Articles tagged with Infertility
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A recent study published in The Journal of Urology found that serum hormone ratios can predict the risk of future infertility in children with cryptorchidism. Researchers discovered that inhibin B levels and anti-Mullerian hormone (AMH) are significant markers of spermatogenesis, helping to identify boys at high risk of infertility.
A nationwide study found that weight loss prior to starting infertility treatments did not increase the chances of having a healthy baby. Women with obesity and unexplained infertility who lost weight before beginning therapy did not have a greater chance of delivering a healthy baby than those who did not lose weight.
Research involving nearly 250,000 US families found that medically assisted reproduction techniques, including IVF, do not significantly affect birth weight and pregnancy term. Once family circumstances are considered, the differences between MAR-conceived babies and naturally conceived children become insignificant.
A large observational study found that children conceived through assisted reproductive techniques (ART) have generally good mental health throughout adolescence and young adulthood. However, those born after ART had a slightly elevated risk of obsessive-compulsive disorder, which was explained by parental background factors.
A qualitative study of seven women who underwent uterine transplantation found that they experienced a mix of emotions, including anxiety and sense of unreality. The women reported feeling like most other mothers, but also struggled with the medical supervision and feelings of uncertainty.
Researchers have created reconstructable uterus-derived materials (RUMs) to aid in the recovery of damaged uteruses. The materials, which can be formed into different states and shapes, prevent intrauterine adhesion and promote angiogenesis, endometrial regeneration, and muscle collagen rebuilding.
The study reveals that the Cdc42 gene is essential for proper alignment and function of Sertoli cells, which support sperm cell development. Disruptions in this gene can lead to reduced testicular function and infertility. Researchers hope to develop non-invasive diagnostic tests to identify specific causes of male infertility.
Researchers have made a breakthrough in spermatogonial stem cell research, successfully generating functional sperm cells using primate embryonic stem cells. The study, published in Fertility and Sterility Science, shows promise for future clinical therapies to treat male infertility.
A more inclusive definition of infertility could help explain why current diagnostic tests frequently fail to find a reason for reproductive failure. This broader view may also open up novel opportunities for tailoring infertility treatments to each couple, considering the complex network of interacting male and female genes.
Research found significant discrepancies in delivery and funding of fertility preservation services across the UK, with unequal access to options for child cancer patients. Experts are calling for consistent, centralized funding to ensure all children have an equal chance to preserve their fertility after cancer treatment.
Researchers at Kyushu University successfully reconstitute the ovarian follicle from mouse stem cells, generating functional egg cells and growing viable mice. This breakthrough could lead to new treatments for infertility and help conserve endangered animals through egg cell production.
A study published in Cell Reports Medicine reveals the molecular and cellular changes in testicular tissue of infertile men, identifying alterations in spermatogonial stem cell compartment. The research provides new insights into male infertility and prepares ground for better diagnosis.
A new gene ZFP541 has been discovered by researchers at Kumamoto University to control the completion of meiosis in spermatogenesis. The study found that ZFP541 plays an essential role in regulating meiosis and is expressed in late meiotic prophase, binding to regulatory regions of meiosis-related genes.
Researchers from Osaka University identified SPATA33 as a key regulator of sperm motility, which will aid in developing fast-acting male contraceptives. The study also clarified the mechanism by which SPATA33 controls sperm motility, shedding light on the cause of male infertility.
A study published in Developmental Cell reveals that lagging chromosomes contribute to an uneven chromosomal distribution, leading to aneuploidy and infertility. Researchers propose artificially slowing down cell division to limit aneuploidy, offering a potential solution for improving egg quality in older patients.
Researchers at RMIT University have discovered a Teflon-like molecule on the womb's surface that decreases at a certain point in the menstrual cycle, opening the 'golden window' for pregnancy success. This finding could lead to improved IVF success rates and potentially treat underlying causes of infertility.
A new study has found that the absence of Aire protein in mice leads to fertility problems similar to those affecting men with autoimmune polyendocrine syndrome type I (APS-1). Researchers discovered that Aire-dependent central tolerance plays a critical role in maintaining male fertility.
A study of 1,349 Malawian women aged 16-26 found that nearly 13% reported difficulty conceiving, with 85.5% seeking help. Traditional healers were the most common source of support, used by 44.4% of women.
Research found that men diagnosed with inflammatory arthritis before their peak reproductive years have lower fertility rates, fewer pregnancies, and poor sperm quality compared to those diagnosed at older ages. Inflammatory arthritis is linked to male infertility, erectile dysfunction, and insufficient testosterone production.
Researchers from Osaka University found a link between excessive autophagy and reduced sperm production, suggesting a potential mechanism for male infertility. The study suggests that Rubicon regulates autophagic degradation of GATA4, promoting Sertoli cell function.
Researchers at the University of Helsinki have identified short non-coding RNA molecules in human ova and embryos, shedding light on embryonic development. The study's findings may lead to improved infertility treatments and a deeper understanding of early miscarriages.
Researchers identified a novel lncRNA, Teshl, which plays a crucial role in the development of Y-bearing sperm and regulates sex chromosome gene expression. The study provides new insights into sex ratio variations and suggests that genetics may be a key factor in human male infertility.
A study of 692 female surgeons found that nearly half experienced major pregnancy complications, including miscarriages and preterm birth. The researchers call for policy changes to support pregnant surgeons and change the culture surrounding childbearing.
Researchers found a nearly 35,000% increase in COVID-19 vaccine and infertility Google searches following a misinformation event. The study highlights the dangers of misinformation campaigns on public perception and decision-making, particularly among pregnant patients.
Scientists at the University of Cincinnati have developed a blueprint for the protein anti-Müllerian hormone (AMH), which plays a crucial role in reproductive organ development. Understanding how AMH interacts with its signaling receptor may lead to novel treatments for infertility, polycystic ovary syndrome (PCOS), and even feral cat ...
Researchers discovered a genetic mutation in FSIP2 protein that affects sperm flagella, leading to infertility. Mice with the mutation had impaired sperm movement, while those overproducing FSIP2 were fertile with longer, faster-swimming sperm.
A new study by University of Liverpool ecologists finds that climate change will see some species succumb to infertility earlier than thought. The research used fruit fly species to predict temperature tolerance and found that almost half of the species become sterile at lower temperatures, making conservation more difficult.
A lifestyle intervention targeting women with obesity and infertility significantly improves pregnancy rates, especially spontaneous pregnancies. The Fit-For-Fertility program shows promise as a cost-effective alternative to fertility treatments, with a live-birth rate 14.2 percentage points higher than the control group.
A large health insurance database in Taiwan investigated the association between obstructive sleep apnea and male infertility. The study found that obstructive sleep apnea was a significant risk factor for male infertility, with treatment for sleep apnea not necessarily reducing the risk.
A Danish study found that overweight mothers had a higher risk of infertility in their sons compared to those with normal weight. The researchers also highlighted the importance of addressing risk factors for infertility globally and acknowledged the need for further studies to corroborate these findings.
A new study from Keck Medicine of USC shows that men over 50 who undergo a vasectomy reversal achieve the same rate of pregnancy as those under 50. The study analyzed data from 3,000 men and found that age was not a factor in success rates.
Researchers have developed an acoustofluidic process that can isolate sperm with normal head morphology and high DNA integrity from raw semen samples. The device selects over 60,000 high-quality sperm in under 50 minutes, providing a clinically-relevant number for IVF and ICSI.
Researchers have developed a protein delivery system that restored normal sperm development and allowed previously infertile mice to father pups. The treatment delivered a key protein called PIN1 directly to mouse testicles, repairing damaged reproductive cells and improving fertility.
Researchers found that embryo culture is associated with placental abnormalities, preeclampsia, and abnormal fetal growth. Optimizing embryo culture is key to ensuring healthy outcomes for mothers and offspring.
Scientists have identified a crucial protein called SKP1 that drives a key transition step in male meiosis, the process resulting in sperm production. Without this protein, meiosis cannot proceed, and defects can occur, leading to male infertility, pregnancy loss, or birth defects.
A study published in PLOS ONE found that an online program for women with infertility doubled their pregnancy rate, comparable to in-person programs. The Mind/Body Program offers ten hour-long modules of instruction covering stress management, relaxation techniques, and cognitive-behavioral therapy.
A new NIH study found that antioxidant supplements did not improve semen quality or pregnancy and live birth rates in men with infertility. The Males, Antioxidants, and Infertility Trial (MOXI) reported no statistically significant differences between the placebo and antioxidant groups.
Dr. Neal Barnard shares how common conditions like infertility, weight gain, and menopausal symptoms are fueled by hormone imbalances linked to food choices. He offers practical tips and recipes to balance hormones and improve overall health.
Researchers at Kumamoto University have discovered the Meiosin gene, which acts as a control tower to switch on hundreds of genes for germ cell formation. This finding has significant implications for reproductive medicine and infertility treatments.
Ethicists argue that sperm donation after death is morally permissible to plug the UK's shortage of donor sperm and increasing demand. The process would involve collecting and freezing sperm after death through electrical stimulation or surgery, with health checks addressing potential genetic concerns.
A randomized clinical trial examined the effects of daily folic acid and zinc supplementation on semen quality and live births among 2,300 couples. The study found that folic acid and zinc supplementation improved semen quality and increased the chances of conception.
A new study conducted at University of Utah Health found that zinc and folic acid supplements did not improve sperm counts or pregnancy rates in men. The researchers also noted a higher proportion of broken DNA in sperm among those who took the supplements, which could contribute to male infertility.
Research by Lancaster University and the University of Oregon reveals that infertility disproportionately affects working-class people, those with disabilities, and others. The study calls for greater healthcare equity and inclusive reproductive health surveillance to address these disparities.
A new study from Penn Medicine found that direct-to-consumer hormone-based fertility tests for women are both empowering and confusing. The tests, which estimate egg supply or 'ovarian reserve,' are marketed as an accessible option for investigating fertility status but do not predict natural conception.
Researchers at Brigham and Women's Hospital identify a genetic abnormality in the SYCP2 gene as a possible cause of male infertility. The study found that variants affecting this gene were associated with low sperm count and loss-of-function variants, making it a potential diagnostic marker.
Researchers at Penn Medicine identify specific genetic locations of retained histones in sperm DNA, which can affect embryonic development. A new mouse model with a mutated Gcn5 gene allows for closer tracking of defective sperm and potential therapeutic targets.
Men born small for gestational age have a 55% increased risk of infertility as adults, compared to those born within the normal weight range. The study found no link between gestational age and infertility in women.
A new UK study found that nearly half of those dealing with infertility and its treatment lack access to psychological support. The survey, which received over 800 responses, also revealed a 'postcode lottery' in the funding of IVF treatments, with some areas offering more support than others.
A recent study at the University of Virginia has made a groundbreaking discovery about fertilization, revealing that sperm and eggs fuse in a dynamic process where both play an active role. The research may lead to new treatments for infertility, including male contraceptives and improved IVF success rates.
Researchers have identified patterns of epigenetic molecules on sperm DNA that can indicate male infertility. A new diagnostic approach could provide doctors with a reliable method to screen men for infertility, saving couples time and effort in finding suitable treatment options.
A new study at U-M found that the addition of IVF coverage to health insurance plans increased the rate of IVF among university employees, with a nine-fold increase in the lowest-salary bracket. The benefit led to greater equity in fertility rates across income groups.
Researchers from CRCHUM unveiled a mechanism that likely contributes to the low level of pregnancy success in some fertility clinics. Healthy cells usually have one nucleus, but many fertility clinics transfer so-called 'binucleated embryos' with two nuclei back to patients. The study found that binucleation increases the chances of an...
Researchers identified genes that influence the balance between male and female offspring in mice, affecting male fertility. The study found that removing specific gene families led to skewed sex ratios and male infertility, providing a potential model for understanding sperm production.
A recent study has found chlamydia in the testicular tissue biopsies of infertile men with no identified cause, indicating a potential link between the bacteria and male infertility. Chlamydia was detected in 45.3% of fixed testicular biopsies, suggesting a significant impact on fertility.
The Edwards family's journey with uterus transplantation has resulted in the birth of their fourth child through this innovative procedure. Researchers at Baylor University Medical Center have completed 20 uterus transplants as part of a clinical trial, aiming to expand this option for women with absolute uterine factor infertility.
A national register study from Lund University found that fathers who underwent assisted reproduction, such as IVF and ICSI, had a 30-60% higher risk of developing prostate cancer compared to those who conceived naturally. The study also showed that men treated for infertility had a higher risk of prostate cancer at a young age.
Men who became fathers through assisted reproduction techniques have a higher risk of prostate cancer and early onset prostate cancer compared to those who conceived naturally. Early screening and long-term monitoring are advised for these men.
Researchers at Michigan State University are using $2.8M in NIH grants to study the piRNA pathway and its role in controlling male fertility. They hope to identify new targets for male contraception, addressing a significant reproductive health issue affecting one in ten couples.
A third family welcomes a baby after participating in a landmark uterus transplant clinical trial at Baylor University Medical Center. The successful birth is the largest program in the world, having performed a total of 20 uterus transplants.
Scientists have developed a new computational method that reveals genetic patterns in individual cells, enabling the diagnosis of specific genetic defects and potentially rectifying them with CRISPR. This breakthrough advances precision medicine by providing personalized treatment options for patients with unexplained infertility.