A new microscopy technique allows scientists to observe active cells, even in the presence of diseases, and understand how drugs interact with living tissues. The technique has been made available to the scientific community as Open Science, enabling rapid dissemination and further innovation.
A team of scientists from the University of Konstanz has identified the PPM1F enzyme as essential for cell migration in both embryonic development and tumor cell invasion. The study found that increased levels of PPM1F enhance the invasive potential of cancer cells, while its absence impairs cell adhesion and migration.
A new study by Boston University School of Public Health and Harvard T.H. Chan School of Public Health found that energy-efficient strategies can have a significant impact on public health in the European Union. The research reveals dramatic differences in health burdens from electricity use based on the source of energy used, with cou...
A new study finds that risk-reducing mastectomy is cost-effective for women aged 30-55 with a lifetime breast cancer risk of 35% or higher. The findings have significant clinical implications, suggesting that RRM could expand access to the procedure beyond BRCA1/BRCA2/PALB2 pathogenic variant carriers.
A new analysis suggests that preventive mastectomy is a cost-effective way to reduce the likelihood of developing breast cancer compared to breast screening and medication. Women aged 30 or above with a lifetime breast cancer risk of 35% or more may benefit from this treatment option.
Bonn researchers reduce cardiac arrhythmia after heart attacks by using gene therapy to overexpress connexin 43 in fibroblasts of cardiac scar tissue, leading to improved electrical connection between cells and reduced arrhythmias.
Complex organic molecules, precursors to life's building blocks, have been found in a planet-forming disc around the outbursting protostar V883 Orionis. This discovery supports the idea that life's seeds are assembled in space and are widespread.
Researchers have created a new catalyst with an asymmetric single-atom site that dramatically enhances oxygen reduction reaction efficiency. The unique honeycomb-like structure exposes more active sites, improving mass transport and performance.
A study published in the Journal of the American College of Surgeons found that older adults with serious illness before undergoing elective surgery had significantly longer hospital stays, higher rates of readmissions, and almost double the yearly costs of healthcare compared to their counterparts. Depression was found to be a signifi...
Researchers from Northwestern University developed a novel approach to integrate metal-sulfur active sites into metal-organic frameworks, which significantly outperformed their non-sulfur counterparts in hydrogenation catalysis. The study provides a powerful new strategy to design and study metal-sulfur catalysts for various applications.
A new study by the University of Surrey investigates how our brains process face pareidolia and averted gazes, revealing differing mechanisms that influence attention. The researchers found that participants shifted their attention in response to both real faces and imagined face-like objects.
EPFL researchers have developed a 'self-driving' imaging system that can track and analyze protein aggregation in real-time and even anticipate its onset. The approach minimizes the use of fluorescent labels, allowing for accurate analysis. The new technology has important implications for drug discovery and precision medicine.
Researchers discovered complex structures in millipede secretions that can modulate specific neuroreceptors in ant brains, shedding light on potential new medications. The newly found alkaloids, named andrognathanols and andrognathines, have shown potent interactions with the Sigma-1 neuroreceptor.
A new analysis finds that delinking PBM compensation from list prices could lower US annual drug spending by nearly $100 billion. Shifting to a transparent payment model would reduce costs without undermining pharmaceutical innovation, according to USC Schaeffer Center Director Geoffrey Joyce.
A recent study found that a 5 mg dose of olanzapine taken after chemotherapy significantly reduced nausea and vomiting in breast cancer patients, with fewer side effects compared to the standard 10 mg dose. The low-dose regimen was effective for both immediate and delayed symptoms, making it an attractive alternative for patients.
A new method harnessing CYGNSS significantly improves soil moisture retrieval by eliminating vegetation interference and removing dependency on external datasets. The technique enables standalone, high-frequency monitoring of soil moisture, offering a transformative tool for climate research, agriculture, and disaster management.
A novel deep learning approach estimates TOA shortwave radiation using DSCOVR/EPIC satellite images, overcoming traditional challenges and improving accuracy. The method is validated against established CERES data products with a high correlation rate.
A recent study by Florida Atlantic University reveals that up to 40% of hospital transfers from nursing homes can be avoided. The study identified common medical conditions linked to unnecessary hospitalizations, including feeding tube complications and urinary tract infections.
The study found that most plastic bottles and caps on Pacific coast beaches in Central America originated from local companies, while Asian origin bottles were more common on island coasts. The research sampled over 12,000 kilometers of coastline and collected over 92 mainland beaches, 15 island beaches, and 38 human settlements.
Researchers developed an AI platform to design proteins that arm immune cells to attack and kill cancer cells. The method reduces the process from years to just 4-6 weeks, offering a new approach to precision cancer treatment.
Researchers developed a novel deep learning-based framework that improves five-day regional weather forecasting accuracy, even with limited data. The method achieved significant improvements in temperature, precipitation, and wind speed forecasts, outperforming mainstream global AI models.
The H-SUP system offers a portable fuel cell electric generator with greater energy per weight than batteries and lower audible and thermal signatures. The system supports distributed operations, extends mission range, and increases lethality of the force.
Researchers found that ibogaine significantly improves cognitive function and reduces PTSD symptoms in veterans with TBI. The study suggests that stronger theta rhythms may promote neuroplasticity, while reduced cortical activity may alleviate PTSD symptoms.
A study by Kaunas University of Technology reveals that digital mental health platform start-ups prioritize simple, scalable services and use subscription models to achieve success. State funding can hinder development rather than encouraging it to become a unicorn.
A wearable technology enables precise drug dosing through continuous monitoring of disease and drug markers, solving the problems of invasive and painful current technologies. The system combines microneedles, nano-enzyme-based sensors, and a smartphone app to provide real-time pharmacologically guided diabetes treatment.
A recent study published in The EMBO Journal reveals that the Setd8 gene plays a critical role in the premature aging of the brain by controlling neural stem cell activity and proliferation. Artificially lowering Setd8 levels mimicked molecular signatures of aging, highlighting its potential as a biomarker for early aging.
An international team of coral scientists calls for urgent regulatory reform to support assisted gene flow, a powerful tool to boost coral resilience. The researchers outline reforms needed to enable cross-border coral exchanges to introduce new genetic diversity and preserve coral diversity.
A nationwide study in Ukraine found substantial lifetime exposure to hepatitis B and C viruses, with significant ongoing circulation among the population. The study emphasizes the need for hepatitis B vaccination among infants and risk groups, as well as regular screening, treatment, and awareness-raising efforts.
Two research teams will use AI to advance screening and treatment for cardiovascular disease, a leading cause of death in the US. The projects aim to improve health outcomes and save lives by detecting early signs of kidney and liver disease, as well as personalizing CPR techniques.
Researchers at Fralin Biomedical Research Institute have identified a potential target for experimental drugs that block PRMT5, a naturally occurring enzyme some tumors rely on for survival. The study found a new drug combination that works against certain hard-to-treat cancers.
A plant virus, cowpea mosaic virus (CPMV), has shown promise as a low-cost and potent cancer immunotherapy. CPMV stimulates type I, II, and III interferons, which have well-known anti-cancer properties, and activates toll-like receptor 7 to prime antiviral and anti-tumor immune responses.
Researchers found that standard DNA testing does not detect NUT carcinoma fusion genes in over 75% of patients. Additional tests like NUT immunohistochemistry and RNA fusion testing can reliably identify gene fusions, leading to more accurate diagnoses and potentially life-saving treatments.
Worcester Polytechnic Institute has received a National Science Foundation grant to study an electrochemical system for removing insoluble mineral deposits in water treatment. The goal is to develop a lower-cost, environmentally friendly system that can selectively remove scale-forming cations and prevent the buildup of harmful minerals.
The Obesity Society has appointed a new CEO, Sherlyn Celone-Arnold, and several key experts to its leadership team, enhancing its commitment to addressing obesity through innovative strategies and expert guidance.
Researchers developed a new defense strategy, LSH-FL, to protect federated learning from poisoning attacks in healthcare, autonomous vehicles, and finance. The approach maintains accuracy losses below 1% using short-term perturbations and long-term gradient history, ensuring secure and private decentralized AI.
A team of researchers has discovered that ancient nectocaridids, thought to be cephalopods, are actually an early descendant of arrow worms. This finding reveals complex predators in the food chain and sheds light on the evolution of these creatures.
Two studies found that industrial fishing is rare in fully and highly protected marine areas, averaging just one vessel per 20,000 square kilometers. However, nearly half of the world's coastal MPAs showed evidence of industrial fishing, with factors like MPA size and remoteness more predictive of fishing presence than official protect...
A research team has experimentally demonstrated a nonlinear wave phenomenon that changes its frequency depending on the direction of incoming waves. The system exhibits different responses to waves entering from one side versus the other, with potential applications in medical ultrasound imaging and noise control.
A recent study published in Brain reveals that a mathematical model can classify genes into four categories based on their interaction with the brain's network patterns. This classification helps explain why some brain regions deteriorate rapidly while others remain intact, providing new insights into Alzheimer's disease.
Chronic cellular senescence disrupts tissue homeostasis, creating a self-propagating
Researchers found that ChatGPT-4 performed better across demographic groups, while LLaVA showed significant sex-related biases in diagnosing skin diseases from medical images. The study emphasizes the need to address these biases to ensure AI models are safe and effective for all patients.
Researchers at National Institutes for Quantum Science and Technology developed a technique to decompose polytetrafluoroethylene (PTFE) into gaseous products using electron beam irradiation. This process reduces energy required by 50% compared to traditional methods, making large-scale recycling of fluoropolymers more viable.
The study reveals significant differences in transition duration, location, and mechanism among four clusters of ETCs. Recurving ETCs undergo transition during track recurvature, while westward ETCs transform rapidly after landing. Northwestward ETCs typically undergo transition in the baroclinic zone, and abnormal track ETCs complete ...
A new study reveals that fully and highly protected marine reserves successfully curb industrial fishing activity, offering a powerful new way to assess fishing compliance. The research combines satellite imagery and AI technology to detect previously untraceable vessels, finding that most MPAs are well-respected and effective in deter...
A study published in iScience found that cells in breast tissues of women with African ancestry send cues promoting breast cancer growth. Researchers discovered that PZP cells activate epithelial cells, allowing them to invade surrounding tissue.
VCU Massey Comprehensive Cancer Center is the first US site to enroll patients in a global Phase 2a clinical trial of PTX-100, a small molecule inhibitor for cutaneous T-cell lymphoma. The trial aims to evaluate the efficacy and safety of PTX-100 in patients with relapsed or refractory disease.
A new study uses deep learning to map microscopic structures and simulate mass transport in CO₂RR catalyst layers, providing a scalable blueprint for industrial CO₂ electrolyzers. By optimizing catalyst layer composition, high current densities can be sustained without sacrificing selectivity or durability.
A recent study by JAMA Network Open reveals racial differences in care quality among men with newly diagnosed prostate cancer. Black men had lower odds of overtreatment, suggesting better care, while having lower odds of confirmatory testing on active surveillance, indicating worse care.
Researchers have identified two brain waves, alpha and delta waves, as key markers for obsessive-compulsive disorder (OCD). These findings could lead to more targeted deep brain stimulation treatments, improving outcomes for patients. The discovery provides a significant breakthrough in understanding OCD and its neural mechanisms.
A new study has identified genetic changes in the parasite responsible for trichomoniasis that may have helped it adapt to human hosts. The research found dozens of genes associated with key functions such as phagocytosis and exosomes, which could be exploited for future treatments.
Researchers discovered antibiotic-resistant Staphylococcus saprophyticus in the Southern Ocean, showing complete resistance to multiple antibiotics. The study highlights the need for greater awareness of human impact on pristine ecosystems like Antarctica, which may exacerbate public health issues through the food chain.
Researchers found that billing codes may mistakenly identify diseases in up to 45% of cases, highlighting a significant limitation in using administrative data for clinical research. The study examined records of 1.36 million patients and found discrepancies between coded diagnoses and actual disease presence.
A new study has found that TAF1 operates as a key molecular switch in adult hematopoietic stem cell maintenance and lineage commitment. This discovery challenges prevailing models of gene regulation and has the potential to lead to new therapeutic strategies targeting the molecule, which could improve blood production and transplantation.
Answer ALS is launching a groundbreaking collaboration with Tulane University and the Pennington Biomedical Research Center to harness AI for ALS treatment discovery. The Louisiana AI Drug Development Infrastructure for ALS (LADDIA) will prioritize therapeutic targets using AI-driven insights from the Answer ALS' Neuromine Data Portal.
The Josep Carreras Leukaemia Research Institute is launching a joint research programme on childhood leukaemia, aiming to develop common strategies and improve treatments for the disease. Paediatric leukaemia remains a significant challenge due to its low incidence and high mortality rate.
Physicists developed a method to control atomically thin semiconductors using terahertz light pulses, enabling ultrafast signal control devices. The technique allows real-time control of electronic structure on timescales of less than a picosecond.
Colorectal cancer claims more lives in Black communities than any other racial group, with incidence and mortality rates about 20% and 30% higher respectively. A new review by UCLA researchers highlights the need for equal access to screening, diagnosis, and treatment to eliminate these disparities.
Recent advances in chemistry have led to innovations in industrial carbon capture technologies, reducing energy consumption by over 30% and improving efficiency. The research highlights novel amine blends, metal-organic frameworks, and electroswing technologies that can selectively capture CO2 with high efficiency.
Scientists discovered that marine copepods rely on both genetic and epigenetic changes to survive climate change. Epigenetic changes, which are temporary chemical modifications, play a crucial role in helping these tiny crustaceans adapt to ocean acidification and warming conditions.
Researchers have discovered star-shredding black holes in dusty galaxies, confirming that these events are powered by dormant black hole accretion. The study uses the James Webb Space Telescope to detect clear fingerprints of black hole activity in four galaxies, revealing key differences between active and dormant black holes.