Articles tagged with Joints
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new measure ranks US hospitals based on complications following hip and knee replacements, revealing a significant four-fold difference in risk-adjusted complication rates. The study found no disparities in outcomes between hospitals caring for higher proportions of Medicaid-eligible or black patients.
A traditional Chinese herbal remedy, Tripterygium wilfordii Hook F, has been shown to be as effective as methotrexate in treating rheumatoid arthritis. Combining the herbal remedy with methotrexate resulted in improved outcomes for patients, including significant reductions in disease activity and remission rates.
Prolotherapy injections have shown substantial improvement in knee osteoarthritis symptoms, including pain, function, and stiffness. Patients experienced symptom improvement ranging from 19.5-42.9% compared to baseline status.
A new study published in the Journal of Bone and Joint Surgery found that economic downturns did not significantly impact the growth trends for hip and knee arthroplasty in the US. The study's results support previous projections, indicating a recession-proof demand for total joint replacement through at least 2021.
A new study by Mayo Clinic reveals that CT scans are effective in detecting uric acid crystals around joints, particularly in patients with multiple gout-like flares. Accurate diagnosis is crucial as gout patients require different medication than those with other forms of inflammatory arthritis.
Researchers at Hospital for Special Surgery found that patients who lose weight after hip or knee replacement have better clinical outcomes, including improved function and activity levels. Meanwhile, patients who gain weight experience inferior outcomes, highlighting the importance of maintaining good health and a suitable weight.
Researchers at Scripps Research Institute found a gene called stumble that helps detect leg-joint angles in fruit flies, similar to human nerve cells. This discovery could improve understanding and treatment of balance and limb movement disorders.
A study analyzing 301,718 revision total knee replacement surgeries found that periprosthetic joint infections were the most common reason for failure, occurring in 25% of patients. Mechanical loosening was also a significant cause of failure, accounting for 18.5% of cases.
Research suggests that patients with metabolic syndrome are more likely to experience complications after total joint replacement surgery. Obesity is a significant factor in postoperative complications, with risks increasing for those with a BMI of 30 kg/m2 or higher.
A study found that total joint replacement (TJR) reduces the risk of heart attack, stroke, or other 'cardiovascular events' in patients with moderate-to-severe arthritis. This may be due to increased mobility and physical activity levels, which have a positive impact on cardiovascular health.
A study found that a lower ratio between the length of the index and ring fingers is associated with a higher risk of developing severe osteoarthritis in the knees. This association was stronger for total knee replacements than hip replacements, suggesting hormonal influences may play a role.
A new study by Mercyhurst University, UPMC Hamot, and Shriners Hospitals for Children is exploring the correlation between pitch count and throwing arm injuries. The researchers will use high-speed motion-capture cameras, shoulder muscle power tests, and biomarkers to analyze the effects of consecutive pitches on fatigue.
A multicenter study found a mobile compression device to be as effective as blood thinners in preventing deep vein thrombosis (DVT) after lower extremity joint replacement surgery. The device improved blood flow and had no negative side effects, making it an equally safe alternative to blood thinners.
Researchers developed antibiotic-containing microspheres to prevent implant-associated bone infections. The study found that coated implants prevented infection in 100% of specimens, while uncoated ones showed a 64% infection rate.
Scientists from the University of Manchester identified Leri's pleonosteosis as caused by extra genetic material on chromosome 8. The condition is also linked to scleroderma and offers opportunities for understanding and treating both diseases.
A novel study found that a single stem cell injection following meniscus knee surgery can provide significant pain relief and aid in meniscus regrowth. The treatment showed no 'clinically important' safety issues, with some patients experiencing strong improvement in pain and meniscal regrowth.
Researchers at Scripps Florida Institute developed a compound that dramatically reduces joint inflammation in animal models of rheumatoid arthritis. The study showed the compound, SR2211, blocked symptoms and bone erosion in mice within eight to ten days of treatment.
Researchers found compelling evidence that gout clusters in families, with a significant increase in risk for those with first and second-degree relatives affected. The study also highlights the role of shared environmental factors, such as diet and lifestyle, in predisposing individuals to gout.
A Vanderbilt University study found nearly half of orthopaedic surgeons sustain injuries during their careers, with inadequate resources available to them. The study also revealed that 38% of respondents reported no institutional resources, leading to increased lost productivity.
Recent advances in robotics enable the creation of prosthetics that mimic natural movement, allowing users to navigate stairs and uneven ground with reduced stress. Studies have shown improved walking speed, decreased energy expenditure, and reduced fall rates compared to passive prostheses.
Researchers have developed a squishy gel that releases an anti-inflammatory drug when compressed, like a painful knee joint. The new material could deliver medications on-demand to alleviate osteoarthritis symptoms.
A new study reveals that rising rates of obesity among young adults are contributing to an increase in knee replacement surgeries. Younger patients are more obese and experience the same level of pain and functional disability as older patients, according to researchers at UMass Chan Medical School.
Researchers discovered that abnormal citrullination in rheumatoid joints is linked to pore-forming pathways in cell membranes. These pathways, called perforin and complement, are normally used by the immune system to fight pathogens, but their disruption produces enzyme-activating imbalances of calcium ions.
New findings show STELARA significantly inhibits structural damage progression at week 24 and maintains effect through two years. Treatment with STELARA results in reduced total psoriatic arthritis modified vdH-S scores compared to placebo.
A study found that wearing high heels while running leads to increased knee motion, joint forces, and risk of ankle sprains. Regular use may contribute to osteoarthritis in the knees.
Early, aggressive drug treatment shows promising results in patients with psoriatic arthritis, reducing joint damage and disability. A £550,000 clinical trial involving over 200 patients found significant improvements in joint and skin outcomes with tight control of disease activity.
A new study from Hospital for Special Surgery found that achieving low disease activity within six months significantly reduces disability at two years. Patients who reached this state had better functional ability and fewer joint damages compared to those who delayed treatment.
EPFL scientists have created a hydrogel that promotes cartilage regeneration by delivering therapeutic drugs in response to mechanical stimulation. This method has the potential to revolutionize the treatment of joint injuries and degenerative conditions such as arthritis.
A new study by Rush University Medical Center found that mobility shoes significantly reduced knee loading in osteoarthritis patients, even after the shoes were no longer worn. The study suggests that footwear choice may be an important consideration in managing knee osteoarthritis.
The 2013 classification criteria for systemic sclerosis are more sensitive than the 1980 measures, enabling earlier identification and treatment of this autoimmune disease. The new criteria improve the classification of systemic sclerosis by clustering items and simplifying the weighting of different criteria.
A recent study found that using DVDs, booklets, and health coaches can help patients arrive at an informed treatment decision within their first visit with an orthopaedic surgeon. The study showed a significant increase in patient confidence in knowing what questions to ask their doctor, leading to better shared medical decision making.
Researchers will validate new MRI techniques and biomarkers to identify early stages of osteoarthritis and test therapies for prevention. The study aims to develop biomarkers that reflect joint environment changes predictive of arthritis development.
A study led by University of East Anglia found that sulforaphane in broccoli slows down cartilage destruction and osteoarthritis. Researchers hope to replicate the effect in humans through a small-scale trial.
A new study highlights the economic benefits of knee replacement surgery, finding that patients can save nearly $40,000 in indirect costs, resulting in lifetime societal savings of $10,000-$30,000. The study estimates that total knee replacement surgeries will exceed 3 million by 2030 due to an aging population.
A randomized clinical trial found that calcium and vitamin D supplementation did not reduce joint pain or swelling in postmenopausal women. The study analyzed data from the Women's Health Initiative calcium plus vitamin D supplementation trial, which included 1,911 participants.
Duke University researchers identified TRPV4 as a critical protein contributing to temporomandibular joint disorder (TMJD) pain. The study found that inhibiting TRPV4 reduced bite force and pain, suggesting it may be an attractive target for developing new treatments.
Researchers from the University of Leicester show that insect limbs can move without muscles, using a close interplay of neuronal control and passive joint forces. This finding may provide engineers with new ways to improve robotic and prosthetic limb control.
Researchers have found a naturally occurring molecule, Urocortin, which protects cells in the joints from being destroyed in osteoarthritis. The discovery could lead to the development of new medicines to prevent joint degradation.
A study found that knee shape can affect ACL reconstruction decisions after a tear. Knees with more stable shapes, such as deeper tibial plateaus and less concave areas, may not require surgery. This discovery could help clinicians identify patients who can skip ACL reconstruction.
A new study by McGill University researchers suggests that the nervous system and nerve-growth factor (NGF) play a major role in arthritis. The findings support the idea that reducing elevated NGF levels may be an important strategy for developing treatment of arthritis pain.
Patients with Systemic Juvenile Idiopathic Arthritis (SJIA) who received canakinumab successfully tapered off corticosteroids, achieving a CS-free status in 42 out of 128 patients. This reduction in corticosteroid use has significant long-term health benefits for children suffering from SJIA.
A new study demonstrates the efficacy of a radiographic scoring method to evaluate joint damage in rheumatoid arthritis, revealing progressive destruction even under TNF-blocking therapies. Patients with pre-existing damage showed significant increases in joint damage, highlighting the importance of early and accurate evaluation.
Researchers at Mayo Clinic found that patients with gout who initially experience pain in other joints, such as the knee or elbow, are at higher risk of future flare-ups. Additionally, chronic blood pressure variability and smoking are linked to increased cardiovascular risk in rheumatoid arthritis patients.
A retrospective study found that higher numbers of lumbar epidural steroid injections (LESI) were associated with increased risk of bone fragility and vertebral fractures. Patients at high risk for fractures include older women, those who have had an earlier fracture, smokers, and underweight individuals.
A large multi-generational family study has identified a genetic mutation that increases the risk of developmental dysplasia of the hip (DDH). The researchers found a common variant co-inherited by all affected family members, which may affect cartilage formation and delay development.
Scientists at Johns Hopkins Medicine discovered that blocking critical bone regulation protein halts OA progression in mice, suggesting a new therapeutic approach to joint replacement surgery. The theory proposes that initial harm to cartilage causes excessive bone growth, leading to disease exacerbation.
Researchers have developed a blood test that can detect allergies to nickel, cobalt, and bone cement, allowing patients to avoid miserable reactions and expensive revisions. The new test is expected to be widely used in the next couple of years, improving patient outcomes and reducing healthcare costs.
Researchers found that pro-factor D, a protein secreted by fat cells in the knee joint, is linked to rheumatoid arthritis. The discovery could lead to new gene therapies to eliminate the protein and prevent disease progression.
A team of researchers has developed a new synthetic polymer supplement that mimics natural synovial fluid, providing superior lubrication and reducing wear on cartilage surfaces. The biopolymer remains in the joint for more than two weeks, unlike current treatments which last only one or two days.
Researchers at UC San Diego have developed a flexible robotic arm inspired by the seahorse's tail, which can be compressed to 50% of its size without permanent damage. The design uses bony plates that slide past each other, providing exceptional flexibility and protection.
Research by University of Exeter scientists reveals that hydrogen sulfide gas reduces inflammation and swelling in arthritic joints. The study suggests H2S-based compounds may be effective in treating arthritis without uncomfortable side effects.
Researchers used atomic force microscopy to measure the mechanical properties of single cells in articular cartilage. They found that vimentin protein plays a key role in maintaining cell integrity, and that adult tissue has higher mechanical properties than young or old tissue.
Researchers found that mobility shoes significantly reduced knee loading and improved gait in patients with knee osteoarthritis. Long-term use of the shoes helped participants adapt their walking pattern, leading to a 18% reduction in knee adduction moment.
Orthopedic surgery faces challenges with obese patients due to increased risk of complications, poor nutrition, and diminished treatment outcomes. Weight loss is recommended for pre-joint replacement surgery to improve outcomes.
Only half of patients with hip or knee replacements reported significant improvement in pain and mobility. Patients who had worse joint pain to begin with but fewer general health problems were more likely to report benefits.
Researchers at Rhode Island Hospital have discovered a new strategy to effectively treat and prevent osteoarthritis by adding lubricin protein to joint fluid. This breakthrough finding may reduce the risk of or even prevent OA, which affects 27 million adults in the US.
A recent study by the American Academy of Orthopaedic Surgeons found that smoking significantly increases the risk of nonunion in fractures involving long bones. The average time to fracture healing is also longer for smokers compared to nonsmokers, highlighting the negative impact of smoking on bone health.
Researchers at Thomas Jefferson University have found that the traditional thresholds for ESR and CRP may need to be refined to improve accuracy in diagnosing periprosthetic joint infections. The study analyzed 1,993 patients and revealed differences in inflammatory marker elevation between knees and hips.
A recent study found that current and past smokers have a higher risk of hip replacement failure compared to non-smokers. The study, which reviewed records of total hip replacement patients between 2007 and 2009, found a significant correlation between smoking and increased revision rates.
New research found that total hip and knee replacement surgeries significantly improve sexual function in 90% of patients, with women experiencing a higher rate of improvement. The study also revealed that psychological issues related to osteoarthritis were common among patients, but improved following surgery.