Eternygen presents preclinical study data demonstrating INDY inhibition reverses nonalcoholic steatohepatitis (NASH) in a diet-induced mouse model. The treatment also reduces liver injury and inflammation.
A study from George Washington University found that apolipoprotein A-I binding protein (AIBP) inhibits HIV-1 replication by targeting lipid rafts and reducing virus-cell fusion. This innate immunity factor provides a novel target for developing new therapeutic approaches to inhibit HIV infection.
Researchers have discovered a new material that could lead to the creation of even smaller transistors, enabling faster computing and lower power consumption. The material, shaped like a one-dimensional DNA helix, is made from tellurium and can be encapsulated in nanotubes to build functional transistors.
Intranasal insulin-like growth factor-1 (IGF-1) treatment reduces trigeminal pain pathway activation and oxidative stress levels in a rat model of migraine. The therapy has a unique potential to safely prevent migraine headaches through multiple novel mechanisms.
Scientists at Inserm have cultivated human cells in the lab to produce extracellular matrix deposits high in collagen, which can be woven into yarn to replace damaged blood vessels. This biologically derived material is expected to be well-accepted by the body and could lead to clinical trials.
A new study by Purdue University researchers found that a family history of alcoholism can alter the brain's ability to switch between active and resting states. The brain reconfigures itself after completing a mentally demanding task, but those with a family history of addiction may not experience this process.
A global initiative aims to harness digital data and wearable technologies to detect neurodegenerative diseases like Alzheimer's. The project, backed by Bill Gates and £100m investment goal, will develop 'fingerprints' of disease that can be detected early.
A phase 2/3 clinical trial evaluating two investigational drugs for their ability to slow memory loss and cognitive decline in people with a rare, inherited form of Alzheimer's disease did not meet its primary outcome. Despite disappointing results, the researchers continue to explore data from the trial's cognitive and clinical outcomes.
Scientists at the University of Münster demonstrated energy quantization in nanowires made of high-temperature superconductors, enabling simplified cooling technology and longer lifetimes for resonators. This breakthrough paves the way for new experimentally verifiable theoretical descriptions and technological developments.
A new study suggests that scaling up cervical cancer screening coverage in the US to 90% can expedite elimination of the disease and avert more than 1,000 additional cases per year. Increasing HPV vaccination coverage also plays a critical role in reducing cervical cancer burden.
Tropical cyclones have a drying effect on the Maritime Continent, exacerbating dry seasons. Forecasting tropical cyclone activity can improve predictions for this region's circulation patterns.
Researchers from Ruhr-University Bochum successfully detect protein structures in Escherichia coli bacteria using EPR spectroscopy and nanobodies. They can measure distances between proteins within native membranes, opening up new possibilities for studying membrane protein dynamics and functions.
New research at CCNY suggests that carbon gases released by ancient volcanoes do not match geochemical clues of past mass extinctions, implying an unknown factor drove these events. The study provides insights into Earth's climate and how volcanic CO2 release affects the planet.
A global surveillance system for antimicrobial resistance can be established through genomic analysis of sewage, providing valuable information about the types of bacteria present in specific areas. This approach has great potential as a tool for monitoring diseases and managing outbreaks globally.
A new study estimates that improving handwashing rates by travelers passing through just 10 major airports could significantly reduce the spread of many infectious diseases. The findings suggest that focusing handwashing messaging in these 10 airports could potentially slow the disease spread by as much as 37 percent.
A young student at DTU Space has demonstrated that global sea level rise has accelerated over the past four decades using data from European satellites. The new research supports previous studies and provides a more comprehensive picture of the global rise in sea levels.
Researchers found long guns were used more often in suicides by kids and teens than adults, particularly in rural counties. Rifles were also used during hunting season, increasing by 60%. Adopting safety measures for rifles or shotguns may prevent suicides.
Three finalists, Humanitarian OpenStreetMap Team, Field Ready, and Hala Systems, will receive $3.7 million to develop innovative solutions for humanitarian crises caused by conflict. The projects aim to provide accurate maps, essential items, and early warning systems to help vulnerable populations.
Scientists have developed a new model to predict the speed of epidemics in networks, providing insights into the trajectory and rate of global spread. The analysis assesses each node's likelihood of infection by a certain time, enabling more accurate forecasting of epidemic dynamics.
A research team at Pohang University of Science & Technology (POSTECH) has developed a new type of polymer ionic conductor that can be stretched and crumpled by water. This innovation enables the creation of stretchable thermometers that can measure body temperature with simple contacts, such as wearing clothes or shaking hands.
Researchers applied the 40Ar/39Ar dating technique to young volcanoes in southeastern Australia, providing independent age constraints for sites older than 10,000 years. The study reveals that oral traditions surrounding volcanic activity may be among the longest-lived in the world.
A team of researchers used a virtual unrolling technique to analyze a lithium battery's electrode layers, revealing unseen trends in performance degradation. By combining X-ray and neutron tomography with a mathematical model, the team gained a fuller understanding of how the battery works and how it degrades over time.
The DELIVER trial examines the safety of PrEP and a dapivirine vaginal ring in pregnant women, providing critical data for HIV prevention choices. The study will enroll 750 healthy, HIV-negative women aged 18-40 years and assess the acceptability and feasibility of these tools.
Researchers at Tokyo Institute of Technology and Socionext Inc. designed the smallest all-digital PLL, reducing area, power consumption, and jitter while achieving best performance. The synthesizable PLL is commercially viable for 5 nm semiconductors, crucial for cutting-edge applications like AI and IoT.
A recent study found that diabetes prevalence is higher among First Nations people and women, particularly those of reproductive age. The gap has narrowed over time, but the risk factors persist. Understanding these determinants is crucial for effective prevention and management strategies.
A team of researchers from Harvard SEAS has designed deployable dome using bistable joints linked by rigid bars, demonstrating the potential for morphing surfaces, reconfigurable devices, and controlled energy absorption
Researchers at University of Tsukuba found that tumor cells produce a protein called soluble CD155 to disable the immune system in mice. Soluble CD155 prevents NK cells from releasing toxic proteins to cancer cells by binding to DNAM-1, allowing tumors to grow and spread.
A study in mice reveals that new nerve insulation, myelin, plays a critical role in laying down long-lasting emotional memories. Increased myelin formation is necessary for the consolidation and maintenance of fear memories, which could lead to new treatments for post-traumatic stress disorder.
Researchers developed a mechanical linkage containing bistable joints that can transform into stable, locked curves through state-transitioning wave propagation. The approach enables the creation of deployable 3D structures of arbitrary shapes with potential for larger-scale applications.
The one-child policy increased women's educational attainment, helping to close the gender gap. Women's delayed entry into parenthood allowed them to pursue more education.
A signaling molecule, c-di-GMP, initiates a clock-like mechanism in bacteria that determines individual reproduction. The molecule activates enzymes called kinases, which prepare the cell for division under favorable living conditions.
A new study found that a cancer education intervention improved cancer literacy in middle and high school students in Kentucky by 30%. The study's results highlight the importance of providing cancer education material to vulnerable populations like young students, who are at risk for developing unhealthy behaviors.
A new study by researchers at the University of Washington found that increases in minimum wages had no overall effect on the health of working-age people. However, they did find a mix of negative and positive effects associated with the health of certain subgroups, including increased obesity rates among working-age people of color.
A new study shows that female dolphins in southern Australia form social clusters with mothers' groups, while maintaining loose bonds with same-sex individuals. The research highlights the importance of conservation efforts to protect marine sanctuaries and regulate aquaculture and fishing practices.
Researchers at the University of Oxford have identified six previously unknown cell types in human Fallopian tubes using single-cell RNA sequencing, which may lead to a screening tool for ovarian cancer. The discovery sheds new light on the complexity of ovarian cancers and could lead to personalized treatments.
A study by UC Davis Health researchers found that a Western diet rich in fat and sugar can induce inflammatory skin diseases like psoriasis. The diet's components, rather than obesity, may lead to skin inflammation and its development.
University of Kansas researcher Jorge Sobero'n proposes a new method for calculating the correlation between geographic space and species numbers, refining the species-area relationship. The Grinnellian-niche approach accounts for factors beyond area size, such as temperature and environmental conditions.
A study by NIH researchers found that higher maternal blood pressure during pregnancy is associated with chemical modifications to placental genes, including DNA methylation. The findings suggest a potential link between early origins of cardiovascular disease and high blood pressure in pregnancy.
Researchers at UC San Francisco, UNC and UB have discovered novel melatonin receptor molecules that can modulate circadian rhythms. These molecules attach to the MT1 melatonin receptor with high selectivity, generating cellular responses opposite to those of melatonin.
The MSTARS consortium aims to further develop mass spectrometry technology for clinical application and detection of treatment resistance in various diseases. By combining expertise in mass spectrometry, patient care, and data analysis, the team hopes to improve precision medicine and tailor treatments to individual patients.
Scientists at Michigan Technological University created nanowires made of tellurium and boron nitride nanotubes, which hold promise for wearable tech. The new material exhibits strong electrical properties and can be controlled by light and pressure.
A 100-plus page report presents a vision for the strategic path to unleashing AI's full potential, with applications in healthcare, education, business innovation, and more. The roadmap aims to address the tremendous social change that will result from AI research.
Researchers at Penn State are using a $2.8 million NIH grant to explore 3D bioprinting for craniomaxillofacial reconstruction. They will investigate bioprinting bone, skin, and other tissues directly during surgery to correct defects in the face, mouth, and skull.
A new study led by the University of Sydney has found that common medication can reduce the risk of heart attack during early bereavement. The research used a low daily dose of beta blockers and aspirin to mitigate cardiac risks without affecting grief, with reduced levels of anxiety persisting even after stopping treatment.
Researchers at City College of New York developed a hydrogenation process that bypasses external hydrogen gas sources, reducing safety risks and costs. The new method has potential applications in undergraduate chemistry labs and medicinal fields.
Researchers found that urban sustainability rankings neglect complex causalities and lack transparency in data gathering, weighting, and aggregation processes. The study analyzed 21 similar rankings, indexes, and tools to identify methodological weaknesses and called for caution when using these tools.
Researchers found that bats' unique immune response drives viruses to replicate faster, making them deadlier in humans. The study suggests that disrupting bat habitats could increase the threat of zoonosis.
The Desarc-Maresanus project uses an alkalinization process to counteract ocean acidification and remove CO2 from the atmosphere. The study found that dispersing calcium hydroxide on the surface of the sea could make it possible to halt the trend of ocean acidification, making it a promising solution to combat climate change.
A new study found that higher genetic testosterone levels increase the risk of type 2 diabetes by 37% in women and reduce it by 14% in men. Similarly, higher testosterone levels increase the risk of breast and endometrial cancers in women and prostate cancer in men.
Scripps Research scientists have developed a 'warp drive' method to create unique 3-D structures resembling those found in nature, which can lead to more effective medicines. The technique has potential applications for treating inflammatory diseases and may help identify new drug leads.
A study published in Psychological Science found that people who help strangers are generally viewed as morally better and more trustworthy than those who help family members. However, this judgment changes when the helper has to choose between helping a stranger or a family member. The researchers suggest that familial obligations pla...
A new machine learning algorithm, SELSER, has been developed to analyze EEG data and predict individual treatment response to sertraline. The study found that specific brain signals, such as alpha waves, recorded when participants had their eyes open, can reliably identify people likely to benefit from the medication.
Researchers estimate that more than half of African mothers have experienced the death of a child under age five, and nearly two thirds have experienced any child's death. This study highlights the burden of bereavement as a public health threat in low-income regions.
A novel vaccine called Triplex reduced CMV complications by half and induced immunity in patients undergoing allogeneic hematopoietic stem cell transplant. No vaccine-associated safety concerns were identified in the phase 2 randomized clinical trial.
A new research review argues that societal adaptation to climate change should focus on collective action and systems-level thinking, rather than individual coping strategies. The authors propose transformational change to ensure society's resilience in the face of increasing hazards.
Researchers have elucidated the mechanisms that mediate the establishment of epigenetic histone modifications following cell division. The team found that methylation patterns influence each other and are associated with specific regions of the genome, known as domains.
Research suggests that inflammation-related genes are associated with biobehavioral factors like body mass index and smoking, while interferon-related genes are linked to individual demographic factors such as sex and race/ethnicity. The study's findings could help explain social disparities in chronic diseases that emerge decades later.
Researchers at Rutgers University have developed a new 'bio-ink' for 3D printing that can serve as scaffolds for growing human tissues. The ink combines modified hyaluronic acid and polyethylene glycol to form a gel with controlled stiffness and binding sites for cells, enabling precise tissue growth and repair.
A new study published in The Journal of Urology found that most patients who underwent prostate cancer surgery experienced low levels of decision regret. Patients who played a more active role in treatment decision-making were less likely to experience regret about their choices, regardless of whether they opted for robot-assisted or o...
A single dose of the human papillomavirus (HPV) vaccine is as effective as multiple doses for preventing preinvasive cervical disease, which can later develop into cervical cancer. The risk of preinvasive cervical disease was lower in adolescents who received one, two, or three doses of the HPV vaccine compared to unvaccinated teens.