Articles tagged with Infertility
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A study published in the Proceedings of the National Academy of Sciences found that 54 mouse testis-enriched genes are not crucial for male fertility. This discovery helps scientists narrow down the number of possible genes involved in male infertility, allowing them to focus on essential genes first.
A recent study published in PLoS One has revealed that opioid receptors participate in spermatogenesis, a process crucial for male fertility. The researchers identified the activation of these receptors as regulating the formation of machinery responsible for correctly segregating genetic information during spermatozoa production.
A new study from Brigham and Women's Hospital suggests that the majority of women with endometriosis do not experience infertility, contradicting previous estimates. The study found a higher risk of subsequent infertility in women under age 35, but only half of cases previously thought to be related to endometriosis.
A study by Vrije Universiteit Amsterdam has identified two genetic variants that increase the chance of mothers having dizygotic twins. These variants are associated with fertility measures such as age of first menstruation and polycystic ovary syndrome, a major cause of infertility in women.
Research highlights the impact of dietary habits on male reproductive potential, with obesity found to promote hormonal dysfunction and affect fertility. The study emphasizes the need for policymakers and media attention to address this growing health issue.
A large study of 43,313 women found that infertility and hormone treatment may be linked to higher breast density, a known risk factor for breast cancer. The association was strongest among women who had undergone controlled ovarian stimulation (COS), a common fertility treatment.
Researchers found that a cannabinoid receptor called CB2 helps regulate the creation of sperm, providing evidence for marijuana's impact on male fertility and suggesting a potential therapeutic strategy for treating male infertility. The study suggests that a balance of CB2 activation is required for proper spermatogenesis.
A new review suggests that Americans are not using infertility treatments and technologies as much as they could due to limited insurance coverage. The number of women aged 25-44 who have used infertility services decreased by 16% between 1995 and 2010, with usage rates being only 40% of the likely need in the US population.
A study by NIH researchers found that children conceived through infertility treatment have similar developmental scores to those conceived naturally, with some increased risks for twins but not ART treatment groups.
A study of over 156,947 U.K. women found that extending IVF cycles beyond 3 or 4 treatment cycles can increase the likelihood of a live birth. Live-birth rates continued to rise with each additional cycle, with 65% of women achieving a live birth by the sixth cycle.
A large study of over 93,000 women found that active and passive smoking are associated with an increased risk of infertility and earlier menopause. Women who smoked daily had a 14% greater risk of infertility, while those exposed to second-hand smoke had a 26% heightened risk of menopause before age 50.
A Stanford study found that infertile men have a higher risk of developing heart disease, diabetes, and other health problems. The research suggests that male infertility is associated with increased rates of mortality and general health issues, even after adjusting for obesity and smoking.
Polycystic ovary syndrome (PCOS) affects up to 5 million women nationwide, causing diverse symptoms and varying levels of severity. Research is needed to understand the genetic and environmental factors contributing to PCOS, as well as its long-term effects on reproductive health.
Researchers identified a novel pathway in the normal development and maintenance of the ovary, discovering a mutation in the Nucleoporin 107 gene linked to ovarian dysgenesis. This finding has significant implications for diagnosing infertility and lack of puberty in women.
A new study published in the New England Journal of Medicine (NEJM) has found that clomiphene citrate is a more effective treatment option than ovarian stimulation with letrozole or gonadotropins for unexplained infertility, reducing multiple gestations without lowering pregnancy rates.
A study published in the New England Journal of Medicine found that letrozole did not improve pregnancy rates and live birth rates for women with unexplained infertility, but clomiphene remained the best option. Clomiphene enabled production of more eggs and hormones, while gonadotropin had the highest rate of pregnancy and live births.
A new study published by the NIH finds that clomiphene is more effective than letrozole for treating unexplained infertility, resulting in more live births. The study compared over 900 couples undergoing fertility treatment and found that clomiphene resulted in higher pregnancy rates and fewer multiple pregnancies.
Researchers at the University of Delaware have discovered oviductosomes, tiny particles that help sperm prepare for fertilization. These particles are attached to the sperm like decorations and transfer critical molecules, including a calcium clearance pump, that aid in the fertilization process.
A new study found that same-sex couples encounter more obstacles to infertility treatment, including psychological evaluations and high costs of treatments. The research highlights the need to recognize inequalities in the medicalization of infertility and its effects on marginalized groups.
A research team from NUS Medicine has demonstrated that applying an external source of hydrogen sulphide can protect testicular germ cells against heat-induced injury, a major cause of male infertility. The findings provide a potential therapeutic value for H2S in treating male infertility.
Researchers developed a diagnostic test for sperm RNA based on next-generation sequencing, which may help determine the best infertility treatment for couples having difficulty conceiving. The test can identify those who benefit from assisted reproductive technologies and those who may be successful with minimal intervention.
New research reveals mutations in the X chromosome gene TEX11 are linked to 1% of azoospermia cases, a condition where men produce no sperm. The study found that reintroducing the gene restores fertility in mice, highlighting the protein's role in sperm formation and chromosomal arrangements.
Researchers at Penn have identified a specific gene, TEX11, responsible for some cases of male infertility. The study found that mutations in this gene are present in approximately 1% of men with azoospermia, a condition where males produce no sperm.
Researchers at Karolinska Institutet have discovered a new link between male infertility and autoimmune prostatic inflammation. The study found that the immune system reacts to a protein called transglutaminase 4 in men with autoimmune polyendocrine syndrome type 1, leading to reduced fertility.
A recent study by the University of Michigan found that African-American women are equally likely to experience infertility as their white counterparts, yet they often cope with it alone due to social stigma. The study reveals that these women face discrimination in medical settings and feel a negative impact on their self-esteem.
A recent study published in the New England Journal of Medicine found that X-linked gene mutations can contribute to azoospermia and male infertility. Researchers identified a deletion in the TEX11 gene on the X chromosome as a potential cause, which can lead to meiotic arrest and prevent the development of viable sperm.
A new review emphasizes the psychological impact of infertility and the need for healthcare professionals to consider emotional well-being. Counselling plays a critical role in providing comprehensive care, integrating medical and mental health aspects.
A comparison study found that IVFpredict is more accurate than the Templeton method in predicting the chances of successful live births after IVF treatment. The study analyzed data from 130,960 IVF cycles and showed that both models underestimated live birth rates, but IVFpredict remained more accurate.
Researchers at the University of Gothenburg and Karolinska Institute have failed to successfully treat infertility with stem cells, contradicting previous claims. The study shows that female mice can only produce eggs from birth, rendering stem cell-based treatment unrealistic.
The use of ICSI in IVF procedures for male infertility has doubled between 1996 and 2012. Despite this increase, studies found no association with improved reproductive outcomes such as implantation or pregnancy rates.
Researchers discovered that knocking down a single gene can prevent stress-induced female infertility and miscarriage in rats. The study found that this genetic silencing restored reproductive success to levels comparable to non-stress controls.
Researchers at UC Berkeley discovered that chronic stress activates a hormone reducing fertility long after stress ends, and blocking this hormone restores female reproductive behavior to normal in rats. The study's findings suggest the potential for a gene therapy approach to help women overcome infertility caused by stress.
A study of 9,387 men with fertility issues found a correlation between poor semen quality and various health conditions, including hypertension and skin/endocrine disorders. The study suggests that treating male infertility may also benefit overall health.
A single mutation in the beta-catenin gene can lead to abnormalities in sexual organ morphology, making natural reproduction impossible. The study found that this mutation affects specific tissues, causing malformations that prevent successful reproduction.
Researchers at the University of Gothenburg have discovered a signaling pathway in granulosa cells that plays a key role in enabling immature eggs to survive. This mechanism serves as a biological clock monitoring the onset of menopause, allowing the granulosa cells to decide when eggs will begin to grow and when they will die.
The world's first child was born from a transplanted uterus, marking a major step forward in treating uterine factor infertility. The baby boy was delivered via caesarean section due to preeclampsia, but is developing normally and the mother and child are doing well.
Fertility experts advocate for making ovarian tissue and egg freezing options widely available to healthy women. The techniques have restored fertility in female cancer patients and enabled the birth of nearly 2000 babies without an increase in birth defects.
A large-scale study of over 7,000 women found that sustaining a desire for children after failed fertility treatment is linked to worse mental health. Women who still wished to have children were up to 2.8 times more likely to develop clinically significant mental health problems than those who did not sustain a child-wish.
A study by the Endocrine Society found that women with vitamin D deficiency were nearly half as likely to conceive through IVF as those with sufficient levels. Women with adequate vitamin D levels had higher-quality embryos and increased chances of successful implantation.
Researchers discovered that synthetic PAWP can initiate fertilization, promising a new method for diagnosing and treating male factor infertility. The protein's potential as a molecular marker for diagnosis and improvement of fertility treatments is being explored.
A nationwide study found that letrozole increased live births by 27.5% compared to clomiphene, and improved ovulation rates and reduced twin pregnancies. Fewer side effects were reported with letrozole, but further research is needed for safety clarification.
A recent study published in Human Reproduction found that men with male infertility are more likely to die sooner than those with normal semen quality, with a doubling of mortality risk. The study examined data from over 12,000 men aged 20-50 and found an inverse relationship between semen quality and mortality rate.
A study at the University of Iowa found that infertile women want more than just practical aid but also emotional reassurance and empathy. The researchers suggest spouses, friends, and family can help by being more supportive and emotionally invested in the process.
Researchers at UNC School of Medicine discovered that cellular interactions can affect aging and infertility in nematodes. Tweaking a specific signaling pathway allowed worms to overcome infertility while living longer lives.
Researchers found that women with high levels of stress biomarkers are more than twice as likely to meet the clinical definition of infertility compared to those with low levels. The study also suggests that managing stress using techniques like yoga and meditation may help women conceive, although it's not the only factor involved.
Girls born unexpectedly small or underweight may face fertility problems in adulthood, research suggests. Analysis of 1206 Swedish women found those with female infertility causes were almost 2.5 times more likely to have been underweight at birth.
Researchers have identified a genetic cause for premature ovarian failure, finding that mutations in the STAG3 gene lead to infertility. The study analyzed samples from a consanguineous family and confirmed that the mutation affects both males and females, making it a strong candidate for male infertility as well.
A team of Bay Area researchers explores factors that differentiate fertile sperm from infertile sperm, identifying crucial proteins known as ion channels critical for sperm fertility. The discovery may lead to the development of new diagnostic testing and treatments for male infertility.
A comprehensive study of over 300,000 births in South Australia found that babies conceived through assisted reproductive therapies had a higher risk of stillbirth, preterm birth, low birth weight, and neonatal death compared to naturally conceived babies. The risks varied depending on the type of assisted conception used.
Georgia Regents University has joined the Cooperative Multicenter Reproductive Medicine Network to conduct large-scale clinical trials on male and female infertility. The network aims to develop novel diagnostic and treatment strategies for complex reproductive health issues, including polycystic ovary syndrome and delayed puberty.
Couples undergoing fertility treatment face significant out-of-pocket expenses, with IVF cycles costing up to $19,234, while medication-only treatments cost around $912. The study's findings aim to inform couples and physicians about the true costs of infertility care.
Scientists at Oxford University have developed a technique using nanoparticles to investigate the mechanisms underlying 'mystery' cases of infertility. The method involves loading porous silica nanoparticle envelopes with compounds to identify or treat causes of infertility, demonstrating no detrimental effects on sperm function.
A recent study by Celmatix Inc. suggests that women may be stopping IVF treatment prematurely, with 68% conceiving within two cycles and over half (60%) becoming pregnant if they proceeded with an additional two cycles. The study also explored genetic markers for female infertility and IVF success.
A study by researchers at the Hebrew University of Jerusalem found that women with PCOS who ate a big breakfast had improved glucose levels, insulin resistance, and fertility rates. This suggests that timing of calorie intake may play a crucial role in overcoming reproductive difficulties.
Researchers at University of Otago discover key cellular location of kisspeptin-Gpr54 signalling, crucial for fertility. The study reveals that targeting this signalling can enable new therapies for infertility and approaches to controlling fertility.
Researchers found that BPA exposure can dramatically inhibit egg maturation, leading to decreased maturity, increased degeneration, and spontaneous activation. This study adds to growing evidence about the impact of BPA on human health and may explain why some couples struggle with infertility.
Women who survived childhood cancer face an increased risk of infertility, but nearly two-thirds conceive after trying unsuccessfully for at least a year. The study found that 64% of survivors conceived after six months, compared to 55% in the control group.
Childhood cancer survivors were nearly 50% more likely to experience clinical infertility compared to their siblings. Around two-thirds of those who reported clinical infertility eventually became pregnant, comparable to the historical pregnancy rate in all women with clinical infertility.
A study of egg banking for anticipated gamete exhaustion found that many women believe they'll never use their stored eggs, but still consider the experience positive. Most wish they had done so at an earlier age to preserve fertility.
A new low-cost method of in-vitro fertilization developed at the University of Colorado Boulder showed successful human clinical trials in Belgium, suggesting infertility care may be universally accessible. The simplified laboratory system, estimated to cost between $250, performed roughly the same as conventional IVF programs.