Articles tagged with Joints
A study published in Nature Communications found that microRNA-455 helps regulate cartilage homeostasis and slows cartilage degeneration in osteoarthritis. By targeting the gene hypoxia-inducible factor-2α, miR-455 treatment inhibits cartilage breakdown.
Magnetomicrometry offers a new approach to controlling prosthetic limbs by measuring muscle length and speed, providing more precise control than existing methods. The technology involves inserting small magnetic beads into muscle tissue, which can be precisely measured within milliseconds.
A study confirmed the safety of a novel stem cell therapy for knee pain caused by osteoarthritis. The treatment, which involves transplanting patient's own mesenchymal stem cells into the affected knee, showed no serious side effects over five years.
A CU Denver study found that greater trunk flexion can significantly impact stride length, joint movements, and ground reaction forces in runners. The researchers discovered that a larger lean can lead to a shorter stride length and increased leg swings, which may contribute to overuse injuries.
Researchers identified regulatory variants near the GDF5 gene associated with knee osteoarthritis and hip dysplasia. The study found two distinct mutations that can cause both diseases, paving the way for potential screenings and treatments.
EULAR taskforce develops guidelines to standardize intra-articular injection (IAT) care, emphasizing patient-centered outcomes and contextual factors. The new recommendations aim to improve IAT quality, providing patients with personalized information and support.
A study published in the Journal of Investigative Dermatology found that a Western diet rich in sugar and fat disrupts gut microorganisms, leading to psoriasis flares. Switching to a balanced diet restores gut health and suppresses skin inflammation, offering a potential solution for managing the condition.
A new international guidance on HR-pQCT provides an overview of current clinical applications and future directions in adults. The technology holds promise for fracture risk prediction, monitoring anti-osteoporosis therapy response, and assessing metabolic bone disorders.
Researchers at the Max Planck Institute have developed a new type of joint inspired by spiders' hydraulic actuation mechanisms. The joints use electrohydraulic forces to enable robots to move rapidly and interact with various environments, making them ideal for small-scale robotic systems.
Researchers at Baylor College of Medicine discover a protein signaling mechanism driving joint and tendon dysfunction in OI, finding that inhibiting this pathway can prevent tendinopathy problems. The study used mouse models with deleted Fkpb10 gene, leading to contracture, joint inflammation, and cartilage piece formation.
A new imaging technique, flexed elbow valgus external rotation (FEVER) view, has been shown to improve the evaluation of ulnar collateral ligament (UCL) injuries in Major League Baseball pitchers. This study found increased joint space width and diagnostic confidence with FEVER view compared to standard positioning.
A novel chemical blocker targeting chemokine proteins significantly reduces skin and joint inflammation in a mouse model with psoriasis and psoriatic arthritis. The study identifies CCR6 as a critical agent for joint inflammation, making it an attractive target for arthritis therapy.
A new bone shape measure, SBL, has been identified by researchers using AI to determine the severity of knee osteoarthritis. The study found that SBL values were consistently different from knees without joint space narrowing and associated with greater pain and disability.
UNIST has been honored with iF Design Awards 2021 for ten outstanding design products and concepts. The award-winning designs, led by Professors Hwang Kim and KwanMyung Kim, have showcased innovative solutions in healthcare, smart safety helmets, and digital services.
New research reveals that dinosaurs kept a joint in their lower jaw steady like an alligator, not flexible like a snake, to chomp through bone. The study's findings suggest that bones along the inside of the jaw acted as a strain sink to counteract bending at the intramandibular joint.
Scientists from Trinity College Dublin found that skeletal defects caused by lack of movement in the womb can be partially recovered after movement resumes. The study used chicken embryos and suggests that this finding may also apply to humans.
A new study by the University of South Australia reveals that shoes one size too small restrict normal foot movement and comfort during walking. Well-fitted school shoes are crucial for children's comfort and participation in everyday activities.
Researchers at Washington State University have discovered that GBP5 protein suppresses inflammation in rheumatoid arthritis by reducing the effects of interleukin-1 beta and supporting interferon gamma's anti-inflammatory function. This finding could lead to new treatments for the disease, affecting an estimated 1.5 million Americans.
A new center at the University of Delaware will focus on musculoskeletal research, including tendonitis and osteoarthritis. The center aims to accelerate fundamental research and establish a comprehensive basic-to-clinical research pipeline.
A randomized trial of telemedicine versus office-based follow-up after arthroscopic meniscal surgery found equivalent patient satisfaction scores between the two groups. Patients using telemedicine for postoperative follow-up had similar pain scores and complication rates as those making in-person visits.
A new randomized controlled trial shows that digital treatment for knee osteoarthritis is more effective than traditional self-management care in reducing pain by 41 percent compared to 6 percent. The digital treatment also offers benefits such as lower costs and increased accessibility for patients living in rural areas.
Scientists create magnesium-based micromotors that produce hydrogen bubbles, which propel the motors and release hydrogen gas into inflamed joints. This therapy shows promise in reducing joint pain, swelling, and bone erosion in animal models of rheumatoid arthritis.
The Kessler Foundation is conducting a two-year study on the role of hemarthroses in the development of osteoarthritis of the knee in military personnel. The team aims to explore regenerative processes to counter toxic effects of joint injury and prevent long-term damage.
Researchers use innovative 3D imaging technology to analyze joint mobility in living animals and apply patterns to reconstruct extinct dinosaurs' walking and running cycles. The study provides new perspectives on understanding animal biomechanics and its applications in evolutionary transitions.
A new study published in CMAJ found that high tibial osteotomy is successful in reducing the need for total knee replacement in younger patients with early-stage knee osteoarthritis. The procedure delays or prevents knee replacement in up to 79% of patients within 10 years.
Cartilage cells engineered to respond to mechanical stress can produce an anti-inflammatory drug to reduce joint pain and limit arthritis-related damage. The technology could lead to more effective treatments for osteoarthritis by delivering drugs in response to specific movements or weight-bearing.
The study incorporates fluid dynamics and roughness of joint surfaces to evaluate artificial hips, aiming to advance the design of more robust prostheses. The model could help clinicians personalize hip joints for patients depending on gender, weight, age, and gait variations.
A new study by Shriners Hospitals for Children finds that biochemical signals released by fat cells are responsible for osteoarthritis. The investigation, led by Dr. Farshid Guilak, suggests a factor given off by fat cells makes cartilage susceptible to degeneration.
A study published in PLOS ONE found that patients with rheumatoid arthritis in remission display significantly higher temperatures in the forefoot regions compared to healthy adults. The research used thermal imaging to analyze temperature patterns in over 31 patients and more than 52 healthy individuals.
Research suggests Neanderthals used power 'squeeze' grips to hold tools, which provided greater stability and leverage. This finding contrasts with the preferred precision grip of modern humans, highlighting differences in thumb anatomy and tool use behaviors.
A study by Shibaura Institute of Technology found that non-muscle tissues, specifically nerves, contribute more to joint flexibility as individuals age. Researchers measured ankle ROM and tissue stiffness in young and old adults, revealing a correlation between nerve stiffness and increased ROM in older participants.
A new study presents research on the effects of racket sports and exercise on knee joint degeneration in overweight individuals. The study found that racket sports accelerated degeneration, while elliptical trainer use was associated with reduced progression. High-speed lateral movements in racket sports may be driving this effect.
A new outpatient procedure has been shown to provide significant pain relief for patients with moderate to severe osteoarthritis in their hip and shoulder joints. Treatment involves the placement of needles where sensory nerves exist, followed by a low-grade current that 'stuns' them, slowing pain transmission to the brain.
Researchers have pinpointed two new potential therapeutic targets for rheumatoid arthritis, a painful inflammatory disease affecting millions worldwide. The study reveals a novel cell population and mechanism driving joint inflammation, offering new avenues for therapy development.
A new rapid test has shown solid diagnostic performance in distinguishing between patients with and without periprosthetic joint infection (PJI), a serious complication of total joint replacement. The test, which measures alpha-defensin levels in synovial fluid, achieved high sensitivity and specificity rates.
A study by Hospital for Special Surgery found that children with polyarticular juvenile idiopathic arthritis (JIA) from less affluent families were twice as likely to report over an hour of morning joint stiffness. This may indicate early disease symptoms and the importance of timely referrals for expert diagnosis and treatment.
The new RA guideline recommends starting patients on methotrexate and continuing with treatment, rather than rapidly switching to other drugs. The guideline also aims to minimize the use of glucocorticoids due to their serious side effects.
A new study shows that methotrexate significantly improves physical function and reduces inflammation in adults with primary knee osteoarthritis. Patients who received methotrexate treatment had improvements in WOMAC scores and reduced inflammatory markers, while those taking glucosamine showed no significant benefits.
Researchers found chikungunya can infect the central nervous system, impairing cognitive and motor functions. The study also showed that patients with diabetes are at a higher risk of death during the subacute phase, which is seven times greater than for non-diabetics.
Researchers found that compression garments reduce immediate and delayed strength loss after strenuous exercise, allowing athletes to resume high-intensity training sooner. The study suggests wearing a below-knee compression garment during regular workouts provides mechanical support and tissue compression, reducing the risk of musculo...
Researchers at the University of Missouri School of Medicine found that younger patients are more likely to require revision surgery after knee replacement due to higher infection rates and mechanical complications. Smoking cessation efforts may be key to improving outcomes for this age group.
A panel of experts recommends imaging for hip and knee steroid injections to mitigate joint collapse and total replacement risks. Current evidence is insufficient to draw a definitive conclusion, highlighting the need for further research.
A new study published in Scientific Reports found that lubricin, a protein that lubricates joints, increases in dogs with ACL injuries before signs of arthritis appear. The discovery has implications for human ACL and other orthopedic injuries, suggesting increased lubricin may be a biomarker for predicting future osteoarthritis.
A multidisciplinary team has bioengineered living cartilage-bone TMJ grafts using the recipient's own cells, demonstrating effectiveness in a clinically sized swine model. The grafts integrated well with surrounding tissues and provided biological and mechanical function similar to the native joint.
Researchers discovered that immobilizing extremities alters the way stem cells interact with their extracellular environment, switching their fate from becoming debilitating bone to benign fat. This finding could help doctors optimize healing in patients with extremity injuries.
Researchers found a connection between amino acid metabolism and joint hypermobility in autistic children, with increased levels of hydroxyproline linked to joint issues. The study suggests that amino acid balance may be an additional tool for ASD therapy.
The study found that tackling is linked to a high risk of injury for the attacking player, while injuries without physical contact often occur due to fast running. To prevent these injuries, experts recommend training consisting of aerobic and anaerobic elements.
A nationwide study led by OHSU finds that the Comprehensive Care for Joint Replacement model improves health outcomes for Black patients, with reduced spending and hospital readmissions. Hispanic patients showed mixed results, but overall disparities persisted despite improvements in post-acute care use.
A computational study of Euparkeria capensis reveals a 'mosaic' of functions in its hindlimb, shedding light on the evolution of locomotion in archosaurs. The fossil's unique hip structure suggests it could have assumed an upright posture, despite conflicting evidence from its ankle joint.
Researchers have identified a specific receptor in immune cells from psoriatic arthritis patients, suggesting a single cause for the disease. This finding could lead to developing targeted treatments and offers new insights into the intricate mechanisms behind psoriatic arthritis.
Researchers developed a machine-learning algorithm that can detect subtle signs of osteoarthritis on MRI scans taken years before symptoms begin. The algorithm predicted osteoarthritis with 78% accuracy from MRIs performed three years before symptom onset, offering hope for preventative treatments.
Researchers found that toe springs can reduce power output from the foot, leading to weaker muscles. The study suggests that this could contribute to conditions like plantar fasciitis.
A study found that patients with Medicaid expansion plans receive joint replacement surgery significantly faster than those without, highlighting an unmet need. The results suggest a 'surge in demand' rather than gradual increase, and policymakers must consider access to care.
A study analyzing over 650,000 hip replacement patients found that consistent use of reliable implants is a key factor in long-term success, not surgeon skill. The findings suggest that patients should ask their surgeons about the long-term evidence of an implant's effectiveness.
A new fossil discovery has provided critical evidence for the evolution of the mammalian middle ear, revealing the first unequivocal evidence of the five auditory bones from an extinct group. The findings have narrowed the morphological gap between ancient and modern mammals.
A Norwegian study shows that a structured conservative therapy programme can improve quality of care, increase patient satisfaction, and delay the need for surgery. The programme included patient education and exercise, leading to better outcomes for patients with osteoarthritis.
A new study from UC Davis found that mixed-breed dogs weighing over 44 pounds are at higher risk for joint disorders if neutered before 1 year of age. The study suggests that dog owners should consider their options carefully when deciding whether to spay or neuter their pet.
A study published in Advanced Science has revealed that joint implants can release metals into the surrounding bone tissue, leading to osteolysis and premature loosening. The researchers used a unique synchrotron-based X-ray fluorescence imaging setup to determine the concentration and distribution of metallic degradation products.
A new analysis of the CANTOS trial found that patients receiving canakinumab had significantly lower rates of total hip or total knee replacements over an average follow-up of 3.7 years. The study's findings are important as no treatments currently exist to prevent or slow osteoarthritis progression.
Researchers developed a new robotic prosthetic leg that consumes half the battery power of state-of-art robotic legs while producing more force. The streamlined design features regenerative braking, which charges the battery with energy captured when the foot hits the ground, enabling users to walk for over twice as long on one charge.