Articles tagged with Liver Cancer
Researchers analyzed clinical data from 11 liver cancer patients who underwent caudate lobectomy using specific skin incision, mobilization of liver, vascular exclusion, and ideal hepatectomy procedures. The study demonstrates that caudate lobectomy for cancer in the candate lobe can be safely performed with an appropriate procedure.
Combining stents and photodynamic therapy significantly improves survival rates for patients with advanced liver bile duct cancer, increasing it from 7 months to over 16 months. The treatment's effectiveness is attributed to the number of stent-replacement procedures and PDT sessions.
Researchers at Penn School of Medicine have developed a targeted therapy combination that overcomes treatment resistance in liver cancer by combining sorafenib with the TRAIL pathway. This combination restores sensitivity to cell death and kills cancer cells, offering new hope for patients.
Researchers have found that increasing SULF2 expression enhances cancer cell growth and migration, while decreasing it reduces both. The study suggests that blocking SULF2 may lead to an effective treatment for liver cancer and potentially other types of cancer.
A randomized controlled trial found that combining TACE and RFA therapies resulted in longer survival times for patients with large liver cancer tumors. The therapy improved survival by slowing tumor progression and blocking the blood supply to the tumor.
A new clinical trial at Thomas Jefferson University aims to test the effectiveness of radioembolization using radiation-emitting beads in treating advanced liver cancer. The treatment, which blocks blood supply and emits targeted radiation, has shown promise in shrinking tumors and improving patient survival.
Researchers at Georgetown University Medical Center have discovered both normal and abnormal liver stem cells, which may provide a new target for experimental treatment. The study found that blocking the stat3 gene was effective in preventing liver cancer in mice, opening up new possibilities for treating this devastating disease.
Research suggests that Acanthus ilicifolius, a popular Indian medicinal plant, can prevent hepatic DNA alterations and sister-chromatid exchanges in tumor-bearing mice. The study also showed that ALE treatment was able to limit liver metallothionein expression and lengthen the mean survival of animals.
A study by MIT researchers reveals that genetic differences between males and females contribute to the higher incidence of liver cancer in men. The research suggests that chronic inflammation and male sex hormones play a role in this increased risk.
A study published in Clinical Cancer Research demonstrates that a novel mass-spectrometry based proteomic profiling method is more accurate than traditional biomarkers in distinguishing liver cancer patients from patients with hepatitis C liver cirrhosis. The technique, SELDI-TOF MS, identified an 11-protein signature that accurately d...
Dr. Lars Zender receives grant to continue identifying new tumor suppressor genes in liver cancer using advanced sequencing technologies. His groundbreaking research at CSHL has the potential to shift the paradigm in cancer treatment.
Researchers found that silibinin reduces cancer cell proliferation and enhances programmed death of cancer cells, making it a potential treatment option. The study also suggests that other herbal supplements may have similar anti-tumor effects, warranting further investigation.
Research reveals ultraconserved non-coding RNAs may play a role in cancer development and could help diagnose the disease, determine prognosis, and even guide treatment. The study found specific activity patterns for these molecules in different types of cancer, suggesting they might serve as genetic markers.
Postmenopausal women consuming two or more alcoholic beverages daily may double their risk of endometrial cancer, according to a USC study. The study found that lean women are more sensitive to alcohol's effects on hormone levels, increasing their cancer risk.
Researchers found that taking vitamins and minerals did not reduce liver cancer death rates in a study conducted by the National Cancer Institute. However, some vitamin-mineral combinations reduced risk in subgroups defined by age, sex, and alcohol consumption. In contrast, gene expression patterns identified 11 genes in noncancerous l...
Research reveals how microRNA miR-21 helps cancer develop by blocking tumor-suppressor gene PTEN. High levels of miR-21 are found in many kinds of cancer cells, providing a potential marker for patient prognosis.
Researchers developed a new treatment for liver cancer using a monoclonal antibody targeting PDGFRá. The antibody significantly reduced tumor cell proliferation and increased programmed cell death in human and mouse liver cancer cell lines.
Eating uncooked fish dishes is associated with an increased risk of developing cholangiocarcinoma, a type of liver cancer caused by the SE Asian liver fluke Opisthorchis viverrini. In Thailand alone, 6 million people are thought to be infected with the parasite.
Research at University of California, San Diego reveals that male mice produce more IL-6 in response to liver injury, leading to a higher incidence of liver cancer. The study suggests therapies targeting IL-6 production or estrogen-like compounds may reduce liver cancer risk in males.
Researchers at Georgetown University Medical Center have found a new molecular mechanism that may cause spontaneous liver cancer, but also identified a potential cure. By reintroducing the ELF gene to cancer cells, proteins driving cell division and growth can be kept in check, suggesting an effective new therapy.
A prospective study found that aspirin use was associated with lower risk of cancer incidence and mortality, particularly among former and non-smokers. In contrast, integrin α7 gene mutations were identified in various cancers, including prostate and liver cancer, suggesting a potential role in cancer development.
A new treatment, Sorafenib, has been shown to increase overall survival by over 40% in patients with advanced liver cancer. The study, SHARP, involved 602 patients and found that Sorafenib delays tumor progression and improves survival.
Researchers have made significant advancements in diagnosing and treating chronic hepatitis C, with potential new markers for detecting liver cancer. Studies have also explored the role of autotaxin in linking hepatitis C to hepatocellular carcinoma.
A recent study has established a significant correlation between bile duct obstruction and the growth rate of bile duct cancer cells in animals. In fact, cancer cells in obstructed bile ducts grew up to five times faster than those without obstruction, leading to increased metastasis outside the liver.
A recent study found that colchicine significantly reduces the risk of developing hepatocellular carcinoma (HCC) in patients with hepatitis virus-related end-stage liver disease. Colchicine treatment delays HCC diagnosis by an average of 72 months and improves survival rates.
Scientists are exploring the health benefits of functional foods, including mandarin oranges which may reduce liver cancer risk and a new type of flour with enhanced antioxidants. Researchers have also developed a 'designer soybean' that boosts calcium levels and fights osteoporosis.
Researchers have developed a non-invasive method to detect bladder cancer using DNA found in urine, while a study suggests high pesticide exposure increases the risk of liver cancer. Additionally, a growth factor has been found to inhibit lung tumor metastasis by stopping blood vessel growth and breaking down specific proteins.
A study by UCSD researchers found that the absence of IKKƒÒ in hepatocytes leads to increased JNK activation after exposure to toxic chemicals, resulting in accelerated tumor development. Deletion of JNK1 gene prevented liver cancer, suggesting a critical role for this isoform in tumor growth.
Studies have shown that glycerrhetinic acid and glycerrhizic acid, found in liquorice, preferentially accumulate in the liver and can target tumors effectively. This could lead to improved treatment outcomes with reduced toxic effects on other parts of the body.
A study found that patients with advanced liver, gallbladder, and bile duct cancers who developed a skin rash while treated with lapatinib lived for an average of 10 months, compared to five months for those without the rash. The treatment was well-tolerated, with two patients experiencing partial responses to treatment.
Researchers discovered that blocking the Hedgehog pathway kills cancer cells while leaving healthy liver tissue intact. This finding offers hope for targeted treatments and diagnostic tests for liver cancer.
Researchers discovered a compound called CDDO-Im that protects against liver cancer at extremely low doses. The compound activates a protein called Nrf2, which stimulates the cell's defense mechanisms and detoxifies harmful agents.
Researchers at Johns Hopkins Bloomberg School of Public Health have developed a new compound, CDDO-Im, which shows strong protective effects against liver cancer. The compound works by activating Nrf2, a master switch that stimulates the cell's defense mechanisms and removes harmful chemicals.
Researchers found that a hepatitis C virus protein accelerates the breakdown of a critical tumor suppressor, leading to liver cell proliferation and increasing cancer risk. This discovery could lead to improved treatment strategies for patients with chronic hepatitis C.
Researchers at U-M found that focused radiation combined with chemotherapy significantly improves survival rates for liver cancer patients. The new method delivers an intensive punch directly to tumors while limiting exposure to normal tissue.
Research suggests that consuming broccoli sprouts daily can improve chronic bacterial gastritis and potentially prevent stomach cancer. The compound sulforaphane in broccoli sprouts also has been shown to have anti-cancer effects, including preventing skin cancers caused by sun damage.
Tulane University has received $4.1 million to continue its work on the President's Emergency Plan for AIDS Relief in several countries. The university will also conduct a five-year study on liver cancer due to liver fluke infection in Southeast Asia.
A study published in Nature Genetics indicates that loss of one copy of Plk4 is a major risk factor for primary liver cancer, increasing likelihood by half when enzyme levels are reduced. The research provides insight into genetic predisposition to hepatoma and implications for screening and early detection.
Scientists have found that the hepatitis B virus primes liver cells to turn cancerous by 'turning off' an enzyme called GSK-3ß, which normally suppresses tumor formation. This discovery has potential relevance for other cancers and could lead to novel therapeutic approaches, including gene therapy and small molecules.
A simple packaged intervention improved storage of groundnuts among farmers in Guinea, reducing aflatoxin levels by over half. The intervention significantly lowered disease burden related to the potent environmental toxin, which is associated with increased risk of liver cancer and impaired child growth.
Researchers have developed oncolytic viruses that can infiltrate and destroy tumor cells while leaving surrounding healthy tissue intact. These 'cancer-killing' viruses are being tested in patients with various tumor types, including melanoma, breast, head and neck, and colorectal cancer.
Researchers found that RF ablation was a safe and effective treatment option for early-stage liver cancer patients, with survival rates comparable to surgical resection. The procedure proved more successful with smaller tumors, offering a viable alternative for inoperable patients.
A study of 124 radiologists found that the accuracy of mammographic interpretation is more closely related to characteristics such as direct feedback and training than years of experience or volume. The study suggests that increasing volume requirements may not improve performance.
Researchers found that stronger, more flavorful onion varieties have higher antioxidant activity and can fight colon cancer cells more effectively. Shallots were also found to be strong cancer-fighters, outperforming milder-tasting onions.
Researchers at Université de Montréal found that diabetes patients are three times more likely to develop liver cancer and twice as likely to get pancreatic cancer. The study analyzed data from over 3,000 cancer patients and healthy individuals.
Researchers found a three-fold increased risk of liver cancer among diabetic patients, which rose to almost four-fold when medication was used. Diabetes did not increase risks for other types of cancer, such as melanoma or colon cancer.
Scientists have discovered a compound that blocks both ways cancer cells make energy, leading to the complete halt of tumor growth. The chemical, 3-bromopyruvate, targets cancer cells' high appetite for sugar and appears to have little effect on normal tissues.
Researchers found that turning off a single cancer-causing gene can eliminate aggressive liver tumors in mice within four weeks. The discovery involves manipulating the Myc protein, which drives cancer cell division, and has potential applications for treating common types of cancer.
Three University of Houston students, Jose Figueroa, Adham Bear, and Marisa Rodriguez, won awards at a recent symposium for their research in liver disease, cancer and insomnia. Their studies focus on biological clocks, protein-tRNA interactions and liver development.
Researchers at UIC discovered a gene, Foxm1b, essential for the multiplication of cancer cells. A potential drug was created to block Foxm1b activity, starving tumor cells and preventing their growth.
Researchers developed a biomarker to detect HBV mutations that speed up liver cancer development. Studies found HBV mutations predicted major liver disease, including liver cancer, up to eight years before diagnosis.
A new test can detect cirrhosis of the liver in its early stages, using changes in sugar production to identify the condition. The test has been shown to be accurate and could lead to earlier detection of liver cancer, improving treatment outcomes.
Liver cancer patients who undergo transplantation show improved five-year survival rates, increasing steadily from 25.3% to 61.1% over the past two decades. Regular screening of patients with cirrhosis is essential for early detection and optimal outcomes.
Chemoembolization is the treatment of choice for widespread or diffuse tumors, enabling patients with primary liver cancer to live longer and maintain a quality of life. The procedure uses oil droplets to transport chemotherapy agents directly to the tumor, reducing toxicity and improving outcomes.
The tob gene is a newly characterized tumor suppressor that prevents cell proliferation by constraining the cell growth cycle. Tob-deficient mice develop various spontaneous tumors, including liver cancer, at a significantly higher rate than normal mice.
Researchers discover 3-bromopyruvate selectively kills liver cancer cells while sparing healthy tissue. The compound, which blocks energy production in cells, may offer a promising alternative to existing treatments for liver cancer.
HPV vaccination has shown high safety and efficacy, inducing high antibody titers against papillomaviruses. Hepatitis B vaccination is also highly effective in preventing chronic infection, with a 95% effectiveness rate in children.
In developed countries, cancer mortality is more than twice as high as in developing countries due to factors like tobacco consumption and Western nutrition. In contrast, up to 25% of malignancies in developing countries are caused by infectious agents, whereas chronic infections account for only 8% in developed nations.
Researchers at Stanford University Medical Center have identified genes needed by cancerous liver cells but ignored or used at different levels by normal liver cells. This discovery could lead to more effective treatments and screening tests for liver cancer in Asian populations, who are 10 times more likely to develop the disease due ...
A multicenter randomized trial found that chemoembolisation significantly improves survival rates compared to conservative treatment, with 82% and 63% survival probabilities at 1 year and 2 years, respectively.