Articles tagged with Joints
Researchers identified a potential new approach to combating rheumatoid arthritis by blocking the effects of the disease using epigallocatechin-3-gallate (EGCG), a molecule with anti-inflammatory properties found in green tea. The compound markedly reduced ankle swelling in an animal model of human rheumatoid arthritis.
Researchers at the University of Southampton found that bone marrow lesions on MRI scans can predict more rapid progression of osteoarthritis. Individuals with BMLs had a loss rate of 0.10mm per year faster than those without, potentially leading to earlier need for joint replacement.
Scientists have developed a method to regrow functional joints in frogs using a 'reintegration' mechanism. This approach could potentially be used to regenerate limbs in mammals and humans. The research paves the way for further studies on functional joint regeneration.
A study published in Arthritis Care & Research found that both prefabricated foot orthoses and rocker-sole shoes alleviate big toe joint pain, with orthoses potentially being the better option due to reduced discomfort and impaired balance. Additionally, these interventions also affect peak pressure under other toes and midfoot.
Researchers at Queen Mary University of London have found that arthritic cartilage can be treated by a patient's own microvesicles, which can travel into cartilage cells and deliver therapeutic agents. The study suggests that these microvesicles could be a novel form of therapy for patients with cartilage damage due to various diseases.
Researchers identified Irx genes' role in protecting joint cartilage cells, promoting flexibility by repressing stiffening genes. The study suggests harnessing these genes to encourage stem cell differentiation into new joint cartilage.
Researchers have developed an injectable drug that inhibits the Wnt pathway, causing endogenous stem cells to regenerate knee cartilage in animals. Clinical data suggest slowing joint space narrowing and increased joint space, indicating potential preservation or regrowth of cartilage.
Samumed's Phase II clinical trial aims to evaluate the safety, tolerability, and efficacy of SM04690 in treating moderately to severely symptomatic OA patients. The trial will assess changes in WOMAC pain and function subscores at Week 13.
A new study by researchers at SISSA found that individuals with autism have difficulty interpreting facial expressions due to impaired facial mimicry, which can be exacerbated when making joint attention. The study suggests that understanding the interaction between these two functions is crucial for social interaction.
Research published in the British Journal of Sports Medicine found that exercising up to five times a week before pregnancy can help prevent pelvic girdle pain. High-impact activities like jogging and ball games were most beneficial.
A commentary published in CMAJ argues that prescribing antibiotics after joint surgery has little evidence to support it. Research suggests that bone cement impregnated with antibiotics is a more effective practice, but its use is not widespread.
A study from the University of Eastern Finland found that infrared thermography can detect joint inflammation in ankle joints, but not knee joints. The technique also showed potential in evaluating office ergonomics and assessing musculoskeletal conditions, which could ease the workload in specialized healthcare and reduce costs.
Researchers developed an algorithm to automatically tune powered prosthetic legs, tracking joint angles while walking. The system allows patients to walk comfortably with reduced prosthesis-related costs and easier adjustments.
Bunostegos' forelimb anatomy reveals unique characteristics allowing it to stand with legs under the body. This finding indicates the earliest known example of an upright posture in pre-reptiles, dating back 260 million years.
Studying kangaroo cartilage reveals how shoulder and knee joints behave differently, leading to improved treatments and better implants. The researchers identified the collagen network as a key factor in absorbing forces without damaging.
A study published in Arthritis & Rheumatology found that osteoarthritis patients who underwent total knee or hip joint replacement surgery were at increased risk of heart attack immediately following arthroplasty. However, long-term risk was insignificant, while the risk for venous thromboembolism remained years after the procedure.
A new protein (C5orf30) has been identified as a genetic marker for rheumatoid arthritis severity, allowing for early diagnosis and targeted treatment. This breakthrough discovery has the potential to improve patient outcomes and reduce tissue damage caused by the condition.
A new protein (C5orf30) has been identified as a genetic marker that can help regulate the severity of tissue damage caused by rheumatoid arthritis. This discovery enables early identification of patients at risk of severe joint damage, allowing for fast-tracked treatment with more aggressive therapies.
A recent study highlights the risk of catastrophic complications from failure of modular head-neck prostheses in hip-replacement surgery. The Journal of Bone and Joint Surgery has issued a 'Watch' to raise awareness and encourage further research into this issue.
Scientists at the University of York have developed a technique to rejuvenate human cells from older people with osteoarthritis, allowing them to repair worn or damaged cartilage and reduce pain. The researchers recreated similar conditions in the laboratory by growing human cells as 3D aggregates, enabling them to generate new tissues.
A study found that nearly two-thirds of meniscal transplants remain viable at 10 years, relieving pain and improving knee function. However, many patients required additional surgery within 15 years.
A study of high-intensity interval training in women with rheumatic disease found significant reductions in arthritic inflammation and improvements in cardiovascular health. Participants experienced less inflammation, increased oxygen intake, and a small reduction in BMI after ten weeks of twice-weekly sessions.
Researchers found that total knee replacement reduces knee pain and improves subjective quality of life indices in rheumatoid arthritis patients. However, improvements were not as great as those experienced by osteoarthritis patients.
A study found that GPR40 deficiency leads to an aggravated OA phenotype characterized by higher cartilage breakdown and subchondral bone sclerosis. Activation of GPR40 protects joints from OA, providing new insights into innovative strategies for OA management.
Patients who received telerehabilitation had similar outcomes to those receiving in-person physical therapy following total knee replacement surgery. Telerehabilitation was found to be effective for patients with travel limitations or rural/underserved areas, offering the same quality services in their home environment.
Researchers identified IL-1β as a crucial factor in blood-induced cartilage damage. A new treatment targeting IL-1β may provide protection for cartilage after trauma or bleeding due to hemophilia, potentially reducing subsequent disability.
A large population study found an increased risk of developing Psoriatic Arthritis among psoriasis patients exposed to physical trauma, particularly bone and joint traumas. The study suggests further investigation into the complex factors leading to arthritis in psoriasis patients may lead to modified risk.
A study found that RA patients with moderate disease activity are at risk of needing joint surgery, challenging existing treatment guidelines. The findings suggest updating disease activity cut-off points to allow moderate-disease-activity patients to receive biologics.
Researchers at Disney Research Pittsburgh have developed a 2-legged robot that can mimic an animated character's walking motion, using a combination of 3D-printed links and servo motors. The robot is designed to duplicate the character's gait as closely as possible, while also being stable and physically realizable.
A team of researchers from Montana State University has identified a new chemical compound called IQ-1S that shows promise in treating rheumatoid arthritis. The study found that IQ-1S significantly reduced the severity of collagen-induced arthritis and inhibited the destruction of cartilage and bone.
A new class of medications could prevent joint damage and provide relief to patients who don't respond to available treatments. The novel drug target, RPTPσ, inhibits the aggressive invasion of synoviocytes into joint cartilage by acting as an inhibitory signal.
The TGen study identified over 50 rare disorders associated with muscle contractures and stiff joints in newborns. The researchers matched these conditions to specific genes on the X chromosome, offering potential therapies for diagnosis and treatment.
A new University of Alberta study reveals that older workers (65+ years old) are more susceptible to severe injuries but less likely to receive modified work duties or rehabilitation. Researchers call for a revised approach to assess and treat injured workers, prioritizing their return to work.
Researchers at Empa use computer simulations and 3D X-ray imaging to study back pain caused by mechanical issues. They aim to identify misalignments in the spinal column and develop personalized therapy recommendations.
Researchers observed a rapid gas-filled cavity forming within the synovial fluid, causing the distinctive popping sound when cracking knuckles. The findings may lead to new research into the therapeutic benefits and harm of joint cracking, shedding light on potential long-term effects.
Dielectric elastomers have made significant breakthroughs in soft robotics applications, enabling the creation of flapping robotic wings with high-energy conversion efficiencies. The new resonance phenomenon discovered by researchers can make the artificial joint bend up and down, mimicking the motion of a bird's wing.
A new study found that black and Hispanic patients were 62% and 50% more likely to be readmitted within 30 days after TJR surgery compared to white patients. Longer hospital stays and comorbidities increased the risk of readmission.
Researchers developed two predictive models to identify patients at risk for serious complications after joint replacement surgery. The first tool identifies patients with conditions like chronic obstructive pulmonary disease and congestive heart failure, while the second model predicts which patients require intensive care unit admiss...
Two new studies at Hospital for Special Surgery found that bariatric surgery prior to joint replacement significantly improves outcomes in obese patients. The research shows that weight-loss surgery can reduce the risk of heart disease, diabetes, and certain cancers, while also decreasing costs and complications associated with hip or ...
Researchers created an algorithm to determine factors contributing to arthritis pain in a national representative sample of adults. The study found that physical health status, diabetes, and previous joint pain were the greatest predictors of pain, with an accuracy rate of 98.6%.
The study found a 12% reduction in blood transfusions and increased discharge to home by 9.3%, reducing hospital stays and healthcare costs. Topical tranexamic acid administration enables precise control over drug concentration, potentially reducing infection rates.
Researchers found increased pocket depth and clinical attachment loss in patients with rheumatoid arthritis, highlighting the link between gum disease and joint inflammation. The study also identified Porphyromonas gingivalis antibodies as biomarkers for identifying patients who may benefit from periodontal treatment.
Researchers at the University of Manchester developed a protocol to grow and transform embryonic stem cells into cartilage cells, which could be used to treat osteoarthritis. The study showed that cartilage formed from embryonic stem cells was partially repaired in rats and demonstrated healthy, functional tissue after 12 weeks.
Researchers developed a new technology that preserves tissue quality in donated tissues, extending storage life to at least 60 days. This will allow surgeons to provide patients with more natural joint repair options, reducing the need for metal and plastic implants.
Researchers found that modern human skeletons have significantly lower bone density than other animals and even ancient ancestors. The decrease is especially pronounced in lower limbs, suggesting a link to humans' shift from foraging to agricultural lifestyles.
Researchers at UC Davis have developed a method to toughen up engineered cartilage and keep natural tissues strong outside the body. By depriving native or engineered cartilage of oxygen and using an enzyme called lysyl oxidase, they found that cross-linking occurs, making the material stronger.
A recent report in the Journal of Bone and Joint Surgery has highlighted the potential issue of flexible reamer breakage during single-bundle ACL reconstruction. This has prompted a 'Watch' from JBJS to alert orthopaedic surgeons about the problem. The 'Watch' aims to help surgeons avoid similar mishaps by understanding the causes and ...
Obesity affects orthopaedic care, healthcare systems, and individual organs, increasing the risk of musculoskeletal pain, osteoarthritis, and joint injuries. Patients with obesity face higher surgical complication rates, but orthopaedic procedures can minimize pain and improve bone function.
Researchers used CT scans to investigate royal Egyptian mummies from the 18th-20th Dynasties, ruling out signs of ankylosing spondylitis. Instead, they found evidence of diffuse idiopathic skeletal hyperostosis (DISH) in four Pharaohs, suggesting a degenerative spinal condition, not inflammatory arthritis.
Researchers found that Montmorency tart cherry juice lowered blood uric acid levels and increased specific anthocyanin compounds, which may help alleviate joint pain and inflammation associated with conditions like gout. The study also detected increased C-reactive protein in the bloodstream after consuming tart cherries.
Researchers at Oregon State University have developed a simple pulley mechanism that improves hand function in cadaver hands after surgery. The device reduces the force needed to close all four fingers by 45% and prevents slippage by 52%. This technology may offer new options for people who have lost hand function due to nerve trauma.
Research by Bruce Beynnon and colleagues found that the size of the femoral notch and ACL volume increase the risk of noncontact ACL injuries. Female college athletes are two times more at risk than males, with soccer and rugby participants showing significantly greater injury risks. Targeting interventions for these high-risk athletes...
Researchers found cartilage plays an active role in rheumatoid arthritis destruction and remodelling, contradicting the long-held assumption that it's a passive victim of inflammation. Cartilage produces enzymes driving tissue degradation and releases signaling molecules triggering an autoimmune response.
A team of researchers at the University of Illinois Chicago has identified a single receptor, TLR5, that triggers inflammation and bone degradation in rheumatoid arthritis. Blocking this receptor may provide a new therapeutic target to interrupt the disease's vicious cycle.
A recent study by researchers found no conclusive evidence to support the use of new hip and knee implants, highlighting concerns over inadequate regulatory oversight. The review of 15,384 implants in 13,164 patients revealed higher rates of repeat surgery associated with some devices.
Researchers have successfully engineered cartilage tissue using nasal septum cells, showing promising results in repairing articular cartilage defects. The treated patients' knees were replaced with the engineered cartilage grafts, demonstrating the potential of this innovative clinical treatment for cartilage damage.
Johns Hopkins scientists develop a new material that binds slippery molecules, potentially delivering long-lasting lubrication and easing painful joints. The material, inspired by natural functions lost in synthetic materials, has shown promise in animal tests.
A recent study published in Clinical Microbiology and Infection warns of the high risk of Chikungunya virus spread in the Americas and Europe due to mosquito-borne transmission. The disease can cause severe symptoms, including fever, joint pain, and muscle aches, with no available treatment.
A study by University of Liverpool scientists has identified a new mechanism of joint destruction caused by high-density mineralised protrusions (HDMPs) in human hip joints. These protrusions, seen only in horses, can snap off and grind against healthy tissue, worsening osteoarthritis.
Researchers found a systematic connection between FMD, bone abnormalities, and TGF-beta pathway activation. The study suggests that FMD may not be limited to arteries and is a systemic disease with altered TGF-β expression.