Articles tagged with Liver Cancer
A study found that diets high in protein and cholesterol increase the risk of hospitalization or death due to cirrhosis or liver cancer, while those high in carbohydrates reduce the risk. The study also identified associations between dietary nutrient composition and liver disease progression.
A study published in The Lancet found that excessive alcohol consumption in Russia is responsible for more than half of all premature deaths among adults, with men being particularly affected. The researchers analyzed data from three Russian cities and found that alcohol use was linked to an increased risk of deaths from accidents, vio...
Researchers at Ohio State University have identified two potential anti-cancer agents that target multiple genes associated with invasive liver cancer behavior. The compounds, Resveratol and 17-allylamino-geldanamycin (17-AAG), may reverse gene changes linked to tumor progression.
The study found that DKK-3 and WIF-1 proteins are associated with liver cancer development, suggesting potential as biomarkers for early detection. The research suggests blocking this pathway may improve treatment options for liver cancer through further study.
Researchers found that a high-fat diet increases the risk of liver cancer in genetically susceptible mice, while switching to a low-fat diet reverses this outcome. The study could lead to screening methods for precancerous conditions and cancer prevention strategies related to obesity.
A new study published in Hepatology found that women with a history of hypothyroidism are at a significantly higher risk of developing liver cancer. The study revealed that subjects with a prior history of hypothyroidism had twice the risk of liver cancer, particularly for females, and those who had it for over 10 years had a threefold...
Researchers found that phosphatase regenerating liver 3 (PRL-3) is a new independent prognostic indicator for gastric cancer, predicting tumor recurrence and survival rates. Positive PRL-3 expression was associated with advanced TNM stages, lymph node metastasis, and poorer overall survival rates.
A study found that removing a protective protein called STAT5 from liver cells leads to an overabundance of TGFbeta, a damage-inducing protein. This results in the activation of a cancer-promoting protein, STAT3, which can promote tumor growth.
Researchers found that long-term L-carnitine supplementation prevented the development of liver cancer in rats, reversing abnormal liver enzymes and histology. This study suggests carnitine may be used to prevent or slow liver cancer progression.
A study by the University of Edinburgh found that Scotland and Ireland have twice the rate of alcohol-related deaths compared to the rest of England and Wales. Men born in India showed similar rates of alcohol-related death as Scottish- and Irish-born people, highlighting cultural differences in drinking habits.
A Million Women Study found that low to moderate alcohol consumption among women increases cancer risk for breast, liver, rectum, and upper aero-digestive tract cancers. The risk is highest after one drink per day, with an excess of about 15 cancers per 1000 women.
A new study reveals liver cancer incidence has tripled in the US since 1975, with African-Americans and Hispanics experiencing significant increases. Survival rates have improved significantly, with one-year rates rising from 25% to 47%, thanks to earlier diagnosis and treatment.
A team of researchers at Cold Spring Harbor Laboratory has discovered 13 new tumor-suppressor genes in liver cancer, which can help improve diagnosis and treatment. The study used a powerful genetic screen to validate the functional contributions of these genes in living animals.
Mortality rates for most Canadian cancers are declining, while others are increasing, including liver and lung cancer. Research shows that at least half of all cancers are preventable, emphasizing the need for effective cancer control measures.
Using a novel combination of technologies, researchers identified 13 previously unknown tumor suppressor genes that, when mutated, can lead to liver cancers. These findings may provide new avenues for cancer therapy and have implications for understanding the molecular causes of the disease.
The study found that liver transplantation can significantly improve survival for patients with lung metastasis from primary liver cancer. The researchers identified liver transplantation as a key factor in extending patient survival, and recommended it as a standard treatment option for these patients. Additionally, the study suggeste...
Researchers have identified a genetic signature in normal tissue surrounding liver tumors that can help predict patient recurrence. This finding has the potential to unlock biological information in millions of clinical samples previously inaccessible to genomic study.
Researchers identified specific HBV genotypes and mutations associated with increased liver cancer risk, including genotype C and basal core promoter mutation A1762T/G1764A. A combination of doxorubicin and zoledronic acid was found to reduce tumor size substantially in a mouse model of breast cancer.
Researchers at Mount Sinai School of Medicine found that sorafenib increases overall survival by 44% compared to placebo in advanced liver cancer patients. The study also showed a significant delay in cancer progression.
Researchers at CSHL confirm DLC1 as a tumor suppressor gene that, when deleted or inactivated, leads to liver cancer. The team also identifies RhoA as a key signaling intermediary required for tumor formation, paving the way for new therapeutic targets.
Indigenous Australians are more likely to have preventable cancers, such as lung and liver cancer, with poorer prognosis and late diagnosis. Improving tobacco control and health services is crucial to reducing cancer burden.
A nested case-control study found that high HBV DNA levels are associated with an increased risk of hepatocellular carcinoma. Patients with higher viral loads have a heightened potential for developing liver cancer, suggesting a potential correlation between viral load and liver cancer development.
Researchers analyzed clinical data from 11 liver cancer patients who underwent caudate lobectomy using specific skin incision, mobilization of liver, vascular exclusion, and ideal hepatectomy procedures. The study demonstrates that caudate lobectomy for cancer in the candate lobe can be safely performed with an appropriate procedure.
Combining stents and photodynamic therapy significantly improves survival rates for patients with advanced liver bile duct cancer, increasing it from 7 months to over 16 months. The treatment's effectiveness is attributed to the number of stent-replacement procedures and PDT sessions.
Researchers at Penn School of Medicine have developed a targeted therapy combination that overcomes treatment resistance in liver cancer by combining sorafenib with the TRAIL pathway. This combination restores sensitivity to cell death and kills cancer cells, offering new hope for patients.
Researchers have found that increasing SULF2 expression enhances cancer cell growth and migration, while decreasing it reduces both. The study suggests that blocking SULF2 may lead to an effective treatment for liver cancer and potentially other types of cancer.
A randomized controlled trial found that combining TACE and RFA therapies resulted in longer survival times for patients with large liver cancer tumors. The therapy improved survival by slowing tumor progression and blocking the blood supply to the tumor.
A new clinical trial at Thomas Jefferson University aims to test the effectiveness of radioembolization using radiation-emitting beads in treating advanced liver cancer. The treatment, which blocks blood supply and emits targeted radiation, has shown promise in shrinking tumors and improving patient survival.
Researchers at Georgetown University Medical Center have discovered both normal and abnormal liver stem cells, which may provide a new target for experimental treatment. The study found that blocking the stat3 gene was effective in preventing liver cancer in mice, opening up new possibilities for treating this devastating disease.
Research suggests that Acanthus ilicifolius, a popular Indian medicinal plant, can prevent hepatic DNA alterations and sister-chromatid exchanges in tumor-bearing mice. The study also showed that ALE treatment was able to limit liver metallothionein expression and lengthen the mean survival of animals.
A study by MIT researchers reveals that genetic differences between males and females contribute to the higher incidence of liver cancer in men. The research suggests that chronic inflammation and male sex hormones play a role in this increased risk.
A study published in Clinical Cancer Research demonstrates that a novel mass-spectrometry based proteomic profiling method is more accurate than traditional biomarkers in distinguishing liver cancer patients from patients with hepatitis C liver cirrhosis. The technique, SELDI-TOF MS, identified an 11-protein signature that accurately d...
Dr. Lars Zender receives grant to continue identifying new tumor suppressor genes in liver cancer using advanced sequencing technologies. His groundbreaking research at CSHL has the potential to shift the paradigm in cancer treatment.
Researchers found that silibinin reduces cancer cell proliferation and enhances programmed death of cancer cells, making it a potential treatment option. The study also suggests that other herbal supplements may have similar anti-tumor effects, warranting further investigation.
Research reveals ultraconserved non-coding RNAs may play a role in cancer development and could help diagnose the disease, determine prognosis, and even guide treatment. The study found specific activity patterns for these molecules in different types of cancer, suggesting they might serve as genetic markers.
Postmenopausal women consuming two or more alcoholic beverages daily may double their risk of endometrial cancer, according to a USC study. The study found that lean women are more sensitive to alcohol's effects on hormone levels, increasing their cancer risk.
Researchers found that taking vitamins and minerals did not reduce liver cancer death rates in a study conducted by the National Cancer Institute. However, some vitamin-mineral combinations reduced risk in subgroups defined by age, sex, and alcohol consumption. In contrast, gene expression patterns identified 11 genes in noncancerous l...
Research reveals how microRNA miR-21 helps cancer develop by blocking tumor-suppressor gene PTEN. High levels of miR-21 are found in many kinds of cancer cells, providing a potential marker for patient prognosis.
Researchers developed a new treatment for liver cancer using a monoclonal antibody targeting PDGFRá. The antibody significantly reduced tumor cell proliferation and increased programmed cell death in human and mouse liver cancer cell lines.
Eating uncooked fish dishes is associated with an increased risk of developing cholangiocarcinoma, a type of liver cancer caused by the SE Asian liver fluke Opisthorchis viverrini. In Thailand alone, 6 million people are thought to be infected with the parasite.
Research at University of California, San Diego reveals that male mice produce more IL-6 in response to liver injury, leading to a higher incidence of liver cancer. The study suggests therapies targeting IL-6 production or estrogen-like compounds may reduce liver cancer risk in males.
Researchers at Georgetown University Medical Center have found a new molecular mechanism that may cause spontaneous liver cancer, but also identified a potential cure. By reintroducing the ELF gene to cancer cells, proteins driving cell division and growth can be kept in check, suggesting an effective new therapy.
A prospective study found that aspirin use was associated with lower risk of cancer incidence and mortality, particularly among former and non-smokers. In contrast, integrin α7 gene mutations were identified in various cancers, including prostate and liver cancer, suggesting a potential role in cancer development.
A new treatment, Sorafenib, has been shown to increase overall survival by over 40% in patients with advanced liver cancer. The study, SHARP, involved 602 patients and found that Sorafenib delays tumor progression and improves survival.
Researchers have made significant advancements in diagnosing and treating chronic hepatitis C, with potential new markers for detecting liver cancer. Studies have also explored the role of autotaxin in linking hepatitis C to hepatocellular carcinoma.
A recent study has established a significant correlation between bile duct obstruction and the growth rate of bile duct cancer cells in animals. In fact, cancer cells in obstructed bile ducts grew up to five times faster than those without obstruction, leading to increased metastasis outside the liver.
A recent study found that colchicine significantly reduces the risk of developing hepatocellular carcinoma (HCC) in patients with hepatitis virus-related end-stage liver disease. Colchicine treatment delays HCC diagnosis by an average of 72 months and improves survival rates.
Scientists are exploring the health benefits of functional foods, including mandarin oranges which may reduce liver cancer risk and a new type of flour with enhanced antioxidants. Researchers have also developed a 'designer soybean' that boosts calcium levels and fights osteoporosis.
Researchers have developed a non-invasive method to detect bladder cancer using DNA found in urine, while a study suggests high pesticide exposure increases the risk of liver cancer. Additionally, a growth factor has been found to inhibit lung tumor metastasis by stopping blood vessel growth and breaking down specific proteins.
A study by UCSD researchers found that the absence of IKKƒÒ in hepatocytes leads to increased JNK activation after exposure to toxic chemicals, resulting in accelerated tumor development. Deletion of JNK1 gene prevented liver cancer, suggesting a critical role for this isoform in tumor growth.
Studies have shown that glycerrhetinic acid and glycerrhizic acid, found in liquorice, preferentially accumulate in the liver and can target tumors effectively. This could lead to improved treatment outcomes with reduced toxic effects on other parts of the body.
A study found that patients with advanced liver, gallbladder, and bile duct cancers who developed a skin rash while treated with lapatinib lived for an average of 10 months, compared to five months for those without the rash. The treatment was well-tolerated, with two patients experiencing partial responses to treatment.
Researchers discovered that blocking the Hedgehog pathway kills cancer cells while leaving healthy liver tissue intact. This finding offers hope for targeted treatments and diagnostic tests for liver cancer.
Researchers discovered a compound called CDDO-Im that protects against liver cancer at extremely low doses. The compound activates a protein called Nrf2, which stimulates the cell's defense mechanisms and detoxifies harmful agents.
Researchers at Johns Hopkins Bloomberg School of Public Health have developed a new compound, CDDO-Im, which shows strong protective effects against liver cancer. The compound works by activating Nrf2, a master switch that stimulates the cell's defense mechanisms and removes harmful chemicals.
Researchers found that a hepatitis C virus protein accelerates the breakdown of a critical tumor suppressor, leading to liver cell proliferation and increasing cancer risk. This discovery could lead to improved treatment strategies for patients with chronic hepatitis C.
Researchers at U-M found that focused radiation combined with chemotherapy significantly improves survival rates for liver cancer patients. The new method delivers an intensive punch directly to tumors while limiting exposure to normal tissue.
Research suggests that consuming broccoli sprouts daily can improve chronic bacterial gastritis and potentially prevent stomach cancer. The compound sulforaphane in broccoli sprouts also has been shown to have anti-cancer effects, including preventing skin cancers caused by sun damage.
Tulane University has received $4.1 million to continue its work on the President's Emergency Plan for AIDS Relief in several countries. The university will also conduct a five-year study on liver cancer due to liver fluke infection in Southeast Asia.
A study published in Nature Genetics indicates that loss of one copy of Plk4 is a major risk factor for primary liver cancer, increasing likelihood by half when enzyme levels are reduced. The research provides insight into genetic predisposition to hepatoma and implications for screening and early detection.