Articles tagged with Joints
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A recent study published in The Journal of Bone & Joint Surgery found that patients undergoing total hip replacement surgery experience significant improvements in quality of life (QOL) through at least five years after the procedure. The SF-6D score, a widely used measure of patient-perceived QOL, showed lasting improvements in scores.
A new study found that patients who live alone can recover effectively and safely at home after total hip or knee replacement surgery. The study, involving 769 patients, found no increase in complications or pain, but significant cost savings for those recovering at home.
A new study from Ohio State University Wexner Medical Center reveals that body mass index (BMI) has no effect on meniscus repair surgery failure rates. The research found similar success rates for patients with average and higher BMI, challenging common assumptions about weight and joint pressure.
A new review suggests that improved ACL reconstruction techniques can restore normal knee motion and slow degenerative changes associated with osteoarthritis. The placement of a graft on the femur is crucial for preventing cartilage thinning, a key factor in maintaining joint health and function.
Current smokers have a significantly higher rate of septic reoperation compared to nonsmokers, with each additional pack-year contributing to total reoperations. Smoking history affects the risk of hospital readmissions among patients undergoing total joint replacement.
New research uncovers a connection between Crohn's disease and spondyloarthritis, finding that IgA-coated E. coli bacteria trigger inflammation in Th17 cells. This discovery may lead to the development of diagnostic tools and therapies targeting both conditions.
A research team at Brigham and Women's Hospital has identified a unique subset of T-cells that collaborate with other immune cells to drive inflammation in peripheral tissues. These cells display unusual biological features and stimulate B-cells to produce antibodies, contributing to tissue damage in autoimmune diseases.
Researchers developed a self-contained robotic bat with soft, articulated wings that mimic biological bats' key flight mechanisms. The robot's morphing skeleton and silicone-based membrane skin allow for smooth aerodynamic surfaces and safe collision detection.
A combination of a rheumatoid arthritis drug and an antiviral targeting the chikungunya virus eliminates signs of arthritis in mice at its earliest stage. The treatment shows promise for patients with no existing treatment options, with further studies planned to investigate human efficacy.
Researchers investigated using two approved autoimmune drugs to reduce joint swelling in mice infected with Chikungunya virus, a mosquito-borne illness with no known therapies. Fingolimid and Abatacept showed promise in stopping T cell trafficking and inflammation, potentially paving the way for new treatments.
A new study finds that CMS and care providers lack predictive models needed to assess risks patients face after joint replacement. Hospital systems are apprehensive of getting penalized inadvertently because CJR's current payment model does not include a risk adjustment method.
Researchers used imaging technology to track immune cells in living animals and identified a molecule required for their entry into the joint, which sets off inflammation. This discovery could lead to new treatments for inflammatory arthritis.
New research from Brigham Young University finds that running decreases pro-inflammatory molecules in the knee joint, reducing inflammation. The study suggests exercise can be a type of medicine for preventing osteoarthritis and delaying its onset.
Researchers identified a gene variant that raises risk of severe rheumatoid arthritis, potentially leading to targeted treatment. The study found that the variant correlates with increased MIF production and structural changes in cells, resembling cancerous tissues.
Researchers reveal that cartilage has a more complicated zonal organization than previously thought, with at least six identifiable zones. This discovery could help scientists develop better engineered cartilage materials to treat joint disorders.
A new Wnt inhibitor drug has shown significant improvements in knee OA pain, joint function, and even slowed or reversed cartilage loss. The study found that the drug improved outcomes for 76% of patients in the high-dose group compared to 36% on placebo.
Researchers argue that treating gout to avoid symptoms may not effectively address the underlying high uric acid levels causing the condition. They propose a 'treat-to-target' approach to reduce uric acid levels to prevent crystallization and alleviate symptoms.
Researchers have developed a bio-inspired lower-limb exoskeleton that features natural knee movement, improving patients' comfort and willingness to wear it for gait rehab. The exoskeleton is designed to help strengthen physical fitness, aid rehabilitation training, and assist with daily activities.
A novel nanofiber coating with antibiotic-releasing properties has shown promise in preventing serious bacterial infections related to total joint replacement surgery. The coating was found to completely eradicate infection and prevent bone loss, a common complication that leads to prosthetic loosening and failure.
A new study investigated ACL injury's effect on osteoarthritis development. The study found that the knee adduction moment significantly influences joint contact forces after surgery.
Researchers developed a smart textile that can sense and move like a muscle, enabling new device applications. The textile generates a mechanical work capacity and power output higher than human muscles, with potential uses in robotics, sensors, and smart clothing.
Researchers at Columbia University Irving Medical Center have identified stem cells in the temporomandibular joint that can generate cartilage and bone. The discovery suggests a potential new approach to repairing damaged joints, particularly for patients with TMJ disorders.
A PolyU study reveals that running in minimalist shoes can significantly increase leg and foot muscle volume. The experimental group showed a 7.05% increase in extrinsic foot muscles and an 8.8% increase in intrinsic foot muscles compared to the control group.
A study found that implementing an analytic tool to allocate clinical care costs and quality measures led to significant improvements in value of care for three designated outcomes. The program resulted in reduced costs and improved quality, with notable decreases in hospitalist laboratory testing and sepsis management.
The study found that the marsupial lion's elbow joint had a unique rotational capacity, similar to arboreal mammals, but also features not seen in living climbers. The researchers suggest this allowed the animal to use its dew claw to kill prey. The incisors were blunt and functioned better for gripping than piercing flesh.
A study found an association between Zika virus infection and arthrogryposis, a joint deformity condition at birth. Children with arthrogryposis and congenital Zika virus syndrome showed signs of brain calcification.
Researchers have developed a technique to program stem cells to grow new cartilage on a 3-D template shaped like the ball of a hip joint. The cartilage can release anti-inflammatory molecules to fend off arthritis. The discovery may provide an alternative to hip-replacement surgery, particularly in younger patients.
A new character animation technique has been developed by Disney Research, eliminating unsightly artifacts that occur when bending joints in computer animations. The method uses pre-computed centers of rotation to calculate skin deformation, minimizing volume losses and bulging.
A Canadian hospital implemented strategies to reduce operating room traffic, which led to a significant decrease in orthopedic surgical site infections. The hospital reduced door openings from 42-70 to 3.2 per case, resulting in a 1.7% decrease in SSIs.
Scientists have discovered that zebrafish are susceptible to arthritis, mirroring the condition in humans and other mammals. The study uses zebrafish as a model to accelerate therapeutic research into preventing or easing osteoarthritis.
Researchers at Mayo Clinic have identified intestinal bacteria as a possible cause of rheumatoid arthritis and found a link between specific microbiota and the disease. Testing for certain gut bacteria may help predict and prevent rheumatoid arthritis, with potential applications in personalized treatment.
The study found that the distinctive ball-and-socket vertebrae arrangement in sauropods allowed for greater flexibility and reduced stress on the spine. This design enabled the evolution of long-necked sauropod dinosaurs, which reached lengths of over 100 feet and weighed up to 70 metric tons.
A new study from the University of Eastern Finland has developed a computational model that can predict the onset and progression of knee osteoarthritis in overweight people. The model analyzes the degradation of the collagen fibril network in articular cartilage and simulates the effect of various loadings on cartilage cells.
Studies reveal distinct differences in key cellular processes and molecular signatures between rheumatoid arthritis (RA) and osteoarthritis (OA), as well as joint-specific variations in RA. These findings may enable precise targeting of treatment for each ailing joint, explaining why drugs vary in effect.
A study of 574 patients undergoing knee or hip replacement surgery found that 30% were taking opioids prior to surgery, with 35% continuing to take them six months later. High-dose opioids and higher pain scores on the day of surgery were associated with persistent opioid use.
New imaging methods, including computer-assisted analysis of X-ray images and ultrasound imaging, show promise in detecting early stages of arthrosis. The methods could lead to targeted treatment and improved prediction of disease progression.
Researchers at Georgia Tech are creating a knee band that transcribes crackling knee sounds into moving graphs, which could help doctors determine if the joint is healthy or needs therapy. The device aims to provide valuable patterns from injured knees, potentially benefiting athletes and elderly patients with musculoskeletal injuries.
Researchers at UMass Chan Medical School are developing a web-based care plan for osteoarthritis patients, utilizing a national database of total joint replacement patients. The care plan aims to improve patient-clinician interaction and informed decision-making, enhancing the quality of care and outcomes.
Recent studies have identified biomarkers associated with cartilage degradation and new genes linked to osteoarthritis (OA) development. Researchers used a non-invasive mouse model of post-traumatic osteoarthritis (PTOA) to analyze whole-joint gene expression, providing insights into the disease's progression.
Researchers found that combining TXA delivery methods reduced blood loss by 37% compared to IV alone following TKR. The study showed no thromboembolic complications, with one patient requiring a postoperative blood transfusion.
Researchers discovered that albumin and globulin proteins improve the tribology of artificial joint implants, suggesting a potential solution to reduce wear and tear. The findings have implications for extending the lifespan of prosthetic joints and improving patient quality of life.
A new study has identified four symptoms that predict septic arthritis in children with swollen, painful knees. The study found that patients with these characteristics were more likely to have septic arthritis than Lyme disease.
A flexible exosuit developed by Harvard University researchers reduces the metabolic cost of loaded walking by 7.3% on average, allowing wearers to return to a natural walking profile. The device is composed of textiles and assists the hip and ankle joints, reducing work done without impacting movement freedom.
A large study of nearly 29,000 outpatient hand and shoulder surgeries found a 0.2 percent complication rate, with most complications being post-operative infections or blood clots. The study suggests that proper patient selection can make these procedures safe at freestanding ambulatory surgery centers.
Researchers discovered that resolvin D1 promotes cartilage repair and reduces joint damage in mouse models of inflammatory arthritis. Administration of resolvin D1 dramatically reduced disease symptoms and promoted remission.
A new computational modelling method developed by the University of Eastern Finland uses MRI data to assess the patient-specific progression of osteoarthritis in the knee joint. The study found significant degeneration in overweight individuals, with healthy cartilage thickness remaining unchanged over a four-year period.
Two studies found that patients who reduced their opioid use prior to joint replacement surgery had improved patient satisfaction and outcomes, fewer complications, and a reduced need for post-surgical opioids. Patients with chronic opioid use were more likely to experience prolonged pain and higher rates of post-operative complications.
Researchers at NYU Langone Health successfully performed ultra-low dose CT scans to diagnose joint fractures with 14 times less radiation, achieving 98% sensitivity and comparable image quality. The protocol, called REDUCTION, has significant implications for public health and safety.
Researchers found that TXA reduced the need for a blood transfusion by more than 50% in hip and knee replacement surgery. Topical versus intravenous administration of TXA showed similar effectiveness in reducing blood loss and transfusion rates.
Researchers at the University of Missouri have developed a new biological technique for hip joint replacement that uses larger, size-matched grafts with beveled edges to provide longer-lasting repair. The study shows that these larger grafts maintain joint viability and structural integrity throughout the six-month study period.
A study at Hospital for Special Surgery found that patients who received one-on-one education with a physical therapist before knee or hip replacement surgery were more satisfied and better prepared for recovery. They also needed fewer physical therapy sessions in the hospital.
A study finds that bariatric surgery prior to total knee replacement improves quality of life in morbidly obese patients with end-stage knee osteoarthritis. The research suggests a cost-effective option to reduce complications and costs associated with joint replacement, with a predicted cost per QALY of $13,910.
Researchers identified a potential new approach to combating rheumatoid arthritis by blocking the effects of the disease using epigallocatechin-3-gallate (EGCG), a molecule with anti-inflammatory properties found in green tea. The compound markedly reduced ankle swelling in an animal model of human rheumatoid arthritis.
Researchers at the University of Southampton found that bone marrow lesions on MRI scans can predict more rapid progression of osteoarthritis. Individuals with BMLs had a loss rate of 0.10mm per year faster than those without, potentially leading to earlier need for joint replacement.
Scientists have developed a method to regrow functional joints in frogs using a 'reintegration' mechanism. This approach could potentially be used to regenerate limbs in mammals and humans. The research paves the way for further studies on functional joint regeneration.
A study published in Arthritis Care & Research found that both prefabricated foot orthoses and rocker-sole shoes alleviate big toe joint pain, with orthoses potentially being the better option due to reduced discomfort and impaired balance. Additionally, these interventions also affect peak pressure under other toes and midfoot.
Researchers at Queen Mary University of London have found that arthritic cartilage can be treated by a patient's own microvesicles, which can travel into cartilage cells and deliver therapeutic agents. The study suggests that these microvesicles could be a novel form of therapy for patients with cartilage damage due to various diseases.
Researchers identified Irx genes' role in protecting joint cartilage cells, promoting flexibility by repressing stiffening genes. The study suggests harnessing these genes to encourage stem cell differentiation into new joint cartilage.
Researchers have developed an injectable drug that inhibits the Wnt pathway, causing endogenous stem cells to regenerate knee cartilage in animals. Clinical data suggest slowing joint space narrowing and increased joint space, indicating potential preservation or regrowth of cartilage.
Samumed's Phase II clinical trial aims to evaluate the safety, tolerability, and efficacy of SM04690 in treating moderately to severely symptomatic OA patients. The trial will assess changes in WOMAC pain and function subscores at Week 13.