Articles tagged with Infertility
A national register study from Lund University found that fathers who underwent assisted reproduction, such as IVF and ICSI, had a 30-60% higher risk of developing prostate cancer compared to those who conceived naturally. The study also showed that men treated for infertility had a higher risk of prostate cancer at a young age.
Men who became fathers through assisted reproduction techniques have a higher risk of prostate cancer and early onset prostate cancer compared to those who conceived naturally. Early screening and long-term monitoring are advised for these men.
Researchers at Michigan State University are using $2.8M in NIH grants to study the piRNA pathway and its role in controlling male fertility. They hope to identify new targets for male contraception, addressing a significant reproductive health issue affecting one in ten couples.
A third family welcomes a baby after participating in a landmark uterus transplant clinical trial at Baylor University Medical Center. The successful birth is the largest program in the world, having performed a total of 20 uterus transplants.
Scientists have developed a new computational method that reveals genetic patterns in individual cells, enabling the diagnosis of specific genetic defects and potentially rectifying them with CRISPR. This breakthrough advances precision medicine by providing personalized treatment options for patients with unexplained infertility.
A study led by Massachusetts General Hospital researchers reveals that Misr2+ cells play a critical role in forming a healthy uterus. The cells, which express the receptor for Mullerian Inhibiting Substance (MIS), are found to continue expressing MIS past sexual differentiation, contributing to uterine development.
A Michigan Medicine study found that white women and those with higher education levels are more likely to seek fertility treatment than other groups. Nearly 12.5% of women reported experiencing infertility, but only 33% of those with lower education levels sought care.
A large multicentre study of almost 5000 patients found no benefit from ICSI in terms of fresh and cumulative live birth rate in non-male factor cases, challenging the global trend of ICSI adoption
A study has identified new potential genetic causes of male infertility, which will help develop better diagnostic tests. Researchers found de novo mutations in genes involved in spermatogenesis, none of which were previously known to cause human infertility.
The study reveals that dietary phytoestrogens are metabolized by the gut microbiota of southern white rhinoceroses, leading to infertility. The researchers also found species differences in estrogen receptor sensitivity to phytoestrogen metabolites.
Scientists have identified a crucial role for GDNF in regulating the length of the ureter, a tube connecting the kidneys to the bladder. Excessive GDNF production can lead to reproductive organ malformations and infertility in males and females.
A study published in Fertility and Sterility found that female reproductive endocrinology and infertility subspecialists make $67,000 less than their male counterparts annually. Researchers attribute the pay gap to factors such as salary compression and women's reluctance to negotiate over salary.
Researchers at Kyoto University have made a breakthrough in understanding the root cause of abnormal sperm morphology in infertile mice. By modifying a single amino acid on a key protein, they were able to restore fertility in test mice, opening up new possibilities for treating infertility.
A new study reveals that long-term opioid users are at risk of hormone deficiencies, including hypogonadism and hypocortisolism. Up to 65% of men using opioids long term have low testosterone levels, leading to symptoms such as erectile dysfunction and infertility.
A study of over 64,000 women found that infertility is associated with a higher risk of developing cancer compared to non-fertile women. The absolute risk is very low at just 2%, but still significantly higher among infertile women.
Women who undergo infertility treatment are more likely to experience severe pregnancy complications, such as postpartum hemorrhage and sepsis. Researchers found a 40% increased risk among women who received in vitro fertilization compared to those without treatment.
A randomised controlled trial involving over 2,700 couples found that the new IVF technique PICSI did not significantly improve success rates for male infertility, with a success rate of around one in four couples. However, it did reduce miscarriages by 39% compared to standard ICSI treatment.
A study published in the Harvard Review of Psychiatry found that antidepressants may affect fertility in women, but the evidence is limited. In contrast, the impact on male fertility is unclear and requires further research.
Scientists at Newcastle University have identified a gene crucial for sperm production, shedding light on why some men may be infertile. The RBMXL2 gene's deletion blocked sperm production, paving the way for further research into male factor infertility.
A study of 1644 infertile men found that longer durations of infertility were associated with lower sperm counts and impaired sperm parameters. Older age and higher body mass index were also linked to prolonged infertility.
Researchers have successfully performed the world's first uterus transplant from a deceased donor, allowing a woman with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome to give birth. The recipient received immunosuppression drugs and had a healthy pregnancy, resulting in the birth of a baby girl via caesarean section.
UTSA scientists create world's most comprehensive digital roadmap for male fertility by analyzing individual cells' gene expression. This innovation could help diagnose and treat infertility issues, as well as inform the development of new contraception methods.
Researchers have identified three proteins that regulate each other with surprising complexity, potentially leading to treatments for some forms of infertility and fighting aggressive cancers. The discovery could also inform precision medicine treatments for certain types of aggressive cancers.
A study published in Human Reproduction found that accounting for cellular variability in endometrial gene expression profiles improves the accuracy of biomarker discovery. This approach can increase IVF success rates for couples who have experienced repeated IVF failure.
A new study by Lancaster University highlights the issue of men's invisibility in fertility research, particularly in low- and middle-income countries. The study found that surveys like the Demographic and Health Surveys often exclude or unfairly represent men's experiences, leading to gender inequalities.
A population-based cohort study found that boys with undescended testes had a 2.4 times increased risk of adult testicular cancer compared to unaffected boys, as well as a 20% lower chance of paternity and higher use of assisted reproductive technologies for infertility.
New guidelines and resources have been published globally to address the complexities of Polycystic Ovary Syndrome (PCOS), affecting up to 13% of reproductive-age women. The initiative aims to improve diagnosis, treatment, and health outcomes for women with PCOS.
Recent studies suggest a potential relationship between air pollution and infertility, menstrual irregularity, uterine fibroids, and endometriosis. Researchers emphasize the need for further exploration of these findings to support policy guidelines on air pollution and human health.
Men treated with ICSI for infertility have a significantly higher risk of developing early-onset prostate cancer, which is considered more aggressive. The study found that this risk is associated with male sub-fertility, not the ICSI procedure itself.
A study at the University of Toledo identifies a new centriole in human sperm that functions in zygotes, potentially contributing to male infertility and early embryo developmental defects. The research provides new avenues for diagnostics and therapeutic strategies.
A new study found that combination CC+AZ therapy is safe and effective for patients with elevated estradiol or low testosterone/estradiol ratios. The treatment improves testosterone levels and reduces estradiol levels by lowering conversion of testosterone to estradiol.
The prevalence of twin births in PRE horses is higher than previously thought, with 14 documented cases. Chimerism was found to be associated with twin births but not linked to infertility, contrary to previous studies.
A recent study published in Human Reproduction found that women who consume more fast food and less fruit take longer to become pregnant. The research, which analyzed data from over 5,500 women, suggests that a diet rich in fruits and low in fast food can improve fertility and reduce the time it takes to get pregnant.
A study by researchers at the University of Adelaide found that women who eat less fruit and more fast food take longer to get pregnant. The study also showed that a diet rich in fruits can improve fertility and reduce the time it takes for women to conceive.
Chemotherapy-induced DNA damage triggers apoptosis in oocytes due to p63 activation. Researchers found that inhibiting specific enzymes can prevent this process, offering new hope for fertility preservation.
A study published in Fertility and Sterility found that infertility is significantly associated with a shorter gestation and diminished birth size. Infertile women's infants weighed less, were shorter, and had smaller head circumferences compared to non-infertile women.
A protein called ZFP36L2 is essential for eggs to complete normal development and fertility. Female mice lacking this protein in their eggs are infertile due to a failure in global transcriptional silencing.
Research suggests that women with unexplained infertility have higher levels of a hormone stimulating the thyroid gland, negatively impacting their ability to conceive. The study found nearly twice as many women with unexplained infertility had elevated TSH levels compared to those with known infertility causes.
A new study by Lancaster University reveals that marginalized groups are often excluded from fertility data due to biases in survey design and sampling. This exclusion can lead to unequal access to reproductive healthcare and misguided policies.
A new study led by researchers at the University of Pennsylvania School of Medicine found that vitamin D deficiency may be a key factor for pregnant women with polycystic ovary syndrome (PCOS) getting pregnant. The research revealed that women with PCOS who were vitamin D deficient had a 40% lower chance of achieving a pregnancy compar...
Women with a history of infertility have a 10% increased risk of death compared to those without reported infertility struggles. Infertility is also linked to an increased risk of breast cancer and diabetes mortality, highlighting the need for further research into the long-term effects of infertility on women's health.
A new law in Rhode Island requires coverage for fertility preservation prior to gonadotoxic medical therapy. The authors of the perspective published in NEJM recommend revising existing non-infertility-related mandates or establishing a separate definition for fertility preservation, which could encourage other states to follow suit.
A new NIH-funded study finds that biomarkers for ovarian reserve do not predict fertility in older women attempting to conceive. Hormone levels linked to menopause onset were also found to have no association with conception rates.
Clomid's development and impact on assisted reproduction are celebrated in a new paper at Brown University. The drug has helped millions of people conceive, making it one of the globe's essential medicines.
A study by Case Western Reserve University researchers has identified long non-coding RNAs that play a critical role in orchestrating sperm development. The lncRNAs help regulate various stages of sperm development and are found exclusively in the testes, suggesting they could be used to develop novel infertility drugs.
Researchers reprogrammed cells carrying an extra chromosome in mice, resulting in the loss of the extra chromosome. This technique, known as trisomy-biased chromosome loss, successfully generated fertile offspring and offers a potential solution to infertility related to extra chromosomes.
Researchers identified a new genetic mutation that prevents sperm production in five men from a single Bedouin family. The mutation inactivates the function of the gene TDRD9, which normally protects full DNA sequence in sperm, leading to azoospermia.
A large nationwide study involving over 40,000 women found that fertility treatment does not increase the risk of divorce. The study, which followed couples for 16 years, revealed that the majority of couples had children with their baseline partners and around one-fifth ended up separated or divorced.
A study has shown that an inexpensive fertility drug can be just as effective as more recent reproductive hormones in treating unexplained infertility. The 50-year-old drug, taken orally, was found to have a comparable pregnancy rate to newer hormones used in intrauterine insemination (IUI) with ovarian stimulation.
A new study found that long-term exposure to noise above 55 dB, equivalent to a suburban street, is significantly linked to male infertility. The researchers analyzed data from 206,492 men and found that those exposed to higher levels of noise had a greater chance of being diagnosed with infertility.
Two studies published in JAMA found that electroacupuncture improved symptoms of stress urinary incontinence, with effects persisting beyond treatment. However, acupuncture did not increase the likelihood of childbirth among women with infertility, suggesting further research is needed to understand its long-term efficacy.
A study by University of Illinois Chicago sociologist finds that parental infertility is associated with lower test scores and grade point average at age 16. The research suggests a cumulative physical and social experience of infertility affecting child outcomes beyond the point of birth.
A new study from the University of Pittsburgh reveals that nearly 40% of reproductive-aged women in the US have limited or no nearby access to assisted reproductive technology clinics. This leaves 25 million women without choice and adds to their already stressful experience.
A new study from Lancaster University finds that infertility is strongly linked to an increased risk of relationship disruption in Ghana. Women with infertility are more likely to experience relationship breakdown, particularly those in polygynous relationships.
Researchers develop Markov model to provide personalized information for women undergoing infertility treatment, considering factors like age, body weight, and AMH blood levels. The model can be updated in real-time and translated into a physician-friendly app.
A new model estimates the number of eggs a woman should freeze based on her age and family-building goals, providing data-driven guidance for women considering elective egg freezing. The model considers maternal age by individual year and incorporates the likelihood of embryo development to result in a live birth.
A study revealed that it takes two years or more for one-third of women with PCOS to receive a diagnosis, highlighting the need for improved education and support. The authors call for international guidelines and resources to improve diagnosis experience and health outcomes for women with PCOS.
Fertility preservation for girls and young women with cancer is hindered by lack of awareness and funding. Despite guidelines, access to treatment is restricted due to variable oncologist awareness and conflicting funding policies.
A recent survey found that men generally lack awareness of risk factors contributing to male infertility, with only about 50% identifying potential dangers. This lack of knowledge can lead to devastating psychological impact and stress on relationships, emphasizing the need for public education to promote reproductive health among men.
Researchers are developing a system using phase-contrast imaging and mathematical analysis to identify the best-fitting sperm, leading to improved fertility treatment decisions. This new approach aims to reduce distress and expense associated with infertility treatments like IVF.