A Hospital for Special Surgery (HSS) study has identified a previously unknown role for skin immune cells in shaping the development of the lymphatic system. Langerhans cells play a critical role during early life in helping lymphatic vessels grow and develop properly, influencing lifelong immune function.
Researchers at Hospital for Special Surgery identified SPP1ʰmacrophages that promote excessive joint tissue expansion in rheumatoid arthritis. These cells work with structural cells and protein scaffolds to drive abnormal growth, suggesting a coordinated interaction between immune cells, structural cells, and the extracellular matrix.
Researchers from Hospital for Special Surgery (HSS) conducted three studies on osseointegration, a surgical procedure attaching prosthetic limbs directly to bone. The studies found substantial improvements in mobility and patient satisfaction for both femur- and tibia-level amputations, challenging prevailing beliefs about patient bene...
Dr. Austin Fragomen has been named Chief of the Limb Lengthening and Complex Reconstruction Service at Hospital for Special Surgery, succeeding Dr. S. Robert Rozbruch. He will oversee a highly specialized service providing treatment for patients with limb length discrepancies or deformities.
Researchers at Hospital for Special Surgery (HSS) have received President’s Choice Awards for their groundbreaking studies on pain management. Two studies found that cannabidiol use is prevalent among patients undergoing sports medicine procedures, and that robotic-assisted total hip replacement surgeries resulted in lower opioid consu...
A HSS study using artificial intelligence identifies two distinct pain archetypes and determines key predictive factors for severe pain after knee replacement. The study utilizes machine learning to analyze patient data and provide personalized pain management plans.
Researchers at Hospital for Special Surgery found that mesenchymal stromal cells produce cytokines stimulating resident macrophages to proliferate and accumulate, contributing to chronic inflammation. Existing therapies may help control muscle inflammation by suppressing macrophage infiltration and FAPs' CSF-1 production.
A landmark clinical trial found that blocking inflammation with certolizumab significantly reduces the risk of serious adverse pregnancy outcomes in women with antiphospholipid syndrome. The study showed a dramatic improvement in pregnancy outcomes, including lower complication rates and healthier babies.
A new study by Hospital for Special Surgery researchers found that young, active patients who underwent total knee replacement were unlikely to require knee replacement revision in their lifetime. The study, which tracked outcomes for patients under 55 undergoing total knee replacement between 1977 and 1992, showed that 70% of patients...
A preclinical study by HSS investigators found that earlier ACL reconstruction led to lower immune cell activity, less inflammation, and fewer joint changes associated with knee osteoarthritis. The results suggest that immediate ACL reconstruction may lower the risk of developing knee arthritis.
Researchers at HSS present two studies, limiting tourniquet use reduces post-operative pain and opioid consumption, while NSAIDs reduce risk of fibrosis needing further treatment after knee replacement surgery. These findings suggest that reducing tourniquet use can lead to faster recovery with less pain.
Researchers at Hospital for Special Surgery have uncovered key biological mechanisms driving systemic sclerosis, a rare autoimmune disease that disproportionately affects women. The studies reveal potential treatment targets, including drugs targeting plasmacytoid dendritic cells and CXCL4 cytokine.
A study at Hospital for Special Surgery found that both robotic-assisted navigation and augmented reality techniques demonstrate superior accuracy in pedicle screw placement, with 99.6% of robotic screws rated as Grade A or B and 92.6% of augmented reality screws achieving the top rating.
Researchers found that strengthening blood vessel integrity with S1PR1 can prevent inflammation and damage in joints. The study suggests a new therapeutic strategy that could be used in combination with existing immunosuppressive drugs.
Researchers identified a new mechanism by which SARS-CoV-2 induces inflammatory responses in COVID-19 patient lungs, leading to 'cytokine storm' and lasting tissue damage. The discovery highlights the role of plasmacytoid dendritic cells in triggering this response.
A recent HSS study analyzed trends and complications in patients undergoing outpatient hip and knee replacements, finding no significant difference in readmission rates for hip replacements but slightly higher odds for knee replacements. The study suggests same-day discharge joint replacement is safe but requires additional monitoring.
The study found that robotic-aided pedicle screw placement showed accurate positioning, even for experienced surgeons, with a significant decrease in time required. The technology saved time in the operating room, making it an efficient option for spine surgery.
A study developed by HSS experts shows improved patient outcomes, including reduced hospital stays and readmissions, after implementing an optimized recovery pathway for complex spine surgeries. The new approach also lowered complication rates and enabled patients to recover faster at home.
Researchers at Hospital for Special Surgery found that oral tranexamic acid (TXA) is non-inferior to intravenous TXA in preventing blood loss during total knee and hip replacement surgeries. The study suggests that oral administration of TXA may be logistically easier, less costly, and equally effective as IV TXA.
A study by Hospital for Special Surgery found hip fracture patients during COVID-19 had longer hospital stays, higher complication rates and more nonsurgical treatments. In contrast, those without the virus were discharged earlier with less use of intensive care units.
Researchers at Hospital for Special Surgery found that duloxetine reduced cumulative opioid use by 30% in patients undergoing total knee arthroplasty compared to those receiving placebo. Patients who received duloxetine also reported higher pain management satisfaction and less pain interference with daily activities.
Researchers found gaps in patients' understanding of opioid use, pain management, and proper storage/disposal. Patients may benefit from educating them on multimodal analgesia and safe opioid use practices.
A study at Hospital for Special Surgery found that older age, female sex, and higher comorbidities are associated with persistent opioid use in pediatric patients. The research aims to inform clinicians about risk factors for opioid dependence in this vulnerable population.
Researchers are developing new classification criteria for antiphospholipid syndrome (APS), a life-threatening autoimmune disorder, to improve its diagnosis and treatment. The new criteria will help identify patients most likely to have APS, allowing for high-quality research and better prevention and treatment options.
A new study by HSS researchers found that patients with skeletal abnormalities are more likely to experience complications after spinal fusion surgery. The study used high-resolution peripheral quantitative computed tomography (HR-pQCT) scans to assess bone quality and identified specific abnormalities linked to postoperative complicat...
A study found that surgeons' expectations were more accurate than patients' expectations in predicting patient-reported outcomes two years after lumbar spine surgery. Surgeons predicted a higher degree of improvement, while patients had higher expectations for complete recovery.
Researchers found lower utilization and higher complication rates among African American patients for unilateral knee replacement, but no significant differences for bilateral knee replacement. The study suggests physicians may offer bilateral procedures less often to African American patients or they may choose not to have the procedure.
Researchers from HSS presented studies on renal disorders, venous thromboembolism after total knee replacement, and pediatric patients with rheumatologic diseases. The surveys also explored perceptions of COVID-19 risk among rheumatologists and the use of clinical disease activity indexes in telemedicine.
Chronic nonbacterial osteomyelitis (CNO) is underdiagnosed and characterized by multiple painful bone swellings. A new study identifies common features among CNO patients, including predominantly female sex, intermittent pain, and symmetric patterns of bone lesions. These findings can help clinicians improve diagnosis and treatment.
Researchers have identified a unique population of CD38hiCD127- CD8 T cells in patients with checkpoint inhibitor-induced arthritis, which are both cytotoxic and proliferating. This discovery could lead to the development of targeted treatments for this side effect.
A study by Hospital for Special Surgery found that children with polyarticular juvenile idiopathic arthritis (JIA) from less affluent families were twice as likely to report over an hour of morning joint stiffness. This may indicate early disease symptoms and the importance of timely referrals for expert diagnosis and treatment.
A new study found that patients with rheumatoid arthritis taking biologic DMARDs have a 17% lower risk of developing dementia compared to those on conventional synthetic DMARDs. The treatment reduces inflammation, which may explain the decreased risk.
A multidisciplinary team of specialists at Hospital for Special Surgery successfully performed microsurgery to repair damaged nerves and restore muscle strength and movement to patients with Parsonage-Turner Syndrome. The surgery allowed 11 out of 24 patients to regain function of their arm.
Researchers at HSS are using magnetic resonance neurography to study Parsonage-Turner Syndrome, a painful nerve disorder that can cause sudden weakness. High-resolution images of peripheral nerves will be obtained to discover biomarkers for detection and monitoring, as well as aid in surgical planning.
The article discusses the importance of peak performance in surgical training, citing the need for perseverance, stoicism, and grit. HSS physicians offer practical advice on achieving peak performance, including growing self-awareness through mindfulness activities and refining physical skills through deliberate practice.
Researchers at Hospital for Special Surgery have discovered a molecule in the lymphatic system that may play a role in autoimmune disease. The study found that this molecule, CCL2, limits antibody responses and can help regulate immune cell function.
Researchers found that patients with rheumatic diseases have a higher proportion of culture-negative prosthetic joint infections, which can make diagnosis challenging. The study highlights the need for better diagnostic tests and management strategies for these patients.
Researchers found that a 'pre-habilitation' program with trained peer coaches could empower and inform patients, leading to better outcomes. The study's results suggest that preparation and expectations for surgery are influenced by patients' prior experience and social support.
The HSS Education Institute develops impactful educational programs using the Community-Based Participatory Research approach, addressing the needs of culturally and geographically diverse patient populations. Evaluation and dissemination of program results are critical to shaping future initiatives.
A new study found that the community's socioeconomic status affects hip replacement surgery discharge destinations. Patients from low-income communities are more likely to be discharged to an inpatient rehabilitation or skilled nursing facility rather than home care. The level of community deprivation has no effect on readmission rates.
A nationwide survey of male patients with lupus found that nearly half reported feeling depressed, while over 80% indicated that lupus limits their daily activities. The study also revealed a high interest in psychosocial support and online platforms for men with lupus.
A large study analyzing 107,000 knee replacement surgeries found significant racial variation in post-operative care. African American patients were more likely to be discharged to an inpatient rehabilitation or skilled nursing facility rather than home care after the procedure.
A new study conducted at Hospital for Special Surgery found that race and poverty are not risk factors for total knee replacement revision or failure. Factors associated with a higher risk of revision included younger age, male sex, and use of constrained prosthesis.
Researchers at Hospital for Special Surgery found that insulin-like growth factor 1 (IGF1) plays a crucial role in tendon growth and adaptation. The study suggests targeting IGF1 may be useful in treating painful tendon injuries, and clinical trials are underway to test this approach.
Pregnancy outcomes for lupus patients have dramatically improved, with a decline in maternal and fetal mortality rates over the past two decades. The study found that more women with lupus are attempting pregnancy and delivering successfully, with minimal risk of complications.
Researchers identified Roseburia intestinalis as a gut bacterium triggering antiphospholipid antibodies in patients with antiphospholipid syndrome. The study suggests that eliminating this bacterium may help decrease antibody levels and open doors for future treatment options.
Researchers have identified 18 unique cell populations in RA joint tissue, including a fibroblast subset that produces pro-inflammatory cytokine interleukin-6. COX inhibitors like NSAIDs also alter these macrophages, but not TNF responses, suggesting new treatment approaches may be needed.
Patients with insulin-dependent diabetes are more than five times as likely to experience post-operative hyperglycemia compared to those without the condition. The risk is linked to higher blood glucose levels over the previous three months, regardless of insulin dependency.
A recent study at Hospital for Special Surgery found that multi-level anterior cervical discectomy and fusion (ACDF) can be safely performed in an outpatient setting without increased risk of complications. The study compared outcomes between 57 outpatient and 46 inpatient patients, with results showing shorter operative times and hosp...
Dr. Parks, clinical director of Orthopedic Surgery at Hospital for Special Surgery, received the 2019 Diversity Award from the American Academy of Orthopaedic Surgeons. He has led research projects on socioeconomic and racial disparities in arthritis care and total joint replacement surgery.