Articles tagged with Obesity
A recent study published in Heart journal found that extreme weight fluctuations significantly increase the risk of death among obese individuals with cardiovascular disease. Both weight loss and gain above 10kg raise mortality risk, highlighting the importance of maintaining a stable weight even within the obese range.
A cohort study found that healthier diets and lower waist-to-hip ratios were associated with improved brain connectivity and memory in older adults. The study suggests that interventions targeting diet and central obesity may be most effective between ages 48 and 70 to promote better cognitive health.
Breast cancer death rates are predicted to increase in EU patients aged 80 years and older, while falling in all other age groups. This is attributed to a lack of regular screening and access to modern treatments.
A new study suggests that chronic stress and an unhealthy diet may work together to fuel the early development of pancreatic cancer. Researchers found that both stress-related neurotransmitters and obesity-related hormones activate a protein called CREB, which is linked to cancer cell growth.
A recent study by Professor Mamas highlights the significant risk of cardiovascular diseases (CVD) in patients with cancer, particularly in aging populations. The review emphasizes the need for early diagnosis and regular monitoring to improve quality of life.
Researchers found that high-fat diets caused significant changes in the brains of aged rats, including inflammatory markers and impaired memory functions, even after only three days. The study suggests that aging and diet-related inflammation may be key factors contributing to age-related memory decline.
Researchers found that dogs carrying the genetic variant DENND1B had higher body fat content, while humans also carry this gene linked to obesity. The study highlights the importance of fundamental brain pathways in regulating appetite and body weight.
A study of 350 patients found that taking semaglutide before bariatric surgery did not increase total weight loss and had similar health outcomes to surgery alone. Researchers suggest a surgery-first strategy may lead to better obesity treatment outcomes.
A new study published in Nutrients found that eating two cups of mango daily can help lower insulin concentration levels and improve insulin sensitivity in overweight or obese adults. The study, conducted at the Illinois Institute of Technology, showed significant reductions in insulin resistance and improved beta-cell function.
A new drug candidate has been developed to target and eliminate senescent cells in the liver, reducing fat buildup and preventing liver damage. The study demonstrates a safer and more effective approach to treating metabolic dysfunction-associated steatotic liver disease (MASLD) and potentially inhibiting liver cancer development.
A new Northwestern Medicine study suggests that muscle injuries heal faster when they occur during the body’s natural waking hours. The findings could have implications for shift workers and may also prove useful in understanding the effects of aging and obesity.
Researchers discovered that dysregulation of amino acids methionine and leucine leads to hyperactive mTOR in obese mice. Using rapamycin, an mTOR inhibitor, they reversed leptin resistance and found significant weight loss with minimal effects on muscle mass.
Researchers discovered a gene called Plvap enables the body's metabolic shift from burning sugar to fat when fasting. When Plvap is turned off, the liver continues burning sugar, potentially increasing the effectiveness of weight-loss and diabetes medications.
A major new analysis predicts that over half the world's adult population (3.8 billion) and a third of all children and adolescents (746 million) will be living with overweight or obesity by 2050. The study forecasts a substantial rise in obesity among young people globally, with an additional 186 million cases predicted by 2050.
A recent study found that a brief consumption of highly processed foods can alter the brain's sensitivity to insulin in healthy individuals, potentially leading to obesity and type 2 diabetes. This effect was observed even after returning to a balanced diet for one week.
Researchers found that administration of fish oil reduced insulin resistance and improved blood sugar levels in non-obese rats, reversing a condition similar to type 2 diabetes. The study suggests that omega-3 fatty acids may be a key factor in reducing inflammation and improving glucose metabolism.
Researchers found that CD44-deficient mice stayed lean despite a high-fat diet, while control mice developed obesity. The study suggests CD44 inhibitors could serve as a complementary treatment for obesity and related metabolic disorders.
A recent study published in Frontiers in Psychiatry reveals a strong link between antidepressant use and weight gain, with an average 2% increase in body weight among participants. The study highlights the need to consider this association when prescribing antidepressants and monitor weight changes accordingly.
A recent study published in JAMA Network Open has found that higher adherence to the Mediterranean diet is associated with a modest reduction in the risk of obesity-related cancers. The findings suggest that further research is needed to clarify the mechanisms by which the Mediterranean diet may contribute to cancer prevention.
A cohort study found that patients with obesity undergoing joint replacement who experienced significant weight loss after initiating anti-obesity medications had a lower risk of 5-year and 10-year revision. This suggests that safe and sustainable weight loss may improve implant survivorship in obese patients.
A two-month intervention targeting ultra-processed foods resulted in a significant reduction of UPF intake, with participants consuming almost half the amount initially. Participants also experienced weight loss, improved mood, and reduced sugar, saturated fat, and sodium consumption.
The Adiposetissue.org platform integrates transcriptomic, proteomic, and clinical data from over 6,000 individuals to explore obesity-related changes and weight-loss effects. Researchers can now analyze comprehensive datasets without bioinformatics expertise.
A large-scale study examined the relationship between nutrients and sleep using data from people who used mobile applications to track their eating and sleeping habits. The results showed that participants with high protein, monounsaturated fatty acid, and polyunsaturated fatty acid intake had improved sleep outcomes.
A long-term study found that Roux-en-Y gastric bypass outperforms sleeve gastrectomy in treating obesity, with patients losing more excess body mass index. The Swiss Multicenter Bypass or Sleeve Study demonstrated the superiority of Roux-en-Y gastric bypass over sleeve gastrectomy for patient weight loss.
Researchers at Virginia Tech have developed a method to convert gut bacteria into mini protein factories that produce and release sustained flows of targeted proteins within the lower intestine. This approach eliminates a major roadblock in delivering drugs to this part of the body, offering potential treatment for chronic diseases.
The American Heart Association has chosen five US regions to implement a new preventive health initiative aimed at improving care for people with cardiovascular-kidney-metabolic (CKM) syndrome. The initiative will increase awareness and screening for CKM syndrome and facilitate collaboration among healthcare professionals.
Researchers explore the connection between Alzheimer's and metabolic syndrome, finding links between insulin regulation, high blood pressure, and obesity. The study suggests that maintaining healthy blood fat levels may be crucial for brain health, paving way for potential therapeutic developments.
A new study from the University of East Anglia finds that European life expectancy has slowed down since 2011 due to factors such as poor diets, lack of physical activity, and obesity. The research suggests that prioritizing healthier lifestyles in younger years is crucial for extending old age.
New guidelines from European Association for the Study of Obesity aim to improve patient safety in obesity surgery medical tourism. The guidelines recommend multiple aspects of care, including at least 2 years of follow-up and pre-operative alcohol screening, to prevent serious injuries and death.
Researchers found that teens with obesity consumed more calories in the late afternoon and early evening compared to their peers of healthy weight. The study, published in PNAS, demonstrates that the body's biological clock directly impacts food intake throughout the day.
Researchers discovered that adolescents with higher body mass indexes consumed more calories later in the day than their peers of healthy weight. The study controlled for environmental and behavioral influences to isolate the role of the circadian system in shaping eating patterns.
A new study identified unique subpopulations of fat cells with complex predicted functions, and even found differences between human fat tissues in intercellular communication. The discovery provides a basis for further research to advance personalized medicine in obesity.
Scientists at Brown University and Cincinnati Children's found that suppressing opsin 3 in the brain of mice makes them eat less. The study suggests that opsin 3 plays an important role in regulating food consumption via the melanocortin 4 receptor MC4R.
A group of nerve cells called POMC neurons are responsible for dessert cravings, releasing a feel-good opiate when mice eat sugar. This pathway is activated even before eating, and blocking it reduces sugar consumption in full animals.
Small increases were observed in childhood obesity rates and severe obesity among US adults between 2013 and 2023. The study found no significant changes in waist circumference or other obesity-related measures during this period.
A study by University of Gothenburg researchers found that consuming sulforaphane from broccoli sprouts improved blood sugar levels in people with prediabetes. The compound had a significant effect on fasting blood sugar levels, particularly in those with certain pathophysiological and microbiome characteristics.
Researchers at Virginia Tech have developed a way to convert gut bacteria into miniature protein factories that produce and release targeted proteins inside the lower intestine. This breakthrough could potentially treat chronic diseases.
A clinical trial found that semaglutide significantly reduced weekly alcohol craving, drinking quantity, and the frequency of heavy drinking days in adults with symptoms of alcohol use disorder. Participants who received semaglutide also consumed lower amounts of alcohol during laboratory tests.
A study published in the Archives of Gerontology and Geriatrics Plus found that the prevalence of older Americans without disabilities increased from 61% in 2008 to 65% in 2017. This represents a significant improvement, with an additional 2.07 million older Americans potentially having had disabilities if trends had remained constant.
UD researchers found significant differences in gene expression in adipose tissue, a vital endocrine organ linked to cardiovascular and metabolic diseases. The study identified four genes related to metabolism, calcium handling, and inflammation that warrant further investigation.
Columbia scientists identified specialized neurons in the brains of mice that monitor food intake and decide when to stop eating. These neurons are located in the brainstem, process complex signals, and integrate information from multiple sources to determine fullness, leading to new potential treatments for obesity.
A recent study introduces an innovative method for analyzing body composition, providing accurate assessments of body fat and muscle distribution. The approach utilizes deep, nonlinear methods to enhance estimation accuracy, surpassing previous linear models.
A narrative review of over 1,700 papers found only seven papers addressing dexamphetamine addiction directly. The study raises questions about the evidence underpinning its restriction by regulatory agencies. Dexamphetamine is effective in treating ADHD and narcolepsy but may have benefits in treating obesity.
A cohort study found that patients without type 2 diabetes had higher discontinuation rates and lower reinitiation rates of GLP-1 receptor agonist therapy. Inequities in access and adherence to effective treatments exacerbate disparities in obesity.
A cohort study of Canadian children found that high ultraprocessed food consumption during early childhood is associated with obesity development, particularly in males. The study suggests that targeted public health initiatives can help reduce ultraprocessed food intake and prevent obesity.
Two organizations, a health monitor developer and an addiction recovery platform creator, are honored for their innovative work supporting equitable health outcomes. The recognition highlights the importance of addressing social and economic barriers to cardiovascular disease.
The study found a significant increase in obesity drug prescriptions from 0.76 million in July 2017 to 1.5 million in February 2024, mirroring rising public online search activity for semaglutide and tirzepatide. This correlation highlights the real-time association between public awareness and prescription trends.
A new study from University of Florida researchers finds that heatstroke can lead to lasting, multi-organ damage and obesity in mice for months afterward. The animals' hearts metabolically crashed two weeks after the initial injury, leading to chronic deterioration and weight gain.
The BP-CATCH trial found significant racial and ethnic disparities in pediatric counseling for children with high blood pressure, but no disparities were observed among those with or without obesity. The study highlights the need to address these disparities to provide equitable care to all patients.
The European Society for Paediatric Endocrinology and the European Society of Endocrinology will host the first-ever joint Congress on May 10-13, 2025. The event aims to bring together paediatric and adult endocrine specialists from across Europe and the world to collaborate and celebrate endocrinology.
A recent study by Murdoch University reveals that moderate-intensity exercise significantly influences appetite-related hormones and perceptions in males with obesity. The study confirms the benefits of incorporating regular exercise into daily routines for weight management and overall health improvement.
A Cleveland Clinic study shows that bariatric surgery significantly lowers the risk of developing serious liver complications in patients with obesity and fatty liver-related cirrhosis. The study found a 72% lower risk of liver disease complications and an 80% lower risk of progression to decompensated stage among surgical patients.
A new study from the Salk Institute has discovered that a protein called BCL6 plays a crucial role in maintaining healthy muscle mass. Increasing BCL6 levels successfully reversed muscle losses in mice, suggesting that pairing GLP-1 medications with a BCL6-boosting drug could help counteract unwanted muscle loss.
A large population-based analysis found that genetic variants in the GLP1R gene are associated with cardiometabolic traits and behavioral changes, such as risk-taking behavior and anxiety. These findings suggest that any observed behavioral changes with GLP1RA medications are unlikely to be a direct result of the medication.
Researchers investigate how sex-specific immune responses affect disease outcomes in obesity and helminth infections, aiming to develop new treatments for metabolic disorders and parasitic infections. The study focuses on macrophage-eosinophil interactions and the role of RELMalpha protein.
A new study found disparities in access to semaglutide based on insurance plan, job industry, sex, and other factors. Individuals with female identities, preferred provider organization coverage, and antidepressant use were more likely to start taking semaglutide compared to males or those with certain employment industries.
A study published in JAMA Pediatrics found that childhood obesity treatment can reduce the risk of serious health problems such as type 2 diabetes, hypertension, and dyslipidaemia in young adults. However, it did not have a lasting impact on depression and anxiety, which remained unchanged regardless of treatment outcomes.
A recent study found that effective pediatric obesity treatment is associated with lower incidences of mortality in young adulthood. The treatment was also linked to reduced long-term morbidity, such as type 2 diabetes, dyslipidemia, and hypertension.
A study found that a simple blood test could predict breast cancer risk in older women by measuring biological aging via DNA methylation changes. Lifestyle factors, such as obesity and hormone replacement therapy, also influenced epigenetic aging and breast cancer risk.
A cohort study found that insurance plan type and structure play a crucial role in determining access to semaglutide for adults with obesity. The findings suggest that targeted interventions at the insurance level could improve equity in obesity treatment access.