Articles tagged with Joints
A new strategy for treating rheumatoid arthritis has been proposed, integrating small interfering RNAs and Prussian blue nanoparticles to silence proinflammatory cytokines and scavenge reactive oxygen species. The approach was tested in a mouse model, showing improved therapeutic efficacy and real-time monitoring capabilities.
A study published in Diabetes Care found that trigger finger is more prevalent among individuals with diabetes, particularly those with poorly regulated blood sugar. The risk of trigger finger increases with poor HbA1C levels, highlighting the potential link between blood sugar dysregulation and this condition.
A genome-wide association study identified three significant loci for frozen shoulder, including WNT7B, associated with a nearly sixfold increase in the odds of developing the condition. The findings may provide new insights into the development and treatment of adhesive capsulitis.
Researchers found that calf muscle stiffness contributes to passive ankle joint stiffness, especially when dorsiflexed. The study suggests that exercises to relieve triceps surae stiffness can improve joint flexibility and reduce injury risk.
For seven years after bariatric surgery, participants showed clinically important improvements in pain levels, physical function, and work productivity, with some backsliding over time. The study found durable effects on walking speed, fitness, and most metrics of pain, even among older adults.
A new poll reveals that nearly half of people over 50 experience joint pain, and many turn to prescription-based treatments despite potential health risks. The poll's authors stress the need for healthcare providers to discuss medication interactions and non-drug options with patients.
A new study reconstructs the skeletal structure of Coelurosauravus elivensis, a Late Permian reptile that likely used tree canopy changes to facilitate its evolution. The research reveals the gliding apparatus was supported by either the gastralia or musculature of the trunk.
Dr. Nathan Hogaboom has won the prestigious Ernest Bors, MD Award for Scientific Development for his pioneering work on regenerative rehabilitation research in spinal cord injury. His award-winning study applied novel principles to treat debilitating shoulder pain in wheelchair users with spinal cord injury.
A study at Washington State University has identified sulfatase-2 as a critical protein driving damage caused by rheumatoid arthritis. The discovery sheds light on molecular processes behind inflammation in the disease and could lead to improved treatments.
Researchers found gout is more prevalent among Black adults in the US compared to White adults, with differences attributed to factors like poverty and body mass index. The study used nationally representative data from 2007-2016 and suggests that culturally sensitive efforts could help reduce disparities.
Researchers at Houston Methodist found that injecting morphine into the tibia during knee replacement surgery reduces postoperative pain and the need for pain medication. This method, known as intraosseous infusion, may also facilitate a swifter recovery of the knee joint.
Researchers at the University of Connecticut have developed a potential breakthrough treatment for rotator cuff tears, using an advanced polymer to stimulate regeneration of both the tendon and muscle. This approach addresses the real problem of muscle degeneration and fat accumulation that often leads to re-injury after surgery.
Researchers at Duke University have created a lab-made cartilage substitute that is stronger and more durable than natural cartilage. The hydrogel material can withstand even more stress from pulling and squishing, with improved strength and durability compared to previous methods.
A new study by Edith Cowan University identified the most common injury types and body regions affected among police recruits, with knee injuries having the greatest impact. The study also found that men under 30 had a substantially reduced injury risk, highlighting the importance of tailored training programs to reduce injury rates.
Researchers developed a new framework to measure stability during walking by analyzing mechanical energetics, enabling deeper insights into human movement and fall responses. The approach can help pinpoint specific muscles or joints to target with rehabilitation therapy and inform advanced exoskeleton design.
A new breath-driven hand prosthesis offers a lightweight, low-maintenance option for children and those in low-resource settings. The device is powered by the user's breathing and provides simultaneous control and actuation, with minimal maintenance required.
A recent study published in The Journal of Bone and Joint Surgery found that only 35.9% of articles reported patient race, 15.4% reported ethnicity, and 8.3% reported income. Including demographics in multivariable analyses is crucial to determine the applicability of study results to diverse patient populations.
A new wearable technology project aims to empower older women to continue participating in sports and exercise without fear of pain or injuries. The project, MISFIT, will develop smart textiles and footwear insoles to monitor injury risk and provide personalized advice to health professionals.
New research reveals NHS weight policies are associated with a decline in knee replacement surgery rates, disproportionately affecting less affluent groups. The study found that regions introducing BMI-based policies saw a decrease in surgery, potentially worsening health inequalities.
A study published in Arthritis & Rheumatology found that walking for exercise can reduce new frequent knee pain and slow joint damage in people with knee osteoarthritis. Researchers analyzed data from the Osteoarthritis Initiative and found a 40% decrease in odds of new frequent knee pain among walkers compared to non-walkers.
A study found that walking for exercise reduced frequent knee pain in individuals with knee osteoarthritis. Preliminary evidence also suggested that it might modify structural effects of osteoarthritis on the knees.
A Swedish study found that rates of adverse events after hip replacement surgery are essentially the same for procedures performed by female and male orthopaedic surgeons. The overall rate of adverse events was lower for THA procedures performed by female surgeons, at 6%, compared to 7% for male surgeons.
Researchers at Hokkaido University discovered that ATP secreted from sensory neuron-interneuron crosstalk triggers inflammation spread across joints, acting as a neurotransmitter and inflammation enhancer. Blocking this pathway prevents the spread of inflammation.
A recent study published in Obesity Reviews found that resistance training, in conjunction with a reduced calorie diet, can lead to significant fat mass and muscle loss. This breakthrough highlights the importance of considering non-aerobic exercise options for individuals struggling with obesity.
A new machine-learning tool can speed up the diagnosis of psoriatic arthritis by identifying patients up to 4 years prior to a clinician's diagnosis. The tool, PredictAI, analyzed medical records and accurately identified 32-51% of confirmed PsA patients.
A bundled care Medicare program has led to reductions in some outcome disparities for Black patients compared to White patients undergoing hip and knee replacement surgery. The Comprehensive Care for Joint Replacement (CJR) Model has improved key outcomes such as hospital readmission rates, length of stay, and Medicare payments.
Patients with lower levels of sex hormones are more likely to undergo surgery for rotator cuff tears, according to a study published in The Journal of Bone & Joint Surgery. Estrogen deficiency was associated with a 48% higher incidence of rotator cuff repair in women, while testosterone deficiency was linked to an 89% higher rate in men.
A recent study suggests that many older adults with rheumatoid arthritis are not prescribed disease-modifying medications, despite guidelines calling for early and aggressive treatment. Only 45% of patients over 65 were prescribed these medications, highlighting the need to improve prescribing practices among primary care physicians.
The Virtual WCO-IOF-ESCEO 2022 Congress will feature leading experts on osteoporosis, osteoarthritis, and musculoskeletal diseases, with a focus on new clinical research and advances in prevention and patient care. Prestigious awards will also be presented.
A study using data science and mathematical models identifies the most suitable rehabilitation method for each patient with osteoarthritis. The research aims to provide personalized treatment recommendations for healthcare professionals, ultimately leading to more effective care for patients.
A recent study found that sleep bruxism can lead to temporomandibular joint disorders due to increased mechanical loading. The research discovered that specific combinations of tooth shape and location during grinding significantly impact the risk of TMJ problems.
A recent analysis published in Arthritis & Rheumatology found that osteoarthritis prevalence increased by 113.25% globally from 247.51 million in 1990 to 527.81 million in 2019. The study also revealed higher prevalence rates in females and among countries with higher development status.
Patients who discontinue biologic disease-modifying anti-rheumatic drugs (bDMARDs) before orthopaedic surgery are more likely to experience a disease flare following surgery. However, discontinuing bDMARDs does not appear to increase the risk of surgical site infections or delayed wound healing. The review and meta-analysis highlights ...
Researchers at Marshall University's Joan C. Edwards School of Medicine have successfully applied robotic arm technology to revision total knee arthroplasty, achieving well-aligned components and excellent range of motion in patients. The study utilizes computer-assisted technology to improve component positioning and reduce the burden...
Researchers aim to determine if knee structure changes predict clinical outcomes in people with osteoarthritis. The study will examine 76,000 X-rays and clinical data from diverse cohorts to establish healthy knee structure ranges.
Researchers discovered that the IL-6 family of proteins is required for maintaining and regenerating cartilage in joints and growth plates. The study found that blocking this gene could lead to severe cartilage and skeletal changes, particularly in females.
A recent HSS study analyzed trends and complications in patients undergoing outpatient hip and knee replacements, finding no significant difference in readmission rates for hip replacements but slightly higher odds for knee replacements. The study suggests same-day discharge joint replacement is safe but requires additional monitoring.
Regrowing healthy cartilage in damaged joints is a promising approach to treating arthritis. UConn bioengineers successfully regrowed cartilage in a rabbit's knee using piezoelectricity, a phenomenon that also exists in the human body.
Researchers develop ice-inspired lubricant that enhances lubrication and reduces friction and inflammation in a rat model of osteoarthritis. The treatment, which uses microfluidic technology to create drug-loaded particles, shows promise as a potential solution for joint pain and degeneration.
Researchers at Washington State University discovered that combining gallic acid with stretching decreases inflammation markers and improves protein production in arthritic cartilage cells. This finding suggests a potential new procedure for treating osteoarthritis by growing healthy cartilage tissue.
Researchers at Keck School of Medicine of USC have developed a stem cell-based bio-implant to repair cartilage and delay joint degeneration. The Plurocart implant successfully integrates into damaged articular cartilage tissue and survives for up to six months.
Researchers at Durham University have developed a sugar-containing polymer coating that can repair damaged artificial joint implants by mimicking the way cartilage works to lubricate human joints. The coating uses water to create a slippery surface, protecting the surfaces from wear and tear.
A study suggests that total hip replacement may contribute to sacral insufficiency fracture (SIF), a type of pelvic stress fracture. SIF is more likely to occur on the side opposite from previous THA, and bone loss leading to SIF begins within the first postoperative year following THA.
A recent clinical trial published in the Journal of the American Medical Association found that platelet-rich plasma injections had no significant benefits for reducing knee pain in people with mild to moderate osteoarthritis. The study, which involved 288 participants, compared platelet-rich plasma injections to placebo injections and...
Research from Harvard University reveals that physical activity later in life shifts energy towards mechanisms that extend health, reducing chronic illnesses. The study highlights the importance of staying physically active as we age to allocate energy to physiological processes that slow down deterioration.
A new study by Boston Children's Hospital researchers found that tissue-resident memory T cells in joints anchor themselves after a flare and wait for another trigger to react. Deleting these cells prevents arthritis flares from occurring, opening up new therapeutic avenues for rheumatoid arthritis treatment.
Researchers have identified key genes involved in osteoarthritis, a leading cause of pain and disability worldwide. The study, conducted on over 800,000 individuals, sheds light on the genetic factors contributing to the disease and may pave the way for new treatments.
A novel computational model predicts that articular cartilage can partially heal after injury by controlling inflammation. The study uses biomechanical and inflammatory aspects of osteoarthritis progression to develop a physics-based computational model.
A textile-based implant containing cartilage derived from stem cells reduced pain and restored hip joint function to baseline levels in a study of dogs with moderate osteoarthritis. The implant successfully integrated into the hip joints, effectively resurfacing them and allowing the dogs to regain activity levels.
A new algorithm provides accurate solutions that mimic natural human movement, reducing the risk of injury. The Pro-ISADE approach improves calculation speed while ensuring calculated joint angles are feasible for robotic use in daily activities like drinking water and brushing teeth.
A new study suggests that same-day discharge for high-risk patients undergoing hip and knee replacement surgery is safe and feasible. The research found no increase in complications or adverse outcomes with same-day discharge compared to inpatient surgery.
A new study examines the similarities and differences among disease activity indices used to monitor rheumatoid arthritis. Researchers found that while there are high correlations among the indices, they were not interchangeable, highlighting the need for further analysis of RA in patients using various indices.
Researchers have genetically engineered cells that can deliver a biologic drug in response to inflammation, reducing inflammation and preventing bone damage in mice with rheumatoid arthritis. This approach could provide personalized treatments for arthritis patients, limiting side effects associated with current therapies.
A multi-center study found micro-fragmented adipose tissue injections to be highly effective in reducing knee pain, improving function, and enhancing quality of life. Positive effects were observed for up to 12 months, with notable differences in efficacy among demographics.
A study published in Current Rheumatology Reviews found that rehabilitation exercises significantly improved functional strength and reduced weight in knee osteoarthritis patients. The researchers also noted an increase in exercise adherence among the rehabilitation group compared to the control group.
A study published in Nature Communications found that microRNA-455 helps regulate cartilage homeostasis and slows cartilage degeneration in osteoarthritis. By targeting the gene hypoxia-inducible factor-2α, miR-455 treatment inhibits cartilage breakdown.
Magnetomicrometry offers a new approach to controlling prosthetic limbs by measuring muscle length and speed, providing more precise control than existing methods. The technology involves inserting small magnetic beads into muscle tissue, which can be precisely measured within milliseconds.
A study confirmed the safety of a novel stem cell therapy for knee pain caused by osteoarthritis. The treatment, which involves transplanting patient's own mesenchymal stem cells into the affected knee, showed no serious side effects over five years.
A CU Denver study found that greater trunk flexion can significantly impact stride length, joint movements, and ground reaction forces in runners. The researchers discovered that a larger lean can lead to a shorter stride length and increased leg swings, which may contribute to overuse injuries.
Researchers identified regulatory variants near the GDF5 gene associated with knee osteoarthritis and hip dysplasia. The study found two distinct mutations that can cause both diseases, paving the way for potential screenings and treatments.