Articles tagged with Obesity
Researchers reconstituted VcINDY into liposomes to analyze its properties as a transporter, providing insights into the cellular level functionality of SLC13 transporters. This study paves the way for targeting these transporters to combat metabolic disease and obesity.
A study found that overweight children with a common gene mutation are more likely to have elevated liver values. The research highlights the importance of healthy lifestyle habits from an early age, particularly for children carrying the risk gene.
Research has linked kisspeptin signaling to increased weight gain and glucose intolerance in mice lacking the pathway. This study found that reduced metabolism and decreased energy led to excess weight gain, not increased food consumption. The findings have potential for treating human obesity.
Research published in Nature Communications reveals a faulty electrical switch in the uterus of overweight women, causing irregular contractions and increasing the risk of caesarean sections. This breakthrough discovery sheds light on the mechanism behind labour complications in overweight women, paving the way for potential treatments.
Research in southern Ontario found that adults living in more walkable neighborhoods experienced a lower risk of developing diabetes over a 10-year period. The most walkable neighborhoods had the lowest incidence of obesity, overweight and diabetes.
Researchers discovered that retinoic acid stimulates brown fat to increase basal energy metabolism, preventing obesity-related diabetes complications. The study suggests a potential therapeutic approach for treating type 2 diabetes through the use of retinoids.
A soft-drink tax has been found to be an effective way to reduce consumption and lead to significant weight losses. The study estimated that middle-income heavy consumers would lose up to 3.64 kg, making it a cost-effective solution for obesity prevention.
Researchers found a correlation between affluence and obesity rates, with women typically having higher levels of obesity than men in developing countries. However, in the Western world, male obesity often exceeds female obesity, suggesting an alternative cause may be at play.
Researchers develop computer model to speed up search for compound that activates FFA4 protein, a key player in appetite regulation and glucose uptake. The model aims to identify molecules that bind to the protein, potentially leading to a new obesity treatment.
A new study from the University of Pennsylvania School of Medicine reveals that weight loss is the single most important factor for improving cardiovascular health in obese obstructive sleep apnea (OSA) patients. Weight loss alone significantly reduced inflammation, insulin resistance, dyslipidemia, and high blood pressure.
A recent EULAR study found that obese patients with rheumatoid arthritis (RA) have higher disease activity scores than non-obese patients, irrespective of their disease stage. This suggests that treatment to target protocols may result in obese patients being treated more aggressively than non-obese patients.
A long-term follow-up of obese patients with type 2 diabetes shows that bariatric surgery leads to more frequent diabetes remission. The study found that bariatric surgery results in a lower incidence of microvascular and macrovascular complications compared to usual care.
Researchers discovered a new hormone called Metrnl that activates brown and beige fat, leading to improved metabolic health in obese mice. Interleukin-4 signaling also played a crucial role in stimulating beige fat formation.
Researchers at the University of Texas Health Science Center at San Antonio have identified a protein called Grb10 as the on-off switch for converting unhealthy white fat into beige fat, a process that increases energy expenditure and reduces obesity. The finding could lead to the development of novel diabetes and obesity drugs.
Research reveals a key role for HIF-1 alpha in insulin resistance, type 2 diabetes, and obesity-related inflammation. The protein's inhibition shows promise as a potential treatment for these conditions, including its application to cancer.
A study associates depression with atypical features, including increased appetite, with obesity. The researchers emphasize the importance of screening for these atypical features in individuals with depression and recommend dietary measures during depressive episodes.
Researchers found that antidepressants with certain properties contribute less to weight gain than others, which could influence treatment preferences for patients at risk of weight gain. The study analyzed data from a large healthcare system and identified differences in weight gain rates among various antidepressant medications.
A new study found that individuals with a high genetic risk score for obesity who consume more saturated fat have higher Body Mass Index (BMI). Limiting saturated fat may help people with a genetic predisposition to obesity.
A study found that the number of total knee replacement surgeries more than tripled between 1993 and 2009, with a 95% increase attributed to obesity. Younger patients experienced a greater rise in overweight and obesity, leading to a surge in knee replacements.
Research suggests that resveratrol supplements during pregnancy can cause pancreatic abnormalities in fetuses, posing a risk to human health. The study found benefits of resveratrol for blood flow and obesity protection but negative effects on the fetal pancreas.
Researchers investigated whether obese patients with stroke experienced a 'weight loss paradox', where heavier individuals have better outcomes than expected. The study found no such correlation, contradicting previous hypotheses on the topic. Obesity status did not affect stroke mortality rates in this cohort.
A University of Liverpool study found that eating prunes daily improved weight loss by 1.5kg over 12 weeks, while also reducing waist circumference. Prune consumption enhanced feelings of fullness and was well-tolerated despite high doses.
A new study suggests that how one compares weight-wise with others in their community impacts life satisfaction. In areas with high obesity rates, being 'normal weight' has little benefit, while the difference between obese and non-obese individuals' life satisfaction is smaller.
A recent survey found that 60% of adults support health warnings similar to those on cigarette packets, while 70% favor banning sugary drinks in schools or limiting sugar content.
A study published in Cell Metabolism reveals that variations in the FTO gene indirectly affect the function of the primary cilium, a hair-like appendage on brain and other cells. This abnormality increases body weight by affecting leptin receptors, leading to increased food intake and obesity.
A recent study found that the US obesity epidemic is affecting all segments of the population, with no significant differences in weight gain among groups based on race or education level. The report suggests that environmental factors such as cheap and easily accessible food are driving the increase in obesity rates across the country.
A new review by the American Cancer Society concludes that inexpensive food is a key factor in rising obesity rates in the US. The study finds that Americans are spending less on food than ever before, yet consuming more calories, contributing to the growing obesity epidemic.
Researchers have found that blocking a pain receptor in mice extends their lifespan and boosts their metabolism, including an improved insulin response. This discovery provides potential insights into treating obesity and diabetes, as well as improving metabolic health.
Researchers will analyze fat stem cells from obese patients to understand the mechanism underlying excess fat storage and insulin response. The study aims to identify potential therapeutic strategies for treating different groups of obese individuals at varying risk of developing diabetes and other health issues.
A seven-year study of nearly 900 middle-aged overweight women found that physical activity reduced the risk of developing heart disease. Low-to-moderate physical activity was the only lifestyle factor that protected these women from becoming at-risk for heart disease.
A newly discovered gene called Samd4 plays a critical role in regulating metabolism, with abnormal distribution of fat and diminished insulin responses observed in the lean 'Supermodel' mouse. The study provides new potential avenues for research into diseases such as diabetes and obesity.
Dr. Timothy J. Bartness, a world-renowned obesity researcher, has been awarded a five-year, $2.5 million MERIT grant to investigate lipolysis and thermogenesis in specialized fat cells. His research aims to understand the bidirectional communication between fat and the brain, which is thought to control body fat breakdown and metabolism.
A new study found that physical activity is the most important factor in slowing the progression from metabolically healthy to at-risk obesity in overweight women. Over seven years, researchers identified a significant reduction in cardiovascular disease risk among those who were physically active.
A study of over 1,100 patients with severe PH found that higher BMI was associated with lower one-year mortality rates, even after adjusting for other factors. The researchers suggest that increased levels of serum lipoproteins in obese individuals may play a role in neutralizing circulating toxins and inflammatory proteins.
A new study by Arizona State University researchers found that overweight youth choose non-overweight friends more often than they are selected in return. This leads to overweight youth having one fewer friend on average compared to their normal-weight peers.
A recent study found that obesity is associated with longer hospital stays and higher costs for total knee replacement patients, regardless of comorbidities. The study analyzed data from over 8,000 patients and found that every 5-unit increase in BMI beyond 30 kg/m² resulted in higher hospitalization costs and longer hospital stays.
A Texas A&M-led study has found that body clock dysregulation plays a key role in the development of metabolic diseases, including obesity and diabetes. The researchers discovered that overnutrition causes circadian clock dysregulation, leading to pro-inflammatory activity in adipose tissue and worsening insulin resistance.
Drs. Brian E Chen and Stephanie L Borgland were awarded the CAN Young Investigator Award for their innovative work in neuroscience, with Dr. Chen studying brain wiring encoded in DNA and Dr. Borgland exploring neural mechanisms behind addiction and obesity.
Researchers link BMI at age 25 to increased risk of class III obesity after age 35. Current weight is a better indicator of cardiovascular and metabolic risk than duration of obesity.
A study of home food environments found that while fruits and vegetables were plentiful, preparation methods and availability of high-calorie foods contributed to obesity. The study also highlighted the challenges of eating healthy in front of the TV.
A study by Changcheng Zhou and colleagues found that IKKβ deficiency in smooth muscle cells decreases vascular inflammation and atherosclerosis, while also blocking fat cell differentiation. This suggests a novel therapeutic target for treating obesity, atherosclerosis, and metabolic disorders.
A new study reveals that severely obese teens are at risk of nutritional deficiencies, particularly low iron and mild anemia, even those who did not undergo weight loss surgery. Researchers found durable weight loss in teens who received gastric bypass surgery, but significant nutritional problems persisted.
Researchers found that lean patients with nonalcoholic fatty liver disease (NAFLD) had a higher overall mortality rate and were more likely to be male and of lower socioeconomic status. They also showed signs of liver inflammation despite having less body fat and lower levels of liver damage.
A comprehensive US study found that pregnant women with sleep apnea are five times more likely to die in the hospital than those without the condition. The researchers also linked sleep apnea to an increased risk of severe medical conditions, including preeclampsia and pulmonary blood clots.
A clinical study by Pennsylvania State University found that consuming one Hass avocado daily as part of a moderate fat diet significantly decreased low-density lipoprotein particle number and small, dense LDL cholesterol in overweight and obese subjects. The researchers observed a significant lowering of oxidized LDL particles, sugges...
A new study reveals the link between obesity and increased risk of myeloma, a cancer of plasma cells. The researchers found that adiponectin, a protective protein, can be used to suppress fatty acid production in myeloma cells, leading to their demise.
Young people in the UK predominantly felt that social implications of a large body size were more important than health consequences. They associated excess weight with negative stereotypes, bullying, and teasing, making it hard for them to lose weight
Researchers found obese patients with no heart disease have greater risk of future disease due to early plaque buildup in the arteries. The study's lead author emphasizes the importance of counseling obese individuals about their risks and providing tips for achieving a healthy weight.
Research at the University of Missouri-Columbia found that information technology, such as smartphone apps, can aid in weight loss by streamlining tracking and providing visual feedback. Social support, however, remains essential for long-term success, with in-person connections preferred over online networks.
Two studies from the University of Pennsylvania School of Medicine show that patients are often unaware of proper weight gain during pregnancy, highlighting the importance of improved communication. Additionally, research on prenatal testing for morbidly obese women reveals no increased risk of complications or early delivery.
A new UCLA-led study suggests that people taking statins in the 2009-10 year consumed more calories and fat than those who used statins 10 years earlier. Researchers found a significant increase in caloric intake among statin users, with no similar change among non-statin users.
Researchers found that bariatric surgery increases levels of bile acids in the blood, improving glucose metabolism and weight loss. The study suggests a new target for treating obesity and diabetes, offering a potential future therapeutic approach.
Researchers have identified a new syndrome called osteosarcopenic obesity, which combines the deterioration of bone density and muscle mass with obesity. This can lead to a higher risk of falls and breaking bones, particularly in older women.
A meta-analysis of 14 randomized controlled trials found that whey protein can lead to a decrease in body weight by 4.2 kg and body fat by 3.74 kg, while increasing lean body mass by 2.24 kg. Whey protein's unique combination of branched-chain amino acids may be responsible for these benefits.
Severely obese individuals with low vitamin D levels exhibited reduced physical functioning and lower activity levels compared to those with healthy vitamin D levels. The study suggests that improving vitamin D status could enhance quality of life and potentially decrease mortality risk in this population.
A new delirium severity score helps predict hospital outcomes in patients with delirium. The Confusion Assessment Method (CAM) scoring system is validated for predicting adverse outcomes, including prolonged hospital stay and functional decline. Additionally, a US survey shows that obesity contributes to the dramatic increase in diabet...
Researchers identified a protein, nicotinamide N-methyltransferase (NNMT), that can be altered to increase energy expenditures. Reducing NNMT levels in fat and liver cells dramatically reduces obesity and diabetes development in mice.
Research identifies cellular signaling dysfunction causing brown fat cells to lose blood vessels and mitochondria, leading to energy production failure and increased risk of metabolic disorders.
New research by Andrew Stokes suggests that excess weight in the US substantially increases mortality risk, contrary to previous findings. Using individuals' highest BMI in life to predict mortality rates, Stokes found a 33% attributable risk for overweight and obesity.
A new study by Monash University has shown that gastric banding can lead to remission of diabetes in people who are overweight but not obese. The research, published in The Lancet Diabetes and Endocrinology, found that weight loss surgery significantly improved the condition in over half of participants.