Articles tagged with Joints
A major change in human ancestors' movement took place between 3 million and 1.8 million years ago, combining regular tree-climbing with walking on two legs. Early human ancestors like Australopithecus used trees as much as modern chimpanzees and gorillas do today, but when on the ground, they walked on two legs.
A recent study published in Cell Death & Differentiation highlights the role of endoplasmic reticulum stress proteins in osteoarthritis, revealing their contribution to inflammation and tissue remodeling. The research identifies a promising protein, PDIA4, which may serve as a therapeutic target for limiting disease progression.
Researchers found that parents who ran with a stroller were less likely to sustain an overuse injury during the first three years after becoming a parent. For every 1,000 miles run, stroller runners saw a 55% lower injury rate compared to those who ran without a stroller.
A new study published in Radiology found that embolization of abnormal blood vessels using rapidly resorbable gelatin-based microspheres is safe and effective in providing significant, lasting pain relief and functional improvement for patients with osteoarthritis-related knee pain. The procedure significantly reduces inflammation and ...
Researchers discovered that exercise enhances oxygen delivery to arthritic joints through tiny vesicles released from red blood cells, relieving tissue hypoxia and promoting joint health. Physical activity drives the circulation of these EVs into the joint, where they deliver oxygen and maintain joint function.
A new study from Aarhus University reveals that weight-loss drugs containing GLP-1 hormone may influence joint inflammation in arthritis patients. The study found that high doses of GLP-1 in medication could have a dual effect, both through weight loss and by increasing levels in the joints.
A new clinical trial at the University of Cincinnati is testing a peptide solution to treat prosthetic joint infections after total knee replacement. The trial aims to reduce the need for repeat surgeries and expand the treatment window beyond two weeks.
Research suggests that Kinesio taping (KT tape) may reduce pain intensity in the immediate and short term, but evidence for long-term benefits and its use in various musculoskeletal conditions is inconclusive. The majority of systematic reviews found inconsistent findings, and potential skin irritation remains a concern.
Researchers identified two fundamental coordination patterns in underwater dolphin kick, accounting for over 99% of movement across performance levels. Faster swimmers exhibited greater shoulder extension and increased lower trunk movement, enabling reduced water resistance and improved propulsion.
A large-scale study of over 20,000 elective shoulder replacement surgeries in the UK and Denmark found that higher BMI is not linked to increased risk of death or complications. Underweight patients, however, were found to have a slightly higher risk of death.
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
Researchers create map of T cell responses to Chikungunya virus, shedding light on chronic disease triggers. They found that people with chronic disease have T cells targeting the same viral epitopes as those who cleared the virus.
Researchers found corticosteroid injections accelerated structural knee degeneration, while hyaluronic acid injections slowed down damage. The study challenges common clinical practice and suggests alternative pain management strategies for patients with osteoarthritis.
Researchers analyzed a skeleton with a severe knee injury to uncover the complexities of social attitudes towards individuals with disabilities in medieval Europe. The study found that despite negative cultural views, some individuals with disabilities received long-term care and prominent burials.
A robotic hand developed at EPFL can pick up 24 different objects with human-like movements that emerge spontaneously due to compliant materials and structures. The device uses 'self-organized' grasps that mimic natural human grips with a high success rate, making it suitable for highly unpredictable environments.
A global research initiative analyzing data from nearly 2 million people in diverse populations worldwide has uncovered multiple new genes associated with osteoarthritis. The study also identified key genetic pathways and 69 genes whose protein products are targeted by approved drugs, paving the way for repurposed treatments.
A recent study published in the International Journal of Sports Physical Therapy identified five risk factors for athletes developing shoulder pain, including range of motion, strength, and training load. The research also examined treatment options for frozen shoulder, an inflammatory condition that causes unrelenting stiffness and pain.
A surgical procedure called Birmingham hip resurfacing enables aging athletes to remain highly active, even many years after the procedure. Studies have shown that patients who underwent this procedure were able to return to high-impact sports and maintain their activity levels for an average of 14 years after surgery.
A study found that New York's opioid restriction law led to decreased opioid quantities after total joint replacement surgeries. The findings suggest refining laws may further reduce opioid prescribing nationwide.
A new study from the University of Bath reveals that delays in diagnosing and treating psoriatic arthritis often result in irreparable damage to joints. Early diagnosis and effective treatment can prevent this damage and improve physical function and quality of life for patients with PsA.
Queen Mary University of London has launched a new regenerative medicine spinout, ReFleks, which aims to repair osteochondral defects and prevent osteoarthritis. The innovative treatment uses Agrin to block cartilage degradation and form new cartilage faster, providing a cheaper and easier alternative to existing approaches.
A new study suggests that ACLR patients have a higher riding patella, shifting load-bearing areas and potentially contributing to osteoarthritis. This finding is observed in both the injured knee and the uninjured contralateral knee.
Researchers have discovered a novel imaging tool that captures functional activity in mouse models of TMJ injury and inflammation, revealing the simultaneous activity of over 3,000 trigeminal ganglion neurons. This finding suggests that CGRP antagonists could offer a promising solution for TMJ pain relief.
A new study found that people with chronic obstructive pulmonary disease (COPD) and arthritis have a significantly increased risk of death compared to those with only arthritis. The research analyzed data from over 11,000 individuals in the US and discovered a strong association between COPD and mortality rates in people with arthritis.
A new study by Weill Cornell Medicine researchers has identified a potential biomarker for joint inflammation in Crohn's disease patients, the bacterium Mediterraneibacter gnavus. The study found that M. gnavus is associated with increased immune cell responses and disease activity scores in patients with joint inflammation.
Researchers discovered synovial joints in ancient fish lineages, suggesting these features first evolved in jawed vertebrates. The study's findings shed light on the origins of humans' flexible joints and provide critical information for research into vertebrate skeletal architecture.
A cohort study found that patients with obesity undergoing joint replacement who experienced significant weight loss after initiating anti-obesity medications had a lower risk of 5-year and 10-year revision. This suggests that safe and sustainable weight loss may improve implant survivorship in obese patients.
A new study by Johns Hopkins University suggests that jumping workouts could be a preventative measure for cartilage damage in long space journeys. Mice subjected to reduced movement experienced cartilage thinning, while those performing jump training showed thicker, healthier cartilage.
A study of 153 people between the ages of 60 and 89 suggests a modification to the well-established clinical test for assessing balance in the elderly to make it more efficient, accessible, and predictive. The assessment can predict the risk of falling over a six-month period with accuracy.
Researchers created a 'Hyperelastic Torque Reversal Mechanism' that enables fast and powerful movements in soft robots made from rubber-like materials. The mechanism leverages the characteristics of soft hyperelastic materials to rapidly stiffen as they compress, allowing for rapid and efficient movement.
A new soft wearable robot called WeaRo has been developed to help workers avoid job-related injuries while lifting, lowering, and carrying objects. The robot effectively reduces muscle activation levels by up to 27.0% without constraining users' movements.
Researchers will analyze tissue samples from 100 patients over three years to understand why some respond better than others to biologic and targeted therapies. The study aims to improve matching of treatments to individual patients, reducing the guesswork and cost associated with ineffective treatment.
Researchers have developed a new diagnostic test that uses two markers found in the synovial fluid of patients' joints to differentiate osteoarthritis from inflammatory arthritis. The algorithm, based on the ratio of cartilage oligomeric matrix protein and interleukin-8, has been validated with high accuracy.
Research published in the Journal of Orthopaedic Research reveals that individuals with ACL reconstruction exhibit persistent aberrant gait biomechanics, which can lead to joint loads contributing to long-term knee problems. Early rehabilitative measures may help maintain long-term knee joint health.
Researchers developing standardized approach for ACJ reconstruction, evaluating three surgical techniques to restore stability and minimize complications. The study aims to identify most effective technique for long-term shoulder health in young athletes.
A minimally invasive procedure called Genicular artery embolization (GAE) has been shown to effectively relieve knee pain and improve quality of life in people with osteoarthritis. The study found that GAE can significantly reduce knee pain and improve quality of life, even in advanced cases.
Researchers found that hip implants with delta ceramic or oxidised zirconium head and highly crosslinked polyethylene liner or cup had the lowest risk of revision during 15 years after surgery. The study used data from over 1 million hip replacement patients in England and Wales to identify optimal implant materials.
Researchers from Kyushu University found that precisely replicating a patient's native alignment during knee replacement surgery is crucial for optimal recovery and a higher quality of life. Patients who underwent changes in knee alignment after surgery had significantly worse long-term outcomes.
A new intervention will be developed by University of South Australia researchers to help young people with chronic childhood arthritis overcome barriers to physical activity and mental wellbeing. The VITAL Project aims to validate, understand, and empower activity in people with Juvenile Idiopathic Arthritis, reducing pain invalidatio...
A genome-wide association study found that inherited genetics is a key factor in why some people develop gout, while others don't. The research identified new targets for preventing gout attacks and hopes to lead to improved treatment options.
A recent study published in Knee Surgery, Sports Traumatology, Arthroscopy found that children who undergo surgery for discoid lateral meniscus are at higher risk of developing further knee injuries with age. Younger patients were particularly prone to relapse after surgery.
Researchers propose a better understanding of inflammation in rheumatoid arthritis, identifying an early pathogenic macrophage cell/gene signature that shapes the inflammatory environment. This discovery offers a unique opportunity for early diagnosis and therapeutic intervention, potentially leading to improved patient outcomes.
The study found that home discharge rates increased more for Hispanic compared to non-Hispanic white patients, highlighting the importance of considering differential outcomes in Medicare payment policies. These findings suggest the need for tailored approaches to address racial and ethnic disparities in joint replacement care.
A University of Kansas researcher has found that single leg backward hopping can accurately measure knee strength and recovery in patients after ACL reconstruction. This method shows significant changes in knee mechanics compared to forward hopping, making it a potentially superior indicator of quadriceps strength deficiency.
Patients with periprosthetic joint infection (PJI) after total hip replacement have a five-fold increased risk of mortality within 10 years. Researchers found that PJI patients had a significantly higher 10-year mortality rate than those who didn't develop an infection, highlighting the need for prevention efforts and best practice gui...
A recent study published in the Scandinavian Journal of Medicine & Science in Sports found that reduced body flexibility is associated with poor survival in middle-aged men and women. After analyzing data from 3,139 participants, researchers discovered an inverse relationship between Flexindex scores and mortality risk.
Researchers developed a bioactive material that successfully regenerated high-quality cartilage in animal models, promoting enhanced repair and growth of new cartilage containing natural biopolymers. The material's effectiveness was tested in sheep with cartilage defects, showing promising results for potential use in humans.
A study by the University of Bristol found that nearly nine months of joint replacement surgery was lost since the start of the COVID-19 pandemic, with knee, shoulder, and ankle surgery being affected more severely. The recovery from this deficit is expected to take many years, if not decades.
A study comparing traditional and new hip replacement stems found larger contact areas in certain femur regions with the new stems. Traditional HA stems, however, demonstrated superior long-term preservation of bone density.
Sub-elite female Australian football players experience different injury patterns compared to males, highlighting the need for targeted training and injury prevention strategies. Ankle sprains, concussions, and anterior cruciate ligament injuries are the most common and burdensome, resulting in the most missed matches.
A study published in Journal of Bone & Joint Surgery found that laboratory values such as hemoglobin level, platelet count, and inflammatory markers can predict the risk of periprosthetic joint infection (PJI) in patients with morbid obesity. These findings may help surgeons identify high-risk patients and improve outcomes.
A study in São Paulo state found that chikungunya virus circulated silently for years before causing major epidemics. The researchers monitored residents for four years and discovered a significant rise in seroprevalence from 0.35% to 2.3%. This finding underscores the need for strengthened disease surveillance.
A new biomarker database, Space Omics and Medical Atlas (SOMA), has been developed to improve astronaut health, but its findings may also be useful for people on Earth with limited mobility or bedridden conditions. The database provides insights into short and long-term health impacts of spaceflight.
Research from the University of South Australia found that people with knee OA unconsciously believe exercise is dangerous, despite medical advice. The study developed a tool to detect and evaluate these implicit beliefs, suggesting they can be a better predictor of actual behavior than reported attitudes.
A new study led by UCSF found that COVID-19 vaccine side effects like headache and tiredness indicate a strong immune response. Those with more symptoms had nearly double the antibody levels of those without, suggesting the vaccine is effective in preventing infection.
Dr. Melissa Grunlan's team creates regenerative osteochondral plugs, a potential off-the-shelf device to treat OCDs and avoid total knee replacement surgery. The technology offers an alternative to autografting or total knee replacement, providing immediate support for joint function and potentially reducing post-operative complications.
Researchers at UC Davis have updated their guidelines on neutering popular dog breeds, finding major differences in joint disorders and cancers. The study emphasizes personalized decisions, considering breed, sex, and context, and provides a table with guidelines for all 40 studied breeds.
Researchers at Clemson University have developed a simulation-based optimization approach to overcome challenges in vitrification of larger tissues. The new technology results in high viability rates for vitreous grafts, making them suitable for transplantation.
Researchers will develop 'live' joints with biocompatible bone and cartilage grown from human cells, aiming to scale up the technology for commercial use. The project, valued at $47.7M, targets 40 patients within five years with knee replacements.
The World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases will showcase new clinical research from over 1507 submitted abstracts. The event will offer valuable knowledge to help clinicians treat patients more effectively in their daily practice.