Articles tagged with Joints
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A drug derived from omega-3 fatty acids has been found to reduce osteoarthritis inflammation caused by a high-fat diet, according to researchers at Queensland University of Technology. The study also identified another effective treatment option, clodronate liposomes.
Researchers discovered that white blood cells respond to microparticles from prosthetic devices as harmful invaders and engulf them, leading to inflammation, tissue damage, and bone destruction. The study may lead to new therapies to reduce pain and prevent follow-up surgery for joint replacement patients.
Researchers developed an intelligent system for 'tuning' powered prosthetic knees using reinforcement learning, allowing patients to walk comfortably in minutes. The system adapts 12 control parameters to address prosthesis dynamics, such as joint stiffness, during the entire gait cycle.
A study found that automated text messaging systems can improve clinical outcomes after total knee or hip replacement surgery, including faster recovery times and higher patient satisfaction. The system sent personalized messages to patients, increasing their adherence to home exercises and reducing opioid use.
Researchers discovered rare subsets of unconventional T cells in SpA patients, which produce pro-inflammatory cytokines like IL-17. These cells can be targeted with RORγt inhibitors, potentially treating IL-17 driven diseases, including spondyloarthritis.
Researchers found that small limbs like insect legs can execute fast movements without central nervous system control, thanks to dynamic passive forces generated by the flexor muscle. These findings contradict previous notions of how small limbs move quickly and highlight the importance of active-muscle and opponent interactions.
Research found a significant association between Heberden's nodes and imaging measures of knee osteoarthritis. The study suggests a link between finger joint enlargements and structural damage in the knee joint.
Researchers at University of British Columbia discovered that gulls can adapt their wing shape to gusty conditions by flexing a single elbow joint, which could inspire improved aircraft design. This novel mechanism enables gulls to sacrifice stability for maneuverability.
Researchers at OSU Wexner Medical Center are testing a new device designed to extend the functional life of joints affected by osteoarthritis. The Calypso Knee System aims to reduce pain and delay knee replacements, allowing patients to remain active without discomfort.
A new study from Harvard T.H. Chan School of Public Health and Harvard Medical School found that Medicare's bundled payment model for hip and knee replacement surgeries resulted in a 3.1% reduction in costs, with $812 in savings per procedure. The model also reduced the use of skilled nursing care after hospitalization.
A new study published in The Journal of Bone & Joint Surgery found no increase in complications for patients undergoing overlapping orthopedic surgery. The analysis included over 22,000 outpatient procedures and showed a comparable complication rate between overlapping and nonoverlapping surgeries.
A new artificial joint, developed by Chalmers University of Technology, has restored important wrist-like movements to forearm amputees. The joint works with an osseointegrated implant system, allowing for much more naturalistic movements and intuitive control without sacrificing useful biological actuators.
A charged molecule, called a dendrimer, is designed to deliver osteoarthritis drugs to knee joint cartilage. The nanocarrier effectively binds to cartilage tissue, allowing for deeper penetration and longer half-life in joint spaces.
MIT engineers have designed a material that can administer drugs directly to the cartilage, delivering IGF-1 and stimulating cell growth and production of proteoglycans. The treatment has shown promising results in animal studies, preventing cartilage breakdown and reducing joint inflammation.
A multicenter study of 14,135 orthopaedic procedures found that overlapping surgeries did not increase complication rates and had lower hospital stay lengths. The researchers emphasize the importance of patient informed consent and disclosure of this practice.
Biomechanical forces play a key role in the development of joint inflammation and erosions in chronic inflammatory rheumatic diseases. The study identifies hot spots in the musculoskeletal system where mechanical loading leads to increased inflammation and tissue damage.
Researchers identify non-arthritis conditions causing joint pain and stiffness, emphasizing the importance of accurate diagnosis through imaging techniques.
A new 'dual mobility' hip replacement implant has been found to reduce the risk of dislocation in patients undergoing revision surgery. The study, conducted by Dr. Geoffrey Westrich and colleagues at Hospital for Special Surgery, showed a low rate of instability with good functional improvement.
Researchers discovered a nearly complete skeleton of the ancient fish Rhizodus hibberti, featuring a novel skeletal pattern in its pelvic fins. The findings suggest that developmental mechanisms were more flexible in early tetrapods, allowing for varied skeletal patterns before the familiar one-to-two limb structure emerged.
Researchers discovered that articular cartilage degenerates specifically around injury areas due to excessive fluid flow velocity, potentially leading to osteoarthritis. The novel mechanobiological model can predict osteoarthritis in personal medicine and suggest optimal rehabilitation protocols.
Researchers developed an arthroscopic near infrared spectroscopic probe to evaluate articular cartilage and subchondral bone structure and composition. This technique provides comprehensive information on joint tissue health, enhancing the treatment outcome of arthroscopic intervention.
ANP32A protein protects cartilage from oxidative stress, which contributes to osteoarthritis development. Antioxidant treatments like NAC may prevent further cartilage damage and reduce osteoarthritis symptoms.
Researchers at the University of California San Diego have developed nanosponges that can safely absorb and neutralize a variety of proteins involved in rheumatoid arthritis progression. These nanosponges effectively treated severe rheumatoid arthritis in two mouse models, reducing swelling and minimizing cartilage damage.
A study published in PLOS ONE found that the jaw joint bone structure of carnivorans is more closely related to their body size than their diet. Researchers used 3D printing and CT scans to analyze the mandibular condyle, a key joint in the jaw, and discovered no significant correlation between diet and jaw joint strength or complexity.
Researchers at FAU have identified ILC2 as a key player in the development of rheumatoid arthritis. By increasing ILC2 levels during therapy, symptoms can be reduced. However, treatment must start before disease onset to be effective.
Researchers found that a high-carb diet, particularly with high sugar and low fiber content, increased signs of joint inflammation and altered cartilage genes in laboratory mice. The study suggests that dietary carbohydrates may be a contributing factor to osteoarthritis risk, even in the absence of obesity.
Researchers at Marshall University Joan C. Edwards School of Medicine discovered dynamic signals from sense organs are crucial for normal leg movements. The findings suggest mechanisms to make prosthetic joints more adaptable, enabling more natural movements in amputees.
A long-term study confirms that cross-linked polyethylene hip implants significantly lower the rate of repeat surgery, with a cumulative revision rate of 11.7% compared to 6.2% for conventional polyethylene implants over 16 years. The use of XLPE implants also encourages total hip replacement in younger patients.
A new study published in Molecular Genetics and Metabolism identified the drug nitisinone as a treatment for alkaptonuria, also known as black bone disease. The treatment significantly reduces the accumulation of homogentisic acid, stopping disease progression and partially reversing ochronosis.
Researchers at Mount Sinai Hospital discovered a new gene, HIP1, linked to disease severity in rheumatoid arthritis. The study found that knocking out the gene reduced synovial fibroblast invasiveness and protected against arthritis progression.
A study by researchers from the University of Bristol identified key risk factors for hip replacement infections, including patient age and health conditions. The research found that certain surgical approaches and implant materials reduced the risk of infection, while others increased it.
Intractable hiccups can occur with underlying medical conditions and impair quality of life. Various treatments including medications, nerve blocks, and alternative remedies are being studied.
A study published in The Journal of Bone & Joint Surgery found that patients taking prescription opioids for more than 60 days before total knee or hip replacement surgery are at higher risk of hospital readmission and repeat joint-replacement surgery. Prolonged opioid use was associated with an increased risk of both adverse outcomes,...
UCI-led researchers developed a groundbreaking tissue implant to treat temporomandibular joint dysfunction (TMJ) defects, successfully testing it in a large animal model. The innovative approach involves isolating cartilage cells from rib tissue and using them to engineer new jaw disc cartilage.
A new algorithm detects subtle changes in arthritic joints using 3D CT images, outperforming current x-ray methods in sensitivity. This could lead to earlier osteoarthritis diagnosis and more accurate treatment assessments.
A 23-year follow-up study suggests early, intensive treatment of rheumatoid arthritis can lead to long-term benefits, including normalization of mortality rates. The study found that patients treated with a combination of medications had lower mortality rates compared to those treated with a single medication.
The frequency of joint replacements in rheumatoid arthritis patients decreased by 51.9% over the past decade, suggesting improved treatment strategies. Biological therapy was found to have a limited impact on this reduction, with no significant association with total hip replacement or knee replacement procedures.
A new study from Uppsala University reveals that a wide range of anti-citrullinated protein antibodies (ACPA) in immune complexes from the joints can cause local inflammation and drive joint damage in rheumatoid arthritis. This finding supports the suspicion that ACPAs are pathogenic by forming immune complexes in the joints.
Researchers used a novel approach to study the movement of ancient birds and reptiles, finding that many assumed poses were impossible due to ligament limitations. This challenges traditional views on pterosaur flight and provides new methods for assessing joint mobility in extinct species.
A large study published in CMAJ found that gout is not associated with an increased risk of fracture. Researchers from Keele University studied over 31,000 patients with gout and their matched controls, finding a similar rate of fractures in both groups.
Researchers developed a novel PET tracer that targets joint inflammation and can visualize active inflammation sites in arthritic joints. The tracer, fluorine-18 F-FEDAC, shows promise for early detection of rheumatoid arthritis, potentially improving treatment outcomes.
A recent study published in JCI Insight found that gut bacteria can contribute to the development of osteoarthritis in obese individuals. The researchers discovered that a high-fat diet altered the gut microbiome, leading to inflammation and joint deterioration. However, supplementing the diet with a common prebiotic oligofructose reve...
A recent study has found that treating an infected hip replacement in a single stage procedure may be as effective or better than the widely used two-stage procedure. The one-stage revision strategy is shown to have advantages for patients, including shorter hospital stays and reduced functional impairment. However, further research is...
A study published in The Journal of Bone & Joint Surgery found that scoliosis surgery significantly improves the quality of life for children with severe cerebral palsy and their caregivers. The procedure reduces spinal curvature and leads to long-term gains in personal care, positioning, and comfort.
Scientists at Brigham and Women's Hospital have created a hydrogel that responds to increased disease activity during flares, releasing drugs to alleviate symptoms. The technology has shown promise in preclinical models and could provide a new treatment option for patients with arthritis.
A recent study found that the rate of hip replacement revision surgery has decreased in all age groups except those between 45 and 64 years old. In this age group, the revision rate increased by over 30%, indicating a need for longer-lasting implants.
Researchers at ETH Zurich developed a self-folding material inspired by the earwig's wing, which can operate without muscular actuation. This innovation has potential applications in space travel, foldable electronics, and everyday objects.
A study published in Nature Genetics has identified nine novel genes associated with osteoarthritis. Researchers used the UK Biobank resource and found that five of these genes differ significantly in their expression between healthy and diseased cartilage, offering new targets for future research into therapies.
Researchers used joint tissue biopsy to identify genes linked to disease progression and response to treatment in rheumatoid arthritis patients. This new technique holds promise for personalized therapy and improved patient outcomes.
Young recreational and elite athletes often accumulate excess fluid in bone marrow around joint connecting spine to pelvis. Magnetic resonance imaging detects this excess fluid in healthy individuals, raising debate about diagnostic thresholds for axial spondyloarthropathy.
Babies' movement in the womb is crucial for developing strong bones and joints. Research has identified that cells receive incorrect molecular signals when movement is absent, leading to brittle bones or abnormal joints. Understanding this mechanism can lead to improved treatments for joint injuries and diseases.
Researchers Nelly Andarawis-Puri and Johnny Huard received Kappa Delta Awards for their work on tendon healing and remodeling, and the use of adult stem cells in musculoskeletal tissue repair. Their research has led to a better understanding of how tendons heal and how to develop more effective treatments for musculoskeletal injuries.
Mark C. Gebhardt, MD, is recognized for his efforts to increase diversity in orthopaedics, particularly among women and minority groups. He has mentored numerous medical students and residents, and advocates for recruiting and hiring diverse talent into the field.
Rick D. Wilkerson, DO is the recipient of the American Academy of Orthopaedic Surgeons (AAOS) 2018 Humanitarian Award for his humanitarian efforts abroad. He has made significant contributions to orthopaedic care in countries such as Haiti, Iraq, Vietnam, Afghanistan, Pakistan, Libya, and Uganda.
Ramon L. Jimenez, MD, is awarded the AAOS' highest leadership honor for his outstanding contributions to advancing important causes in orthopaedics, including mentoring physician leaders and promoting cultural competency. He has worked diligently to improve patient care and diversify the orthopaedic workforce.
Research finds that patients with undiagnosed neurocognitive deficits have poorer short-term outcomes after hip and knee replacements. Neurocognitive impairment was prevalent in older patients and those with depression, leading to increased hospital resources and slower physical therapy progress.
The study projects a significant increase in total joint replacement procedures, with primary THR expected to grow 171% by 2030 and 330% by 2060. Revision TJR procedures are also expected to rise, particularly for TKR, which has been slowing its growth rate since 2008.
A new study by Johns Hopkins researchers found that a common knee operation in elderly patients provides little benefit and may be considered low-value care. The procedure, called arthroscopic partial meniscectomy (APM), accounted for an estimated two-thirds of all orthopaedic knee arthroscopy procedures in older patients.
A study found that patients undergoing elective total hip arthroplasty (THA) have a slightly improved survival rate compared to the general population. After ten years, higher survival rates were observed among THA patients, particularly those with primary osteoarthritis.
Researchers at Baylor College of Medicine discovered that a scorpion venom component, iberiotoxin, can specifically block the potassium channel in fibroblast-like synoviocytes, reducing rheumatoid arthritis severity. Treatment with iberiotoxin reversed joint damage and inflammation in rat models without inducing side effects.