Articles tagged with Obesity
Researchers at UTMB discovered a molecule that blocks the metabolic brake in obese white fat cells, increasing metabolism and reducing fat tissue mass. The drug-treated mice lost over 7% of their body weight and had lower blood cholesterol levels compared to placebo group, without suppressing appetite.
Experts argue that sugar may play a key role in obesity and type 2 diabetes due to its unique metabolic effects, potentially beyond just excess calories. The World Health Organization describes the twin epidemics as a 'slow-motion disaster,' but critics say current recommendations targeting only calories are insufficient.
A new Northwestern Medicine study finds that blacks have the same risk of developing diabetes as whites when all biological factors are considered over time. Obesity is identified as the primary cause of early onset diabetes in blacks, with black women developing diabetes at triple the rate of white women.
New research suggests that a diet low in branched-chain amino acids (BCAAs) may improve metabolic health and promote leanness. The study found that obese mice on a specialized diet experienced improved glucose metabolism and energy expenditure despite not reducing overall calorie intake.
Researchers at WashU Medicine identified a way to prevent fat cells from growing larger, leading to weight gain and obesity. By activating a specific protein pathway in mice, they found that high-fat diets did not lead to obesity.
A smartphone app, SlipBuddy, uses machine learning to uncover patterns and predict eating trouble spots, providing interventions and helping change behavior. The app showed positive results in a pilot study, with nine participants losing an average of five pounds.
A study published in The Lancet Public Health found that people living within a kilometre of physical activity facilities have smaller waist circumferences, lower BMI, and lower body fat percentages. Increasing access to physical activity facilities and reducing fast food outlets may help reduce obesity.
A new study by NYU College of Global Public Health and the University of Michigan found no evidence of an 'obesity paradox' among people with new cases of cardiovascular disease. This contradicts prior research that suggested obesity may be associated with improved survival in people with existing cardiovascular disease. The study used...
Researchers at McMaster University have identified nine genes that contribute to weight gain in individuals with a high body mass index. These genes can amplify weight gain by up to four times, making them a significant factor in the development of extreme forms of obesity.
A study published in Obesity found that individuals with Type 2 diabetes and obesity who continue to binge eat while trying to lose weight drop significantly less weight than those who don't or stop binge eating. Researchers recommend targeting treatment for this behavior, such as cognitive behavioral therapy.
Two studies in mice and human subjects reveal exercise can alter gut microbiota, promoting healthy intestinal cells and reducing inflammation. Exercise-induced changes persisted even after returning to a sedentary lifestyle, with lean participants showing more significant improvements.
Research indicates that being overweight or obese can lead to poorer RA treatment outcomes and higher mortality risk. Studies show that patients with healthy weights are more likely to achieve remission, while those who are overweight or obese face a 25-47% lower chance of sustained remission despite similar treatments.
A global longitudinal study confirmed that people with high body mass index (BMI) are more likely to develop dementia than those with normal weight. The study analyzed data from over 1.3 million adults in the US and Europe, finding that individuals near dementia onset tend to have lower body weight.
A new study found that fat distribution patterns, not just overall weight, are linked to heart attack risk in women and men. Women had higher subcutaneous fat but lower lean mass compared to men, who had more visceral adipose tissue and ectopic fat.
A new study published in The Lancet Diabetes & Endocrinology found that diabetes and being overweight or obese are responsible for nearly 800,000 new cancer cases globally. High BMI was linked to twice as many cancers as diabetes, with liver cancer and endometrial cancer being the most common types.
A new study found that weight loss through diet and exercise significantly slows down the degeneration of knee cartilage in obese individuals. However, weight loss achieved solely through exercise had no significant impact on cartilage degeneration, suggesting that a balanced approach involving diet is crucial for protecting the knees.
Researchers from UNIGE have identified a key role for the liver in the development of type 2 diabetes, linked to obesity and inflammation. By targeting the protein PTPR-γ, scientists may uncover new therapeutic strategies to prevent insulin resistance and related metabolic conditions.
The study reveals huge inequalities persist with heart disease accounting for over 50% of all deaths in many middle income countries, compared to less than 30% in high income countries. The UK has the highest prevalence of adult obesity in males and 2nd highest in females, and ranks joint 5th for raised blood cholesterol.
New research reveals cinnamaldehyde's ability to induce thermogenesis in fat cells, improving metabolic health. The compound may offer a non-pharmacological approach to combating obesity and related health issues.
A new test predicts which people with type 2 diabetes will benefit from weight loss surgery. The DiaBetter score and percentage weight loss two years post-surgery are key predictors of T2D remission.
Scientists at University of Basel find feedback mechanism to maintain insulin production in overweight patients, using ILC2 immune cells and retinoic acid. The study highlights the complex interactions between endocrine and immune cells in regulating insulin release.
A study found that women who underwent sleeve gastrectomy may need to limit their alcohol consumption due to faster absorption rates. The surgery speeds up the transfer of alcohol into the bloodstream, leading to higher blood alcohol levels and increased risk of binge drinking and associated health issues.
Researchers have identified a three-molecule signature that accurately indicates insulin resistance, or pre-diabetes, in mice. This discovery could enable earlier detection of pre-diabetes in humans and tailor healthcare treatments to individual patients' needs.
A recent Drexel University study discovered that when vegetables and dairy products are pricier than unhealthy snacks like chips, people's dietary quality suffers significantly. The researchers found a strong link between the price gap and lower odds of having a healthy diet, particularly among middle-income groups.
A study published in The BMJ found that weight-reducing diets, mostly low in fat, may decrease all-cause early death in adults with obesity. This supports the implementation of public health measures to prevent weight gain and promote weight loss. However, the evidence for reducing heart disease and cancer deaths is limited.
A genetic variant in ankyrin-B gene causes cells to store more fat, leading to obesity. This variant is carried by millions of Americans and can be identified through family history and physiological traits.
Women with anorexia nervosa and obesity have lower levels of allopregnanolone, a key player in regulating mood, compared to normal-weight women. Low allo levels are associated with greater severity of depression symptoms, suggesting a potential new target for treating these disorders.
Research suggests that obese older adults who undergo cardiac surgery may experience greater functional decline over two years. The study analyzed data from 1,731 participants and found a complex relationship between obesity and functional ability in those aged 80 and older.
A recent study has identified Neuregulin 4 (Nrg4) as a key driver of nonalcoholic steatohepatitis (NASH) progression. Increasing levels of Nrg4 protected liver cells from metabolic stress in mice, while loss of the hormone led to accelerated disease progression.
A comprehensive study reveals that displaying calories on menus reduces consumer calorie intake by 27 calories per meal, while retailers respond by offering more low-calorie options.
A new study found that phenylalanine reduces food intake by affecting the gut and brain, suggesting it may be used to treat or prevent obesity. The amino acid suppressed appetite by releasing hormones in the gut and activating areas of the brain involved in appetite regulation.
The prevalence of obesity in the UK has almost doubled over two decades, with food taxes being suggested as a measure to correct this trend. However, experts disagree on its effectiveness, with some arguing it is too simplistic and overlooks other factors influencing obesity.
Research suggests that obesity is prevalent among axSpa patients, associated with increased disease activity, physical function impairment, and poorer quality of life. The study found that nearly two-thirds of the patient cohort were overweight or obese, highlighting the need for weight management strategies in treatment plans.
Research findings from the ACR/ARHP Annual Meeting reveal that obesity is independently associated with worse patient-reported outcomes in women with systemic lupus erythematosus, including increased disease activity and depressive symptoms. Obesity was linked to higher levels of pain and fatigue as well.
Research finds that obesity is associated with a higher degree of synovitis in RA patients, leading to worse clinical responses to treatment. Patients who are overweight or obese tend to have higher histological scores and more inflammation in their joints.
Research reveals obesity is associated with reduced rates of remission and increased rates of disability in RA patients. Effective weight screening and management should be a central feature of RA treatment plans.
A study of over 19,000 knee dislocation cases found obesity increases complications and costs of care. Obese patients are more likely to experience vascular injury, which can lead to amputation if left untreated. Hospital stays for obese patients with vascular injury were 15.3 days, costing $131,478 on average.
A large Danish study found that whole grains reduce inflammation in the body and lead to weight loss in overweight adults. The study suggests that choosing whole grains over refined grains can have numerous health benefits, particularly for individuals at risk of cardiovascular disease or type 2 diabetes.
Researchers at the University of Michigan found that some obese adults store their body fat more healthily than others, breaking down fat at slower rates and having fewer inflammatory cells. Aerobic exercise may lead to healthier fat storage, with regular exercisers showing increased blood vessels in their fat tissue.
Researchers from University of Copenhagen find that cycling to and from work is just as effective in reducing fat mass as moderate- or high-intensity leisure-time exercise. The study involved 130 overweight participants who cycled, exercised, or did neither for six months, with significant weight loss found in all groups.
A UC Riverside study highlights significant health problems affecting historically ignored racial groups, including multiracial, Native Hawaiian, and American Indian populations. The research reveals high rates of obesity and diabetes among these groups, with disparities exceeding those experienced by non-Hispanic white adults.
A recent study published in the journal Appetite found that marketing food as a 'meal' rather than a 'snack' can lead to reduced consumption and overeating. Researchers discovered that participants who consumed pasta labelled as a 'snack' ate more at a subsequent taste test compared to those who had eaten it as a 'meal'. This suggests ...
A study characterises the clinical, physical, physiological and dietary patterns of the overweight/obese population with primary hypertension. The researchers found that a profile of high cardiovascular risk includes hypertension diagnosis, excess weight/obesity, poor cardiovascular fitness, and unhealthy dietary habits.
Researchers aim to understand why eating late disrupts natural circadian rhythms and affects weight, glucose, and hormone levels. They will conduct a randomized, long-term study on adults with obesity to compare weight and metabolic effects of daytime versus delayed eating schedules.
A high waist-to-hip ratio is associated with a significantly higher rate of complications, longer hospital stays, mortality, and 30-day readmissions after emergency general surgery procedures. The study suggests that measuring waist-to-hip ratio via CT scan may be a reliable predictor of adverse outcomes.
A new study found that weight loss after bariatric surgery can lead to significant improvements in heart health, including a return to natural shape and function. The study also showed a decrease in ventricle size by 15.7 percent, reducing the risk of heart failure.
Researchers found that genetic predisposition increases risk of high triglycerides, but maintaining a healthy body weight or changing diet can help reverse the risk. A specific gene mutation was associated with higher circulating triglycerides, but the correlation was dependent on BMI and dietary intake.
Researchers found that semaglutide reduced hunger and cravings for food, leading to an average weight loss of 5kg (11lbs) from body fat. The study suggests the drug's potency is due to its action on appetite control receptors in the brain.
A large-scale study found that low physical activity and inefficient sleep patterns intensify genetic risk factors for obesity, confirming previous findings with new, more objective measurements. The study also showed a gene-activity interaction between physical activity levels and genetic variants associated with obesity.
A new Yale study reveals decreased brain glucose levels in individuals with obesity and type 2 diabetes compared to lean individuals. This finding might explain the underlying mechanisms of disordered eating behavior and an increased risk of Alzheimer's disease among obese and diabetic individuals. The researchers suggest that impaired...
Performing cholecystectomy before gastric bypass surgery may lower risks for patients with obesity and symptomatic gallstone disease. The analysis, based on 79,386 and 36,098 patient data from 2007 to 2013, suggests that the best strategy is to perform cholecystectomy prior to gastric bypass surgery.
A study by University of Pennsylvania School of Nursing found delayed lactogenesis II and excessive gestational weight gain associated with breastfeeding difficulties in obese women. The research highlights the need for targeted interventions to support these women in achieving their personal breastfeeding goals.
A study published in Cell Research found that intermittent fasting can be beneficial for the metabolism, reducing fat build-up and stabilizing glucose and insulin systems. After sixteen weeks of on-and-off fasting, mice weighed less and had lower body fat compared to control groups.
A study by the London School of Hygiene & Tropical Medicine found that introducing a small levy of 10 pence per drink to the price of sugar-sweetened beverages sold in Jamie's Italian restaurants contributed to a significant decline in SSB sales, with a 9.3% decrease observed six months later. The study suggests that financial measures...
A study published in Science Advances found that mice born by C-section gained an average of 33% more weight than those born vaginally over the course of 15 weeks after weaning. The researchers also discovered significant differences in bacterial species in their guts, with mice born by C-section having a less mature microbiome structure.
A study published in Nature Communications identifies MKK6 as a key protein controlling white-to-brown fat conversion. This process enables lipids to be burned for heat instead of stored, potentially reducing obesity. Mice lacking MKK6 exhibit reduced body weight and protection against obesity.
Researchers discovered specialized macrophages called SAMs that interact with sympathetic neurons to affect neuronal activation and fat mass reduction. Blocking SAM-mediated norepinephrine clearance boosts fat breakdown and weight loss in mice.
A new study from the University of Edinburgh found that lifestyle factors such as diet and activity levels have a major impact on regional obesity rates in Scotland. By addressing these factors, public health initiatives can help narrow the health divide between regions.
A study by Georgia State University researchers found that brown fat's role in generating heat is more complex than previously thought. They discovered that lipolysis, which breaks down stored fat, is not essential for heat production in response to cold exposure, but rather regulates fuel selection and white fat browning.
A 28-study analysis reveals night shift workers are more likely to develop abdominal obesity and experience an increased risk of obesity compared to permanent day workers. Modifying working schedules to avoid prolonged exposure to long-term night shifts might help reduce this risk, according to the study.