Articles tagged with Obesity
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A nationwide study found a significant increase in GLP-1RA prescriptions for weight loss management, with a notable uptick since 2020. The researchers hope their findings will inform healthcare policies to ensure equitable access to these essential treatments.
A UC Riverside-led research team found that obesity causes chronic changes in the brain, leading to reduced connections between neurons and lower testosterone levels. The study suggests that the primary site of obesity's effects on reproductive function is the brain, rather than the testes or pituitary gland.
Researchers analyzed fecal samples from fat cats undergoing different dietary changes and found striking similarities to human studies, particularly in the presence of short-chain fatty acids. The study suggests that feline gut microbiome shifts may correlate with metabolic outcomes and provide valuable insights for obesity treatment.
A major study found that people who gained excess weight from their 20s onwards had less healthy hearts by the time they were in their 60s. The researchers linked weight gain in young and middle-aged adults to enlarged hearts that pump blood less well, over and above the effect of being overweight in later years.
Severe obesity can alter metabolism and psyche, leading to impulsive behavior and a willingness to take risks. A study found that massive weight loss improved glucose metabolism and mood, allowing for more metabolically driven decision-making.
A study reveals that the gene SH2B1 controls feeding and energy expenditure, with mutations associated with obesity and metabolic diseases. Enhancing SH2B activity may offer a promising treatment for obesity and related conditions with fewer side effects.
Researchers found that mice lacking certain signal molecules produced during exercise had reduced oxygen consumption and fat burning, leading to increased susceptibility to weight gain. In humans, those producing more of these alternative versions consumed less oxygen and had lower body fat.
A new study found that surgical weight loss significantly reduces widespread pain in Black and Hispanic patients, with the greatest benefit seen within the first three months after surgery. However, disparities persist, with these groups still experiencing a higher pain burden than the general population.
Researchers from Monell Chemical Senses Center discovered a population of neurons controlling food intake without inducing nausea in an animal model. The study found that targeting these neurons could lead to improved weight loss medications with fewer side effects.
Research suggests that metabolically healthy obese individuals have a significantly lower risk of cardiovascular disease and death compared to those with metabolic unhealthy obesity. Fat distribution plays a crucial role in defining metabolic health, according to a recent review article.
Tirzepatide was associated with significantly greater weight loss than semaglutide in adults with overweight or obesity. Future studies are needed to explore differences in other outcomes.
A new framework for diagnosing and managing obesity in adults proposes modernizing obesity diagnosis to take account of all the latest developments in the field. The authors recognize that BMI alone is insufficient as a diagnostic criterion and that body fat distribution has a substantial effect on health.
Researchers found GLP-1 receptor agonists lower risks of certain obesity-associated cancers in patients with type 2 diabetes, suggesting potential benefits for cancer prevention in high-risk populations. The study provides preliminary evidence supporting further preclinical and clinical studies to prevent specific obesity-linked cancers.
A new study found that patients prescribed semaglutide for diabetes or weight loss have a higher risk of developing NAION, a potentially blinding eye condition. The study revealed a significant risk increase in diabetic and overweight/obesity patients taking semaglutide.
Researchers found that high blood levels of saturated fatty acids, particularly palmitate, cause pre-activation of innate immune cells in obese non-diabetics. This leads to elevated inflammatory molecules when infected with SARS-CoV-2, increasing the risk of severe COVID-19.
African American woman breast cancer survivor talking about her experience with breast cancer and the impact of breast cancer on women's lives. The American Cancer Society is a leading organization in cancer research, patient services, and advocacy.
A study published in Journal of Bone & Joint Surgery found that laboratory values such as hemoglobin level, platelet count, and inflammatory markers can predict the risk of periprosthetic joint infection (PJI) in patients with morbid obesity. These findings may help surgeons identify high-risk patients and improve outcomes.
Researchers found that older female mice receiving daily whole-body heat treatment gained less weight and showed improved insulin sensitivity. The therapy also mitigated weight gain induced by a high fat diet and reduced fat accumulation in key areas.
A new mouse study suggests that elenolic acid can lower blood sugar levels and promote weight loss in obese mice with diabetes. The compound was found to induce the release of metabolic hormones GLP-1 and PYY, leading to improved glucose regulation and insulin sensitivity.
Research emphasizes the impact of parental factors on offspring's health outcomes. The study discovered a significant association between parents' weight status at 17 and their children's risk of obesity. This finding suggests that health issues can be inherited across generations, with parental characteristics playing a crucial role.
A study published in Gut reveals that specific bacteria in the gut are involved in compulsive eating and obesity, with a beneficial bacterium called Blautia showing protective effects. The research also highlights the role of microRNAs in food addiction and suggests potential new treatments involving beneficial bacteria and dietary sup...
At least seven out of 42 ICBs across England have had to close a specialist weight management service list in their area due to overwhelming demand. Experts say a lack of consistent government policy is hindering the ability of weight management services to keep up with the growing need for obesity treatment.
A new study led by UCL researchers found that cardiovascular health is a significant risk factor for future dementia rates. The study analyzed data from 27 papers and found that rates of obesity and diabetes have increased over time, contributing to higher dementia risk.
The ARMMS-T2D study found that bariatric surgery yields greater long-term improvements in quality-of-life compared to medical management, with sustained weight loss correlating with better health and reduced pain.
Research reveals close relationship between midlife diet and healthy aging; Limiting ultra-processed foods may not improve diet quality. Baby-led weaning meets nutritional needs for healthy growth, while whole grains retain more nutrients during milling.
Women with obesity-related heart failure experienced greater weight loss and improved HF symptoms compared to men. Semaglutide improved HF-related symptoms, physical limitations, exercise function, reduced inflammation, and lower blood pressure across both sexes.
Researchers have developed a novel drug therapy for obstructive sleep apnea (OSA), which has shown significant improvements in reducing breathing interruptions and improving overall health. The treatment targets both respiratory and metabolic complications, providing a promising alternative to existing therapies.
A randomized clinical trial found that an intermittent fasting plan consisting of two nonconsecutive fasting days and five days of meal replacement diet improved glycemic outcomes and weight loss in the short term compared to metformin or empagliflozin. The study suggests a promising initial intervention for type 2 diabetes management.
Researchers are exploring inflammation caused by COVID-19 as a trigger for Long Covid, a condition characterized by persistent symptoms like fatigue, brain fog, and shortness of breath. The study aims to identify potential causes and treatments for Long Covid, with findings that could lead to enhanced immune function in patients.
A Cleveland Clinic study finds bariatric surgery cuts the risk of major cardiovascular events by 42% and all-cause mortality by 37% in patients with obesity and moderate to severe obstructive sleep apnea. The study analyzed data from 13,657 adult patients who underwent weight loss surgery between 2004 and 2018.
A new genetic cause of obesity has been discovered, linking it to the SMIM1 gene variant. People with this variant tend to expend less energy when at rest, leading to excess weight and increased risk of obesity.
A study found that overexpressing a gene responsible for amino acid transport in the placenta can cause fetal growth to increase by 27%, while also providing insights into pregnancy complications like IUGR and obesity. The research has therapeutic implications, potentially informing treatments to prevent or treat these conditions.
A new study found that regular snoring is associated with elevated blood pressure and uncontrolled hypertension, particularly in overweight middle-aged men. The research used multiple night home-based monitoring technologies and objective assessments to explore the connection between snoring and hypertension.
The USPSTF recommends providing or referring children and adolescents with a high body mass index (BMI) to comprehensive behavioral interventions. Approximately 19.7% of US children aged 2-19 have a BMI at or above the 95th percentile, with higher prevalence among Hispanic/Latino, Native American/Alaska Native, and lower-income families.
A new study found that Americans are eating better, but disparities in diet quality persist among marginalized communities. The proportion of adults with poor dietary quality decreased from 48.8% to 36.7% between 1999 and 2020, while those with intermediate diet quality increased.
Researchers from the University of Granada found that accumulating moderate-to-vigorous physical activity in the evening improves glucose regulation in overweight and obese adults. The study's results have significant implications for individuals at risk of developing insulin resistance or type 2 diabetes, highlighting the importance o...
A Vanderbilt University Medical Center-led research team discovered a connection between obesity and cancer, revealing that macrophages play an unexpected role in the complicated connection. Obesity increases macrophage frequency in tumors and induces PD-1 expression, which can contribute to both increased cancer risk and enhanced resp...
Research shows people with obesity are more sensitive to price when buying unhealthy foods, while those with normal weight are not. A 10% price hike on these categories can lead to a significant reduction in consumption, such as decreased frozen pizza purchases.
The Pennington Biomedical Research Center is conducting a clinical trial to better understand lipedema. Participants will undergo comprehensive assessments and imaging techniques to help advance medical knowledge related to chronic disease. Compensation of up to $475 is offered for participation in the three-month study.
The study found that 1 in 5 children and adolescents experience excess weight, with rates varying by region. Excess weight is linked to multiple factors, including inherent, behavioral, environmental, and sociocultural influences.
In individuals with a diabetes duration of 10 years or less, bariatric metabolic surgery was associated with greater weight loss and reduced mortality compared to first-generation GLP-1RAs. No differences were observed between treatment modalities in patients with longer diabetes duration.
A recent study from the Women's Health Initiative found that both obesity and metabolic syndrome increase breast cancer risk, but in distinct ways for different subtypes. The research highlights the importance of controlling waist circumference and metabolic conditions to reduce breast cancer risk.
A meta-analysis of 15 randomized studies found that patients taking GLP-1 medications experienced only mild differences in gastric emptying, delaying solid food by about 36 minutes. The findings suggest it may be safe to continue these medications before surgery without a high risk of aspiration.
Current medical training neglects to educate future doctors on how to encourage healthier eating habits and focuses on weight loss and BMI. Researchers advocate for small changes in medical education to address anti-obesity bias and promote cardiometabolic health, a stronger predictor of overall well-being.
A study suggests that women who underwent sleeve gastrectomy before pregnancy had children who gained more weight per month in the first three years of life. In contrast, those born to mothers who had Roux-en-Y gastric bypass surgery experienced slower weight gain. Researchers found this difference after adjusting for various factors, ...
A new study found that people exposed to higher levels of airplane noise were more likely to have a higher body mass index, an indicator for obesity that can lead to cardiometabolic diseases. The study highlights the role of environmental factors in shaping health outcomes.
Researchers found that GLP-1 receptor agonists and SGLT-2 inhibitors lower the risk of major cardiovascular events, such as heart attacks, and severe liver complications compared to other diabetes treatments. These medications also showed no significant increase in severe adverse events.
A study found that nearly 20% of breast cancer survivors experience excess weight gain of more than 10% over six years. Factors associated with this weight gain include lower body weight, younger age, hormone-positive breast cancer, and certain genetic mutations.
A comprehensive study found that living with obesity for 10 years or more significantly increases the risk of heart attacks and strokes. The research, published at ENDO 2024, analyzed data from over 109,000 participants and revealed a 25-60% increased risk in younger adults.
A recent study funded by tirzepatide maker Eli Lilly Inc. found that the medication resulted in significant weight loss regardless of the number of obesity-related complications patients had at the outset. The study combined data from four trials involving over 4,700 subjects with obesity or overweight conditions.
A new study found that children who are sedentary for more than six hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood. Engaging in light-intensity physical activity for at least 3 hours a day can reverse premature liver damage.
A new study found that tirzepatide significantly reduced weight in Chinese adults with obesity, with both 10mg and 15mg doses showing clinical benefits. The treatment also demonstrated an acceptable safety profile.
A mouse study found that heart failure with preserved ejection fraction (HFpEF) differs between male and female mice, with females exhibiting altered heart filament proteins and males showing slowed calcium removal. This may lead to different treatment strategies for women compared to men with HFpEF.
Researchers emphasize the importance of addressing socioeconomic, cultural, and epigenetic factors in the Latin American obesity epidemic. The study suggests that public policies and strategies must acknowledge these drivers for effective weight loss.
A new study highlights the benefits of intermittent fasting and protein-pacing on gut health, weight loss, and metabolic responses. Participants showed improved diversity of the gut microbiota, decreased symptoms of gastrointestinal problems, and increased beneficial microbes linked to a lean body type.
A new study reveals TNIK's role in various diseases, including fibrosis, cancer, obesity, and Alzheimer's. The protein has been found to drive cancer cell proliferation and treatment resistance, while also regulating metabolic processes.
Researchers at USask have discovered a new peptide that lowers lipid accumulation in human liver cells, offering new avenues for treating metabolic diseases. The finding is hopeful news as there's a lack of new therapies available for these diseases.
A new study reveals that a cancer drug can improve insulin sensitivity and lower blood glucose levels, but eliminating a specific gene related to fat metabolism worsens insulin resistance. The research highlights the interconnectedness of fat metabolism in organs and the need for simultaneous treatment of obesity and insulin sensitivity.
Dr. George Bray's paper tracks the development of obesity research over 100 years, from early explorations to modern medication interventions. The study highlights the chronic and relapsing nature of obesity as a disease process.
Research published in the Journal of Investigative Dermatology reveals that UV exposure increases energy expenditure by inducing the 'browning' of subcutaneous fat, thereby preventing weight gain. This breakthrough discovery opens up new possibilities for treating obesity and metabolic disorders.