Professor Lillian Siu receives TAT 2020 Honorary Award for her contributions to early drug development and phase I trials in head and neck malignancies. She advances the field of cancer drug development with innovative clinical trial designs and methodologies.
Researchers at Mass General Hospital identified Argonaute 4 as a key protein protecting cells against viral infections. Boosting levels of AGO4 could provide protection against multiple viruses, and the study aims to understand how the immune system works to create treatments that target various viruses.
A new blood test uses a carbon nanotube-based sensor to detect Alzheimer's disease with high accuracy, measuring key biomarkers in human plasma. The test achieved an average sensitivity of 90.0% and selectivity of 90.0%, outperforming conventional biosensors.
Researchers at KAIST have discovered mechanisms that fuel a 'domino effect' in cancer drug resistance, enabling failed responses to paclitaxel to speed up the evolution of resistance to other drugs. The study suggests a new strategy for improving second-line cancer treatment.
A study from Karolinska Institutet found that a combination of markers, including frailty and the epigenetic clock, can predict health risks and mortality. The researchers followed 845 middle-aged and elderly participants over 20 years, revealing associations between these markers and increased risk of early death.
A systematic review from George Washington University finds that telehealth interventions can lead to improved health outcomes in low-risk obstetrics, family planning, and gynecologic conditions. Text messaging and remote monitoring are identified as key components of effective telehealth interventions.
Researchers at Drexel University have found a way to destroy toxic compounds, ominously dubbed 'forever chemicals,' that have contaminated the drinking water of millions across the US. The team uses a blast of charged gas, called cold plasma, to eliminate PFAS from water without heating it up.
Researchers discovered that bush-crickets' ear canals work similarly to mammals' ears, amplifying sound and modulating pressure. This breakthrough could lead to the development of better acoustic sensors for human use, enhancing directional hearing and monitoring applications.
Researchers at RMIT University found that microglia cells can be activated to boost memory performance in rats by up to 50%, reversing damage caused by neuroinflammation. This discovery could lead to the development of new treatments for cognitive decline and dementia.
A recent study examined changes in heroin use and addiction among US adults over 16 years. Heroin use disorder increased significantly between 2002 and 2018, affecting approximately 800,000 adults in the country.
UMass Lowell researchers develop germ-killing fabric with N-halamine, reducing risk of drug-resistant bacteria and hospital-acquired infections. The fabric can be recharged through bleach washing, extending its effectiveness.
Michigan State University research found that optimistic partners contribute to their spouses' health, staving off cognitive decline and Alzheimer's disease. Couples who share healthy habits and positive memories together experience improved well-being.
A new review in the Canadian Medical Association Journal suggests an association between excessive smartphone and social media use and mental distress among adolescents. The authors provide guidance for physicians, parents, and teachers on how to help teens achieve a healthy balance between device use and other aspects of their lives.
A study found high levels of toxic metals in a Himalayan glacier dating back to the late 18th century, indicating human activity's impact on the atmosphere began during the Industrial Revolution. The research suggests that coal emissions from Europe traveled over 6,400 miles to contaminate the glacier.
A recent study by Saarland University researchers identified a potential causal relationship between statin use and muscle pain. Statins are found to increase the production of the GILZ protein, which impairs muscle cell function, leading to increased muscle cell death and inhibition of muscle fiber formation.
Scientists warn that humanity is pushing ecosystems beyond recovery, leading to unquantified insect extinctions. To mitigate this, experts suggest setting aside land for conservation, transforming agricultural practices, and communicating with civil society and policy makers.
A new approach to electrostatic layer deposition has been reported, leading to efficient perovskite solar cells. The technique produces uniform electron transport layers without the need for a vacuum environment, enabling the creation of high-efficiency solar cells with improved power-conversion efficiencies.
NASA measured heavy rainfall around Tropical Storm Uesi's center and in a large band of thunderstorms, triggering warnings for Vanuatu. The heaviest rainfall was falling at 1.2 inches per hour near the center, while a large band of thunderstorms experienced rainfall rates of up to 1 inch per hour.
A recent study explored how some mammals postpone embryonic development to await better conditions. The research, led by Abdiasis Hussein, advances understanding of delayed embryo implantation and suggests a link to rapidly dividing cells in tumors.
Dr. Toriumi discusses the complexity of nasal tip contouring and recommends learning from each case to improve outcomes. He highlights the importance of structural grafting for a better long-term aesthetic and functional outcome.
Research found that middle-aged and young-old women tend to consume alcohol at levels exceeding low-risk guidelines. They prioritize appearing respectable and in control over the quantity of alcohol consumed. Health advice needs to acknowledge that women may socially construct their drinking practices to focus on non-biomedical impacts.
A European Union-funded project is using guided conversations with older adults in rural areas to identify their needs and create innovative solutions. By empowering older people, the project aims to revitalize rural communities and address issues like isolation and loneliness.
A functional MRI study found that social anxiety characterized by fear of making others uncomfortable is associated with weakened connectivity in the cognitive-empathy brain network. This suggests impaired cognitive processing during embarrassing situations may contribute to social anxiety.
Researchers have identified similarities between canine and human gliomas, including genetic mutations and immune system features. These findings suggest that studying dog brain tumors may provide insights into human glioma treatments, particularly in children.
A national trial has produced a computer that can accurately predict which antidepressant will work for patients based on their brain activity. This breakthrough may lead to personalized depression treatments using AI and brain imaging.
Scientists found that periodic changes in Earth's orbit and volcanic activity controlled the global carbon cycle during ancient mass extinctions. The study suggests that solar system processes had a significant impact on climate and environmental change over 200 million years ago.
Researchers at the University of Seville have identified new factors necessary for repairing chromosomal breaks that can cause cell death. The discovery involves proteins modifying histones, which are essential for chromosome structure and cohesion.
A study of carbon-isotope data from a Welsh mudstone core reveals anomalies consistent with orbital cycles of approximately 405,000 years. These findings indicate that the marine carbon cycle is particularly responsive to such astronomical signals.
Researchers created 3D human gut organoids from patient cells to simulate leaky gut conditions, revealing new biomarkers and a potential pathway for tightening the gut lining. The study found that the diabetes drug metformin strengthens the junctions of mini-guts, increasing occludin levels up to six-fold.
A team of researchers at Georgia Institute of Technology has engineered a new chip that cultures the human blood-brain barrier in 3D, allowing astrocytes to function naturally. This improves the model's accuracy and opens possibilities for reliable research of the human blood-brain barrier.
The Cross-Border Science Journalism Project will award financial support to a team of Latin American science writers to produce a cross-border environmental investigative project. The project will be published in Spanish by media partners in Latin America and in English by U.S. media partners.
A global distribution map of fish genetic diversity has been created, revealing uneven distribution across marine and freshwater species. Temperature plays a key role in shaping genetic diversity among marine fish, while habitat complexity and changes over time are crucial for freshwater species.
According to new research, Gulf coast mollusks were able to survive past periods of climate change, including the Paleocene-Eocene Thermal Maximum (PETM), which warmed the planet by 9-14 degrees Fahrenheit. The study suggests that these resilient communities may adapt again to today's climate change.
Elective egg freezing is a common method to increase pregnancy chances at a later age. Patients under 35 with normal ovarian reserve have the best chance of success, but future live births are not guaranteed. The treatment process takes 10-14 days and fees are not covered by Canadian government health insurance.
A petition to the FDA suggests that ED drug labels should recommend a plant-based diet to prevent artery disease and its related risks, including heart attacks, strokes, and early death. A recent meta-analysis found that men with ED have a higher risk of coronary heart disease and stroke compared to those without symptoms.
A new quantum process tomography method based on convex optimization effectively characterizes quantum channels, revealing their true action with high accuracy. The method demonstrates excellent performance in both unitary and non-unitary quantum channels, achieving up to 99.5% accuracy.
A large study found daily exposure to ground level ozone in cities worldwide is associated with an increased risk of death. The study suggests that more than 6,000 deaths each year could be avoided if countries implemented stricter air quality standards.
Astrocytes, a type of cell that supports motor neurons, play an important protective role in the early-stages of sporadic motor neuron disease. When close to motor neurons, these cells help rescue them from misfolded protein TDP-43.
A new study found that biomarker MOG antibodies can accurately diagnose life-threatening autoimmune conditions in children, leading to complete or near-complete recovery after appropriate treatment. The study involved 535 children with central nervous system demyelinating disorders and encephalitis.
The Penn State team aims to create a handheld device that can quickly and cheaply detect evolving viruses in the field using data science and machine learning. The device will utilize laser technology to capture vibrations on the surface of viruses, tracking minute changes to differentiate between emerging strains.
A German research team has identified bony fish as particularly sensitive to climate change, with snails and oysters being less threatened. The study combines fossil data with experimental studies, providing a basis for future collaboration and more precise predictions of species extinction.
Researchers developed a computational model that maximizes economic return on anaerobic digestion systems, accounting for uncertainty and key factors such as farm size and species. The model identifies optimal locations, capacities, and service areas to generate profit from farm-based sustainable energy projects.
A handheld spectrometer has been developed to determine THC levels in cannabis plants, enabling farmers and law enforcement to quickly identify whether a plant is hemp or marijuana. The test distinguishes between various hemp and marijuana varieties with high accuracy.
Researchers develop enhanced device to transform CO2 into valuable chemicals by harnessing electricity. The new design enables gas reactants to reach the catalyst surface fast enough to significantly increase the rate of reaction.
Researchers have developed a wireless, battery-free device that can observe the brain at the single-neuron level, allowing for better understanding of neural interactions. The device uses light to record individual neurons, capturing changes in brightness depending on activity, and transmits information wirelessly.
A study found records of 23 trace metals in an ice core from the Dasuopu glacier, accumulating since 1499 and peaking during winter and spring. The onset of human impact on the Himalayas is unclear due to limited ice core records, but evidence suggests anthropogenic activity may have started around 1780.
A new study called DELIVER will enroll 750 healthy, HIV-negative pregnant women to test the safety of two HIV prevention methods: a monthly dapivirine vaginal ring and daily Truvada. The study aims to provide much-needed information about these products' safety in pregnant women, an area currently lacking in data.
A review of evidence published in The BMJ found that smartphone apps assessing mole risk cannot detect all skin cancers. While AI-powered apps offer potential for earlier detection and treatment, limitations and variable performance indicate insufficient promise to recommend their use.
Nicholas Jakubovics, a renowned oral microbiologist, has been appointed as the new Editor-in-Chief of the Journal of Dental Research. With over 20 years of experience studying dental plaque formation and extensive editorial expertise, he is poised to lead the journal to new heights.
A new study reveals that tropical cyclones can create drying effects in the Maritime Continent due to induced zonal wind anomalies. Observational data shows that these events decrease precipitations in the region not directly affected by typhoons, highlighting their role in regional climate patterns.
A study found a significant association between low maternal vitamin D levels during early to mid-pregnancy and an increased risk of diagnosed attention-deficit/hyperactivity disorder (ADHD) in children. The research used the Finnish Maternity Cohort, which included 1,067 children with ADHD and their matched controls.
Researchers created a field-effect transistor with a diameter of two nanometers using tellurium and boron nitride nanotubes. The material's unique structure allows for smaller transistors, which could lead to faster computing and reduced power consumption.
Researchers successfully measured the full quantum geometric tensor in a solid-state spin system using coupled qubits in diamond. The technique enables precise measurement of the tensor's matrix elements, including Berry curvature and Riemannian metric.
Researchers from Dartmouth College used an acid-loving microbe to improve the accuracy of past climate records by studying its response to food and energy availability. The findings suggest that factors other than temperature can influence the membranes of single-celled archaea, adding complexity to paleoclimate studies.
A Boston University School of Public Health study found that LGBQ teens face high rates of attempted suicide, despite a doubling in identification from 2009 to 2017. The proportion of LGBQ teens attempting suicide remained nearly four times the rate for straight peers.
Physicists at HZB discovered a non-ferromagnetic phase in U2Pd2In crystals under high magnetic fields, with a structure containing 80 magnetic moments. The finding may help develop more precise theories for 5f electron systems and has implications for many other materials.
Researchers have discovered that atomic quantum fluctuations stabilize the record-breaking superconductor LaH10, enabling superconductivity at much lower pressures than previously expected. The study reveals a highly symmetric structure with a single minimum energy landscape, contrary to classical predictions, which could lead to high-...
Cancer cells can change their developmental identity, enabling them to spread and evade the immune system. Researchers identified specific cell types involved in lung development that are also present in cancer metastases.
Researchers at University of Groningen develop novel artificial enzyme using unnatural amino acid and copper complex, demonstrating potential for improved industrial chemical catalysis. The study showcases the power of combining abiological components to achieve active site creation, paving way for new enzymatic options.
A study by Kloft et al. found that cannabis use increases susceptibility to false memories and misinformation in mock crime scenarios. This research has significant implications for the questioning of cannabis-intoxicated eyewitnesses and suspects during investigative interviews.