Articles tagged with Obesity
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Researchers discovered novel regulatory molecules in adipogenesis, specifically membrane receptors like GPCRs. ADGRD1 promotes differentiation of adipose progenitor cells while GPR39 inhibits this process.
A study found that intestinal bacterium Bacteroides vulgatus and its metabolite pantothenic acid regulate sugar preference by activating the GLP-1-FGF21 hormone axis, providing a promising strategy for diabetes prevention.
A new Cochrane review found that calorie labelling in supermarkets, restaurants, and other food outlets leads to a small reduction in the calories people select and purchase. The average reduction was 1.8%, equating to around two almonds per 600-calorie meal.
Researchers discover immune cells regulate blood sugar levels by stimulating glucagon production in the pancreas. This complex neuroimmune-hormonal circuit reveals a new way the body maintains stable glucose levels, especially during periods of low energy.
A new study by Mass General Brigham investigators found that Black people were less likely than non-Black people to undergo metabolic and bariatric surgery, even though both groups were equally likely to discuss it with health care providers. Men were also less likely to discuss and receive MBS than women.
A team of food scientists is developing tempeh products from chickpeas and peas to offset the health risks of a Western diet. The new fermented foods may help with obesity, fatty liver, hyperlipidemia, and diabetes. Preliminary research suggests they are high in fiber and low in fat.
Researchers at the University of Bristol found no increase in cortisol release after waking, contrary to long-held assumptions. The study's findings suggest that daily cortisol rhythms may play a more significant role in regulating stress responses.
A new study reveals that college students and older adults gain weight during the holiday season, but in different ways. College students add muscle mass, while older adults gain fat. This finding highlights the importance of understanding weight and health across major life stages.
A new mechanism by which brown fat is converted into heat has been identified, revealing a potential target for treating obesity and related metabolic diseases. The MCJ protein plays a crucial role in this process, protecting against health problems associated with obesity such as diabetes and increased blood lipids.
Additional research is required to explore the relationship between COPD and metabolic syndrome, focusing on outcomes, intervention trials, and health services research. This will help shift from a COPD-focused approach to an integrated care approach considering all comorbidities.
Researchers analyzed cost-effectiveness of semaglutide for non-diabetic overweight/obese individuals with heart disease. With price reductions, semaglutide shows promise in reducing lifetime costs and improving health outcomes.
Researchers found that brown adipose tissue enhances exercise endurance and supports healthy aging by improving blood circulation and reducing cellular stress. The study suggests that treatments mimicking BAT's benefits could lead to innovative therapies for improved energy levels and heart health.
A 12-week study found that intermittent fasting, especially time-restricted eating, leads to greater weight loss and reduced abdominal subcutaneous fat compared to a nutrition education programme. This study suggests that this strategy can be an effective method for improving cardiovascular health in people with obesity problems.
A large international study of GLP1-RA users and dipeptidyl peptidase-4 inhibitors (DPP-4i) found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer. The study, published in the Thyroid journal, analyzed data from 92,497 GLP1-RA users and 2,484,408 DPP-4i users.
Researchers from Kumamoto University identified SerpinA1 as a key regulator in combating obesity and enhancing glucose metabolism. The study found that activating brown adipose tissue could pave the way for innovative treatments for diabetes and metabolic disorders.
A systematic review of randomized controlled trials found GLP-1 RAs and co-agonists to be effective for weight loss in adults with obesity, including promising options not yet FDA-approved. The study also showed similar safety profiles across agents, with mild gastrointestinal side effects being the most common.
A recent survey found that nearly half of U.S. adults plan to start a new diet in 2025, with the most common diets being low-calorie and low-carbohydrate options. However, plant-based diets have been shown to be effective for weight loss without restricting or counting calories, and also reduce the risk of obesity-related diseases.
Engaging in 30 minutes of aerobic exercise per week modestly reduces body weight, waist circumference, and body fat measures. Aerobic training exceeding 150 minutes per week may be needed for clinically important reductions.
The European Society of Endocrinology (ESE) and ESE Foundation will host the first-ever World Hormone Day on April 24, 2025. The campaign aims to raise public awareness of good hormone health and improve national political engagement for better prevention, diagnosis, and treatment of endocrine disease.
Researchers developed a non-invasive way to assess fat composition around the heart using magnetic resonance imaging. This technique may help doctors identify patients at greatest risk for cardiac problems and predict treatment outcomes.
A recent study discovered that assessing an individual's perceived walking speed relative to peers can identify those at risk of metabolic diseases. Faster walkers had lower risks of diabetes, hypertension, and dyslipidemia.
A new study found significant disparities in the use of obesity-management medications among different racial and ethnic groups. People of Asian, Black, and Hispanic descent were significantly less likely to use these medications compared to whites, even after adjusting for income, education, health insurance coverage, and clinical need.
A recent study published in the Journal of Nutrition Education and Behavior reveals a significant influence of home food environments on adolescent dietary patterns. Home food availability, particularly fruits and vegetables, promotes healthier eating habits, while neighborhood fast-food options negatively affect dietary quality.
A study published in PLOS Biology found that individuals with and without obesity prefer high-calorie foods, regardless of their taste or texture. The researchers used a large group of healthy volunteers to compare food preferences among three groups: individuals with obesity, post-bariatric surgery patients, and non-obese controls.
Researchers at Université de Montréal's CRCHUM discovered that inhibiting a key brain enzyme can reduce body weight and improve physical activity in mice. The study suggests that targeting specific neuronal pathways in the brain could be crucial for fighting obesity and metabolic disorders.
Adult obesity trends in the US have declined for the first time in more than a decade, according to recent data. The South region experienced the largest decreases in body mass index and obesity prevalence, despite also facing high COVID-19 mortality rates among obese individuals.
A new study finds that a blood test using phosphatidylethanol (PEth) can detect liver disease caused by excessive drinking, offering a more reliable alternative to self-reported measures. The test has shown strong correlation with Fibrosis 4, an indicator of liver risk, and could be included in routine blood tests.
Researchers will build a wireless bioelectronic device, named BIOSYNC, to regulate appetite through physiological satiety pathways. The device aims to produce two peptide therapeutics simultaneously with reduced side effects and better adherence to therapy.
Consuming 20-30% of daily energy at breakfast is associated with lower body mass index, smaller waist circumference, significantly lower triglyceride levels, and higher HDL cholesterol. A high-quality breakfast with proper balance of proteins, fats, fiber, and nutrients also contributes to reducing cardiovascular risk factors.
A new study published in the journal Nutres found that adopting a healthy diet can reduce the severity of chronic pain, regardless of body weight. The research, conducted by the University of South Australia, explored associations between body fat, diet, and pain and found that higher consumption of core foods was directly associated w...
The novel compound HPH-15 outperforms metformin by activating AMPK at lower doses, improving glucose uptake and reducing fat accumulation in high-fat diet-induced obese mice. Additionally, it exhibits antifibrotic properties, potentially addressing liver fibrosis.
A cross-sectional study found substantial projected annual savings from weight loss among U.S. adults with obesity, particularly for Medicare and employer-based insurance. The estimated reduction in healthcare spending is substantial, offering a potential benefit for individuals with obesity.
A new study proves a suspected link between poor sleep and MASLD, a liver disorder that affects 30% of adults. Patients with MASLD experience significant sleep fragmentation, waking up 55% more often at night.
A study published at the Radiological Society of North America annual meeting found that ultra-processed food intake is associated with higher amounts of intramuscular fat in thigh muscles. This increase in fat can lead to knee osteoarthritis, a condition affecting millions worldwide.
A new type of gastric balloon has been designed to help people lose weight by making them feel too full to overeat. The balloon can be inflated and deflated as needed, and animal studies have shown that it can reduce food intake by 60 percent before meals.
Researchers found that only programs promoting physical activity or eating more fruit and vegetables showed promise, while others had little effect. Tailored, multi-level and innovative approaches are required to enact positive change among truck drivers.
Researchers have discovered a specific type of body fat linked to abnormal proteins in the brain that are hallmarks of Alzheimer's disease. Higher levels of visceral fat were found to be associated with increased amyloid accumulation and higher PET levels of hallmark pathologic proteins.
A U-shaped association between waist circumference and all-cause mortality was found in women, while a J-shaped trend was observed in men with type 2 diabetes. The study suggests that optimal waist circumference thresholds for minimizing mortality risk are 107 cm for women and 89 cm for men.
Researchers identify caveolae's role in protecting adipocytes from rupture and inflammation; this discovery opens new avenues for treating metabolic diseases like obesity. The study highlights the importance of the caveolin-1 protein in maintaining cellular integrity.
The review explores the pathophysiological relationship between OSA and MetS, revealing a complex cycle of increased cardiovascular risks. Treatment options, including CPAP, weight management, and metabolic surgery, are discussed for improving patient outcomes.
A study of 49 million patients in England found that routine screening for cardiometabolic conditions like obesity and high blood pressure dropped sharply during the pandemic. Blood pressure measurements remained lower than pre-pandemic levels as of March 2024, particularly among lower socioeconomic groups.
A cohort study found that nearly half of participants who consumed alcohol at baseline decreased their alcohol use after initiating anti-obesity medication treatment. The medications, such as naltrexone and glucagon-like peptide-1 receptor agonists (GLP-1 RAs), may have properties that lead to reduced cravings for alcohol.
A new study led by Weill Cornell Medicine found that tirzepatide reduced the risk of diabetes in obese and prediabetic patients by more than 90% after 176 weeks. The treatment also showed significant weight loss and improved blood sugar control.
Researchers discovered a new component of the peripheral nervous system that acts by increasing energy metabolism in the body. This finding paves the way for simpler and cheaper drugs to control obesity and weight gain.
Researchers found that GLP-1 receptor agonists reduced the risk of kidney failure by 16% and worsening of kidney function by 22%. The combined reduction in risk was 19%, showing a clear benefit on kidney protection. This study expands current knowledge about this class of drugs, highlighting their role in treating patients with chronic...
A new study from Northwestern Medicine reveals a significant increase in severe maternal morbidity and birth complications in Illinois between 2016 and 2023. The findings highlight the impact of chronic health conditions such as obesity, hypertension, and mental health disorders on pregnancy outcomes.
A study of U.S. adults on anti-obesity medications found that 25% reported wasting more food since taking the drugs, while changes in diet and eating habits appeared to offset some of this waste, particularly among those who consumed more vegetables.
Christian Wolfrum will serve as NTU's chief academic officer, overseeing educational and research excellence, while strengthening talent development. He brings experience in translating research into real-world applications, having co-founded biotechnology firm Glycemicon AG.
A recent study published in the SUMMIT trial found that tirzepatide significantly reduced deaths and worsening heart failure in patients with diastolic heart failure and obesity. The drug also led to substantial weight loss and improvements in overall health and quality of life.
The study aims to confirm initial findings suggesting that increased step counts correlate with improved health indicators, such as reduced body fat and lower insulin levels. By establishing a model, the team hopes to provide healthcare professionals with a tool to recommend tailored walking goals for their patients.
A recent study published in Nutrition & Diabetes found that consuming over 45% of daily calorie intake after 5 p.m. is associated with increased glucose levels, regardless of individual weight or body fat composition. This can lead to a higher risk of type 2 diabetes, cardiovascular disease, and chronic inflammation.
A study published in PLOS ONE found that adults diagnosed with type 2 diabetes at a younger age are more likely to develop dementia. The researchers analyzed data from over 1,200 U.S. adults and found a graded association between age at diagnosis and dementia risk.
Researchers found that alcohol-related deaths in the US surged dramatically between 1999 and 2020, with a nearly fourfold increase in those aged 25-34. The study highlights significant gender differences and regional disparities, emphasizing the need for targeted interventions to combat the growing US alcohol mortality epidemic.
A study by ETH Zurich researchers has found that epigenetic markers in fat cells can lead to the yo-yo effect, where weight drops but returns. The researchers also found evidence of this mechanism in humans, suggesting that obesity can leave a lasting mark on gene expression.
Researchers from Universidad Miguel Hernandez de Elche found that bisphenol analogs BPF and BPS, marketed as safer alternatives to BPA, accumulate in biological membranes and disrupt endocrine function. The study suggests these compounds pose health risks similar to those of BPA.
Researchers studied heart failure patients in zero gravity to assess the impact on left ventricular filling pressures. They found that external constraint affects cardiac hemodynamics, leading to changes in blood pressure and potential new treatment avenues for heart failure management.
A new study reveals that an AI algorithm can accurately detect early-stage metabolic-associated steatotic liver disease (MASLD) in patients who meet the criteria, leaving 83% undiagnosed. This highlights the need for improved screening and diagnosis methods to prevent progression to advanced liver disease.
The international SUMMIT trial found tirzepatide lowered the risk of worsening heart failure events and cardiovascular death in obese adults with preserved ejection fraction. Participants experienced improved health status, physical function, and exercise tolerance compared to placebo.
New research links ancient Jomon hunter-gatherer genetic signature to higher body mass index (BMI) among individuals in modern Japan. The study found strong support for the tripartite ancestry model, suggesting a significant influence of Jomon ancestry on BMI across populations.
Researchers at Anglia Ruskin University are investigating the complex relationship between fat tissue and colorectal cancer. The study aims to enhance knowledge of the tumour microenvironment, uncover new molecules crucial for cancer growth, and develop more effective treatments.