Articles tagged with Liver Cancer
Researchers found that saffron significantly reduced the number and incidence of liver nodules, with complete inhibition observed at the highest dose. Saffron also inhibited the elevation of proteins indicating liver damage and blocked inflammation.
Inhibiting heat shock transcription factor 1 (HSF1) prevents liver cancer in mice by reducing access to glucose and lipids, which are critical for tumor growth. This finding supports the idea that altering metabolism can be an effective cancer treatment.
A new imaging technology reveals that metabolic shifts in cancer cells occur even before detectable tumors form, suggesting an early diagnostic tool for liver cancer. The study also shows that tumor metabolism changes precede tumor regression, offering potential strategies for cancer treatment and more effective therapies.
Leeds researchers investigate the effectiveness of pure Eicosapentaenoic Acid (EPA) in preventing the spread of bowel cancer to the liver. Previous studies have shown that EPA may prevent large bowel polyps, a precursor to colorectal cancer.
Researchers discover that celecoxib triggers liver cancer cell death by inhibiting a key protein, and combining it with chemotherapy drugs boosts effectiveness. The study suggests the possibility of a new treatment approach for liver cancer, which has a low five-year survival rate.
A recent study published in Gastroenterology highlights the increased risk of gastrointestinal complications in childhood cancer survivors after therapy. Risks for colostomy/ileostomy, cirrhosis or liver biopsy were highest among older patients and those exposed to abdominal radiation or certain chemotherapy treatments.
Boulton's research highlights include discovering key genes and enzymes involved in DNA repair mechanisms, including RTEL1 and ALC1. His work has led to novel therapeutic approaches for cancer treatment, particularly liver cancer.
The number of AIDS-defining cancers decreased, while non-AIDS-defining cancers increased significantly between 1991-2005. Lung cancer emerged as the most common malignancy in people with HIV but not AIDS.
Researchers found that individuals with metabolic syndrome are at higher risk for developing liver cancers, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma. The study, presented at the AACR 102nd Annual Meeting, highlights the importance of metabolic syndrome in increasing liver cancer incidence.
A study found that diabetes is associated with a lower risk of prostate cancer in men, but a higher risk of other cancers and mortality in both men and women. Diabetes was linked to increased risks for colon, rectal, and liver cancers in men and women.
A four-year study confirms that Y-90 radioembolization is a safe and effective treatment for patients with metastatic liver cancer, particularly those who have failed chemotherapy. The procedure preserves patient quality of life and extends life, while also demonstrating anti-tumoral effects.
Researchers at VCU Massey Cancer Center have discovered a novel mechanism in gene regulation that contributes to the development of liver cancer. AEG-1 and SND1 proteins were found to increase RISC activity, leading to increased tumor growth. Inhibiting SND1 is proposed as a potential new avenue for treating liver cancer.
A study at Cold Spring Harbor Laboratory has identified a therapeutic target for liver cancer using a monoclonal antibody that blocks the activity of the FGF19 gene. This approach shows promise in treating patients with FGF19 amplification, which can be used as a biomarker to predict treatment effectiveness.
A long-term study found that consuming three or more drinks a day is associated with an increased risk of pancreatic cancer death in both men and women. Heavy drinking, specifically liquor consumption, also shows a significant association with pancreatic cancer mortality, particularly among never smokers.
A recent study found racial disparities in liver cancer survival rates, with black patients experiencing higher mortality rates compared to white and Hispanic patients. Despite receiving similar treatments, black patients had a 12% increased rate of death, indicating poor access to care and subpar treatment outcomes.
A new study found that black patients with early-stage liver cancer have a higher mortality rate than white patients, with median survival times ranging from 8-10 months. The disparity in treatment access also affects the survival rates of Hispanic and black patients compared to white patients.
Groopman's research identified the link between environmental carcinogens and liver cancer, providing new prospects for prevention in high-risk populations worldwide. His work elucidated the role of aflatoxins in inducing hepatocellular carcinoma, a major cause of mortality in developing countries.
Researchers have found a synthetic molecule, LLL12, that blocks activation of the oncogene STAT3 in liver cancer cells, halting their survival and increasing sensitivity to chemotherapy. This discovery offers potential for an anti-cancer therapy option.
The study found significant disparities in survival rates among Asian-Americans diagnosed with liver cancer, with Laotian/Hmong-Americans having the lowest median survival rate of just one month. The group was also least likely to receive treatment, such as liver transplantation, due to late-stage diagnoses.
Researchers at Columbia University have found that ROCK2 may be a good therapeutic target for treating autoimmune disorders, while targeting CD13+ CSCs in liver cancer could provide a new treatment approach. Additionally, scientists at Stanford University developed ways to enhance RNAi efficacy and persistence while decreasing toxicity.
A case report describes a rare instance of intrahepatic clear cell cholangiocarcinoma, highlighting its distinct characteristics and low risk of metastasis. The cancer's unique cell structure and lack of mucin production set it apart from conventional HCCs.
A study published in Hepatology found that fewer than 20% of patients with cirrhosis and hepatocellular carcinoma received regular surveillance. Despite high-risk patients being recommended for HCC surveillance, population-based studies indicate only 11% are diagnosed early enough to receive potentially curative treatments.
A study at Baylor College of Medicine found that eliminating tumor suppressor C/EBP alpha is key to cancer development in the aging liver. Another protein, gankyrin, is elevated first, leading to degradation of C/EBP alpha and allowing uncontrolled growth.
A rare case of intrahepatic clear cell cholangiocarcinoma was reported in a Japanese man with hepatitis B virus (HBV) infection. The cancer cells were larger than usual and lacked mucin, differing from conventional ICC cases.
A University of Rochester study found a direct link between the androgen receptor and hepatitis B virus in causing liver cancer, explaining why men get the disease more often than women. Researchers showed that targeting the androgen receptor could lead to new treatment approaches for patients with hepatocellular carcinoma.
A University of Illinois study demonstrates that agronomic practices can significantly increase the cancer-fighting compounds in broccoli and tomatoes. Selenium-treated broccoli was found to have six times higher levels of one compound and exhibited increased bioactivity, particularly in the liver.
Researchers have developed a system that uses real-time X-ray images to visualize tumors and minimize radiation damage to surrounding tissues. The tool allows for precise targeting of radiotherapy, increasing the dose of radiation administered to lung and liver cancers.
Virginia Commonwealth University researchers identified a new tumor-promoting gene called LSF, which is significantly higher in more than 90% of patients with liver cancer compared to healthy individuals. Inhibiting LSF may reverse the aggressive properties of human liver cancer cells.
Researchers discovered that immune suppressive cells in the liver may facilitate cancer spread, and targeting these cells could prevent it. Combating immune suppressive cells early after cancer development may keep the disease from spreading to the liver.
A new treatment using intra-arterial yttrium-90 microspheres has shown promising results in extending the lives of patients with hepatocellular carcinoma, particularly those with portal vein thrombosis. The treatment offers a minimally invasive option for patients who cannot undergo surgery.
Research at the University of California, San Diego, reveals that obesity is a tumor-promoting factor for liver cancer, primarily through chronic inflammation caused by cytokines like IL-6 and TNF. This effect may be preventable with anti-TNF drugs, which also reduce liver fat accumulation.
Researchers identified a protein switch that helps prevent liver damage and cancer, offering new insights into the development of liver disease and cancer. The study suggests that TAK1 could be a master regulator of liver function, and its role in liver disease and cancer may enable the development of new therapeutic strategies.
A new study published in the American Journal of Roentgenology found that combining triple-drug TACE with a liver transplant significantly increased long-term survival rates for patients with unresectable liver cancer. The median survival time for patients who underwent the procedure was over 112 months.
A 20-year study revealed a significant drop in liver cancer cases among vaccinated 6- to 19-year-olds. The universal vaccination program in Taiwan has been shown to extend its effectiveness into young adulthood.
A chemical found in blueberry leaves has shown a strong effect in blocking the replication of the Hepatitis C virus, which affects 200 million people worldwide. The compound, proanthocyanidin, is similar to chemicals found in grapes and wine and is considered safe as a dietary supplement.
Researchers discovered Alc1's chromatin remodeling enzyme activity is strongly activated by NAD and Parp1. This suggests a mechanism for Parp1 and poly(ADP-ribose) to function in transcriptional regulation, DNA repair, and DNA replication
Two genes, AEG-1 and LSF, contribute to chemotherapy resistance in liver cancer treatment. The study found that over-expression of AEG-1 increases resistance to 5-fluorouracil, a commonly used chemotherapeutic drug.
A large meta-analysis found certain HBV DNA mutations associated with HCC development and more prevalent in chronic HBV infection progression. The study may help predict liver cancer risk in patients with HBV infections.
A study found that diets high in protein and cholesterol increase the risk of hospitalization or death due to cirrhosis or liver cancer, while those high in carbohydrates reduce the risk. The study also identified associations between dietary nutrient composition and liver disease progression.
A study published in The Lancet found that excessive alcohol consumption in Russia is responsible for more than half of all premature deaths among adults, with men being particularly affected. The researchers analyzed data from three Russian cities and found that alcohol use was linked to an increased risk of deaths from accidents, vio...
Researchers at Ohio State University have identified two potential anti-cancer agents that target multiple genes associated with invasive liver cancer behavior. The compounds, Resveratol and 17-allylamino-geldanamycin (17-AAG), may reverse gene changes linked to tumor progression.
The study found that DKK-3 and WIF-1 proteins are associated with liver cancer development, suggesting potential as biomarkers for early detection. The research suggests blocking this pathway may improve treatment options for liver cancer through further study.
Researchers found that a high-fat diet increases the risk of liver cancer in genetically susceptible mice, while switching to a low-fat diet reverses this outcome. The study could lead to screening methods for precancerous conditions and cancer prevention strategies related to obesity.
A new study published in Hepatology found that women with a history of hypothyroidism are at a significantly higher risk of developing liver cancer. The study revealed that subjects with a prior history of hypothyroidism had twice the risk of liver cancer, particularly for females, and those who had it for over 10 years had a threefold...
Researchers found that phosphatase regenerating liver 3 (PRL-3) is a new independent prognostic indicator for gastric cancer, predicting tumor recurrence and survival rates. Positive PRL-3 expression was associated with advanced TNM stages, lymph node metastasis, and poorer overall survival rates.
A study found that removing a protective protein called STAT5 from liver cells leads to an overabundance of TGFbeta, a damage-inducing protein. This results in the activation of a cancer-promoting protein, STAT3, which can promote tumor growth.
Researchers found that long-term L-carnitine supplementation prevented the development of liver cancer in rats, reversing abnormal liver enzymes and histology. This study suggests carnitine may be used to prevent or slow liver cancer progression.
A study by the University of Edinburgh found that Scotland and Ireland have twice the rate of alcohol-related deaths compared to the rest of England and Wales. Men born in India showed similar rates of alcohol-related death as Scottish- and Irish-born people, highlighting cultural differences in drinking habits.
A Million Women Study found that low to moderate alcohol consumption among women increases cancer risk for breast, liver, rectum, and upper aero-digestive tract cancers. The risk is highest after one drink per day, with an excess of about 15 cancers per 1000 women.
A new study reveals liver cancer incidence has tripled in the US since 1975, with African-Americans and Hispanics experiencing significant increases. Survival rates have improved significantly, with one-year rates rising from 25% to 47%, thanks to earlier diagnosis and treatment.
A team of researchers at Cold Spring Harbor Laboratory has discovered 13 new tumor-suppressor genes in liver cancer, which can help improve diagnosis and treatment. The study used a powerful genetic screen to validate the functional contributions of these genes in living animals.
Mortality rates for most Canadian cancers are declining, while others are increasing, including liver and lung cancer. Research shows that at least half of all cancers are preventable, emphasizing the need for effective cancer control measures.
Using a novel combination of technologies, researchers identified 13 previously unknown tumor suppressor genes that, when mutated, can lead to liver cancers. These findings may provide new avenues for cancer therapy and have implications for understanding the molecular causes of the disease.
The study found that liver transplantation can significantly improve survival for patients with lung metastasis from primary liver cancer. The researchers identified liver transplantation as a key factor in extending patient survival, and recommended it as a standard treatment option for these patients. Additionally, the study suggeste...
Researchers have identified a genetic signature in normal tissue surrounding liver tumors that can help predict patient recurrence. This finding has the potential to unlock biological information in millions of clinical samples previously inaccessible to genomic study.
Researchers identified specific HBV genotypes and mutations associated with increased liver cancer risk, including genotype C and basal core promoter mutation A1762T/G1764A. A combination of doxorubicin and zoledronic acid was found to reduce tumor size substantially in a mouse model of breast cancer.
Researchers at Mount Sinai School of Medicine found that sorafenib increases overall survival by 44% compared to placebo in advanced liver cancer patients. The study also showed a significant delay in cancer progression.
Researchers at CSHL confirm DLC1 as a tumor suppressor gene that, when deleted or inactivated, leads to liver cancer. The team also identifies RhoA as a key signaling intermediary required for tumor formation, paving the way for new therapeutic targets.
Indigenous Australians are more likely to have preventable cancers, such as lung and liver cancer, with poorer prognosis and late diagnosis. Improving tobacco control and health services is crucial to reducing cancer burden.
A nested case-control study found that high HBV DNA levels are associated with an increased risk of hepatocellular carcinoma. Patients with higher viral loads have a heightened potential for developing liver cancer, suggesting a potential correlation between viral load and liver cancer development.