Articles tagged with Infectious Diseases
Researchers have developed a novel assay to test for multiple tumor markers in bladder cancer using custom-designed MLPA with multiple short synthetic probes. The study found paired tumor and urine samples showed identical marker patterns, suggesting this assay may be used for non-invasive diagnosis.
Researchers at Saint Louis University have successfully engineered a new version of the blood-regulator enzyme thrombin with optimized anti-blood clotting properties. This breakthrough opens the door to potential new medications that can treat diseases related to thrombosis without carrying a risk of hemorrhage.
A study of nearly 45,000 patients found that many with HIV in the US and Canada do not receive care early enough, resulting in lower CD4 cell counts. This delay increases the risk of clinical disease progression and ongoing transmission.
A Saint Louis University study shows that a residential summer weight-loss camp improves the health of obese children by reducing their weight, BMI, and blood pressure. The program also boosts their physical fitness and self-esteem, as they connect with peers who share similar struggles.
A study on the Darwin/Wedgwood dynasty found a statistical association between child mortality and inbreeding. Charles Darwin's children faced health problems, with three dying before adulthood, due to inbreeding depression.
African wild dog populations decline due to domestic dogs' presence, illustrating the impact of human behavior on disease transmission. Human behavior, such as range differences and animal husbandry practices, shapes disease risk and is a key driver of emerging infectious diseases.
The journal will support high-quality continuing professional development and enable travel medicine practitioners to share research and recent developments. The partnership aims to promote best levels of health and high standards of healthcare worldwide.
A new study by the University of Michigan Health System shows that 20% of Americans born between 1966-1985 were obese by age 20-29, a significant increase from previous generations. This trend is expected to worsen racial disparities in health, with black Americans already experiencing a higher burden of obesity-related diseases.
A Saint Louis University doctor found no evidence supporting the use of natural treatments like St. John's wort for anxiety, instead recommending selective serotonin reuptake inhibitors (SSRIs) as a safe and effective first-line treatment option.
Researchers at Ohio State University have developed a rapid and accurate method to genotype single nucleotide polymorphisms (SNPs) that affect warfarin dose, enabling personalized treatment for patients. This new approach has the potential to improve patient outcomes and reduce adverse effects associated with warfarin therapy.
Researchers at St. Michael's Hospital and Children's Hospital Boston are using real-time intelligence systems to monitor potential infectious disease threats to mass gatherings like the Olympics. The collaboration is providing actionable intelligence to help organizers prepare for and respond to emerging infectious diseases.
A mandatory influenza vaccination policy improved the vaccination rate among 26,000 employees at a large health care system from 54% to 98%. The study found that medical and religious exemptions were granted to 411 employees, with eight terminated for non-compliance.
A recent study by Queen's University researchers reveals that sharing a hospital room significantly increases the risk of acquiring serious infectious diseases like C. difficile. The study concludes that private rooms are safer and should be considered for future hospital design.
A new Saint Louis University research suggests that individuals with type 2 diabetes and coronary artery disease have a more favorable prognosis when properly managed with medical care. The BARI 2D trial found significant improvements in treatment outcomes for patients receiving intensive medical therapy or bypass surgery.
The Radiation Effects Research Foundation will study the impact of atomic bomb radiation on the aging immune system, analyzing biological samples from elderly Japanese survivors. Understanding how the immune system ages may help care for the growing population of older adults worldwide.
Classifying molar pregnancy is crucial for clinical treatment due to increased risk of persistent gestational trophoblastic disease. Researchers used STR genotyping and p57 immunohistochemistry to differentiate complete hydatidiform moles from partial moles and non-molar specimens.
Scientists have characterized the detailed structure of prions using unconventional X-ray diffraction methods. The results show significant structural differences between natural and synthetic prions, which may explain their infectious behavior.
Researchers have characterized the detailed structure of prions using unconventional X-ray diffraction methods. The study found surprisingly large structural differences between natural prions and synthetic analogs, shedding new light on their infectious behavior.
The UK International Health Links Centre (IHLC) aims to promote effective international health links between the UK and developing countries. The centre will provide a 'one-stop-shop' for information and guidance on strengthening existing links, as well as a library of resources for international users.
The new European Society of Cardiology guidelines update the treatment approach for infective endocarditis, emphasizing a multidisciplinary care team and earlier surgery. The guidelines also reduce antibiotic prophylaxis for high-risk dental procedures and highlight the importance of echocardiography in diagnosis and management.
Researchers developed a novel methodology to extract microRNAs from cancer tissues, identifying 17 new and 53 known miRNAs. These miRNAs were well-preserved in long-preserved tissue samples, leading to improved predictions of disease prognosis and treatment response.
The number of people aged 60 or over in South Africa is projected to triple by 2025, leading to a doubling of cardiovascular deaths. The burden of non-communicable diseases is expected to increase as antiretroviral therapy reduces mortality from HIV/AIDS.
Dr. Lin's work reveals a modified sexual cycle of C. neoformans with only one mating type, suggesting increased genetic diversity and pathogenic characteristics
A new study on Tasmanian devil social networks may help prevent the spread of an extinction-threatening disease. The research found that all individuals in a population are connected within a single social network, making it easy for disease to spread.
A new international partnership aims to improve African institutions' capacity to detect infectious diseases affecting humans and animals. The Southern African Centre for Infectious Disease Surveillance (SACIDS) will develop courses, research skills, and biosafety systems to tackle major livestock and wildlife diseases.
Researchers at Case Western Reserve University and University Hospitals Cleveland Medical Center found that two simple clinical measurements failed to identify TB patients who could benefit from a shorter treatment course. The study involved over 1,000 TB patients in Africa, Brazil, and Asia, but ultimately showed that these measures w...
Researchers have developed a specific and quantitative method to measure FMRP protein levels, which is mutated in fragile X syndrome. This test will help correlate protein levels with clinical severity of the disease.
A study of 5,434 patient records found that physicians failed to report clinically significant abnormal test results in nearly one in every 14 cases. Implementing simple processes such as routing all test results to the responsible physician and documenting patient notification can greatly lessen error rates.
The Northeast Biodefense Center, a regional collaboration of major centers, will conduct interdisciplinary research on diagnostics, therapeutics, and vaccines to address emerging infectious diseases. The center has made significant contributions to global health, including the development of diagnostics for SARS and pandemic influenza.
Global health is defined as an area of study that prioritizes improving health globally, particularly in achieving equity among all people worldwide. The definition emphasizes transnational health issues, determinants, and solutions, involving multiple disciplines and promoting interdisciplinary collaboration.
Researchers at Scripps Florida have created a faster method to distinguish between different infectious prion strains, which can cause diseases in animals and humans. The new approach reduces the time lag for identification from six months to four months, allowing scientists to accelerate research and better understand disease risks.
A study finds that inner city rodents form distinct neighborhoods, with most spending majority of their lives within a city block. This understanding provides information on which populations may spread disease, highlighting the need to target entire families for eradication efforts.
Genetic screening for cystic fibrosis carrier mutations is universally recommended for the reproductive-age population. New reference materials have been developed to ensure accuracy in genetic testing, but some mutations may lead to false results due to large deletions or interference with laboratory methods.
Elsevier has launched a new journal called Epidemics, which will focus on infectious disease dynamics. The journal aims to bring together researchers from various disciplines and provide a platform for high-quality papers in this emerging field.
Researchers have developed a new technique to determine tumor methylation status in archived tissue samples, providing a potential biomarker for early cancer diagnosis and risk assessment. The technique uses high-resolution melting analysis and has been validated on archival and fresh tissues.
Researchers found that patients who lost at least 9% of body weight showed reversal of their liver damage, while those who lost 5% or more experienced improvement in insulin resistance and fat accumulation. Weight loss was the key factor in improving fatty liver disease.
A new clinical trial suggests that long-term use of candesartan may significantly reduce symptoms of genetic heart disease, including left ventricular hypertrophy. The study found no adverse effects of candesartan use and highlights the need for customized treatment protocols based on individual patient gene mutations.
Levels of drug-resistant TB in China are nearly twice the global average, with 10% resistant to first-line drugs. The prevalence varied greatly between provinces, with an average weighted mean of 9.3% among all cases.
A University of Michigan researcher found that men who overspend on consumer goods have higher mating intentions and past success in attracting mates. The study suggests an evolutionary link between financial consumption and mating behavior, with men competing for status and resources to attract partners.
Researchers developed a transgenic mouse model expressing mutant prion protein, resulting in a fatal neurological disorder. The discovery may help unravel the mystery of this progressive disease affecting humans and animals.
A study found that the World Health Organization's (WHO) budget allocations do not align with global disease burdens. The WHO allocated 87% of its budget to infectious diseases, while non-communicable diseases received only 12%. This disparity in funding is concerning, particularly for injuries and violence, which are largely underfunded.
A study found that undocumented immigrants with tuberculosis exhibit longer symptom durations and more severe symptoms before seeking care. This raises concerns about the value of improving access to healthcare for these individuals.
Researchers at Saint Louis University have identified an investigational vaccine that induces a better immune response and is more effective at protecting against tuberculosis. The vaccine uses a weakened TB germ from one of the strains of the current tuberculosis vaccine.
China faces a significant health and economic challenge due to rising chronic diseases, including high blood pressure and smoking. The country has an ageing population and increasing rates of obesity, diabetes, and cardiovascular disease, with tobacco use being a major factor in these trends.
A low-cost egg-beater-based centrifuge can separate plasma from blood in minutes, used to detect deadly infectious diseases common in developing countries. The device requires no training or electricity and can be sterilized with boiling water.
A new study published in BMC Infectious Diseases reveals a significant increase in human rabies cases in China since the new millennium. The researchers found that the number of cases jumped dramatically from 159 to 3,279 between 1990 and 2006, with most patients contracting the disease after being bitten by dogs.
New research from Saint Louis University found that combining nuclear medicine clinicians and treating physicians to interpret PET-CT scans reduces false positive results by 51%, resulting in fewer unnecessary biopsies. This collaboration improves scan accuracy, sparring patients from painful and potentially catastrophic complications.
A new system called HealthMap has been developed to gather, organize, and disseminate online intelligence on disease outbreaks. This can facilitate early outbreak detection, increase public awareness of disease outbreaks prior to formal recognition.
A new study found that Mexico's southern region has the highest rates of infectious and nutritional diseases, as well as non-communicable diseases such as heart disease and diabetes. The study also identified being overweight, high blood glucose, and alcohol use as major risk factors for these diseases.
A Saint Louis University study found that patients with advanced heart failure may not benefit from implantable cardiac devices due to their underlying illness. The researchers identified two red flags: prolonged hospitalization and use of inotropic therapy, which are associated with higher risk of in-hospital mortality.
Researchers develop model predicting disease outbreaks based on weather patterns and climate variability. The study shows an association between high temperature and daily incidence of cryptosporidiosis in Massachusetts, highlighting the need for better understanding of how climate affects disease spread.
Exposure to secondhand tobacco smoke increases the risk of severe infectious illnesses and hospital admissions in young children. Children born prematurely or with low birth weight are particularly vulnerable to these risks.
Women with a family member who has had a hernia or prolapse are more likely to develop the condition themselves. Lifestyle changes, such as avoiding heavy lifting and maintaining a healthy weight, can help reduce the risk of pelvic organ prolapse.
Researchers found that affluent college students attempt to trade sexual currency for provisions, such as tickets or study assistance. The study suggests that these behaviors are hard-wired and persist regardless of wealth or security.
Researchers developed a special filter that quickly removes prion proteins, causing mad cow disease and Creutzfeldt-Jakob disease, from blood. The device has been approved for use in Europe and is expected to be commercialized in Ireland and the UK in mid 2008.
A phase III study of 15,183 healthy infants found that two doses of an oral live attenuated human rotavirus vaccine reduced cases of severe gastroenteritis by 32% compared to placebo. The vaccine efficacy was 80.5-82.1% against the wild-type G1 rotavirus strain.
Researchers have developed an assay to identify antibodies specific to Mycobacterium avium complex (MAC), distinguishing MAC-related pulmonary disease from tuberculosis in under eight hours. The test showed high sensitivity and specificity, reducing the risk of misdiagnosis and inappropriate treatment.
A study by SLU cardiologist Melda Dolan found that ultrasound contrast agents are safe and beneficial for diagnosing life-threatening heart disease. The researchers examined nearly 24,000 patients who received contrast agents during echocardiograms and compared their results to those of approximately 6,000 patients without the agents.
A new study by researchers at the University of Southern California and University of Pennsylvania reveals that male infants in developed nations are more likely to die than female infants. The disparity has narrowed in recent decades due to medical advancements such as C-sections and intensive care units.
Research shows that men are more likely to eat meat and poultry products, including duck and veal, whereas women favor vegetables like carrots and tomatoes. Women also have a preference for dry foods and certain fruits, such as strawberries and blueberries.