Articles tagged with Obesity
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A study published in Science Signaling reveals that enhanced natriuretic peptide signaling in adipose tissue protects against obesity and insulin resistance. Boosting levels of NPs in adipose tissue may be an important avenue for combating metabolic disease.
Studies on red raspberries found that consuming the fruit may improve glucose control and reduce hunger. Researchers also discovered that red raspberry consumption can alter gut microbiota and show promise in reducing inflammation and obesity risk.
Researchers found that increasing BMP4 levels can improve metabolic health in lean mice by promoting beige fat cell activity, but overweight mice showed reduced effectiveness. Gene therapy with BMP4 also protected against insulin resistance in both lean and overweight mice.
Researchers at the University of Birmingham have discovered that GLP-1 agonist extendin-4 significantly reduces brain pressure in an animal model, with effects lasting at least 24 hours. The treatment shows promise as a novel new way to lower brain pressure, potentially benefiting patients with conditions such as traumatic brain injury...
A study using fMRI scans found that reduced neural activity in teens at high risk of adult obesity may be an early predictor. The researchers discovered that lean adolescents with a family history of overweight parents showed less self-regulation activity than their peers.
Research reveals NPGL, a newly discovered protein involved in brain signalling, controls appetite and increases body fat storage even on low-calorie diets. The study also shows NPGL's role in increasing food intake when high caloric foods are consumed.
Researchers found that being overweight or obese increases a person's risk of coronary heart disease by up to 28% even if they have healthy blood pressure, blood sugar, and cholesterol levels. The study showed that excess weight is linked with an increased risk of heart disease, even when people have a healthy metabolic profile.
A study published in Hormones & Cancer found that obese rats with sensitive androgen receptors had more aggressive tumors, even after anti-estrogen treatment. Researchers identified inflammation and cytokine interleukin 6 as key factors contributing to this sensitivity, highlighting the potential for personalized therapeutic strategies.
A systematic review found that lifestyle-modification programs have no significant impact on body weight in Arab countries, highlighting the need for adapted treatment programs. The studies cited methodological flaws, including linguistic and socioeconomic context neglect, and sociocultural obstacles to female participation.
Research by American Psychological Association highlights the negative impact of fat shaming on patients' physical health and well-being. Studies show that overweight individuals may receive inadequate medical treatment, including under-dosing of antibiotics and chemotherapy, due to weight-based assumptions.
Researchers found that low leg fat mass is a crucial factor in lean individuals at increased risk of cardiometabolic diseases, similar to lipodystrophy phenotypes. The study suggests personalized prevention and treatment strategies for metabolically unhealthy lean people.
Researchers at Monash University have discovered a brain mechanism that controls the conversion of white fat into brown fat after eating, which could lead to new obesity treatments. The 'switch' is turned off during fasting and on during feeding, promoting weight gain when the switch remains active.
A new educational initiative at Touro University College of Osteopathic Medicine has significantly reduced medical students' negative attitudes toward people with obesity. The program emphasizes the complexities of obesity and focuses on attaining health instead of weight loss, leading to improved patient outcomes.
A study found that heavier Asian Americans are viewed as more American and subject to less prejudice compared to their thinner peers. Researchers believe this phenomenon is linked to common stereotypes about Asians being thin and Americans being heavy.
Research at Cornell University found that people with dulled taste buds prefer sweeter, high-calorie foods. Participants who had their taste receptors temporarily blocked consumed more sugar than those with unaltered taste response.
Researchers at Rockefeller University have discovered two brain cell populations that regulate appetite and may offer a new path to treating obesity. The study found that activating specific neurons in the dorsal raphe nucleus can suppress hunger and promote weight loss, opening up new avenues for developing effective obesity drugs.
A new study by the University of Leeds found that insufficient sleep can lead to weight gain and poorer metabolic health in UK adults. The research, which looked at over 1,600 participants, showed a significant association between short sleep duration and increased waist circumference.
A large new study shows that only one in three patients who have bariatric surgery succeed in getting their body-mass index below 30 in the first year. Patients with lower BMIs before surgery had higher odds of achieving this goal and better health outcomes, including stopping medication for high blood pressure and cholesterol.
Patients who undergo bariatric surgery are more likely to achieve a BMI of less than 30 if they have a preoperative BMI of less than 40. However, delaying surgery until higher weights can result in inferior outcomes.
A new study has found a link between adolescent obesity and an increased risk of developing colon and rectal cancer in adulthood. The study analyzed data from over 1.7 million Israeli males and females, finding that being overweight or obese at age 17 was associated with a significantly higher risk of colorectal cancer.
A new study published in Health Affairs reveals that individuals who adopt healthy behaviors such as maintaining a normal weight, not smoking, and consuming alcohol moderately can expect to live seven years longer than the general population. These extra years are spent in good health, free from disability.
A new study from UMass Medical School found that obese patients who underwent knee or hip replacement surgery reported similar pain relief and improved function as normal-weight patients. The study suggests that obesity is not a barrier to joint replacement surgery, which can provide long-term relief from joint pain.
A study published in JAMA Surgery found that women with certain risk factors, such as obesity and diabetes, may benefit from delayed breast reconstruction after mastectomy. This approach can help decrease the risk of serious wound complications compared to immediate reconstruction.
Researchers have discovered that adding estrogen to brain regions helps regulate weight and glucose levels in rats with induced menopause. The finding suggests that the medial amygdala is crucial for metabolic health, making it a potential target for treatment.
Researchers found a single amino-acid difference between toothed whales and filter-feeding baleen whales that may explain their distinct body shapes. This variation affects the sensitivity of a key receptor, potentially impacting feeding behavior and body size in these species.
Researchers found that obese people tend to ignore future meal timings when selecting portion sizes, unlike lean individuals who generally do. This novel finding highlights the need for targeted interventions to promote future thinking in meal planning and may explain why being overweight is associated with irregular meal timings.
A systematic review of 37 studies found a link between artificial sweetener consumption and higher risks of weight gain, obesity, high blood pressure, diabetes, and heart disease. The evidence suggests that artificial sweeteners may have negative effects on metabolism and gut bacteria, although the evidence is conflicting.
Men who are tall and obese have an increased risk of high grade prostate cancer and death from prostate cancer, according to a study published in BMC Medicine. The research found that height is not associated with overall prostate cancer risk but increases the risk of high grade disease and death by 21% and 17% respectively.
A Wayne State University researcher is leading a clinical research study to develop a better understanding of type 2 diabetes in obesity and improve therapy for veterans and others with the disease. The study aims to characterize a cohort of obese people with and without Type 2 diabetes to distinguish different genetic subtypes.
The USPSTF found a small but positive benefit of behavioral counseling for cardiovascular disease prevention in adults without obesity who do not have high blood pressure, abnormal cholesterol or blood sugar levels or diabetes. Behavioral counseling interventions improve healthful behaviors and reduce CVD risk factors, with minimal harms.
A randomized clinical trial investigated whether allowing infants to self-feed solid foods reduces the risk of overweight. The study found that a baby-led approach did not improve energy self-regulation or body weight but showed benefits in attitudes towards food.
The study analyzed data from 717,000 people in 111 countries and found that big gaps between activity levels coincided with higher obesity rates. The research also highlighted the powerful role of gender in country-to-country differences, with women affected more dramatically by negative consequences.
A large-scale study of daily step data from anonymous smartphone users in over 100 countries reveals how countries, genders, and community types fare in terms of physical activity. The study found that countries with greater activity variation have a larger proportion of inactive women and higher obesity rates.
A study found that age and obesity create a perfect storm that damages the tiny blood vessels that directly feed the heart muscle, leading to reduced blood flow and increased risk of heart failure. The inflammation caused by both factors thickens the walls of these microvasculature, making them less able to dilate and sustain the heart.
A randomized clinical trial found that mindfulness-based stress reduction (MBSR) decreased stress and improved blood sugar levels in overweight women. While MBSR had no significant impact on weight or insulin resistance, it may have potential benefits for the prevention and treatment of diabetes.
A 16-year study found that men who never smoked, maintained a healthy diet, and weren
A recent study published in Cell Metabolism found that brain-resident immune cells called microglia play a crucial role in driving overeating and weight gain in mice fed high-fat diets. The study suggests that targeting microglia could provide a novel approach to treating obesity, potentially avoiding side effects of existing medications.
Researchers discovered that blocking a specific intestinal microbial pathway can prevent obesity, insulin resistance, and promote active fat tissue. High levels of TMAO are linked to Type 2 diabetes and cardiovascular disease.
Researchers found that overweight or mildly obese individuals have better survival rates after a stroke compared to those with normal body weight. The study suggests that increased weight may provide a 'metabolic reserve' that helps recovery from severe disease.
A new study suggests that genetic predisposition to type 1 inflammation protects against NAFLD, but type 2 inflammation actually worsens the condition. Targeted treatments for metabolic syndrome may need reevaluation due to this unexpected finding.
A Swedish study published in Neurology found that teenage weight gain is associated with a higher risk of stroke in adulthood. The study followed 37,669 men and found that those who experienced a significant increase in BMI from childhood to age 20 were more likely to develop high blood pressure and stroke.
A study by UT Southwestern Medical Center found that mildly obese patients who survive a major heart attack tend to have better outcomes, including higher survival rates and shorter hospital stays. Patients considered mildly obese had a 30% increased likelihood of survival compared to those of normal weight.
Researchers at the University of Iowa found that mildly stressing muscle metabolism boosts levels of fibroblast growth factor-21 (FGF21), a beneficial hormone that prevents obesity and diabetes in mice. FGF21 production reversed conditions and returned mice to normal weight and blood sugar levels.
A National Institutes of Health-funded study found that moderate-intensity exercise reduced the risk of major mobility disability by 31% in older adults with extreme obesity. The structured physical activity program improved participants' ability to perform common daily activities, such as walking a block around the neighborhood.
The Endocrine Society issued a Scientific Statement on obesity's causes, emphasizing the need to understand underlying mechanisms that make it difficult to maintain weight loss. The statement highlights the complex interplay between genetics, developmental influences, and the environment in contributing to obesity.
Despite being hailed as the key regulator of leanness, leptin's function in humans remains uncharacterized. Researchers call for experimental evidence to demonstrate its mechanism of action, highlighting a crucial gap in our understanding of metabolism and obesity.
Women who received specialist care were eight times less likely to have a stillbirth. The clinic helps spot signs of complications sooner and provides tailored advice on healthy eating and weight management during pregnancy.
A new reconstruction method for Electrical Impedance Tomography (EIT) is proposed to estimate abdominal fat, improving reproducibility and spatial resolution. The technique has shown promising results in detecting subcutaneous fat thickness, with further research needed to assess visceral fat volume.
A University of Alberta research team found that patients with obesity have a higher risk of infection within 30 days after heart bypass surgery, and 88% of these patients received non-surgical PCI. This increased risk may be due to the fact that patients with obesity are more likely to receive PCI.
A new study published in Cellular and Molecular Gastroenterology and Hepatology found that consuming unsaturated fat can lead to fatty liver disease, contrary to its previously touted health benefits. The research used mice fed diets supplemented with either saturated or unsaturated fat, revealing the latter can cause liver damage.
Researchers from the University of Pennsylvania School of Medicine discovered a molecular player that acts as a pilot light to turn on brown fat, which burns sugar and fat to produce radiant heat. Mice lacking this molecule, histone deacetylase 3 (HDAC3), are unable to activate brown fat, highlighting its crucial role in metabolism.
A population study found that being overweight or obese, as defined by body mass index, abdominal obesity, and higher body fat percentage, is associated with a higher risk of developing rheumatoid arthritis in women. In contrast, no clear association was found between RA risk and BMI criteria for men.
A study published in Obesity Surgery found that only 2,112 out of 37,806 patients (5.58%) underwent subsequent body contouring procedures after bariatric surgery. The majority of these patients had higher incomes or health insurance, and the procedures usually occurred within two years after the initial bariatric procedure.
A new USC study found that a poor diet, combined with the ApoE4 gene variant, can increase the development of Alzheimer's plaques in mice. The study suggests that lifestyle factors such as diet and exercise may play a role in regulating the risk of Alzheimer's disease.
A new University of Iowa study examines the link between obesity and food container chemical substitutes, finding no associations with BPF and BPS. However, the study confirms that BPA is associated with increased obesity in humans.
Among older patients with diabetes, being overweight reduces the risk of early death by 18% compared to normal weight counterparts. However, this survival benefit is only observed in older patients and diminishes over time.
A new study published in Social Science and Medicine found that a rewards programme increased weight loss magnitude and duration by more than twice as much as a control group. The programme, which offered cash or lottery tickets for meeting monthly weight loss goals, also led to higher rates of sustained weight loss.
A study found that obese patients undergoing shoulder joint replacement surgery are at increased risk of complications, including the need for revision surgery and postoperative infections. The risk of revision surgery increases steadily with increasing body mass index (BMI) in obese patients.
Researchers found that vaccinated obese adults are twice as likely to develop influenza and flu-like illnesses compared to those of healthy weight. The study suggests that existing blood tests may provide misleading information for obese individuals.
A new guide from Tulane University aims to address inherent sex bias in pre-clinical research on metabolic diseases. The guide emphasizes the need to consider sex differences in biological mechanisms, not just hormones, to accelerate discovery and treatment.