Articles tagged with Joints
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A systematic review and meta-analysis of 16 studies involving 875 patients with knee osteoarthritis found significant reductions in patient-reported pain from the third month onwards. Stem cell treatment was most effective when using patient's own fat-derived stem cells, leading to better pain alleviation and recovery of joint function.
The University of Basel has successfully treated over 100 patients with focal lesions and two advanced cases of knee OA, reporting beneficial outcomes. The N-TEC procedure uses autologous cartilage cells to grow new cartilage grafts for repairing damaged joints, offering an alternative to knee joint replacements.
Researchers found that stopping TNF inhibitors led to more flares and lower remission rates among RA patients who were already in sustained remission. This contrasts with those who continued treatment, highlighting the importance of personalized treatment approaches for RA patients.
Researchers developed a deep learning system to detect and predict joint space narrowing and erosions in hand radiographs of RA patients. The AI model achieved over 90% accuracy in detecting joints, but its performance may be lower than human radiologists for wrist joint analysis.
A multicenter, retrospective study of Japanese patients treated with JAK inhibitors found impressive remission rates and low disease activity. The study's results contradict previous concerns about the effectiveness of these drugs, suggesting they may be a viable option for patients with other health problems.
Researchers developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to treat rheumatoid arthritis. This approach provides both immediate pain relief through ROS scavenging and long-term immune tolerance by delivering immunomodulatory cytokines.
Researchers at Queen Mary University of London developed a new organ-on-a-chip model of the human synovium to study arthritis mechanisms and develop new treatments. The three-dimensional microfluidic device successfully replicates key features of native synovium biology.
A study has identified genetic markers that can predict whether rheumatoid arthritis will improve or worsen during pregnancy. These markers were found in white blood cells and genes related to B cells, and may help women plan their treatment and avoid unnecessary medication exposure.
Researchers developed a DNA damage-induced senescence model in osteoarthritic chondrocytes, which reliably induces cellular senescence and accumulates senescent cells in OA joint tissues. The study provides a useful model to develop therapeutic approaches targeting senescence in osteoarthritis.
Patients taking non-selective beta-blockers for knee pain have a 54% reduced risk of undergoing total knee arthroplasty. Prolonged use and high adherence to treatment also showed strong protective effects.
A study by Dartmouth researchers reveals that human shoulders and elbows evolved to facilitate 'downclimbing' - the process of descending from trees without dying. This adaptation allowed early humans to navigate their environment safely, gathering food and deploying tools for hunting and defense.
A recent study found that patients over 90 have higher complication and mortality rates after total hip arthroplasty (THA), but the risks can be minimized through careful patient selection and adequate preparation. Comorbidity has a major impact on THA risks, with certain conditions increasing the risk of complications and mortality.
A new study projects nearly 1 billion people will be living with osteoarthritis, the most common form of arthritis, by 2050. Currently, 15% of individuals aged 30 and older experience osteoarthritis, with obesity being a major risk factor.
A new tool called PRESTO identifies patients with psoriasis at high risk of developing psoriatic arthritis. The tool uses a mathematical model to estimate a patient's risk based on factors such as age, sex, family history, and disease severity.
Researchers identified a specific type of CD8 T cell that characterizes inflammatory arthritis induced by ICI therapies. A unique population of CD8 T cells was found to promote joint inflammation and persist in the bloodstream, explaining why ICI-arthritis continues after therapy is discontinued.
A new open-source software, NMSM Pipeline, enables clinicians and engineers to create personalized computer models of patient movement to optimize treatment designs. The software uses physics-based models to predict and optimize functional outcomes for patients with various mobility impairments.
Researchers found osteochondrosis dissecans in fossil bones of Ice Age predators, with an incidence as high as 7% in shoulder and knee joints. The study suggests dwindling populations may have contributed to the disease's prevalence in these ancient species.
Patients undergoing bilateral total knee arthroplasty are at a higher risk of complications such as pulmonary embolism, stroke, and blood loss anemia compared to those undergoing unilateral TKA. The study found that the risks of these complications were approximately doubled in the bilateral TKA group.
The study found that education can protect individuals from undesirable state-level contexts, increasing their vulnerability to pain. States with more generous SNAP benefits and social cohesion had lower pain prevalence rates, highlighting the importance of macro contextual factors in shaping pain risk.
Researchers have made significant progress in understanding osteoarthritis, linking degradation of articular cartilage to inflammatory and metabolic processes. Elevated levels of the protein c-Fos are found in human and mouse cartilage samples with OA, suggesting a new target for therapy.
Patients treated by higher volume surgeons experience lower risks of reoperation and serious complications, as well as shorter hospital stays. A study found that a mean annual volume threshold of 10.4 procedures significantly reduces revision surgery risk.
Researchers at UBC develop biodegradable gel that mimics articular cartilage properties, allowing for faster and more efficient cartilage regeneration. The gel's ability to resist compression and recover its shape after compression makes it a promising material for joint injury repair.
A second-generation all-inside meniscal repair system demonstrates a high successful repair rate of 84-88% at 10 years, with low failure rates and no correlation to patient characteristics or surgical techniques. Patient-reported outcomes improve after meniscal repair and ACL reconstruction.
Researchers found that treatment with tranexamic acid (TXA) is associated with a decreased incidence of heterotopic ossification (HO), a common complication of abnormal bone formation. The study showed a significant reduction in HO risk, with an odds ratio of 0.49 and a 50% lower risk compared to patients not receiving TXA.
A new study found that NHS policies on patient's weight affecting access to hip replacement surgery are inappropriate and worsen health inequalities. The study analyzed nearly 490,000 hip surgeries and found a link between BMI policies and decreased surgery rates in deprived areas.
A recent study published in The Journal of Orthopaedics found that patients who underwent partial meniscectomy using a needle arthroscopic technique experienced significantly less pain and improved patient-reported outcomes at two weeks after surgery. However, differences were not sustained at six weeks.
Researchers developed a fully knitted, circuit-embedded knee wearable for wireless sensing of joint motion in real-time. The wearable overcomes limitations of typical wearable sensors by using a single fabric with high stretchability and sensitivity.
A combination of intravenous and periarticular corticosteroids improves rehabilitation measures after knee replacement, but not pain relief. The study found that patients who received both IV and PA corticosteroids had better knee movement and walking distances compared to those who received either medication alone.
A new study found that marathon running causes significant damage to extrinsic foot muscles, while intrinsic muscles are less affected. The research suggests that marathon runners can take steps to prevent injuries by prioritizing recovery and muscle fatigue management.
Researchers found bacterial DNA in surgical specimens of patients with hip and knee arthritis, revealing a microbiome in previously assumed sterile sites. The most common bacteria were Escherichia, Cutibacterium, Staphylococcus, Acinetobacter, and Pseudomonas.
A study published in The Journal of Bone & Joint Surgery reports high 10-year implant survival and patient satisfaction rates for robotic-assisted medial knee arthroplasty. The procedure showed excellent outcomes, with over 90% of patients remaining satisfied without revision.
A study found that primary arthroscopy significantly improved symptoms and hip function in young adults with borderline hip dysplasia. The procedure showed a low rate of conversion to total hip replacement, with most patients experiencing long-term benefits.
A study of joint replacements in England finds socio-economic inequalities remain, with those living in deprived areas having the least access to surgery. The findings highlight the need for healthcare commissioners to address disparities in joint replacement provision.
Rheumatologists are crucial in detecting neurologic Lyme disease due to its broad spectrum of symptoms and signs. Early treatment has a favorable prognosis, but delayed diagnosis can lead to severe symptoms.
A study by Oregon State University found that a metal bar installed on the crab-sorting table can reduce the strain on fishermen's bodies and prevent injuries. The researchers tested different banger bar configurations and found that higher bars and triangular bars were the most effective in reducing muscle activity and joint moment.
A new study published in Frontiers in Sports and Active Living found that greater breast support during running is associated with increased knee joint stiffness, altering the lower body biomechanics of female runners. High support sports bras can improve running performance by up to 7% for women.
Researchers created a promising injectable cell therapy that reduces inflammation and regenerates articular cartilage in osteoarthritis patients. The treatment was tested in a pre-clinical model and showed ability to reverse cartilage damage and diminish inflammation.
Patients with low sodium levels before or after total knee or hip arthroplasty are at increased risk of complications and adverse outcomes. Postoperative hyponatremia was linked to longer hospital stays, higher rates of discharge to rehabilitation centers, and readmission within 90 days.
Researchers have found a potential treatment for osteoarthritis by targeting the GP130 immune receptor, which causes hyper-inflammation in joints. The new compound R805/CX-011 showed promising results in animal studies, reducing joint pain and stiffness, and may lead to Phase 1 and 2A clinical trials.
Higher body mass index patients undergoing unicompartmental knee replacement (UKR) experience lower revision rates with cementless implants, according to a new study. Cementless fixation is preferred in higher-BMI patients, reducing the risk of revision surgery by up to 40%.
Researchers found a connection between arthritis flare-ups and periodontitis, suggesting that regular dental check-ups could help prevent rheumatoid arthritis. The study also identified potential therapeutic targets for cancer, including the use of mouthwash to prevent flares.
A new numerical model has been developed to predict cartilage degeneration after injury, revealing mechanisms of cell death and inflammation. The model suggests that mitigation of inflammation can lead to partial recovery of cartilage composition, opening avenues for potential therapeutic targets.
A new study finds that plasma D-dimer levels have comparable diagnostic accuracy to other commonly used tests for identifying periprosthetic joint infection (PJI), and sometimes outperform the standard tests. The test showed higher sensitivity and specificity in detecting PJI, particularly in certain patient subgroups.
Researchers found that young adults post-ACLR who exhibited lower patellofemoral joint (PFJ) loading during hopping were more likely to develop PFJ osteoarthritis at 1-year and worsening PFJ osteoarthritis between 1-5 years. Lower PFJ contact force was linked to increased risk of early osteoarthritis.
A randomized trial shows that patients undergoing partial knee arthroplasty (UKA) experience faster functional recovery in walking speed and mobility tests compared to those who had total knee arthroplasty (TKA). UKA also resulted in shorter operative times, reduced blood loss, and improved functional outcomes.
A team of scientists from TIBI, UIC, and POSTECH has elucidated key points on how cartilage generation is facilitated and alternative bone formation can be avoided. They found optimal conditions for better cartilage regeneration while reducing excessive cartilage formation using human mesenchymal stem cells.
A study found that metformin use significantly reduces the risk of total knee and hip replacements in patients with type 2 diabetes. The researchers analyzed data from over 69,000 participants and discovered a significant association between metformin use and lower joint replacement rates.
A study found that joint replacement prices are not associated with quality of care, but rather with the type of insurer. The study analyzed publicly available data from 18 hospitals in California and found significant price differences between different payer types.
Researchers developed a simple and accurate method for markerless gait analysis, combining RGB camera-based pose estimation with IMU sensor data. The new technique outperformed existing methods in measuring gait parameters and joint angles, showing significant promise for clinical settings and diverse applications.
Exposure to common workplace agents is associated with a heightened risk of developing rheumatoid arthritis, which can be exacerbated by smoking and genetic predisposition. The study found that certain agents, such as quartz dust and gasoline fumes, are strongly linked to an increased risk of ACPA-positive disease.
A new study suggests that a transcriptomic technique can help distinguish between infections and non-infectious causes of complications following knee and hip replacement surgery. The technique uses RNA sequencing to determine which genes are expressed and identifies specific immune cell types involved in the response to infection.
A study published in BMJ Open found that adolescents with hypermobile joints are at a higher risk of developing depression and anxiety. Researchers discovered that psychiatric symptoms were more severe among hypermobile participants, highlighting the need for targeted support and treatment.
A new study found that taking NSAIDs for osteoarthritis pain and inflammation may worsen joint inflammation and cartilage quality over time. Researchers used MRI-based structural biomarkers to analyze the association between NSAID use and synovitis in patients with knee osteoarthritis.
A team of researchers from Aarhus University has developed interdisciplinary guidelines to optimise the treatment of patients with juvenile arthritis, focusing on early diagnosis and screening. The guidelines aim to improve treatment outcomes by promoting a more timely initiation of treatment.
A new study from Japan investigated the relationship between training volume and strength gain in young men. The researchers found that training volume was positively correlated with strength gain in participants who were classified as low responders.
A new study has shown that total ankle replacement and ankle fusion surgeries equally improve quality of life for patients with advanced ankle osteoarthritis. However, a fixed bearing joint replacement showed significant improvement over ankle fusion in clinical scores.
The American Roentgen Ray Society (ARRS) named Dr. Sarah Kamel of Thomas Jefferson University Hospital and Dr. Ankur Goyal of the All India Institute of Medical Sciences as Melvin Figley and Lee Rogers Fellows in Radiology Journalism, respectively. They will receive expert instruction in scientific writing and communication through the...
A new strategy for treating rheumatoid arthritis has been proposed, integrating small interfering RNAs and Prussian blue nanoparticles to silence proinflammatory cytokines and scavenge reactive oxygen species. The approach was tested in a mouse model, showing improved therapeutic efficacy and real-time monitoring capabilities.
A study published in Diabetes Care found that trigger finger is more prevalent among individuals with diabetes, particularly those with poorly regulated blood sugar. The risk of trigger finger increases with poor HbA1C levels, highlighting the potential link between blood sugar dysregulation and this condition.
A genome-wide association study identified three significant loci for frozen shoulder, including WNT7B, associated with a nearly sixfold increase in the odds of developing the condition. The findings may provide new insights into the development and treatment of adhesive capsulitis.