Articles tagged with Obesity
A study by UC Riverside researchers found that male mice on high-fat diets experienced neuroinflammation and reduced testosterone levels, while female mice remained protected. The findings suggest ovarian estrogen plays a crucial role in protecting females against weight gain and associated health issues.
Researchers at Cincinnati Children's Hospital Medical Center genetically deleted Ago2 from the livers of mice, stabilizing energy metabolism and preventing obesity and diabetes. The study provides a solid basis for further research into novel therapeutic approaches to treat chronic metabolic disorders.
Research reveals obesity activates microglia, consuming healthy synapses and leading to dendritic spine loss. Microglial activity is causally linked to obesity-induced cognitive decline, suggesting a potential therapeutic target for this condition.
A study of black women found that those who slept less than 7 hours a night had higher blood pressure and lower levels of physical activity. The researchers suggest that addressing sleep quality is crucial for combating obesity and high blood pressure in this population.
Researchers discover gene H19 has a unique protective effect against the development of overweight and related diseases. Genes from mothers primarily lead to the development of brown fat tissue, which has a protective effect against obesity.
Researchers will evaluate the use of negative pressure wound therapy in obese and/or diabetic patients at five university-associated hospitals. The goal is to determine if this technique can help reduce incision site infections, a significant complication that can prevent proper wound healing and even lead to death.
Researchers at Université Laval found that camu camu phytochemicals prevent obesity in mice fed a diet rich in sugar and fat. The extract improved glucose tolerance, insulin sensitivity, and reduced inflammation, suggesting its potential as a natural weight management tool.
Researchers at TUM demonstrated that food increases thermogenesis in brown fat, contrary to the long-held assumption that it only responds to cold. This discovery could lead to new ways to prevent obesity and diabetes.
A new study found that obesity blunts post-workout muscle building and repair in young adults. The research showed that obese individuals had reduced rates of myofibrillar protein synthesis after a weightlifting session compared to normal-weight peers.
New research at McGill University found that people with higher BMI tend to have reduced cognitive flexibility, increased volume in the left amygdala and decreased volume in certain memory structures. The study suggests a model where genetics play a role in obesity through brain anatomy and cognitive functions.
Researchers argue that sugar is not responsible for obesity and metabolic diseases, citing evidence from multiple domains. Experts also highlight the importance of physical activity in determining metabolic health. The debate raises questions about the role of sugar in modern diets and whether restrictive recommendations are effective.
A study published in PLOS ONE found that restricting high-sucrose diet to active times reduced fat levels in rats. The research team limited the diet to nighttime, resulting in lower blood and liver fat compared to an unrestricted diet.
Researchers at Cedars-Sinai Medical Center have developed a simpler and more accurate method to estimate body fat percentage than the widely used BMI. The new relative fat mass index (RFM) formula uses only height and waist circumference measurements, providing a better measure of body fatness without requiring expensive equipment.
A recent study published in the New England Journal of Medicine found that lorcaserin, a weight loss drug, helped patients lose weight without increasing the incidence of heart attacks, strokes, and death from heart disease. The trial involved 12,000 overweight or obese patients at risk for cardiovascular events.
A team of researchers has discovered a molecular mechanism that causes leptin resistance in obese individuals, which blocks the brain's ability to recognize when it's full. By blocking this enzyme, MMP-2, scientists hope to develop treatments for obesity-related issues and explore its broader implications.
Scientists have identified a brain receptor protein that controls the body's 'fat rheostat', regulating energy balance and weight gain. The discovery opens new doors for developing anti-obesity drugs, particularly targeting the melanocortin 3 receptor (MC3R) to treat obesity.
Researchers at University of New South Wales developed a novel drug targeting Ceramide Synthase enzymes linked to insulin resistance. The drug successfully prevented mice from depositing and storing fat by increasing their ability to burn fat.
Researchers found that high-fat diets suppressed a protein called TIGAR, which plays a role in meiotic spindle formation and antioxidant production. This led to increased reactive oxygen species and autophagy in oocytes, impairing development.
Scientists discover that expanding subcutaneous white fat tissue can improve insulin sensitivity and reduce inflammation in obese individuals. A microRNA called miR-30a plays a crucial role in this process, protecting fat cells from inflammation and leading to improved metabolic health.
A study in Guatemala finds type 2 diabetes and pre-diabetes affect 25% of the indigenous population, with age being a significant risk factor rather than obesity. The prevalence has more than doubled since 2003, and researchers attribute this to aging, increased physical inactivity, and insulin resistance.
A new study by the University of Texas Health Science Center at Houston found that Americans who lost more than a fifth of their body weight experienced a significant improvement in metabolic health, with those losing 5-10% showing a 22% lower risk of metabolic syndrome.
A recent study found that gastric bypass surgery increases the risk of fractures, particularly in individuals without diabetes. The researchers compared data from over 38,000 patients who underwent gastric bypass operations with a control group and found a significant increase in fracture rates, with risks ranging from 26% to 32%.
A new study by CU researchers has identified histone deacetylase 11 (HDAC11) as a potential therapeutic target for treating obesity and diabetes. Deleting HDAC11 in mice stimulates the formation of brown adipose tissue, leading to increased energy expenditure and a reduction in white adipose tissue.
A study found that resistance training may help minimize bone loss associated with active weight loss in older adults. However, the results suggest that additional intervention strategies are needed to maximize skeletal benefit and preserve overall bone health.
A recent study published in the European Journal of Preventive Cardiology found that physically active severely obese individuals had a significantly lower risk of developing atrial fibrillation. In contrast, those who were inactive or exercised little experienced a doubling of this risk. The study suggests that regular physical activi...
Researchers found that fat fibrosis in subcutaneous fat is predictive of unhealthy belly fat and insulin resistance in Asian participants. This difference could help explain why Asians develop type 2 diabetes at a lower body weight than Caucasians.
Researchers found that bariatric surgery reduces the risk of nerve, kidney and eye disease in patients with type 2 diabetes. The study included over 3,900 patients who underwent bariatric surgery and compared them to a control group of over 11,000 patients who received usual medical care.
A new study of over 5,000 older Irish adults found a strong association between belly fat and reduced cognitive function. The study suggests that reducing obesity could offer a cost-effective public health strategy for preventing cognitive decline.
Researchers found that obese women had a thicker left ventricle, lower E/A ratio, and higher systolic blood pressure compared to normal or overweight women. These changes may explain their predisposition to preeclampsia and cardiovascular complications during pregnancy.
Lesbian, gay, bisexual, and questioning youth are more likely to develop Type 2 diabetes, be obese, and engage in less physical activity. Minority stress may contribute to the risk of poor physical health among LGBQ youth.
Researchers found that training with an e-bike is as effective as regular bicycling for improving cardiorespiratory fitness. After a month of riding at least three days a week, participants showed significant improvements in oxygen uptake capacity.
Older, overweight scuba divers are at increased risk of dying due to cardiac issues. The study found that one-third of scuba divers are aged 50 years or older, with a significantly greater proportion having smoked cigarettes and high blood pressure.
New research explains how obesity leads to harmful inflammation, causing diabetes and other health problems. The study identifies two ways to combat this inflammation: blocking harmful oxidized lipids or promoting beneficial phospholipids.
A systematic literature analysis by TUM researchers found no evidence for genetic factors affecting total calorie, carbohydrate, or fat consumption. However, genes like FTO and MC4R were linked to energy intake in some studies, but the findings were inconsistent.
A TGen-led study has found a link between DNA methylation and non-alcoholic fatty liver disease (NAFLD) in obese patients. The research identified four genes that may represent potential targets for new therapeutics.
Researchers have identified P38 alpha as a crucial protein in activating brown fat cells to burn excess fat and eliminate the risk of obesity and related diseases. The study found that mice genetically modified to lack P38 alpha were protected against obesity, diabetes, and fatty liver disease.
A new study published in the Society for the Study of Ingestive Behavior found that individuals can improve their food choices by adopting a 'health-focused' mindset during meal planning. This approach triggers activity in the prefrontal cortex, linked to self-control and future meal planning.
A novel drug, Metabocin, based on capsaicin has reversed damaging effects of high fat diet in mice, improving blood sugar, cholesterol levels, insulin response, and symptoms of fatty liver disease. Long-term use of the drug showed no adverse effects or weight regain.
A high-fat diet accelerates prostate cancer growth and increases immune cells that suppress the immune system. Anti-inflammatory drugs may have benefits for obese patients with prostate cancer.
A recent study published in Cell Metabolism found that a high-fat diet was the sole driver of weight gain in mice, with no significant impact from carbohydrates or protein. The researchers believe that fat uniquely stimulates the brain's reward centers, leading to increased calorie intake.
Cecilia Lindgren receives ASHG Mentorship Award for sustained exemplary mentorship, recognizing her wide-ranging impact on mentees' research fields and career paths.
A recent study published in Clinical Obesity found that individuals with metabolic healthy obesity, but no other risk factors, do not have an increased rate of mortality. The study followed over 54,000 participants and contradicts current weight management guidelines.
A 10-year study found that age, low socioeconomic status, obesity, and low physical activity are positively associated with the risk of developing multimorbidity. Promoting healthy lifestyles and targeting an internal locus of control may help empower patients to achieve behavior change and reduce multimorbidity incidence.
The NYC Health and Nutrition Examination Survey (HANES) found that New Yorkers are getting heavier, with obesity rates increasing among certain groups. The survey also showed high rates of depression and sleep problems, as well as persistent racial and ethnic disparities in health outcomes.
Researchers from UAB successfully used gene therapy to treat type 2 diabetes and obesity in mice by inducing the production of FGF21, a hormone that maintains correct energy metabolism. The treatment led to weight loss and improved insulin sensitivity, reducing the risk of related comorbidities.
Researchers are investigating the relationship between obesity-induced changes in fat tissue metabolism and vascular disease. The study aims to characterize the role of protein FSP27 in the pathogenesis of obesity-related vascular disease.
Researchers at Wake Forest Baptist will investigate lifestyle interventions on cognitive resilience in older adults with type 2 diabetes and obesity. The four-year study aims to confirm earlier findings that intensive lifestyle intervention may decrease cognitive impairment, but paradoxically increase it in those with severe obesity.
Researchers found that consuming savory umami-rich broths can cause subtle changes in the brain that promote healthy eating behaviors. The study used laboratory tools to detect changes in brain activity while participants made food choices, and found that the broth reduced saturated fat intake in those at higher risk of obesity.
A recent study published in the Journal of Head Trauma Rehabilitation found that obesity and overweight are associated with chronic disease risks for survivors of moderate to severe traumatic brain injury. The study included 7,287 adults with TBI who underwent inpatient acute rehabilitation.
A new study found that 'skinny fat,' a combination of low muscle mass and high fat mass, may predict cognitive decline in older adults. Sarcopenic obesity was associated with the lowest performance on global cognition tests, followed by sarcopenia alone and then obesity alone.
A recent study found that men with central obesity were at higher risk for lower urinary tract symptoms, characterized by worsened straining and weak stream. The study also revealed a strong association between increased waist-to-hip ratio and these symptoms.
A high-fat, high-sugar diet that leads to obesity may contribute to the development of Alzheimer's disease when paired with normal aging. The study found significant differences in inflammation and insulin resistance markers between obese and healthy mice.
A new study from the University of Warwick blames macro-level factors for the double burden of malnutrition among adolescents in developing countries. The study found that factors including war, lack of democracy, food insecurity, urbanisation and economic growth are to blame.
Research highlights how normalizing plus-size body shapes can lead to underestimation of weight, undermining efforts to tackle obesity. The study shows that socioeconomic inequalities play a significant role in patterns of weight misperception.
Researchers at ETH Zurich discovered a new type of regulatory fat cell called Aregs that inhibits the formation of new fat cells. This discovery opens up promising avenues for future therapies to protect obese people from diabetes and other secondary illnesses.
A systematic review of animal studies found that adipose-derived mesenchymal stem cells (AD-MSCs) have a positive effect on obesity treatment in terms of body weight and related comorbidities. However, the authors caution that further well-designed human studies are needed to confirm these findings and understand the mechanism of action.
Atrial fibrillation, Australia's most common heart rhythm disorder, can be alleviated by losing weight and treating lifestyle factors. Obesity is a leading cause of stroke and heart failure, but research shows that reducing weight by 10% can reverse the progression of the disease.
People with severe obesity report using various weight loss methods, but none prove more effective than maintaining lower caloric intake. Weight loss surgery is a proven method for reducing weight in the long term and lowering disease risk, but not suitable for everyone.
New research published in The Journal of Physiology reveals that exercise can reduce chronic inflammation in obese individuals. By changing the characteristics of their blood-forming stem cells, exercise decreases the number of blood cells associated with inflammation.
Researchers found that a weight loss of 20% or more leads to improved physical health-related quality of life, reduced pain, and better function. Additionally, this significant weight loss results in an additional 25% reduction in pain compared to a 10-19.9% weight loss.