial ability and speed of performance.
Environmental Factors Contribute To High Blood Pressure In African-American Males
A two-year study found that environmental stressors, such as unemployment and lack of health insurance, contribute to high blood pressure in young African-American males. An intervention team's efforts led to a 50% blood pressure control rate and a 75% decrease in emergency room visits.
Hypertension Found To Be A Dominant Risk Factor For Heart Failure In African Americans
A recent study published in the American Heart Association meeting reveals that hypertension is a significant risk factor for heart failure among urban African Americans. The study analyzed data from cardiac catheterization patients and found a higher prevalence of heart failure among African Americans compared to Caucasians.
Hypertension: Getting Pharmacists Involved Can Help
A study of 95 men and women found that pharmacist intervention increased blood pressure control by 55% compared to medical care alone. Pharmacists' counseling on diet, exercise, and medication adherence led to improved outcomes, especially among high-risk minorities.
Trace Amounts Of Nicotine Raise Blood Pressure In An Animal Model
Researchers discovered that trace amounts of nicotine can raise blood pressure in an animal model by releasing the neurotransmitter lutenizing hormone-releasing hormone (LHRH). The study suggests that even small doses of nicotine may cause short-term high blood pressure and potentially hypertension in humans.
Researchers Identify Risk Factors For Preeclampsia In Hypertensive Women
A study found that women with longstanding hypertension are more likely to develop preeclampsia if they have a history of high blood pressure and protein in the urine early in pregnancy. Women who developed preeclampsia were also more likely to experience complications such as premature birth and low birth weight.
Lack Of Data For New Heart Drugs Is Causing Concern
The safety of new high blood pressure drugs is being questioned due to insufficient data. Centrally acting antihypertensives have been found to target brainstem receptors that orchestrate blood vessel dilation, but concerns remain over their long-term effectiveness in reducing heart attacks, strokes, and deaths.
Dermatologists Should Provide Primary Care For Skin Disease, Wake Forest Study Shows
A Wake Forest University School of Medicine study found that patients with skin problems receive inadequate comprehensive care from primary care doctors, who focus solely on the skin issue. Dermatologists provide superior treatment due to their specialized expertise, and previous studies have shown they are cost-effective as well.
Can Pharmacists Help Patients Keep Blood Pressure In Check
A study in Detroit is testing whether extra pharmacist attention can keep patients with hypertension on track. Pharmacists are checking blood pressure, watching for side effects, and suggesting medication changes to doctors.