About The Study: In this multiple-events case-control study, long-term obesity was associated with the expression of biochemical aging markers in adults ages 28 to 31, consistent with epigenetic alterations, telomere attrition, chronic inflammation, impaired nutrient sensing, mitochondrial stress, and compromised intercellular communication. In young adults, chronic health issues may emerge from accelerated biological aging associated with long-term obesity.
Corresponding Authors: To contact the corresponding authors, email Paulina Correa-Burrows, PhD, ( paulina.correa@inta.uchile.cl ) and Christian Gonzalez-Billault, PhD, ( chrgonza@uchile.cl ).
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(doi:10.1001/jamanetworkopen.2025.20011)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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