Articles tagged with Myocardial Infarction
A study led by Yale researchers reveals that hospital mortality rates for older patients with a heart attack are not representative of younger adults. The findings highlight the need to include younger patients in assessments of hospital quality and further investigate age-related differences.
The LSU Health New Orleans Cardiovascular Center of Excellence will receive funding to study the effectiveness of MSI-1436, a novel drug that stimulates heart muscle regeneration. The drug has shown promising results in small animal models and Phase 1 clinical trials for obesity and type-2 diabetes.
Researchers found that a simple index based on systolic blood pressure and left-ventricular end-diastolic blood pressure ratio can predict in-hospital mortality for patients with STEMI. The study included 219 patients and showed that the SBP/LVEDP ratio was more predictive than other indices.
Research shows people of South Asian descent with a family history of coronary heart disease are more likely to have high levels of calcium buildup in their arteries. A CT scan may be an important test for those at risk, according to UT Southwestern cardiologists.
MSI-1436 has shown promise in adult zebrafish and mice by regenerating damaged heart muscle and improving heart function; a two-year grant will test its effectiveness in pigs to move the drug into clinical trials.
Studies have shown that patients with asymptomatic severe aortic stenosis will develop symptoms or cardiac events within four years. Following recommended exams every six to 12 months can improve clinical outcomes, according to a study of 300 patients.
Researchers found that a fatty acid-derived bioactive molecule called lipoxin improved heart function after a heart attack by inducing the resolving immune response. Lipoxin treatment also reduced left ventricle and lung mass-to-body-weight ratios, improving ejection fraction, and decreased kidney inflammation.
A new study analyzing data from the Swedish Coronary Angiography and Angioplasty Registry found no significant benefits of pre-hospital antiplatelet therapy in STEMI patients. The study suggests that pre-treatment may even pose a risk, particularly for patients with contraindications to antithrombotic therapy.
A 16-year study of over 280,000 patients found that colder air temperatures are associated with a higher risk of heart attacks. The study, led by Prof David Erlinge from Lund University, used meteorological data to analyze the relationship between weather conditions and heart attack incidence.
A landmark trial found that a drug targeting inflammation reduced risk of major adverse cardiovascular events, including heart attacks and strokes. Participants who received the anti-inflammatory drug had a 15% lower risk of cardiovascular events compared to those on standard care.
Researchers found that losartan reduced mitral valve scarring and stiffening in an animal model of heart attack. The study supports a new approach to treating heart valve disease, aiming to prevent disease progression at an early stage.
A large clinical trial found that oxygen therapy did not reduce mortality rates in patients with suspected myocardial infarction. The study enrolled over 6,200 patients and showed no significant difference in mortality rates between those who received oxygen and those who did not.
Researchers found that married patients who have had a heart attack are 14% more likely to survive compared to single patients. Marriage also provides protection for patients with high cholesterol, diabetes, and high blood pressure, increasing their chances of survival by 16%, 14%, and 10%, respectively.
A major international study found that combining two drugs, rivaroxaban and aspirin, is superior to aspirin alone in preventing further heart complications in people with vascular disease. The combination reduced strokes, heart attacks, and cardiovascular death by practically 25% compared to either drug alone.
The COMPASS trial found that the combination of rivaroxaban and aspirin reduces major adverse cardiovascular and limb events by 31%, lowering cardiovascular death, stroke or heart attack by 28% and limb-threatening ischaemia by 46%. Rivaroxaban alone does not reduce major adverse cardiovascular events but lowers major adverse limb events.
The COMPASS trial found that combining rivaroxaban and aspirin improved survival by 18% and reduced cardiovascular death, stroke, or heart attack by 24%. The treatment also increased bleeding risk but showed significant net benefits for patients.
A new diagnostic tool uses near-infrared light to identify high-risk arterial plaques, which can lead to blood clots, heart attacks, and strokes. By selectively identifying rupture-prone deposits, doctors may be able to detect the threat of an imminent heart attack earlier.
Researchers at Worcester Polytechnic Institute are developing a patch using biopolymer microthreads seeded with genetically engineered cardiac cells to improve heart function after a heart attack. The goal is to create a composite patch that can restore contractile function and provide additional strength and contractile force.
A genetic predisposition to higher blood calcium levels is associated with an increased risk of coronary artery disease and heart attack. The study used mendelian randomization to examine the association between serum calcium levels and CAD, finding a link between the two.
Researchers at the University of Bristol have made a groundbreaking discovery that could lead to a new treatment for heart attacks. Pericytes, cells surrounding blood vessels, stimulate new blood vessel growth with the help of hormone leptin, which may help restore blood supply to damaged heart muscle after a heart attack.
A new study published in CMAJ found that people who survive a stroke or mini-stroke without early complications have an increased risk of death and stroke for at least 5 years following the initial event. Researchers recommend long-term management of modifiable risks, such as high blood pressure and physical activity, to reduce this risk.
A study found that only about 7% of older adults who smoked used prescription smoking cessation medications within 90 days after a heart attack. Factors associated with early use included being younger and living in areas with higher high school graduate rates.
A new optical clearing technique allows researchers to study the 3D structure of blood clots, which could lead to a better understanding of heart attacks and stroke. The technique enables microscopic imaging up to 1 millimeter into a clot, providing insights into clot contraction and formation.
Research reveals black adults are twice as likely to experience fatal first cardiac events compared to whites. The study suggests social determinants of health and cardiovascular risk factors contribute to this disparity.
A nationwide registry study of 156,000 people found that daily incidence rates of myocardial infarction were higher during winter holidays and on Mondays, but lower during weekends and summer vacation. The study suggests that perceived psychosocial stress may be a trigger for MI rates.
Contracting shingles significantly raises the risk of stroke and heart attack, according to a recent study published in the Journal of the American College of Cardiology. Patients with shingles are more likely to have common risk factors for cardiovascular events, such as high blood pressure and diabetes.
A study by UT Southwestern Medical Center found that mildly obese patients who survive a major heart attack tend to have better outcomes, including higher survival rates and shorter hospital stays. Patients considered mildly obese had a 30% increased likelihood of survival compared to those of normal weight.
A study of 4,162 emergency department patients with chest pain found that certain symptoms are more predictive of heart attack in different racial and gender groups. Symptoms varied significantly among white males, black females, and others, highlighting the need for tailored diagnosis approaches.
Research suggests that breast implants can impede electrocardiogram (ECG) recordings and result in false heart attack diagnoses. The study found that women with breast implants were more likely to have abnormal ECG readings due to the implant interfering with the electrical activity of the heart.
Researchers found that aspirin is marginally beneficial for those who have had a previous heart attack or stroke, but offers no apparent benefit for patients with no prior history of cardiovascular issues. The study suggests that further clinical trials are needed to confirm the findings.
Researchers are developing new imaging tools to identify abnormalities that cause heart attacks, with the potential to save thousands of lives each year. The project aims to create new chemicals to illuminate unstable plaques in patients, enabling doctors to pinpoint people at higher risk of heart attack.
Researchers have discovered a previously unknown cell receptor interaction that can safely prevent blood clots. The new mechanism targets the Mac-1-GPIbα receptor duo, which is required for harmful clots, but blocking its interaction with a therapeutic small molecule has no effect on bleeding risk.
A large-scale registry study found that high-sensitivity troponin T assay is associated with a lower incidence of cardiovascular events in patients with unspecified chest pain. The percentage of serious events dropped from 0.9% to 0.6% after introducing the new method.
A study by University of Leeds researchers found that heart attack patients without heart failure did not live longer with beta blockers, but were still prescribed the medication at a rate of 95%. The findings raise concerns about unnecessary medication costs and the need for further research.
Researchers found a significant association between respiratory infections and increased heart attack risk, with a 17-fold increase in the seven days following an infection. The study suggests that even mild upper respiratory tract infections can elevate the risk of heart attacks.
A new analysis reveals that early treatment for Non-ST-Elevation Myocardial Infarction (NSTEMI) patients leads to a significant reduction in mortality. The study found an 87% lower mortality rate and a 38% lower mortality rate for high-risk patients when treated within 24 hours of symptom onset.
A meta-analysis of prospective studies reveals that individuals with non-O blood groups (A, B, AB) are at a higher risk of heart attacks and overall cardiovascular mortality. The study found a 9% increased risk of coronary events and cardiovascular mortality in non-O blood group carriers compared to O blood group carriers.
A UT Southwestern Medical Center study found no correlation between high early readmission rates and one-year mortality or long-term readmission rates for heart attack patients. However, hospitals with high penalties tend to serve more ethnic minorities and patients with severe disease.
A new study found that consuming excess choline, an essential nutrient in a Western diet, raises levels of the clot-enhancing compound TMAO and platelet clumping in both vegans/vegetarians and omnivores. Taking a daily baby aspirin may reduce this effect.
Cleveland Clinic researchers found that dietary choline and TMAO levels are associated with increased blood clotting risk. Adding a low dose of aspirin may help mitigate this risk.
A substantial proportion of patients prescribed high-intensity statins following a heart attack do not continue taking the medication. High-intensity statin adherence decreases over time, especially among African American and Hispanic patients and those without Medicare/Medicaid coverage or cardiologist visits.
A new study found that areas with trans fat bans in restaurants had significantly fewer hospitalizations for heart attack and stroke compared to areas without restrictions. The decline was 6.2%, highlighting the power of public policy to impact cardiovascular health.
Researchers have developed a 3D-bioprinted patch that can heal scarred heart tissue after a heart attack. The patch was made from cells and structural proteins native to the heart and showed significant improvement in functional capacity in mice after just four weeks.
A Minneapolis Heart Institute study found that over half of patients who suffered major heart attacks had not seen a doctor in two years prior to their attack. The new guidelines are more likely to treat these individuals before their heart attacks occur.
A Yale University study found that areas restricting trans fats in foods had fewer hospitalizations for heart attack and stroke. The finding suggests limiting trans fats could have a widespread impact as the FDA's ban takes effect nationwide.
Research found that participants who exercised had a lower risk of dying from a heart attack, with a dose-response relationship between exercise level and mortality rate. Regular physical activity may help develop collateral blood vessels and improve blood flow to the heart.
A study published in JAMA Cardiology found that New York counties with trans-fatty acid (TFA) restrictions on eateries experienced a significant decrease in hospitalization rates for heart attacks and strokes compared to counties without restrictions. The study, which included data from 2002 to 2013, suggests that TFA restrictions may ...
A recent study from Harvard Medical School found that individuals experiencing heart attacks or cardiac arrests near major marathons are more likely to die within a month. The delays in transportation to nearby hospitals, often caused by widespread street closures during races, contribute to this increased mortality rate.
Scientists at King's College London have developed a new blood test that detects damaged heart muscle caused by a heart attack more sensitively than current tests. This could lead to faster diagnosis and treatment of patients, while reducing unnecessary hospital admissions.
Research links extreme heat and physical exertion in firefighting to blood clotting and impaired blood vessel function, increasing the risk of heart attacks. The study suggests that exercising in extremely high temperatures should be done with proper hydration and cooling time.
A clinical study published in New England Journal of Medicine shows that a single dose of siRNA can significantly reduce LDL cholesterol levels by up to 52.6% after two doses, offering long-lasting protection for high-risk patients.
Researchers found a link between partial loss of the ANGPTL3 gene and lower cholesterol levels, as well as a reduced risk of coronary artery disease and heart attack. The study suggests that inhibiting ANGPTL3 could lead to new therapies for preventing heart attacks.
Research at Technical University of Munich found that diabetes causes loss of small blood vessels around the heart, affecting cardiac muscle. Genetic therapy promoting pericyte growth may offer a remedy, providing new perspectives for treating patients.
A recent study found that direct acting oral anticoagulants and aspirin may increase heart attack risk compared to vitamin k antagonists like warfarin. Researchers are urging more research on the topic as use of these medications increases.
Researchers found that treating secondary blockages after a major heart attack using fractional flow reserve technology can improve patient outcomes and reduce the need for subsequent invasive procedures. This approach resulted in a 65% lower risk of all-cause mortality, non-fatal heart attack, stroke, and revascularization at 12 months.
The new iFR tool has been shown to be equivalent to the current preferred tool FFR in terms of major adverse events and patient outcomes. It also resulted in markedly less patient discomfort and reduced procedure-related adverse events compared to FFR.
A Phase 2 study found that replacing aspirin with low-dose rivaroxaban in addition to an antiplatelet medication does not increase bleeding complications in patients with acute coronary syndrome. The study, which involved over 3,000 patients, suggests that this dual therapy approach may be a safe alternative to lifelong aspirin treatment.
A Phase 2 trial found that synthetic high-density lipoprotein cholesterol (HDL-C) injections had no effect on reducing fatty deposits in arteries, despite being well-tolerated. The study's findings suggest that low-dose CER-001 may not be a promising agent for treating patients with acute coronary syndrome.
A new study by Intermountain Medical Center Heart Institute researchers suggests that calcified plaque is associated with a higher risk of cardiovascular events, contradicting previous assumptions about soft plaque. The study found that patients with more calcified plaque were more likely to experience major adverse coronary events.
A new study published by the American College of Cardiology found that percutaneous coronary intervention (PCI) is not needed in all cases of fully blocked arteries. Treatment with medications alone was shown to be equal to PCI in terms of major adverse events over three years.