About The Study: In this cohort study using a target trial emulation, a higher proportion of weight loss after initiating anti-obesity medications within 1 year was associated with a lower risk of 5-year and 10-year revision among patients with obesity undergoing joint replacement. These results suggest that anti-obesity medication use, with relatively safe and sustainable weight loss, may be an effective strategy for improving implant survivorship of hip and knee replacements in the obese population.
Corresponding Author: To contact the corresponding authors, email Chao Zeng, MD, PhD ( zengchao@csu.edu.cn ) and Guanghua Lei, MD, PhD ( lei_guanghua@csu.edu.cn ).
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(doi:10.1001/jamanetworkopen.2024.61200)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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